Hepatitis C virus,mitochondria and auto/mitophagy:Exploiting a host defense mechanism

作     者：Vitalba Ruggieri Carmela Mazzoccoli Valerio Pazienza Angelo Andriulli Nazzareno Capitanio Claudia Piccoli 

作者机构：Laboratory of Preclinical and Translational Research IRCCS Referral Cancer Center of Basilicata 85028 Rionero in Vulture (PZ) Italy Gastroenterology UnitIRCCS "Casa Sollievo della Sofferenza" Hospital 71013 Foggia Italy Department of Medical and Experimental Medicine University of Foggia 71122 Foggia Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第10期

页      面：2624-2633页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Hepatitis C virus Mitochondrial dysfunctions Immunity Autophagy Mitophagy 

摘      要：Hepatitis C virus(HCV)is the major reason for liver transplantation and the main cause of liver-related morbidity and mortality in a great number of *** for the other viruses,this pathogen interferes in more than one process and in more than one way with host cell biology.A mounting body of evidence points,in particular,toward the drastic alterations of mitochondrial physiology and functions that virus is able to induce,albeit the mechanisms have partly remained *** of the mitochondria in immunity and in quality control systems,as autophagy,as well as the strategies that HCV has evolved to evade and even to manipulate mitochondrial surveillance for its benefit,highlights the importance of deepening the mechanisms that modulate this virus-mitochondrion interaction,not only to intensify our knowledge of the HCV infection pathogenesis but also to design efficient antiviral strategies.