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Comparing the force due to the Lennard-Jones potential and the Coulomb force in the SPH Method

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Journal of Ocean Engineering and Science 2018年第4期3卷 310-315页

作者： D.A.Barbosa F.P.piccoli Octopus Dofleini:Environmental Physics/Laboratory of Simulation of Flows with Free Surface-Federal University of Espírito Santo Brazil Laboratory of Simulation of Flows with Free Surface-Federal University of Espírito Santo Brazil

Seventy years after the Smoothed Particle Hydrodynamics(SPH)method was created,there was the need to use the solid limit to keep the domain particles of a certain *** boundary’s treatment is usually done with the use of force derived from potential *** our paper,a new boundary treatment technique is ***,we use the Coulomb force to exert a repulsive force on the border to avoid outgoing particles leaving the simulation *** test this new technique,the problem of dam break and sloshing was simulated.©2018 Shanghai Jiaotong *** by Elsevier B.V.

关键词： Repulsive force SPH Coulomb Force Lennard-Jones.

Autoimmmune hepatitis

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Cellular & Molecular Immunology 2022年第2期19卷 158-176页

作者： Benedetta Terziroli Beretta-piccoli Giorgina Mieli-Vergani Diego Vergani Epatocentro Ticino&Facoltàdi Scienze Biomediche Universitàdella Svizzera ItalianaLuganoSwitzerland Institute for Research in Biomedicine BellinzonaSwitzerland. King’s College London Faculty of Life Sciences&Medicine at King’s College Hospital LondonUK. Paediatric Liver GI and Nutrition CentreMowatLabsKing’s College HospitalLondonUK. Institute of Liver Studies MowatLabsKing’s College HospitalLondonUK.

Autoimmune hepatitis(AIH)is a T-cell mediated,inflammatory liver disease affecting all ages and characterized by female preponderance,elevated serum transaminase and immunoglobulin G levels,positive circulating autoantibodies,and presence of interface hepatitis at liver *** type 1,affecting both adults and children,is defined by positive anti-nuclear and/or antismooth muscle antibodies,while type 2 AIH,affecting mostly children,is defined by positive anti-liver-kidney microsomal type 1 and/or anti-liver cytosol type 1 *** the autoantigens of type 2 AIH are well defined,being the cytochrome P4502D6(CYP2D6)and the formiminotransferase cyclodeaminase(FTCD),in type 1 AIH they remain to be ***-1 predisposition is conferred by possession of the MHC class II HLA DRB1*03 at all ages,while DRB1*04 predisposes to late onset disease;AIH-2 is associated with possession of DRB1*07 and DRB1**** majority of patients responds well to standard immunosuppressive treatment,based on steroid and azathioprine;second-and third-line drugs should be considered in case of intolerance or insufficient *** review offers a comprehensive overview of pathophysiological and clinical aspects of AIH.

关键词： Autoimmune Hepatitis Immunopathophysiology Treatment Genetic Predisposition

Laparoscopic fundoplication for gastroesophageal reflux disease

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World Journal of Gastroenterology 2014年第39期20卷 14272-14279页

作者： Marzio Frazzoni Micaela piccoli Rita Conigliaro Leonardo Frazzoni Gianluigi Melotti Digestive Pathophysiology Unit Baggiovara Hospital 41100 Modena Italy Digestive Endoscopy Unit Baggiovara Hospital 41100 Modena Italy Department of General Surgery Baggiovara Hospital 41100 Modena Italy

Gastroesophageal reflux disease (GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor (PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen fundoplication, consisting of a total (360°) wrap, is the most commonly performed antireflux operation. To reduce postoperative dysphagia and gas bloating, partial fundoplications are also used, including the posterior (Toupet) fundoplication, and the anterior (Dor) fundoplication. Currently, there is consensus to advise laparoscopic fundoplication in PPI-responsive GERD only for those patients who develop untoward side-effects or complications from PPI therapy. PPI resistance is the real challenge in GERD. There is consensus that carefully selected GERD patients refractory to PPI therapy are eligible for laparoscopic fundoplication, provided that objective evidence of reflux as the cause of ongoing symptoms has been obtained. For this purpose, impedance-pH monitoring is regarded as the diagnostic gold standard.

关键词： Gastroesophageal reflux disease Refractory gastroesophageal reflux disease Laparoscopic fundoplication Impedance-pH monitoring Proton pump inhibitors

Autoimmune hepatitis: standard treatment and systematic review of alternative treatments

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World Journal of Gastroenterology 2017年第33期23卷 6030-6048页

作者： Benedetta Terziroli Beretta-piccoli Giorgina Mieli-Vergani Diego Vergani Epatocentro Ticino Paediatric Liver GI and Nutrition CentreMowat LabsKing’s College Hospital Institute of Liver Studies Mowat LabsKing’s College Hospital

Autoimmune hepatitis is a rare chronic inflammatory liver disease,affecting all ages,characterised by elevated transaminase and immunoglobulin G levels,positive autoantibodies,interface hepatitis at liver histology and good response to immunosuppressive treatment. If untreated,it has a poor prognosis. The aim of this review is to summarize the evidence for standard treatment and to provide a systematic review on alternative treatments for adults and children. Standard treatment is based on steroids and azathioprine,and leads to disease remission in 80%-90% of patients. Alternative first line treatment has been attempted with budesonide or cyclosporine,but their superiority compared to standard treatment remains to be demonstrated. Second-line treatments are needed for patients not responding or intolerant to standard treatment. No randomized controlled trials have been performed for second-line options. Mycophenolate mofetil is the most widely used second-line drug,and has good efficacy particularly for patients intolerant to azathioprine,but has the major disadvantage of being teratogenic. Only few and heterogeneous data on cyclosporine,tacrolimus,everolimus and sirolimus are available. More recently,experience with the anti-tumour necrosis factoralpha infliximab and the anti-CD20 rituximab has been published,with ambivalent results; these agents may have severe side-effects and their use should be restricted to specialized centres. Clinical trials with new therapeutic options are ongoing.

关键词： Autoimmune hepatitis Standard treatment Second-line treatment Adults Children

Hepatitis C virus,mitochondria and auto/mitophagy:Exploiting a host defense mechanism

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World Journal of Gastroenterology 2014年第10期20卷 2624-2633页

作者： Vitalba Ruggieri Carmela Mazzoccoli Valerio Pazienza Angelo Andriulli Nazzareno Capitanio Claudia piccoli Laboratory of Preclinical and Translational Research IRCCS Referral Cancer Center of Basilicata 85028 Rionero in Vulture (PZ) Italy Gastroenterology Unit IRCCS "Casa Sollievo della Sofferenza" Hospital 71013 Foggia Italy Department of Medical and Experimental Medicine University of Foggia 71122 Foggia Italy

Hepatitis C virus(HCV)is the major reason for liver transplantation and the main cause of liver-related morbidity and mortality in a great number of *** for the other viruses,this pathogen interferes in more than one process and in more than one way with host cell biology.A mounting body of evidence points,in particular,toward the drastic alterations of mitochondrial physiology and functions that virus is able to induce,albeit the mechanisms have partly remained *** of the mitochondria in immunity and in quality control systems,as autophagy,as well as the strategies that HCV has evolved to evade and even to manipulate mitochondrial surveillance for its benefit,highlights the importance of deepening the mechanisms that modulate this virus-mitochondrion interaction,not only to intensify our knowledge of the HCV infection pathogenesis but also to design efficient antiviral strategies.

关键词： Hepatitis C virus Mitochondrial dysfunctions Immunity Autophagy Mitophagy

Single‐pixel terahertz imaging:a review

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Opto-Electronic Advances 2020年第9期3卷 15-29页

作者： Luca Zanotto Riccardo piccoli Junliang Dong Roberto Morandotti Luca Razzari Institut National de la Recherche Scientifique(INRS) CentreÉnergieMatériaux et Télécommunications(EMT)VarennesQC J3X 1S2Canada Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China

This paper is devoted to reviewing the results achieved so far in the application of the single-pixel imaging technique to terahertz(THz)*** use of THz radiation for imaging purposes has been largely explored in the last twenty years,due to the unique capabilities of this kind of radiation in interrogating material ***,THz imaging systems are still limited by the long acquisition time required to reconstruct the object image and significant efforts have been recently directed to overcome this *** of the most promising approaches in this sense is the so-called“single-pixel”imaging,which in general enables image reconstruction by patterning the beam probing the object and measuring the total transmission(or reflection)with a single-pixel detector(i.e.,with no spatial resolution).The main advantages of such technique are that i)no bulky moving parts are required to raster-scan the object and ii)compressed sensing(CS)algorithms,which allow an appropriate reconstruction of the image with an incomplete set of measurements,can be successfully ***,this can result in a reduction of the acquisition *** this review,we cover the experimental solutions proposed to implement such imaging technique at THz frequencies,as well as some practical uses for typical THz applications.

关键词： terahertz imaging single-pixel imaging compressed sensing

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使用合成类固醇激素的健美运动员左心室形态和机能的超声心动图研究

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体育与科学 1992年第4期 36+22-36+22页

作者： D.B.piccoli ,姜文凯

1 材料和方法14名健美运动员,年龄19—35岁,第1次自己使用药物(下称用药组)大约2个月左右(8±3周),其中9名分别参加了用药期及停药数月后(9±2周)的2次检查,在此期间,完成通常的训练计划。用

关键词：超声心动图超声波诊断左心室左心室舒张功能机能健美运动员体育工作者 LVM 室间隔室中隔骨骼肌用药期增厚

Generation of quantum-certified random numbers using on-chip path-entangled single photons from an LED

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Photonics Research 2023年第9期11卷 1484-1499页

作者： NICOLÒ LEONE STEFANO AZZINI SONIA MAZZUCCHI VALTER MORETTI MATTEO SANNA MASSIMO BORGHI GIOELE piccoli MARTINO BERNARD MHER GHULINYAN LORENZO PAVESI Department of Physics University of Trento38122 TrentoItaly Department of Mathematics and TIFPA University of Trento38122 TrentoItaly Department of Physics University of Pavia27100 PaviaItaly Centre for Sensors and Devices Fondazione Bruno Kessler38123 PovoItaly

Single-photon entanglement is a peculiar type of entanglement in which two or more degrees of freedom of a single photon are correlated quantum-mechanically. Here, we demonstrate a photonic integrated chip able to generate and manipulate single-photon path-entangled states, using a commercial red LED as light source.A Bell test, in the Clauser, Horne, Shimony, and Holt(CHSH) form, is performed to confirm the presence of entanglement, resulting in a maximum value of the CHSH correlation parameter equal to 2.605 ± *** allows us to use it as an integrated semi-device independent quantum random number generator able to produce certified random numbers. The certification scheme is based on a Bell’s inequality violation and on a partial characterization of the experimental setup, without the need of introducing any further assumptions either on the input state or on the particular form of the measurement observables. In the end a min-entropy of 33% is demonstrated.

关键词： quantum random inequality

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Exploitation of host clock gene machinery by hepatitis viruses B and C

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World Journal of Gastroenterology 2013年第47期19卷 8902-8909页

作者： Manlio Vinciguerra Gianluigi Mazzoccoli Claudia piccoli Tiziana Tataranni Angelo Andriulli Valerio Pazienza Institute for Liver and Digestive Health Division of MedicineUniversity College London (UCL)London SW7 2AZUnited Kingdom Gastroenterology Unit IRCCS "Casa Sollievo della Sofferenza" Hospital71013 San Giovanni Rotondo (FG)Italy Department of Medical Sciences Division of Internal MedicineIRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza"71013 San Giovanni Rotondo (FG)Italy Department of Clinical and Experimental Medicine University of Foggia71100 FoggiaItaly Laboratory of Pre-Clinical and Translational Research IRCCSCentro di Riferimento Oncologico della Basilicata (CROB)85028 Rionero in Vulture (PZ)Italy

Many aspects of cellular physiology display circadian(approximately 24-h)*** of the circadian clock molecular circuitry is associated with human health derangements,including neurodegeneration,increased risk of cancer,cardiovascular diseases and the metabolic *** triggering hepatitis depend tightly on the host cell synthesis machinery for their own replication,survival and *** evidences support a link between the circadian clock circuitry and viruses’biological cycle within host ***,in vitro models for chronobiological studies of cells infected with viruses need to be *** establishment of such in vitro models would be helpful to better understand the link between the clock gene machinery and viral replication/viral persistence in order to develop specifically targeted therapeutic *** we review the recent literature dealing with the interplay between hepatitis B and C viruses and clock genes.

关键词： Hepatitis C virus Hepatitis B virus Antihepatitis therapy Clock genes Chronobiology