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Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells

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World Journal of Stem Cells 2023年第11期15卷 999-1016页

作者： Hang Li Xiao-Qing Ji Shu-Ming Zhang ri-Hui bi Department of Histology and Embryology Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina School of Pharmaceutical Science Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hepatobiliary Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Hospital Affiliated to Shanxi Medical UniversityThe Third Hospital of Shanxi Medical UniversityTaiyuan 030002Shanxi ProvinceChina

bACKGROUND Mesenchymal stem cells(MSCs)have great potential for the treatment of various immune diseases due to their unique immunomodulatory ***,MSCs exposed to the harsh inflammatory environment of damaged tissue after intravenous transplantation cannot exert their biological effects,and therefore,their therapeutic efficacy is *** this challenging context,an in vitro preconditioning method is necessary for the development of MSC-based therapies with increased immunomodulatory capacity and transplantation *** To determine whether hypoxia and inflammatory factor preconditioning increases the immunosuppressive properties of MSCs without affecting their biological *** Umbilical cord MSCs(UC-MSCs)were pretreated with hypoxia(2%O_(2))exposure and inflammatory factors(interleukin-1β,tumor necrosis factor-α,interferon-γ)for 24 *** cytometry,polymerase chain reaction,enzyme-linked immunosorbent assay and other experimental methods were used to evaluate the biological characteristics of pretreated UC-MSCs and to determine whether pretreatment affected the immunosuppressive ability of UC-MSCs in coculture with immune *** Pretreatment with hypoxia and inflammatory factors caused UC-MSCs to be elongated but did not affect their viability,proliferation or *** addition,pretreatment significantly decreased the expression of coagulationrelated tissue factors but did not affect the expression of other surface ***,mitochondrial function and integrity were *** pretreatment promoted UC-MSC apoptosis and senescence,it increased the expression of genes and proteins related to immune *** increased peripheral blood mononuclear cell and natural killer(NK)cell proliferation rates and inhibited NK cell-induced toxicity to varying *** In summary,hypoxia and inflammatory factor preconditioning led to higher immunosuppressive effects of MSCs without damaging their b

关键词： Mesenchymal stem cells Umbilical cord Preconditioning Hypoxia,Inflammatory factors Immune regulation

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Dietary intake of ba.b.o vinegar and charcoal powder(bVC)enhances resistance of African catfi sh Clarias gariepinus to bacterial pathogen

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Journal of Oceanology and Limnology 2022年第1期40卷 336-346页

作者： Kwangjin JU Moyngsuk KIL Sanghyok ri Tongchol KIM Lining ZHANG Maocang YAN Guangxu LIU College of Animal Sciences Zhejiang UniversityHangzhou 310058China College of Aquaculture Wonsan Fisheries UniversityWonsan 999093DPR Korea College of Life Science Kim Hyong Jik University of EducationPyongyang 99903DPR Korea Zhejiang Mariculture Research Institute Wenzhou 325005China

Although the immunomodulatory activity of ba.b.o vinegar and charcoal powder(bVC)has been increasingly documented in domestic animals,the use of bVC as immunostimulant in fi sh aquaculture awaits verifi *** the present study,the immunostimulatory impacts of dietary bVC intake were investigated in an important aquaculture fi sh species,the African catfi sh Clarias *** show that the pathogen resistance of African catfi sh was signifi cantly improved by dietary bVC intake at the tested levels(0.5%-2%),as indicated by higher survival rates(approximately 1.52-1.85 times that without bVC supplementation)upon intraperitoneally injection of bacterial pathogen Aeromonas *** addition,both the count and phagocytic activity of blood cells were signifi cantly up-regulated by a 45-day dietary supplementation of ***,compared to that of the control,fi sh individuals fed bVC containing diets exhibited signifi cant higher activities of superoxide dismutase(SOD),myeloperoxidase(MPO),and lysozyme(LYZ).The content of immunoglobulin M(IgM)in serum of African catfi sh was also induced by dietary bVC ***,the expression levels of interleukin-8(IL-8),toll-like receptor 1 and 5(TLR1 and TLR5),myeloid diff erentiation factor 88(MyD88),and nuclear factor kappa.b.NFκb)in the head kidney were signifi cantly *** fi ndings indicate bVC could be an eff ective immunostimulant in teleost species,which may enhance fi sh immunity through improving hematic parameters,activating bioactive humoral molecules,and up-regulating immune related molecular pathways.

关键词： ba.b.o vinegar and charcoal powder(bVC) African catfi sh immunostimulant pathogen resistance

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Hazards and Landscape Changes(Degradations) on Hungarian Karst Mountains Due to Natural and Human Effects

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Journal of Mountain Science 2013年第1期10卷 16-28页

作者： Móga JNOS Kiss KLAUDIA Szabó MriA Kériné borsodi ANDREA Kéri ANDRS Mari LSZLó Knáb MóNIKA Iván VERONIKA Geography and Earth Science Institute Etvs Loránd University biology Institute Etvs Loránd University

In order to study the karstological processes within the karst ecological system,the geohazards and degradation of karst landscapes on the karst areas of the bakony mountains(Hungary),we investigated the abiotic elements of the environment,soil and cover deposits,erosion soil decay;the changes in the quantity and quality of karst waters:contamination at swallow holes,contamination of karst springs;and the biogenic factors:surface vegetation coverage by the corine land cover method,plant-ecological examinations,qualification of surface waters with the help of biological water *** recognized that the increasing human activities during the past few centuries have had significant impact on the investigated landscapes of karst areas because of their spatial *** the scope of our research we concluded that the landscape changes due to natural and human effects can vary strongly on the different karst *** differences can arise from the climatic and geomorphologic situation,the coverlayer's qualities,etc.,but primarily from the different utilization of the investigated karst areas(*** intensity,characteristics and territorial extension of utilization).On the spot investigation we detected traces of new and fast geomorphological processes(gully formation,landslides,collapses,new sinkhole development) and landforms(sinkholes,gullies,swallow holes),which are clear evidences of the effect of climatic changes.

关键词： Karst landscape Geological hazards Soil erosion Limestone mountain

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Computational temporal ghost imaging based on complementary modulation

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Chinese Physics b 2024年第11期33卷 278-283页

作者： Jia-Wei Li Wei Zhang Xue-Feng Liu Xu-ri Yao Center for Quantum Technology Research and Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements (MOE) School of Physics Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

We report an experimental demonstration of temporal ghost imaging in which a digital micromirror device(DMD)and+1/-1 binary modulation have been combined to give an accurate reconstruction of a nonperiodic time *** to the 0/1 modulation,the reconstruction signal can be improved greatly by+1/-1 binary modulation even with half of the *** results show that 0/1 binary temporal objects up to 4 kHz and sinusoidal time objects up to 1 kHz can be reconstructed by this *** influences of modulation speed and array detector gray levels are also discussed.

关键词： temporal ghost imaging complementary modulation

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Electron states and electron Raman scattering in semiconductor double cylindrical quantum well wire

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Chinese Physics b 2016年第11期25卷 453-460页

作者： M Munguía-Rodríguez ri betancourt-riera Re betancourt-riera R riera J M Nieto Jalil Departamento de Investigación en Física Universidad de Sonora Apartado Postal 5-88 83190 Hermosillo Sonora México Instituto Tecnológico de Hermosillo. Avenida Tecnologico S/N Col. Sahuaro 83170 Hermosillo Sonora México Tecnológico de Monterrey-Campus Sonora Norte. bulevar Enrique Mazón Lopez No. 965 83000 Hermosillo Sonora México

The differential cross section for an electron Raman scattering process in a semiconductor GaAs/AlGaAs double quantum well wire is calculated,and expressions for the electronic states are *** system is modeled by considering T = 0 K and also with a single parabolic conduction band,which is split into a subband system due to the *** gain and differential cross-section for an electron Raman scattering process are *** addition,the emission spectra for several scattering configurations are discussed,and interpretations of the singularities found in the spectra are *** electron Raman scattering studied here can be used to provide direct information about the efficiency of the lasers.

关键词： Electron cylindrical confinement conduction radius decoupling AlGaAs parabolic modeled resonant

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biological treatment of chicken feather waste for improved biogas production

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Journal of Environmental Sciences 2011年第10期23卷 1747-1753页

作者： Gergely Forgcs Saeid Alinezhad Amir Mirabdollah Elisabeth Feuk-Lagerstedt Ilona Srvri Horvth School of Engineering University of Bors501 90 BorsSweden Department of Chemical and biological Engineering Chalmers University of Technology412 96 GteborgSweden School of Engineering University of Boras501 90 BorsSweden

A two-stage system was developed which combines the biological degradation of keratin-rich waste with the production of biogas. Chicken feather waste was treated biologically with a recombinant bacillus megaterium strain showing keratinase activity prior to biogas production. Chopped, autoclaved chicken feathers （4%, W/V） were completely degraded, resulting in a yellowish fermentation broth with a level of 0.51 mg/mL soluble proteins after 8 days of cultivation of the recombinant strain. During the subsequent anaerobic batch digestion experiments, methane production of 0.35 Nm3/kg dry feathers （i.e., 0.4 Nm3/kg volatile solids of feathers）, corresponding to 80% of the theoretical value on proteins, was achieved from the feather hydrolyzates, independently of the pre- hydrolysis time period of 1, 2 or 8 days. Cultivation with a native keratinase producing strain, bacillus licheniformis resulted in only 0.25 mg/mL soluble proteins in the feather hydrolyzate, which then was digested achieving a maximum accumulated methane production of 0.31 Nm3/kg dry feathers. Feather hydrolyzates treated with the wild type b. megaterium produced 0.21 Nm3 CH4/kg dry feathers as maximum yield.

关键词： anaerobic digestion feather waste keratinase, bacillus licheniformis bacillus megaterium gene expression

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A Facial Expression Emotion Recognition based Human-robot Interaction System

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IEEE/CAA Journal of Automatica Sinica 2017年第4期4卷 668-676页

作者： Zhentao Liu Min Wu Weihua Cao Luefeng Chen Jianping Xu ri Zhang Mengtian Zhou Junwei Mao School of Automation China University of Geosciences Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems IEEE

A facial expression emotion recognition based human-robot interaction(FEER-Hri) system is proposed, for which a four-layer system framework is designed. The FEERHri system enables the robots not only to recognize human emotions, but also to generate facial expression for adapting to human emotions. A facial emotion recognition method based on2D-Gabor, uniform local binary pattern(LbP) operator, and multiclass extreme learning machine(ELM) classifier is presented,which is applied to real-time facial expression recognition for robots. Facial expressions of robots are represented by simple cartoon symbols and displayed by a LED screen equipped in the robots, which can be easily understood by human. Four scenarios,i.e., guiding, entertainment, home service and scene simulation are performed in the human-robot interaction experiment, in which smooth communication is realized by facial expression recognition of humans and facial expression generation of robots within 2 seconds. As a few prospective applications, the FEERHri system can be applied in home service, smart home, safe driving, and so on.

关键词： Emotion generation facial expression emotion recognition(FEER) human-robot interaction(Hri) system design

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Electron Raman scattering in semiconductor quantum well wire of cylindrical ring geometry

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Chinese Physics b 2015年第11期24卷 442-447页

作者： Re.betancourt-riera ri.betancourt-riera J.M.Nieto Jalil R.riera Instituto Tecnol ógico de Hermosillo.Avenida Tecnol ógico S/N Col.Sahuaro Departamento de Investigaci ón en Física Universidad de Sonora Tecnol ógico de Monterrey-Campus Sonora Norte.bulevar Enrique Mazón López No.965

We study the electron states and the differential cross section for an electron Raman scattering process in a semi- conductor quantum well wire of cylindrical ring geometry. The electron Raman scattering developed here can be used to provide direct information about the electron band structures of these confinement systems. We assume that the system grows in a GaAs/Al0.35Ga0.65As matrix. The system is modeled by considering T = 0 K and also a single parabolic con- duction band, which is split into a sub-band system due to the confinement. The emission spectra are discussed for different scattering configurations, and the selection rules for the processes are also studied. Singularities in the spectra are found and interpreted.

关键词： electron states Raman scattering selection rules quantum well wires

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baicalin Reduces Early brain Injury after Subarachnoid Hemorrhage in Rats

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Chinese Journal of Integrative Medicine 2020年第7期26卷 510-518页

作者： ZHANG Hua.b.n TU Xian-kun SONG Shi-wei LIANG ri-sheng SHI Song-sheng Department of Neurosurgery Fujian Medical University Union HospitalNeurosurgery Research Institute of Fujian ProvinceFuzhou(350001)China

Objective: To evaluate the effect of baicalin on subarachnoid hemorrhage(SAH) in rats and explore the potential mechanisms. Methods: Sprague-Dawley rats underwent experimental SAH and received treatment with baicalin at 10 or 50 mg/kg after 2 and 12 h of SAH. Neurological scores, brain water content, Evans-blue extravasation, and levels of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD), myeloperoxidase(MPO), and malondialdehyde(MDA) were measured 24 h after SAH. Expression of nuclear factor erythroid-related factor 2(Nrf2), NAD(P)H: quinone oxidoreductase 1(NQO1), matrix metalloproteinase-9(MMP-9), aquaporin 4(AQP4), occludin, and zonulaoccludens-1(ZO-1) were detected in the brain by Western blot. Heme oxygenase-1(HO-1) was detected by quantitative polymerase chain reaction, and tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) were assessed by enzyme-linked immunosorbent assay. Results: baicalin attenuated EbI 24 h after SAH in rats(Pbaicalin elevated neurological scores, GSH-Px, SOD, and increased the expression of Nrf2, NQO1, HO-1, occludin, and ZO-1 in SAH rats(Pbaicalin reduced MPO, MDA, and the expression of MMP-9, AQP4, TNF-α, and IL-1β(Pbaicalin reduced SAH-induced EbI, partially via activation of the Nrf2/HO-1 pathway and inhibition of MMP-9 and AQP4.

关键词： aquaporin 4 baicalin Chinese medicine early brain injury matrix metalloproteinase-9 subarachnoid hemorrhage

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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREb Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： LIU Xiao-rong LI Shuo-fu MEI Wen-ya LIU Xiang-dan ZHOU ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREb),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(Pbited RA-FLS migration and invasion,as well as the levels of TNF-α,IL-6,and IL-1β(Pbound to SRC and reduced the phosphorylation of SRC,ERK,and CREb(Pbitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(Pritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREb matrix metalloproteinase

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