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sARs-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Implications for Antibody Therapy and Vaccinations against COVID-19

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Research 2024年第3期2023卷 1-15页

作者： Xiaoying Ma Jady Liang Guangheng Zhu Preeti Bhoria Aron A.shoara Daniel T.MacKeigan Christopher J.Khoury sladjana slavkovicl Lisha Lin Danielle Karakas Ziyan Chen Viktor Prifti Zhenze Liu Chuanbin shen Yuchong Li Cheng Zhang Jiayu Dou Zack Rousseau Jiamin Zhang Tiffany Ni Xi Lei Pingguo Chen Xiaoyu Wu Hamed shaykhalishahi samira Mubareka Kim AConnelly Haibo Zhang ori Rotstein Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Department of Laboratory Medicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Department of Physiology University of TorontoTorontoONCanada CCOA Therapeutics Inc. TorontoONCanada Canadian Blood services Centre for Innovation TorontoONCanada The state Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Laboratory Medicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharmaceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Department of Medical Microbiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Department of Medicine University of TorontoTorontoONCanada Division of Cardiology.st.Michael's Hospital TorontoONCanada Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine University of TorontoTorontoONCanada interdepartmental Division of Critical Care Medicine University of TorontoTorontoONCanada Department of surgery University of Toronto TorontoONCanada.

The COVID-19 pandemic caused by sARs-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia(VITT)are both associated with thrombosis and thrombocytopenia;however,the underlying mechanisms remain inadequately *** infection and vaccination utilize the spike protein receptor-binding domain(RBD)of *** found that intravenous injection of recombinant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to human and mouse platelets was significantly reduced with relatedαIIbβ3 antagonists and mutation of the RGD(arginine-glycine-aspartate)integrin binding motif to RGE(arginine-glycine-glutamate).We developed anti-RBD polyclonal and several monoclonal antibodies(mAbs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and sARs-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and *** newly developed mAbs 4F2 and 4H12 have potential not only for diagnosis of sARs-CoV-2 virus antigen but also importantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

The combined role of visual and olfactory cues in foraging by Cataglyphis ants in laboratory mazes

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Current Zoology 2023年第4期69卷 401-408页

作者： Tomer Gilad ori Bahar Malak Hasan Adi Bar Aziz subach Inon scharf school of Zoology George S Wise Faculty of Life SciencesTel Aviv University69978 Tel AvivIsrael

Foragers use several senses to locate food,and many animals rely on vision and *** is beneficial not to rely on a single sense,which might fail under certain *** examined the contribution of vision and smell to foraging and maze exploration under laboratory conditions using Cataglyphis desert ants as a *** intensity,measured as the number of workers entering the maze and arriving at the target as well as target arrival time,were greater when food,blue light,or both were offered or presented in contrast to a *** trained to forage for a combined food and light cue elevated their foraging intensity with ***,foraging intensity was not higher when using both cues simultaneously than in either one of the two *** training,we split between the two cues and moved either the food or the blue light to the opposite maze *** manipulation impaired foraging success by either leading to fewer workers arriving at the target cell(when the light stayed and the food was moved)or to more workers arriving at the opposite target cell,empty of food(when the food stayed and the light was moved).This result indicates that ant workers use both senses when foraging for food and readily associate light with food.

关键词： binary-tree maze desert ants diet choice foraging sensual modality spatial learning

多壁纳米碳管对磷酸铁锂正极材料热稳定性及表面形貌的影响(英文)

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新型炭材料 2013年第1期28卷 1-7页

作者： Mária Filkusová Andrea Fedorková Renáta oriňáková Andrej oriňák Zuzana Nováková Lenka skantárová Department of Physical and Theoretical Chemistry Faculty of Science Comenius University Mlynská|Dolina SK-842 15 Bratislava 4 Slovak Republic Department of Physical Chemistry Faculty of Science P.J. afárik University Moyzesova 11 SK-04154 Koice Slovak Republic Department of Electrical and Electronic Technology Faculty of Electrical Engineering and Communication Brno University of Technology Czech Republic Department of Analytical Chemistry Faculty of Science Comenius University Mlynská|Dolina SK-842 15 Bratislava 4 Slovak Republic

合成了一种新型的LiFePO4/多壁纳米碳管(MWCNTs)复合正极材料。通过MWCNTs和PPy-PEG粘结剂有机地在LiFePO4颗粒间构成三维网络导电结构,并借助sEM、TGA和高分辨裂解气相色谱,研究了LiFePO4-MWCNT正极材料的表面形貌和热稳定性。结果表明... 详细信息

合成了一种新型的LiFePO4/多壁纳米碳管(MWCNTs)复合正极材料。通过MWCNTs和PPy-PEG粘结剂有机地在LiFePO4颗粒间构成三维网络导电结构,并借助sEM、TGA和高分辨裂解气相色谱,研究了LiFePO4-MWCNT正极材料的表面形貌和热稳定性。结果表明,500℃下该材料的热分解程度非常小,说明MWCNTs和PPy-PEG的复合是提高LiFePO4正极材料的热稳定性和改善表面形貌的有效途径。

关键词：多壁纳米碳管多吡咯磷酸铁锂锂离子电池

Li, Huaiyin, Reinventing Modern China： Imagination and Authenticity in Chinese Historical Writing

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Frontiers of History in China 2014年第1期9卷 153-156页

作者： ori sela Tel Aviv University

Li Huaiyin＇s new book deals with the dialectic and competing processes ofwriting the history of ＂modem China＂ in China during the past century. Li presents the writing of history as a literary genre that has produced multiple narratives in different periods, narratives that corresponded to or were instigated by particular socio-political （especially political） circumstances of the protagonists of his story. In general, Li depicts these narratives as ＂romantic,＂＂optimistic,＂ or ＂pessimistic,＂ based on two major conflicting paradigms （or ＂grand narratives＂--Li often uses ＂narrative＂ and ＂paradigm＂ interchangeably）：＂modernization＂ and ＂revolutionary.＂

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Ultrafast photonic PCR

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Light(science & Applications) 2015年第1期4卷 267-273页

作者： Jun Ho son Byungrae Cho soonGweon Hong sang Hun Lee ori Hoxha Amanda J Haack Luke P Lee Department of Bioengineering University of CaliforniaBerkeleyCA 94720USA Berkeley sensor and Actuator Center University of CaliforniaBerkeleyCA 94720USA Department of Electrical Engineering and Computer sciences University of CaliforniaBerkeleyCA 94720USA Biophysics Graduate Program University of CaliforniaBerkeleyCA 94720USA

Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental *** multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC ***,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon *** demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 *** this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 *** photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)*** simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications.

关键词： genomics light-emitting diodes(LEDs) molecular diagnostics personalized medicine plasmonics point-of-care(POC)diagnostics polymerase chain reaction(PCR)

Unusual Presenting syndrome of Rheumatoid Arthritis Exacerbation

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Open Journal of Rheumatology and Autoimmune Diseases 2012年第1期2卷 1-2页

作者： Tatiana Reitblat Olga Reitblat ori Elkayam Department of Rheumatology Tel Aviv Medical Centre and The “Sackler” Faculty of Medicine Tel Aviv University Tel Aviv Israel. Rheumatology Unit Barzilai Medical Centre Ashkelon Israel

We herewith report the rare case of a patient with juvenile rheumatoid arthritis who developed on 2 occasions the clinical picture of an isolated unilateral palsy of the inferior oblique muscle—Brown’s syndrome, following pregnancies, each time in a different eye. Although the eye is frequently involved in rheumatoid arthritis (RA), the Brown’s syndrome is seldom reported in literature with regards to RA.

关键词： Brown’s syndrome Juvenile Rheumatoid Arthritis Rheumatoid Arthritis

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

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World Journal of Gastroenterology 2021年第11期27卷 1064-1075页

作者： José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B silva silvio Alencar C sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James s Owen Pierluigi Toniutto Reinaldo B oriá Department of Anesthesia and surgery Liver Transplantation Fortaleza General HospitalFortaleza 60150-160CEBrazil Laboratory of the Biology of Tissue Healing Ontogeny and NutritionDepartment of Morphology and Institute of BiomedicineSchool of MedicineFederal University of CearáFortaleza 60430-270CEBrazil Department of Dental Clinic Federal University of CearáFortaleza 60430-270CEBrazil Department of surgery Liver Transplant Unit of Federal University of CearáFortaleza 60430-270CEBrazil Transplantation Division Hospital Geral de FortalezaFortaleza 60175-742CEBrazil Institute of Virology CharitéUniversitätsmedizin BerlinBerlin 10117Germany UCL Medical school Royal Free CampusLondon NW32PFUnited Kingdom Department of specialized Medicine Hepatology Liver Transplantation UnitAzienda Sanitaria Universitaria Integrata of UdineUdine I-33100Italy

BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular *** E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver *** To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODs This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)*** injury severity was assessed using different criteria,including METAVIR and models for endstage liver *** polymorphisms were analyzed by quantitative real-time polymerase chain *** The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to *** addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 *** fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUsION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

关键词： Apolipoprotein E Polymorphism Liver cirrhosis Hepatitis C virus Hepatocellular carcinoma Liver transplantation

IBM Websphere Application server实用大全 4

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Prevalence and diagnosis of premenstrual dysphoric disorder among adolescent girls in Akron,Ohio and Nigeria

2003年

作者：（美）Ron Ben-Natan （美）ori sasson 熊志辉译

本书系统全面地阐明了从开发、装配、部署到管理Websphere电子商务应用程序的各个方面，本书还覆盖了包括JMs、JsP标记库、EJB扩展、Web服务等内容。

ISBN: (纸本)7894940348

本书系统全面地阐明了从开发、装配、部署到管理Websphere电子商务应用程序的各个方面，本书还覆盖了包括JMs、JsP标记库、EJB扩展、Web服务等内容。

关键词：软件开发电子商务

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Prevalence and diagnosis of premenstrual dysphoric disorder ...