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SinoSCORE:a logistically derived additive prediction model for post-coronary artery bypass grafting in-hospital mortality in a Chinese population

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Frontiers of Medicine 2013年第4期7卷 477-485页

作者： Zhe Zheng Lu Zhang Xi Li Shengshou Hu behalf of the Chinese CABG Registry study Department of Cardiovascular Surgery and State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China 不详

This study aims to construct a logistically derived additive score for predicting in-hospital mortality risk in Chinese patients undergoing coronary artery bypass surgery(CABG).Data from 9839 consecutive CABG patients in 43 Chinese centers were collected between 2007 and 2008 from the Chinese Coronary Artery Bypass Grafting *** database was randomly divided into developmental and validation subsets(9:1).The data in the developmental dataset were used to develop the model using logistic *** and discrimination characteristics were assessed using the validation *** were defined for each model to distinguish different risk *** excluding 275 patients with incomplete information,the overall mortality rate of the remaining 9564 patients was 2.5%.The SinoSCORE model was constructed based on 11 variables:age,preoperative NYHA stageⅢorⅣ,chronic renal failure,extracardiac arteriopathy,chronic obstructive pulmonary disease,preoperative atrial fibrillation or flutter(within 2 weeks),left ventricular ejection fraction,other elective surgery,combined valve procedures,preoperative critical state,and *** the developmental dataset,calibration using a Hosmer-Lemeshow(HL)test was at P=0.44 and discrimination based on the area under the receiver operating characteristic curve(ROC)was *** the validation dataset,the HL test was at P=0.34 and the area under the ROC(AUC)was 0.78.A logistically derived additive model for predicting in-hospital mortality among Chinese patients undergoing CABG was developed based on the most up-to-date multi-center data from China.

关键词： coronary artery bypass grafting risk stratification in-hospital mortality

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Flat limit of the de Sitter QFT in the rest frame vacuum

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Chinese Physics C 2021年第1期45卷 101-112页

作者： ion I.Cot?escu West University of Timi?oara

The problem of the flat limits of the scalar and spinor fields on the de Sitter expanding universe is considered in the traditional adiabatic vacuum and in the new rest frame vacuum we proposed recently, in which the frequencies are separated in the rest frames as in special relativity. It is shown that only in the rest frame vacuum can the Minkowskian flat limit be reached naturally for any momentum, whereas in the adiabatic vacuum, this limit remains undefined in rest frames in which the momentum vanishes. An important role is played by the phases of the fundamental solutions in the rest frame vacuum, which must be regularized to obtain the desired Minkowskian flat limits. This procedure fixes the phases of the scalar mode functions and Dirac spinors, resulting in their definitive expressions derived here. The physical consequence is that, in the rest frame vacuum, the flat limits of the oneparticle operators are simply the corresponding operators of special relativity.

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Noninvasive investigations for non alcoholic fatty liver disease and liver fi brosis

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World Journal of Gastroenterology 2010年第38期16卷 4784-4791页

作者： Carmen Fierbinteanu-Braticevici ion Dina Ana Petrisor Laura Tribus Lucian Negreanu Catalin Carstoiu Carmen Fierbinteanu-Braticevici Ana PetrisorLaura TribusLucian NegreanuCatalin CarstoiuMedical Clinic Ⅱ and Gastroenterology University Hospital Bucharest Department of Gastroenterology St John’s Hospital 7001 Bucharest Carmen Fierbinteanu-Braticevici Ana PetrisorLaura TribusLucian NegreanuCatalin CarstoiuMedical Clinic Ⅱ and GastroenterologyUniversity Hospital Bucharest

Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of diseases that have insulin resistance in common and are associated with metabolic conditions such as obesity, type 2 diabetes mellitus, and dyslipidemia. NAFLD ranges from simple liver steatosis, which follows a benign course, to nonalcoholic steatohepatitis (NASH), a more severe entity, with necroinflmmation and f ibrosis, which can progress to cryptogenic cirrhosis and end-stage liver disease. Liver biopsy remains the gold standard for evaluating the degree of hepatic necroinflammation and f ibrosis; however, several noninvasive investigations, such as serum biomarkers, have been developed to establish the diagnosis and also to evaluate treatment response. These markers are currently neither available in all centers nor validated in extensive studies. Examples include high-sensitivity C reactive protein and plasma pentraxin 3, which are associated with extensive liver f ibrosis in NASH. Interleukin-6 correlates with inflammation, and cytokeratin-18 represents a marker of hepatocyte apoptosis (prominent in NASH and absent in simple steatosis). Tissue polypep-tide specif ic antigen seems to have a clinical utility in the follow-up of obese patients with NASH.

关键词： Non-alcoholic fatty liver disease Biomarkers Necroinflammation Liver fibrosis

Kinemaitcs in spatially flat FLRW spacetimes

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Chinese Physics C 2021年第10期 96-105页

作者： ion I.Cot?escu West University of Timi?oara

The kinematics on spatially flat FLRW spacetimes is presented for the first time in local charts with physical coordinates, i.e., the cosmic time and proper Cartesian space coordinates of Painlevé-type. It is shown that there exists a conserved momentum that determines the form of the covariant four-momentum on geodesics in terms of physical coordinates. Moreover, with the help of this conserved momentum, the peculiar momentum can be defined, thus separating the peculiar and recessional motions without ambiguity. It is shown that the energy and peculiar momentum satisfy the mass-shell condition of special relativity while the recessional momentum does not produce energy. In this framework, the measurements of the kinetic quantities along geodesics performed by different observers are analyzed, pointing out an energy loss of the massive particles similar to that producing the photon redshift. The examples of the kinematics on the de Sitter expanding universe and a new Milne-type spacetime are extensively analyzed.

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Gastroesophageal reflux disease management according to contemporary international guidelines:A translational study

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World Journal of Gastroenterology 2011年第9期17卷 1160-1166页

作者： Fabio Pace Gabriele Riegler Annalisa de Leone Patrizia Dominici Enzo Grossi the EMERGE study Group Division of Gastroenterology Department of Clinical Sciences 'L. Sacco' UniversityHospital 74-20157 Milano Italy 'Magrassi-Lanzara' Department of Clinicaland Experimental Medicine 2nd University of Naples 80100Naples Italy Medical Department BraccoImaging SpA 24100 Milano Italy

AIM:To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor(PPI) in the initial management and maintenance treatment of gastroesophageal reflux disease(GERD)patients. METHODS:Five hundred and seventy seven patients with heartburn were *** completing a psychometric tool to assess quality of life(PGWBI)and a previously validated GERD symptom questionnaire (QUID),patients were grouped into those with esophagitis(EE,n=306)or without mucosal damage (NERD,n=271)according to endoscopy results. The study started with a 2-wk period of high dose omeprazole(omeprazole test);patients responding to this PPI test entered an acute phase(3 mo)of treatment with any PPI at the standard ***,those patients with a favorable response to the standard PPI dose were maintained on a half PPI dose for a further 3-mo period. RESULTS:The test was positive in 519(89.9%)patients,with a greater response in EE patients(96.4%) compared with NERD patients(82.6%)(P=0.011). Both the percentage of completely asymptomatic patients,at 3 and 6 mo,and the reduction in heartburn intensity were significantly higher in the EE compared with NERD patients(Pion. CONCLUSion:Our study confirms the validity of the Genval guidelines in the management of GERD patients. In addition,we observed that the overall response to PPI therapy is lower in NERD compared to EE patients.

关键词： Gastroesophageal reflux disease Proton pump inhibitors Nonerosive gastroesophageal reflux Questionnaire Quality of life

Lie map for the nonlinear transport of continuous intense beams in the axial-symmetric electrostatic fields

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Progress in Natural Science:Materials International 2008年第7期18卷 795-800页

作者： Jianqin L*, Xiaosong Zhao Institute of Heavy ion Physics, Peking University, Beijing 100871, China Institute of Heavy ion Physics Peking University Beijing 100871 China

Nonlinear transport of intense continuous beam in the axial-symmetric electrostatic fields is analyzed with the Lie algebraic method. The K-V particle distribution is adopted in the analysis. The results obtained can be used in the calculations of the intense continuous beam dynamics in the beam optical systems consisting of drift spaces, electrostatic lenses, and DC electrostatic accelerating tubes. A com- puter code has been designed for practical simulations. To meet the needs of accurate calculation, all the elements are divided into many small segments, the electric fields in each segment are regarded as uniform fields, and the dividing points are treated as thin lenses. Iter- ation procedures are adopted in the code to obtain self-consistent solutions. The code can be used to design low energy dc beam transport systems, electrostatic accelerators, and ion implantation machines.

关键词： Intense continuous beam Lie algebraic analysis Nonlinearity

In vitro study of human endothelial progenitor cells behaviour on nitrided Ni-free Ti–27Nb alloy

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Progress in Natural Science:Materials International 2019年第4期29卷 466-471页

作者： Raluca ion Yvan Bédouin Thierry Gloriant Gladiola Andruseac Doina-Margareta Gordin Anisoara Cimpean University of Bucharest Department of Biochemistry and Molecular Biology Univ Rennes INSA Rennes CNRS ISCR (Institut des Sciences Chimiques de Rennes) CHU de Rennes P?le d'Odontologie et de Chirurgie Buccale Department of Biomedical Science Faculty of Medical Bioengineering “Grigore T.Popa” University of Medicine and Pharmacy

A superelastic Ni-free Ti-27 Nb alloy has been synthesized and gas nitrided at high temperature to investigate its suitability for vascular implant *** cellular responses of human endothelial progenitor cells(EPCs)to both bare and nitrided Ti-27 Nb alloy have been analyzed using Live/Dead staining,MTT assay,fluorescence microscopy and ELISA technique,as well as NiTi alloy for ***/Dead staining and MTT assay were performed to assess the cellular viability and proliferation,while fluorescence microscopy was used to analyze cell adhesion,cell morphology,and the expression of endothelial cell markers(VE-cadherin and von Willebrand factor).Secretion of the pro-inflammatory chemokine MCP(monocyte chemoattractant protein)-1 by the cells grown in contact with the analyzed materials was further verified using the enzyme-linked immunosorbent *** results obtained revealed that adhesion,spreading,viability,proliferation rate and phenotypic markers expression of EPCs were similar on the surfaces of Ti-27 Nb and NiTi *** exposed to nitrided Ti-27 Nb surface exhibited significantly decreased inflammatory response,which may be beneficial for reducing in-stent restenosis incidence.

关键词： Titanium alloy Nitriding Endothelial progenitor cells Biocompatibility Inflammatory response

A computer code for beam optics calculation--third order approximation

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Progress in Natural Science:Materials International 2006年第6期16卷 667-670页

作者： Lü Jianqin and LI Jinhai (Institute of Heavy ion Physics, Peking University, Beijing 100871, China) Institure of Heavy ion Physics Peking University Beijing 100871 China

To calculate the beam transport in the ion optical systems accurately, a beam dynamics computer program of third order approximation is developed. Many conventional optical elements are incorporated in the program. Particle distributions of uniform type or Gaussian type in the (x, y, z) 3D ellipses can be selected by the users. The optimization procedures are provided to make the calculations reasonable and fast. The calculated results can be graphically displayed on the computer monitor.

关键词： beam transport computer program third order approximation Lie algebra.

Torsion theories of pseudo-regular S -systems

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Progress in Natural Science:Materials International 2002年第2期12卷 68-70页

作者： QIU Derong(Center for Advanced study, Tsinghua University, Beijing 100084, China) Tsing Hua Univ Ctr Adv Study Beijing 100084 Peoples R China

The concept of pseudo-regular S-system is introduced. A torsion theory τu = ( Us, Us) with its torsion class Us consisting of pseudo-regular S-systems is constructed. Its corresponding quasi-filter is completely described. A number of results on the relations between τu and two special torsion theories, the stable and Lambek torsion theories, are obtained.

关键词： pseudo-regular S-system torsion theory quasi-filter stable torsion theory Lambek torsion theory.