The structure of the human 4F2hc-LAT1 heteromeric amino acid transporter

作     者：Dimitrios Fotiadis Jean-Marc Jeckelmann 

作者机构：Institute of Biochemistry and Molecular Medicine and Swiss National Centre of Competence in Research (NCCR) TransCureUniversity of Bern 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2019年第62卷第6期

页      面：848-850页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

主　　题：Amino acids important molecules functions and their absence 

摘      要：Amino acids are biologically important molecules that serve as energy source, building blocks of proteins, precursors for metabolites and signaling compounds in all living *** of proteinogenic amino acids and related substances across biological membranes is mediated by membrane embedded proteins:the amino acid transporters. These membrane proteins belong to different solute carrier (SLC)families (http://***) and transfer amino acids in and out between compartments inside cells, between different cells and between organs. Amino acid transporters have diverse important physiological functions and their absence, overexpression and malfunction can lead to human diseases.