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Fine-tuning Mast Cells is Essential for the Maintenance and Regulation of the Systemic and Immune Homeostasis

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Journal of Integrative Medicine（双语） 2021年第2期10卷 60-74页

作者： Sylvia Frisancho-kiss Department of Anesthesiology and Intensive Care Hospital KomárnoSlovakia

During the past decades,populous expansion in mast cell scientific literature came forth with more,than forty-four thousand PubMed publications available to *** surge is due to the appreciation of the momentous role of mast cells in the evolution of species,in the development and maintenance of vital physiological functions,such as reproduction,homeostasis,and fluids,diverse immunological roles,and the potential of far-reaching effects despite minute *** the emerging knowledge of the importance of mast cells in equilibrium comes of age when looking at the matter from an evolutionary perspective,the recognition of mast cells beyond detrimental performance in allergies and asthma,during protection against parasites,*** wellknown classical functions,mast cells can process and present antigens,can serve as a viral reservoir,can respond to hormones and xenobiotics,initiate antiviral and antibacterial responses,phagocytosis,apoptosis,and participate in important developmental *** evolution,upon the development of a sophisticated niche of innate and adaptive cell populations,certain mast cell functions became partially transmutable,yet the potency of mast cells remained *** mast cells enables us to reflect on the certitude,that our sophisticated,complex physiology is rooted deeply in evolution,which we carry ancient remnants of,ones that may have decisive roles in our *** communication sets out the goal of characterizing mast cells,particularly the aspects less in limelight yet of immense significance,without the aspiration exhaust it all.

关键词： Mast cells Evolution Degranulation Protease Endocrine disruptors Environmental pollutants Fibrosis Allergy Neuroinflammation

Morphological and microcirculatory evaluation of the rat testis after detorsion with or without a capsular release with a tunica vaginalis flap

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Asian Journal of Andrology 2016年第3期18卷 462-466,I0010,I0011页

作者： Tamas Jozsat Zoltan Klarik Ferenc kiss Eniko Toth Anita Mester Zoltan Hargitai Yi-Che Changchien Magdalena Fossum Norbert Nemeth Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden Department of Pediatric Surgery Division of Urology Astrid Lindgren Children's Hospital. Karolinska University Hospital Stockholm Sweden Department of Operative Techniques and Surgical Research Institute of Surgery Faculty ot MedicineUniversity of Debrecen Hungary Department of Pathology Kenezy Gyula Hospital Uebrecen Hungary

Testicular torsion may lead to serious ischemia, and the viability depends on the duration of torsion and the effect of ischemia-reperfusion. Testicular decompression and tunica vaginalis flap application technique were introduced in 2008 by Kutikov et al. We aimed to examine the impact of this method on the testicular microcirculation and hemorheological parameters in a rat model. Six adult rats underwent bilateral scrotal exploration. Intravaginal torsion of the testis was created by 720° rotation on both sides for 2 h. After detorsion, the right testes underwent tunica albuginea incision and tunica vaginalis flap application. Testicular microcirculation was monitored and hematological parameters, erythrocyte deformability, and aggregation were determined. Measurements were performed before and after torsion, directly after detorsion, on the 1^st-2^nd and 8^th postoperative day. After the last sampling, testicles were removed to determine their volume for histological examinations. The microcirculatory parameters demonstrated slight differences between testicles. Apical zone of the left （nondecompressed） testicles had elevated compared to the middle zone （P 〈 0.05）. On the 2^nd and 8^th day, the microcirculation of the testes normalized but not equally. The erythrocyte aggregation and deformability decreased by the 8^th day. Both testicles underwent atrophy and epithelial necrosis, but the volume of the decompressed ones was lower （1.07±0.08 vs 1.25 ± 0.31）. Histologically, there was no significant difference in epithelial damage score between decompressed and nondecompressed testes. In conclusion, 2-h ischemia led to alteration in testicular microcirculation, reduction in volume, changes in hemorheological parameters and serious epithelial necrosis both in decompressed and nondecompressed testicles without remarkable differences.

关键词： ischemia rat model reperfusion spermatic cord torsion surgical flaps testicular compartment syndrome testis

Trafficking of Vietnamese women and girls for marriage in China

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Global Health Research and Policy 2017年第1期2卷 55-63页

作者： Heidi Stöckl Ligia.kiss Jobst Koehler Dung Thuy Dong Cathy Zimmerman Gender Violence and Health Centre Department of Global Health and DevelopmentFaculty of Public Health and PolicyLondon School of Hygiene and Tropical Medicine15-17 Tavistock PlaceLondon WC1H 9SEUK IOM Vietnam Ho Chi MinhVietnam

Background:Bride-trafficking has been a growing phenomenon in Southeast Asia,particularly in China,where one-child policies have resulted in demographic imbalances favoring ***,empirical evidence about women and girls sold into marriage in China remains ***:This study describes the experiences of 51 Vietnamese women and girls as young as 14 in post-trafficking services who were sold into marriage in China.A consecutive sample of individuals from five services in Vietnam were invited to be interviewed within the first 2 weeks of *** is part of a wider dataset for research on the health of men,women,and children in post-trafficking services in Cambodia,Thailand,and Vietnam,the largest study to date on human trafficking and *** calculated proportions for all variables and conducted bivariate analyses using Fisher Exact Tests for their associations with mental health disorders ***:Before leaving home,31%(n=15)participants were *** reported high levels of sexual violence(n=43;86%)while trafficked and59%(n=30)spent time in detention before returning to *** in post-trafficking care 52.9%(n=27)reported probable depression,anxiety or post-traumatic stress disorders(PTSD),two women(4%)attempted suicide in the past month and 38(75%)remained afraid of their ***(22%)became pregnant while trafficked,and seven(16%)were pregnant at the ***:The cross-border bride trade between Vietnam and China raises complex policy issues,including questions about detention and immigration rights and strategies for supported return processes,including maternal and child health *** the repercussions of China’s absent female population will persist,Vietnam and China must grapple with the political and social conditions to implement prevention strategies,and resources for women who fall prey to this cross-border bride trade.

关键词： Human trafficking Vietnam China Forced marriage Mental health and violence against women

Lactate reloaded–reevaluation of the importance of lactate monitoring in the management of adult sepsis in the emergency department

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BIOCELL 2021年第3期45卷 445-449页

作者： GABOR XANTUS BALINT kiss GYULA MOLNAR CANDICE MATHESON V.A NNA GYARMATHY PETER L.KANIZSAI Cardiff University CardiffCF103ATUK Semmelweis University Budapest1085Hungary Dalhuis University Halifax HalifaxNS B3H 4R2Canada EpiConsult Biomedical Consulting and Medical Communications Agency DoverDE 19901USA Pecs University Clinical CentrePecs7626Hungary

For about a quarter of a century,monitoring lactate levels and/or lactate clearance has been an unquestionable cornerstone in sepsis *** elevated lactate level appeared to be an independent predictor of mortality,and the consequent metabolic acidosis was thought to explain a number of pathophysiological changes seen in septic *** physiological and clinical findings seem to challenge the adverse role of lactic acidosis in *** suggests that lactate levels are not necessarily directly proportional to either tissue or cellular hypoxia,and conversely,despite high lactate levels,increased peripheral tissue oxygen pressure can be measured in adult patients with septic *** to the most recent understanding of in vitro and in vivo evidence,the elevated lactate level in sepsis might be a normal reaction due to adrenergic stress with potential beneficial/protective physiological effects,as *** the one hand,burning lactic may help fuel the body during critical illness,but on the other hand,with a slight drop in pH,the body may counteract certain deleterious changes during the dysregulated host response;reduce the chances of reperfusion myocardial injury,and improve tissue oxygenation by shifting the haemoglobin dissociation curve to the *** the pathophysiological process in sepsis resulting in elevated lactate levels may aid management in an emergency,medicine,and intensive care *** more in-depth physiological knowledge,physicians may inevitably surpass normalisation heuristics and deliver personalized rather than protocolised sepsis resuscitation.

关键词： Reevaluation Lactate Sepsis Resuscitation

利用GRACE重力卫星求解南极洲冰川质量变化的精度研究

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地学前缘 2015年第4期22卷 239-246页

作者： Lorant FOLDVARY Annamaria.kiss 苏子校王广才王林 Department of Geodesy and Surveying Budapest University of Technology and Economics Faculty of Geoinformatics University of West Hungary 中国地质大学(北京)水资源与环境学院北京100083 Faculty of Science Technology and CommunicationUniversity of Luxembourg

GRACE重力卫星可用于观测南极洲冰川的质量变化。由GRACE重力卫星提供的月解重力场能有效探测质量的年变化及长期变化(周期和非周期性)。通过GRACE观测的质量变化时间序列,计算得到南极洲质量的长期变化及周期性年变化。计算结果受多种... 详细信息

GRACE重力卫星可用于观测南极洲冰川的质量变化。由GRACE重力卫星提供的月解重力场能有效探测质量的年变化及长期变化(周期和非周期性)。通过GRACE观测的质量变化时间序列,计算得到南极洲质量的长期变化及周期性年变化。计算结果受多种误差影响,其中GRACE模型误差的影响较小,而研究时段及其跨度的影响较为显著,以不同宽度的时间窗口进行平移,得到无穷时间序列下该误差的参考值为±14.89mm/a。南极地区的气压修正误差可达±10mm/a,GIA修正误差与其量级相同。由此我们认为,目前对于南极洲冰川质量变化的一些认识仍需商榷。南极洲西部地区冰川加速消融,Dronning Maud Land和Enderby Land等地区的质量持续累积;其他地区的质量变化情况仍需进一步研究。

关键词：南极洲地表质量变化误差分析质量变化时间序列

PRELIMINARY STUDY OF AMPELOMYCE QUISQUALIS, THE MYCOPARASITE OF POWDERY MILDEW IN QINLING MOUNTAINS, CHINA

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PRELIMINARY STUDY OF AMPELOMYCE QUISQUALIS, THE MYCOPARASITE...

Sustainability Aspects of the Wheat Sector

The ⅩⅤth International Plant Protection Congress

作者： L.kiss Institute of Plant Protection Hungarian Academy of Sciences H-1525 Budapest POB 102 Hungary

来源： cnki会议评论

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Chinese Business Review 2012年第5期11卷 451-459页

作者： Istvan kiss Szilvia Bencze University ofDebrecen DebrecenHungary BEN-KG Lp. CsomorHungary

In the frame of the present study, we examined the wheat sector with respect to economic and social sustainability. Accordingly, two research questions were formulated：（1） Is wheat production sustainable in economic terms？ and （2） Is wheat production sustainable in social terms？ Our view is that the content of sustainability can be defined on a case-by-case basis, and in our case, wheat production provides this content. To answer the research questions, we collected statistical data on the production area, average yield, production volume, selling price, consumption of wheat, and evaluated the tendencies prevalent in the sector. We suppose that in social terms, sustainability means maintaining consumption at least at a constant level, knowing that this sector produces considerable share of the direct and indirect food raw materials. A chief dilemma is that world population is continuously growing, although the size of the cultivated area in the wheat sector has not indicated significant changes over the past few decades. Unless increasing the yields, severe decrease may occur in the per capita production of wheat in the long run. In this case, the current consumption level will not be sustainable in the medium run. In addition, in the long run, it may even have influence on the consumption level of other commodities.

关键词： wheat sector sustainability competitiveness production consumption level

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YOUNG DREAM

青年与社会（中） 2009年第5期 42-43页

作者： kiss&sigua

kiss的人物链头号闺蜜:sigua。喜欢浪漫的狮子座女王,表面闪亮奢华,内心极简纯良。相熟八年,一起嬉笑怒骂,疯狂天真,荒唐无数,长成现在的"young"子。08年夏天,觉得是时候一起做点事了……miss夏:商场招商部专员。亲和力强,能言善辩,且... 详细信息

kiss的人物链头号闺蜜:sigua。喜欢浪漫的狮子座女王,表面闪亮奢华,内心极简纯良。相熟八年,一起嬉笑怒骂,疯狂天真,荒唐无数,长成现在的"young"子。08年夏天,觉得是时候一起做点事了……miss夏:商场招商部专员。亲和力强,能言善辩,且颇有点姿色。Me:藏起来的自我。God:天知道,老天也来这个故事里插一脚。

关键词：生活风格策划商场云南关键词创业原创设计策略集结形象定位

Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats

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Biomedical and Environmental Sciences 2014年第2期27卷 85-96页

作者： Daniela-Saveta POPA Pompei BOLFA Bela.kiss Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN Department of Toxicology Faculty of Pharmacy Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca Department of Pathology Faculty of Veterinary MedicineUniversity of Agricultural Sciences and Veterinary Medicine Department of Biomedical Sciences Ross University School of Veterinary Medicine Department of Pharmaceutical Technology and Biopharmacy Faculty of Pharmacy ‘Iuliu Hatieganu'University of Medicine and Pharmacy Cluj-Napoca Department of Pharmaceutical Botany Faculty of Pharmacy ‘Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca

Objective To evaluate the influence of an extract of Genista tinctoria L. herba （GT） or methylparaben （MP） on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A （BPA）. Methods Adult female Wistar rats were orally exposed for 90 d to BPA （50 mg/kg）, BPA＋GT （35 mg isoflavones/kg） or BPA＋MP （250 mg/kg）. Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA＋MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA＋MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes.

关键词： Food contaminant Phytoestrogen Morphological effect Lipid peroxidation Hydroxylradical