检索结果-南通市图书馆

维普期刊数据库

Safety and Tolerability of Transdermal Rotigotine in a Clinical Practice Cohort for 2 Years

在线全文

学校读者我要写书评

暂无评论

World Journal of Neuroscience 2014年第5期4卷 443-449页

作者： Iria Rodriguez Constenla Antonio Pato Pato Icíar Cimas hernando José Ramón Lorenzo Gonzalez Servicio de Neurología Hospital Povisa Vigo Spain

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease that occurs as a result of loss of dopaminergic neurons from the substantia nigra. Rotigotine is a non-ergolinic dopamine agonist available as a silicone-based transdermal patch for the treatment of PD. In the European Union, rotigotine transdermal patch is indicated for use as monotherapy in early idiopathic PD, or in combination with levodopa through the disease course to the late stages where motor complications with levodopa become an issue. Objective: To investigate the safety and tolerability of transdermal rotigotine, in patients with PD being treated during routine clinical practice for 2 years. Results: 114 patients were enrolled, and evaluated for adverse events over a 24-month period. Adverse events occurred in 39 patients (34.21%). 23 patients (20.17%) reported application site reactions (dermatitis, erythema, itching), and 16 (14.03%) had systemic adverse events. Sleep disorders were the most common problem;the others were hallucinations, depression, dizziness, and syncope. No patient experienced dyskinesia. Adverse events necessitated the discontinuation of rotigotine for application site reactions in fourteen patients (12.28%) and 11 patients (9.64%);reasons for discontinuation were systemic adverse events. Conclusion: Rotigotine is safe and well tolerated when used to treat PD in routine clinical practice.

关键词： Rotigotine Parkinson’s Disease Tolerability Safety Clinical Practice

Management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第13期28卷 1304-1314页

作者： JoséLuis Muñoz de Nova Jorge hernando Miguel Sampedro Núñez Greissy Tibisay Vázquez Benítez Eva María Triviño Ibáñez María Isabel del Olmo García Jorge Barriuso Jaume Capdevila Elena Martín-Pérez Department of General and Digestive Surgery Hospital Universitario de La PrincesaMadrid 28006Spain Department of Surgery Universidad Autónomade MadridMadrid 28029Spain Gastrointestinal and Endocrine Tumor Unit Medical Oncology DepartmentVall d´Hebron University HospitalVall d´Hebron Institute of OncologyBarcelona 08035Spain Department of Endocrinology and Nutrition Hospital Universitario de La PrincesaMadrid 28006Spain Department of Pathology Hospital Universitario Puerta de HierroMadrid 28222Spain Department of Pathology Universidad Autónoma de MadridMadrid 28029Spain Department of Nuclear Medicine Virgen de las Nieves University HospitalGranada 18014Spain Department of Endocrinology and Nutrition Hospital Universitario i Politècnic La FeValencia 46023Spain Division of Cancer Sciences School of Medical SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom Department of Medical Oncology The Christie NHS Foundation TrustManchester M204BXUnited Kingdom

Appendiceal neuroendocrine tumors(aNETs)are an uncommon neoplasm that is relatively indolent in most *** are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an *** there are numerous clinical practice guidelines on management of a NETs,there is continues to be a dearth of evidence on optimal *** of these tumors is stratified according to risk of locoregional and distant ***,there is a lack of consensus regarding tumors that measure 1-2 *** these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be *** tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk *** receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant *** main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node *** main factor considered is tumor size and 2 cm is the most common threshold for indicating a *** factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be *** the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into *** this review,we present data regarding the current indications,outcomes,and benefits of a colectomy.

关键词： Neuroendocrine tumors Carcinoid tumor Appendiceal neoplasms Colectomy Neoplasm grading Treatment outcome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

求知中学:如何在游戏中求知

当代教育家 2018年第4期 62-63页

作者： Alfredo hernando 赵婉秋

游戏是对生命本质的一种学习,因为生命本身就存在于一场充满偶然的游戏之中。"游戏不仅仅是学习这种或那种技术、这样或那样的才能。游戏是对生命本质的一种学习,因为生命本身就存在于一场充满偶然的游戏之中。"哲学家埃德加·莫兰徜徉... 详细信息

游戏是对生命本质的一种学习,因为生命本身就存在于一场充满偶然的游戏之中。"游戏不仅仅是学习这种或那种技术、这样或那样的才能。游戏是对生命本质的一种学习,因为生命本身就存在于一场充满偶然的游戏之中。"哲学家埃德加·莫兰徜徉于自然、宇宙、科学的探索后,在《科学与良知》中说:"游戏不仅仅处于学习的中心,也处于生活的中心。近年来,技术的无限可能性使其发展了到难以想象的规模。"在二十一世纪的学校中,游戏与学

关键词：游戏化学习

Hazard Assessment of Alternatives to Dicofol

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Protection 2010年第3期1卷 231-241页

作者： Ana I. Sánchez M. Dolores hernando Juan J. Vaquero Eloy García José M. Navas 不详

Dicofol was listed by International POPs Elimination Network (IPEN) as requiring immediate and urgent considera-tion and thus was considered as a new candidate by Persistent Organic Pollutant Review Committee (POPRC) as a possible persistent organic pollutant (POP). Dicofol is structurally similar to DDT. It is persistent in food and water, highly toxic to aquatic life and causes egg-shell thinning in some bird species. High concern, due to the lack of dicofol measurements in the Arctic, proving long range transport and bioaccumulation in wild life species, supports further impact assessment of this product. Under Stockholm Convention, substances identified as POPs are regulated with the objective to protect the environment and the human health. According to this objective, the search of environmental and healthy alternatives is helpful. This paper discusses the use of three groups of chemicals currently applied as alternatives to dicofol. An exhaustive review of the synthesis of dicofol, starting from DDT, and compared to possible substitutes is presented: 1) active principle with fluoralkenyl are proposed as an environmental and healthy alternative to dicofol, 2) inhibitor agents of mitochondrial electron transport as chlorfenapyr, hydramethylnon and pyridaben and 3) pesticides commonly applied in agricultural practices as oxythioquinox, fenbutatin-oxide and formetanate hydrochloride.

关键词： Dicofol POPs Chemical Structure Effects Alternatives

Subcapsular Hepatic Hematoma after ERCP:A Case Report and Revision of Literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2014年第3期3卷 161-166页

作者： Katerina Klímová Camilo Padilla Suárez Cecilia González Asanza Ana Matilla Pena Enrique Cos Arregui Ana.hernando Alonso Department of Hepatogastroenterology and Endoscopy Hospital General Universitario Gregorio MaranónMa-dridSpain

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is a minimally invasive procedure for diagnosis and treatment of biliary and pancreatic diseases. Even in the best hands, complications may occur. Clinically significant hemorrhagic complications associated usually to previous papillotomy are uncommon. Subcapsular hepatic hematoma is excepcional, with only twenty cases described. We present a case of a 52-year-old man who developed a large subcapsular liver hematoma following a therapeutic ERCP. Due to serious anemization and hemodynamic instability, arterial embolization and finally urgent surgical evacuation of the hematoma were performed. In the postoperative period the patient presented infection of the collection, which indicated colocation of percutaneous drainage and broad-spectrum intravenous antibiotics, and gradually recovered.

关键词： Subcapsular Hepatic Hematoma Endoscopic Retrograde Cholangiopancreatography Arterial Embolization Percutaneous Drainage Surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

游戏,让学习不再“苦”

当代教育家 2018年第4期 61-63页

作者： Alfredo hernando[西班牙] 赵婉秋(译)

某社交网站上有人提了一个问题,迅速得到数千个答案：为什么大多数人宁愿吃生活的苦,也不愿意吃学习的苦？这些答案中,有一个被绝大多数网友称为精辟至极：学习的苦需要主动去吃,生活的苦躺着不动也能吃到。

关键词：学习游戏中学生活

维普期刊数据库

Expression of miR-16 is not a suitable reference for analysis of serum microRNAs in melanoma patients

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2012年第11期5卷 647-651页

作者： Erica B. Friedman Shulian Shang Nathaniel H. Fleming Eleazar Vega-Saenz de Miera Eva.hernando Yongzhao Shao Iman Osman Department of Dermatology New York University New York USA Division of Biostatistics New York University New York USA Interdisciplinary Melanoma Cooperative Group New York University New York USA

Background: The evolving paradigm shift towards the molecular characterization of melanoma has expanded to include studies of microRNA (miRNA) expression. As miR-16 has been utilized as a normalizer in serum-based miRNA studies in several cancers, we evaluated miR-16 expression as a potential reference for normalization of serum miRNA expression in melanoma patients. Methods: 143 primary cutaneous melanoma patients who presented to New York University (NYU) Langone Medical Center for surgical resection of AJCC stage I-III disease were studied. In addition, sera samples from 60 control subjects were utilized including 22 healthy volunteers, 13 rheumatoid arthritis patients, 20 non-melanoma cancer patients (10 renal cell carcinoma and 10 bladder cancer), and 5 Atypical Mole Syndrome patients. The Kruskal-Wallis test (k = 6) or Wilcoxon test (k = 2) with Bonferroni correction was used for analyses of miR-16 expression in melanoma patients compared to various control groups, using raw Ct values directly. The Kruskal-Wallis test was used to compare miR-16 expression across stages of melanoma. The equivalence test for independent samples was used to test the equivalence of miR-16 expression among different groups. Results: No significant differential expression of miR-16 was observed between melanoma patients and healthy volunteers (Wilcoxon test, p = 0.37). However, miR-16 did show a significant difference in expression as it related to stage of melanoma (p = 0.015). Additionally, the equivalence test was unable to confirm equivalent expression of miR-16 in any melanoma versus control group pair. Conclusion: Our data indicate that miR-16 cannot be used as a universal normalizer in sera studies of melanoma patients.

关键词： MicroRNA Melanoma Normalization Reference Gene

Spatial Mapping of Metabolites and Neurotransmitter in Rat Brain Section Using DESI Ion Mobility Mass Spectrometry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spatial Mapping of Metabolites and Neurotransmitter in Rat B...

MR成像肝质子密度脂肪分数测量的线性、偏倚和精度:Meta分析

2018年中国质谱学术大会（CMSC2018）

作者： Anthony J.Midey hernando J.Olivos Michael A.Batey Emmanuelle Claude Bindesh Shrestha Wei Rao Huiqin Zhong Waters Corporation Waters Corporation Shanghai Science & Technology Co Ltd

Spatial distribution of small molecules, such as neurotransmitters, alongside lipids, in brain improve our understanding of their biological functions. Mass spectrometry imaging(MSI), such as matrix assisted laser desorption ionization(MALDI) and desorption electrospray ionization(DESI), can be used to map distributions of metabolites on tissue sections. DESI allows for the direct analysis of sample surfaces at atmospheric pressure without tedious sample preparation and matrix deposition. DESI imaging uses a charged jet of solvent to deposit microdroplets onto a surface where analytes are extracted and desorbed into the gas phase at ambient pressure and temperature. Subsequently, they are drawn into the MS inlet where they can be analyzed using a TOF-MS. This technique is compatible with Waters Synapt G2-Si or Xevo G2-XS Mass Spectrometers. Here we show the utility of DESI imaging to detect neurotransmitters, such as serotonin, adenosine, and glutamine directly in brain tissue samples. Coronal tissue sections if rat brain were mounted on microscope slides and imaged without any further sample preparation. DESI imaging platform was coupled with a high definition mass spectrometer(HDMS) with ion mobility separation(Synapt G2-Si), and MS data were collected both positive mode and negative mode. Image creation was performed using High Definition Imaging(HDI) software(Waters Corporation). Interested molecular identification was done using high mass accuracy database searches against curated databases, such as METLIN, also ID confidence was increased by high-fidelity isotopic distribution, collision cross section(CCS). DESI imaging results showed the basic distribution of brain metabolites, such as amino acids(including taurine, aspartic acid, glutamine, and glutamine), neurotransmitters(including GABA, serotonin). Also, some lipids were simultaneously detected, such as free fatty acid(arachidonic acid, docosahexaenoic acid), phospholipids(including cholesterol, phosphati

关键词： mass spectrometry imaging desorption electrospray ionization neurotransmitters metabolites

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

国际医学放射学杂志 2018年第2期 225-226页

作者： T.Yokoo S.D.Serai A.Pirasteh M.R.Bashir G.Hamilton D.hernando 赵亚婧 Department of Radiology University of Texas Southwestern Medical Center

摘要目的利用不同磁场强度、成像设备制造商和重建方法的MR成像,确定肝质子密度脂肪分数(PDFF)测量的线性、偏移和精度。材料与方法本Meta分析是根据系统评价

关键词：脂肪分数质子密度 MR