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Gandalf软件开发环境

计算机科学 1985年第3期 13-22页

作者： a.n.habermann DavidS.notkin 赵和晨张悦

软件开发环境(简称 SDE)支持软件系统的构成和维护。SDE 不是软件设计方法学,而是一种能用来改善软件开发过程的效率和可靠性的机理。本文指出了 SDE 与现有操作系统及编程环境之间的一些差别。首先,SDE在面向目标方面与传统操作系统用... 详细信息

软件开发环境(简称 SDE)支持软件系统的构成和维护。SDE 不是软件设计方法学,而是一种能用来改善软件开发过程的效率和可靠性的机理。本文指出了 SDE 与现有操作系统及编程环境之间的一些差别。首先,SDE在面向目标方面与传统操作系统用户接口不同。其次,SDE 不仅象大多数系统那样对编程提供支持,还对系统版本控制和课题管理提供支持。再次,SDE 以综合的、一致的、交互的方式提供这种支持。GandaIf 课题的主要目的是建立和完善 SDE。所以 Gandalf 课题的结果不仅仅是一个 SDE,而是一个能用来生成许多不同的 Gandalf 环境的 Gandalf系统。本文讨论 Gandalf 系统的特性及其生成环境。

关键词：版本控制课题管理特权用户模块模件程序员 Gandalf 中缀表达式代码生成程序代码生成器数据对象软件

Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial

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World Journal of Diabetes 2023年第12期14卷 1813-1823页

作者： Sebastian Hoerder Isabel Valentina habermann Katrin Hahn Gesa Meyer-Hamme Miriam Ortiz Weronika Grabowska Stephanie Roll Stefan n.Willich Sven Schroeder Benno Brinkhaus Joanna Dietzel Institute of Social Medicine Epidemiology and Health EconomicsCharitéUniversitätsmedizinBerlin 10117Germany Department of neurology CharitéUniversitätsmedizinCharitéplatz 1Berlin 10117Germany HanseMerkur Center of Traditional Chinese Medicine at University Hospital Eppendorff Martinistr 52Hamburg 20246Germany

BACKGROUnD Diabetic peripheral neuropathy(DPn)is a common complication of diabetes mellitus and can lead to serious *** strategies for pain control are available but there are few approaches that influence neurological deficits such as *** To investigate the effectiveness of acupuncture on improving neurological deficits in patients suffering from type 2 *** The acupuncture in DPn(ACUDPn)study was a two-armed,randomized,controlled,parallel group,open,multicenter clinical *** were randomized in a 1:1 ratio into two groups:The acupuncture group received 12 acupuncture treatments over 8 wk,and the control group was on a waiting list during the first 16 wk,before it received the same treatment as the other *** groups received routine *** parameters were evaluated after 8,16 and 24 wk and included neurological scores,such as an 11-point numeric rating scale(nRS)11 for hypesthesia,neuropathic pain symptom inventory(nPSI),neuropathy deficit score(nDS),neuropathy symptom score(nSS);nerve conduction studies(nCS)were assessed with a handheld point-of-care ***-two participants were *** nRS for numbness showed a difference of 2.3(Pn favor of theacupuncture group,the effect persisted until week 16 with a difference of 2.2(Pn groups and 1.8points at week 24 compared to *** nPSI was improved in the acupuncture group by 12.6 points(PnSS score at week 8 with a difference of 1.3(PnDS and the TnSc score improvedfor the acupuncture group in week 8,with a difference of 2.0 points(Pntrol *** were persistent in week 16 with a difference of 1.8 points(PnCS showed no *** both groups only minor side effects were *** Study results suggest that acupuncture may be beneficial in type 2 diabetic DPn and seems to lead to a reductionin neurological *** serious a

关键词： Diabetic peripheral neuropathy numbness nerve conduction study Acupuncture

First record of stable isotopes(δ^(13)C, δ^(18)O) and element ratios(Mg/Ca, Sr/Ca) of Middle to Late Jurassic belemnites from the Indian Himalayas and their potential for palaeoenvironmental reconstructions

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Journal of Palaeogeography 2021年第3期10卷 416-437页

作者： Matthias Alberti Franz T.Fursich Dhirendra K.Pandey nils Andersen Dieter Garbe-Schonberg Suraj Bhosale Ketan Chaskar Jorg M.habermann State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringCenter for Research and Education on Biological Evolution and Environment and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023Jiangsu ProvinceChina GeoZentrum nordbayern Friedrich-Alexander-Universität Erlangen-NürnbergLoewenichstraße 2891054 ErlangenGermany Department of Geology School of EarthBiological and Environmental ScienceCentral University of South Bihar SH 7Gaya-Panchanpur RoadVillage KarharaPost FatehpurGaya 824236(Bihar)India Department of Earth and Environmental Science KSKV Kachchh UniversityBhujIndia Leibniz Laboratory for Radiometric Dating and Stable Isotope Research Christian-Albrechts-Universität zu KielMax-Eyth-Straße 1124118 KielGermany Institut für Geowissenschaften Christian-Albrechts-Universität zu KielLudewig-Meyn-Straße 1024118 KielGermany

Middle to Late Jurassic belemnites from the Spiti and Zanskar valleys in the Indian Himalayas were used for stable isotope(δ^(13)C, δ^(18)O) and element(Mg/Ca, Sr/Ca) analyses. Although the Himalayan orogeny deformed and altered a large portion of the collected fossils, cathodoluminescence and scanning electron microscopy in combination with analyses of iron and manganese contents allowed the identification of belemnites believed to still retain their original chemical composition. Results indicate a long-term temperature decrease from the Middle Callovian–Oxfordian to the Tithonian, which is proposed to have been caused by a concomitant drift of eastern Gondwana into higher palaeolatitudes. Reconstructed absolute temperatures depend on the used equation and assumed δ^(18)O value of seawater, but most likely varied between 17.6 ℃ to 27.6℃ in the Kimmeridgian and Tithonian with average values between 22 ℃ to 24 ℃. This way, temperatures were similar to slightly warmer than today at comparable latitudes. The reconstruction of absolute temperatures for the Middle Callovian–Oxfordian was hindered by a larger number of poorly preserved belemnites representing this time interval.

关键词： Jurassic Palaeoclimate Water temperature Spiti Zanskar India Tethyan Himalaya Eastern Gondwana

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Long-term results of the treatment of Hodgkin’s lymphoma in a resource-constrained setting:Real-world data from a single center

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World Journal of Clinical Oncology 2021年第9期12卷 800-807页

作者： Luisa Fernanda Sánchez-Valledor Thomas M habermann Iván Murrieta-Alvarez Alejandra Carmina Córdova-Ramírez Montserrat Rivera-Álvarez Andrés León-Peña Yahveth Cantero-Fortiz Juan Carlos Olivares-Gazca Guillermo JoséRuiz-Delgado Guillermo JoséRuiz-Argüelles Escuela de Medicina Universidad de las Américas PueblaCholula 72810PueblaMexico Department of Medicine Division of HematologyMayo Clinical and Mayo FoundationRochesterMN 55905United States Centro de Hematología y Medicina Interna Clínica RuizPuebla 72530Mexico Escuela de Medicina Universidad Popular Autónoma del Estado de PueblaPuebla 72410Mexico

BACKGROUnD The outcomes of Hodgkin's lymphoma(HL)in Mexico have not been widely *** and affordable treatments have been adopted in middleincome *** The aim was to evaluate long-used therapies for HL in Mexico in a long-term *** In a 34-year time period,88 patients with HL were treated at a single institution in *** were treated with adriamycin bleomycin vinblastine and dacarbazine(ABVD)or mechlorethamine,vincristine,procarbazine,and prednisone(MOPP).Relapsed or refractory patients were given ifosfamide,carboplatin,and etoposide(ICE)followed by autologous or allogeneic stem cell *** Thirty-seven women and 51 men were included;the median age was 29 *** were followed for a mean of 128 *** 310-mo overall survival(OS)was 83%for patients treated with MOPP and 88%for those treated with *** OS of patients who received autologous stem cell transplantation was 76%(330 mo)vs 93%(402 mo)in those who did *** HL may be less aggressive in Mexican population than in *** chemotherapy renders acceptable results,regardless of clinical stage.

关键词： Hodgkin Lymphoma Treatment ABVD chemotherapy

Absolute Lymphocyte/Monocyte Ratio at Diagnosis and Interim Positron-Emission Tomography Predict Survival in Classical Hodgkin Lymphoma

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Journal of Cancer Therapy 2013年第3期4卷 452-459页

作者： Luis F. Porrata Kay M. Ristow Thomas M. habermann Thomas E. Witzig Joseph P. Colgan David J. Inwards Stephen M. Ansell Ivana n. Micallef Patrick B. Johnston Grzegorz nowakowski Carrie A. Thompson Svetomir n. Markovic Division of Hematology Internal Medicine Mayo College of Medicine Rochester USA

Interim Positron-Emission Tomography (int-PET) and the peripheral blood absolute lymphocyte/monocyte ratio at di- agnosis (ALC/AMC-DX) have been shown to be predictors for progression-free survival (PFS) and time to progression (TTP) in classical Hodgkin lymphoma (cHL). Therefore, we studied if the combination of ALC/AMC-DX and the (int-PET) can further stratified PFS and TTP in cHL patients. Patients were required to be diagnosed, treated, and followed with int-PET at Mayo Clinic, Rochester, Minnesota. From 2000 until 2008, 111 cHL patients qualified for the study. The median follow-up was 2.8 years (range: 0.3 - 10.4 years). Patients with a negative int-PET (n = 98) pre- sented with a higher ALC/AMC-DX (median of 2.32, range: 0.26 - 37.5) compared with patients with a positive int-PET (n = 13) (median of 0.9, range: 0.29 - 3.10), p 1.1. Group 1 experienced superior PFS and TTP in comparison with the other groups. In conclusion, the combination of ALC/AMC-DX and the int-PET provides a simple model to assess clinical outcomes in cHL.

关键词： Classical Hodgkin Lymphoma Absolute Lymphocyte/Monocyte Ratio at Diagnosis Interim PET-Scan Progression-Free Survival Time to Progression

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角膜接触镜用于眼球穿通伤术后视力的恢复

世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 40-41页

作者： Grunauer-Kloevekorn C. habermann A. Wilhelm F. 肖颖 Universitatsaugenklin. mit Poliklin. Martin-Luther-Univ. Halle-Witte n berg Ernst-Grube-Strasse 40 06097 Halle Germany Dr.

Introduction: Visual rehabilitation after open globe injury may be a challengi ng process because of ametropia following aphakia, corneal scarring with high or irregular corneal astigmatism or loss of contrast sensitivity due to traumatic aniridia. We report on contact lens fitting for visual rehabilitation in patient s after open globe injury. Patients: From 2000 to 2003, contact lenses were fitt ed unilaterally for the visual rehabilitation in 13 patients after open globe in jury. In three patients we found unilateral aphakia, in 8 patients a high or irr egular astigmatism after penetrating or autorotation keratoplasty and in two pat ients a traumatic aniridia, in one case combined with aphakia. Results: 11 rigid contact lenses were fitted with different designs of the front and back surface as well as two iris-print lenses. In 11 patients (86%) a good visual rehabili tation was achieved with an increase of visual acuity up to 9 lines while obtain ing a good contact lens tolerance. One patient wearing an iris-print contact le ns was unable to tolerate the contact lens due to its thickness and its weight. In another patient fitting of a contact lens was not possible because of the com plicated corneal condition. We did not observed severe contact lens complication s at any time. Conclusions: In addition to operative procedures for visual rehab ilitation after open globe injuries, the use of contact lenses is another possib le procedure for refractive correction. Different problems such as ametropia fol lowing aphakia, irregular or high astigmatism or aniridia can be solved with goo d visual results, good tolerance and less complications.

关键词：眼球穿通伤术后视力外伤性无虹膜角膜接触镜角膜散光屈光不正角膜瘢痕角膜成形术对比敏感度表面设计

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