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Spinal Analgesia with Intrathecal Morphine versus Conventional Analgesia after Laparoscopic Colectomy: A Retrospective Cohort Study

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Open Journal of Anesthesiology 2024年第7期14卷 159-174页

作者： Lionel Diyamona Manon Colin marc Léone Laurent Zieleskiewicz Joseph Nsiala Wilfrid Mbombo Rachel Mbala Bruno Pastene Chris Nsituavibidila Dan Kankonde Gracia Likinda jean Claude Mubenga Khazy Anga Noelly Mukuna Christel Isengingo Department of Anaesthesia and Intensive Care University Clinics of Kinshasa University of Kinshasa Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Marseilles Nord Hospital Marseille France General Hospital of Kinshasa ex Mama Yemo Kinshasa Democratic Republic of the Congo Department of Anaesthesia and Intensive Care Monkole Hospital Centre Kinshasa Democratic Republic of the Congo

Objective: Postoperative pain (POP) following abdominal surgery can vary from a few hours to several days. This acute, unrelieved pain can become chronic, requiring patients to take analgesics on an almost daily basis for comfort. Analgesia using general opioids has many side effects and intrathecal morphine is a good alternative. This study was conducted to evaluate the efficacy of intrathecal morphine (ITM) versus conventional analgesia in the management of postoperative pain in colectomy performed by laparoscopic surgery. Methods: Cohort study conducted at the Hôpital Nord in Marseille, from 01 January to 31 July 2021 in patients aged at least 18 years undergoing anaesthesia for scheduled colectomy by laparoscopic surgery. The primary endpoint was postoperative pain intensity and the secondary endpoints were morphine consumption, treatment side effects and length of hospital stay. Statistical analysis was performed using XLSTAT software. Results: We included 193 patients: 131 in the control group (conventional analgesia) and 62 in the ITM group. We observed: a significant decrease in pain (assessed by numerical scale) in favour of the ITM group in the post-anaesthetic care room, i.e. 3 (±4) vs 1 (±2), p 0 and H2: 2 (±2) vs. 1 (±2);p Conclusion: These results suggest that intrathecal morphine (ITM) in laparoscopic colectomy provides effective postoperative analgesia with low morphine consumption, and a reduction in morphine side-effects compared with conventional analgesia.

关键词： Intrathecal Morphine Colectomy Laparoscopy Conventional Analgesia

Bacteriological Profile of Infections Encountered in a Pneumology Service in a Moderate-Income Country [Pneumology Department of CHU Cocody (Côte d’Ivoire)]

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Open Journal of Respiratory Diseases 2024年第1期14卷 1-11页

作者： Brou jean marcel Ahui Alitonde Eudoxie Djegbeton Alima Kone marc-Olivier Koffi Kouame Clarisse Elogne Mobio Nancy Hermine Benjamin Kouraogo Erick Akouatia Constante Virginie Brou-Gode Kigninlman Horo Boko Alexandre Kouassi Ngoran Koffi Pneumology Service Teaching Hospital of Cocody Abidjan C&#244te d’Ivoire Medical School of Abidjan University Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Pasteur Institute of Cô te d’Ivoire Abidjan C&#244te d’Ivoire

Introduction: Infections represent a real public health problem aggravating the morbidity and mortality of hospitalized patients. Methods: This was a retrospective study with descriptive purposes over a period of 05 years, in the Pneumology Department of the University Hospital of Cocody. Results: The average age in our population was 42 years. We observed a male predo- minance of 64.5%, with a sex ratio of 1.8. Medical history was dominated by HIV infection (23.5%), followed by tuberculosis (15.6%). Concerning lifestyle, smoking was found in 38% of cases. Symptoms progressed chronically in 80% of cases. An infectious syndrome was found in 75% of cases. Microbial culture was positive in 42% of cases. Pseudomonas aeruginosa and Klebsiella pneumoniae were encountered in 26.4% of cases each, followed by Echerichia coli in 10.4% of cases. Klebsiella pneumoniae in the first three years topped the list, but gradually. Pseudomonas aeruginosa maintained its leadership over the last three years. Pseudomonas aeruginosa isolates expressed a resistance rate of 9.8% to ceftazidime and 8.1% to imipenem;to aztreonam (36%), ticarcillin (33.3%) and levofloxacin. These strains were susceptible to fosfomycin (100%), mero- penem (96.6%) and amikacin (96%). For isolated strains of Entero- bacteria- ceae, resistance was observed about ticarcillin (83.3%) and amoxicillin clavula- nic acid (71.2%). Streptococcaceae showed resistance to tetracycline (69.2%) and erythromycin (50%). Over the years there has been an increase in re- sistance to amoxicillin-clavulanic acid ceftriaxone. The death rate was 14%. Conclusion: The bacterial profile of infections is dominated by germs respon- sible for nosocomial infection with significant mortality.

关键词： Bacterial Pleural Pneumonia Nosocomial Infection Sub-Saharan Africa Antibiotic Therapy

Generalized Backward Doubly Stochastic Differential Equations Driven by Lévy Processes with Continuous Coefficients

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Acta Mathematica Sinica,English Series 2012年第10期28卷 2011-2020页

作者： Auguste AMAN jean marc OWO UFR de Mathématiques et Informatique Université de Cocody

A new class of generalized backward doubly stochastic differential equations （GBDSDEs in short） driven by Teugels martingales associated with Levy process are investigated. We establish a comparison theorem which al... 详细信息

关键词： Backward doubly stochastic differential equations L@vy processes Teugels martingales comparison theorem continuous and linear growth conditions

Wear Behavior of a Bio-inspired Bearing for off-center Loads

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Journal of Bionic Engineering 2020年第6期17卷 1251-1262页

作者： Delphine Sysaykeo jean-marc Linares Emmanuel Mermoz Alix-Marseile Universite CNRSCentre National de la Recherche ScientifiqueISMInstitut des Sciences du MouvementMarseille 13009France Advanced concepts and Dynamic systems architecture department Airbus HelicoptersAeroport International Marseille ProvenceMarignane 13700France

Misalignment is one of the most common causes of wear in bush *** improvements have been proposed by many ***,it did not efficiently reduce the *** geometrical designs sometimes reach their *** this reason,a bio-inspired design is proposed to solve the *** this article,a bio-inspired bearing suited to misalignment was tested and compared to a classical bush *** contact pressures of both bearings were compared with static Finite Element(FE)simulations for off-center *** to the complex shape of the involved contact,the performances of both bearings were also studied over *** wear behaviors were predicted with a numerical *** methodologies emplaced to simulate the wear were described in this ***,the wear coefficient determination obtained by experimental testing was *** pressure value,the contact zone and the wear depth were compared and *** wear results for the classical bearing are in accordance with the *** simulations show a deeper wear on the classical bush bearing than on the bio-inspired *** leads to a longer period of service life for the bio-inspired bearing.

关键词： biologically inspired design bush bearing wear simulation

Joint Loading Estimation Method for Horse Forelimb High Jerk Locomotion:Jumping

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Journal of Bionic Engineering 2019年第4期16卷 674-685页

作者： Joanne Becker Mermoz Emmanuel Linares jean-marc Airbus Helicopters Aeroport de Marseille ProvenceMarignane 13700France Aix Marseille Univ CNRSISMInst Movement SciMarseille 13009France

Maximal local loads in animal joints are necessary to design bio-inspired mechanical *** studies presented methods to determine joint reaction forces in humans and ***,many of these methods are invasive,and no work has been published yet about the joint reaction forces in the horse forelimb during ***-invasive methods to measure the kinematics and ground reaction force of a horse forelimb were used in this work.A musculoskeletal model of horse forelimb was built with mechanical methods for the estimation of joint reaction *** entire forelimb was reconstructed by scanning real bones geometry with a 3D optical scanner and modeling all the muscles on a Computer Assisted Design(CAD)*** model dynamics were simulated with OpenSim in order to estimate the joint *** study allows knowing an order of magnitude of the loads at the joints at jumping in order to determine latter the maximal joint contact loading values that will be a key at designing bio-inspired joints for mechanical assemblies.

关键词： joint loading jumping kinematics modelling OpenSim

Towards standardizing taxonomic ranks using divergence times-a case study for reconstruction of the Agaricus taxonomic system

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Fungal Diversity 2016年第3期78卷 239-292页

作者： Rui-Lin Zhao Jun-Liang Zhou Jie Chen Simona Margaritescu Santiago Sánchez-Ramírez Kevin D Hyde Philippe Callac Luis A.Parra Guo-Jie Li jean-marc moncalvo State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institute of Microbiology and Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijing 100083China Center of Excellence in Fungal Research Mae Fah LuangUniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Natural History Royal Ontario MuseumTorontoON M5S 2C6Canada Department of Ecology and Evolutionary Biology University of TorontoTorontoON M5S 3B2Canada Key Laboratory of Economic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650201China INRA-UR1264 Mycologie et Sécuritédes AlimentsCS 2003233882 Villenave d’Ornon cedexFrance Avda.Padre Claret n°7 5°G09400 Aranda de DueroBurgosSpain

The recognition of taxonomic ranks in the Linnean classification system is largely *** authors have proposed the use of divergence time as a universally standardized ***(Agaricaceae,Agaricales)is a mushroom genus that contains many species of high commercial *** studies using ITS sequence data discovered 11 new phylogenetic lineages within the genus,however their taxonomic ranks were uncertain due to the lack of criteria to define them within traditional *** this study,we analyzed ITS sequence data from 745 collections(nearly 600 being newly generated)including 86 from type specimens of previously recognized subgenera and *** monophyletic groups were recognized,but most basal relationships were *** hundred and fourteen representatives of the identified ITS clades were selected in order to produce a multi-gene phylogeny based on combined LSU,tef-1α,and rpb2 sequence *** times within the multi-gene phylogeny were estimated using BEAST *** on phylogenetic relationships and with respect to morphology,we propose a revised taxonomic system for Agaricus that considers divergence time as a standardized criterion for establishing taxonomic *** propose to segregate Agaricus into five subgenera and 20 *** Pseudochitonia is substantially emended;circumscription of the subgenera Agaricus and Flavoagaricus is restricted to taxa of sections Agaricus and Arvenses,respectively;and two new subgenera(Minores and Spissicaules)are *** Pseudochitonia,sections Bivelares,Brunneopicti,Chitonioides,Nigrobrunnescentes,Sanguinolenti and Xanthodermatei are maintained,but the latter two are reduced because we raise subsection Bohusia to sectional rank and a clade within section Xanthodermatei is formally introduced as section Hondenses;and sections Rubricosi,Crassispori,Flocculenti,and Amoeni are *** Laeticolores is placed in the subgenus Minores and sections Rarolen

关键词： Agaricaceae Divergence times Multi-gene phylogenetics Systematics Taxonomy

The structure of the human 4F2hc-LAT1 heteromeric amino acid transporter

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Science China(Life Sciences) 2019年第6期62卷 848-850页

作者： Dimitrios Fotiadis jean-marc Jeckelmann Institute of Biochemistry and Molecular Medicine and Swiss National Centre of Competence in Research (NCCR) TransCureUniversity of Bern

Amino acids are biologically important molecules that serve as energy source, building blocks of proteins, precursors for metabolites and signaling compounds in all living *** of proteinogenic amino acids and related substances across biological membranes is mediated by membrane embedded proteins:the amino acid transporters. These membrane proteins belong to different solute carrier (SLC)families (http://***) and transfer amino acids in and out between compartments inside cells, between different cells and between organs. Amino acid transporters have diverse important physiological functions and their absence, overexpression and malfunction can lead to human diseases.

关键词： Amino acids important molecules functions and their absence

Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome

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World Journal of Gastroenterology 2022年第7期28卷 732-744页

作者： jean-marc Sabaté Franck Iglicki Department of Gastroenterology Hôpital AvicenneAP-HPSorbonne Paris NordBobigny 93000France INSERM U-987 Pathophysiology and Clinical Pharmacology of PainAmbroise ParéHospitalBoulogne-Billancourt 92100France allée Léon Gambetta Clichy 92110France

BACKGROUND Bifidobacterium longum 35624 has shown efficacy in improving irritable bowel syndrome(IBS)symptoms compared with placebo in double-blind randomized ***,few data are available from real-life clinical practice or from studies that used Rome IV criteria to diagnose *** To assess the effect of *** 35624 on IBS severity and quality of life in a reallife *** From November 2018 to January 2020,278 patients with IBS(according to Rome IV criteria)were enrolled in a prospective,open-label,multicenter observational study by private practice gastroenterologists to received one capsule of *** 35624(10^(9) colony-forming units)per day for 30 *** in the study was independently proposed to patients during spontaneous *** severity(assessed by the IBS severity scoring system)and patient quality of life(assessed by the IBS quality of life questionnaire)were compared between the inclusion visit(baseline)and the visit at the end of 30 d of *** characteristics of patients were described at *** variables comparisons between inclusion and end-of-treatment visits were performed using the t-test and Kruskal-Wallis *** variables comparisons were performed using theχ^(2) *** total of 233 patients,with a mean age of 51.4 years and composed of 71.2%women,were included in the *** these patients,48.1%had moderate IBS and 46.4%had severe *** a 30-d treatment period with one *** 35624 capsule per day,a significant decrease in IBS severity was observed compared to baseline(mean±SD,IBS severity scoring system scores:208±104 vs 303±81,P<0.001)and 57%of patients moved to lower severity categories or achieved *** quality of life of patients was also improved by the treatment(IBS Quality of Life questionnaire score:68.8±20.9 vs 60.2±20.5;P<0.001)and 63.8%of patients were satisfied with the *** Thirty days of treatment with *** 35624

关键词： Irritable bowel syndrome Probiotics Bifidobacterium longum Quality of life Severity of illness index Abdominal pain

Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

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Fungal Diversity 2014年第1期64卷 1-99页

作者： D.jean Lodge Mahajabeen Padamsee P.Brandon Matheny M.Catherine Aime Sharon A.Cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.M.Dentinger Paul M.Kirk a.martyn ainsworth.jean-marc moncalvo Rytas Vilgalys Ellen Larsson Robert Lücking Gareth W.Griffith Matthew E.Smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead Clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis Courtecuisse Anthony Young Manfred Binder Andrew M.Minnis Daniel L.Lindner Beatriz Ortiz-Santana John Haight Thomas Læssøe Timothy J.Baroni József Geml Tsutomu Hattori Center for Forest Mycology Research Northern Research StationUSDA-Forest ServiceLuquilloPR 00773-1377USA Systematics Team Landcare Research231 Morrin RoadAuckland 1072New Zealand Ecology&Evolutionary Biology University of TennesseeKnoxvilleTN 37996-1610USA Department of Botany&Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Science and Technology Universidad del TuraboGuraboPR 00778-3030USA Department of Bioscience Aarhus UniversityFrederiksborgvej 399DK-4000 RoskildeDenmark Komarov Botanical Institute of the Russian Academy of Sciences 2 Prof.Popov Str.St.Petersburg 197376Russia Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale P.A.Mattioli 2510125 TorinoItaly Mycology Royal Botanic GardensKewRichmondSurrey TW93DSUK Royal Ontario Museum 100 Queen’s ParkTorontoONCanada Biology Department Duke UniversityDurhamNC 27708-0338USA Biological&Environmental Sciences University of GothenburgGöteborgSweden Science&Eduaction Integrative Research&Collections(Botany)The Field Museum of Natural History1400 Lake Shore Dr.ChicagoIL 60605-2496USA University of Wales AberystwythCeredigion SY233DDUK Department of Plant Pathology University of FloridaGainesvilleFL 32611-0680USA Pacific Northwest Mycology Service 6720 NW Skyline BvdPortlandOR 97229-1309USA Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA National Mycological Herbarium(DAOM) Science and Technology BranchAgriculture&Agri-FoodsCanada960 Carling AvenueOttawaOntarioCanada ONT K1A 0C6 Department of Biology University of Central OklahomaEdmondOK 73034USA Department of Biology Bridgewater College402 E.College St.BridgewaterVA 22812USA Department of Botany Faculty of Pharmaceutical&Biological SciencesLilleFrance 100 Langton Road BlackbuttQld 4306Australia CBS Fungal Biodiversity Centre Evolutionary PhytopathologyInst.of the Royal Netherlands Academy of Arts&Sciences(KNAW)Uppsalalaan 83584 CT UtrechtThe Netherlands

Molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family *** phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,Cantharellula,Cantharocybe,Chromosera,Chrysomphalina,Cora,Corella,Cuphophyllus,Cyphellostereum,Dictyonema,Eonema,Gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to Chromosera is described as *** were made at the ranks of subfamily,tribe,genus,subgenus,section and *** present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one ***.),26 sections(five new and three new combinations and two ***.)and 14 subsections(two new,two ***.).Species of Chromosera,Gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification *** used a minimalist approach in transferring genera and creating new names and ***,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus,Ampulloclitocybe andCantharocybe,despite weak phylogenetic *** include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are *** lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,Macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula.

关键词： Hygrophoraceae Fungi Revisionary systematics Nomenclatural revision Phylogenetics Pigment chemistry Lamellar trama construction Hymenial morphology Ecology