检索结果-南通市图书馆

24th International Papillomavirus Conference and Clinical Workshop

作者： M. Lace Isacson C J Anson a.lorincz S. Wilczynski T Haugen L Turek The University of Iowa Virginia Mason Medical Center VA Medical Center Digene Corporation City of Hope Medical Center The University of Iowa The University of Iowa

＜正＞Cellular factors binding to cis sequences in the HPV-16 upstream regulatory region（URR）positively and negatively regulate, among other viral genes,the viral E6 and E7 *** determine the functional effects of sequence alterations we found in the URRs of HPV-16 isolates from cervical cancers on early events in the viral life cycle,structural and functional analyses

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

切削刀具:创新带来进步

国防制造技术 2011年第3期 36-39页

作者： Jim lorincz

随着诸如钛合金、高温合金等难加工材料越来越多的被应用于各个领域,以及对加工效率、可靠性的要求越来越高,切削刀具供应商们面临着前所未有的压力。各大刀具厂商在这一技术创新的浪潮中,都提出了各自的难加工材料解决方案,以满足市场... 详细信息

随着诸如钛合金、高温合金等难加工材料越来越多的被应用于各个领域,以及对加工效率、可靠性的要求越来越高,切削刀具供应商们面临着前所未有的压力。各大刀具厂商在这一技术创新的浪潮中,都提出了各自的难加工材料解决方案,以满足市场的需求。

关键词：切削刀具难加工材料高温合金金刚石涂层断屑技术创新高切削速度英格索尔材料去除率数控机

维普期刊数据库

Improvements To A Fast Affordable Sensitive Test For Hpv Detection In Resource-limited Regions

在线全文

学校读者我要写书评

暂无评论

Improvements To A Fast Affordable Sensitive Test For Hpv Det...

24th International Papillomavirus Conference and Clinical Workshop

作者： Sugi Ramachandran John Sellors Bernhard Weigl Roger Peck Attila.lorincz Paul Eder Qiagen PATH PATH PATH Qiagen Qiagen

＜正＞The world disease burden of cervical cancer is disproportionately carried by resource-limited countries Most cases of cervical cancer are associated with a limited number of high-risk（HR）types of human papillomavirus（HPV）Whereas prophylactic vaccines for HPV 16 and 18 are expected to play a major role in the primary prevention of cervical cancer,HPV DNA testing and visual inspection with acetic acid（VIA）are promising alternatives to cervical cytology for s primary screening Methods within

关键词：

Development Of A Fast Affordable Sensitive Test For Hpv Detection In Resource-limited Regions

在线全文

cnki会议

学校读者我要写书评

暂无评论

Development Of A Fast Affordable Sensitive Test For Hpv Dete...

24th International Papillomavirus Conference and Clinical Workshop

作者： Paul Eder David Walmer v Sankarayanayaran Bernhard Weigl Roger Peck John Sellors Attila.lorincz QIAGEN Duke University Medical Center Tata Memorial Hospital Mumbai PATH PATH PATH QIAGEN

＜正＞Cervical cancer incidence worldwide shows a disproportionate prevalence among economically developing regions In the majority of these cases,a limited number of high-risk（HR）types of human papillomavirus（HPV）are associated with the disease Despite the potential of primary prevention measures that include commercially available vaccines for HPV 16 and 18,

关键词：

Digene FastHPV Performance Trial in China

在线全文

cnki会议

学校读者我要写书评

暂无评论

Digene FastHPV Performance Trial in China

24th International Papillomavirus Conference and Clinical Workshop

作者： Laura Bell Arvind Virmani Eric Payne Sugi Ramachandran John Sellors Attila.lorincz Paul Eder QIAGEN QIAGEN QIAGEN QIAGEN PATH QIAGEN QIAGEN

＜正＞Cervical cancer is the second most common cancer among women worldwide 80% of cervical cancer deaths occur in developing countries due to the lack of effective screening programs,as the disease is preventable with appropriate screening and follow-up clinical *** current Digene hc2 HPV DNA Test using Hybrid Capture 2 technology is a nucleic acid hybridization assay with signal amplification that utilizes microplate chemiluminescent ***,women in develop-

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

科技塑造车间加工的新理念

国防制造技术 2011年第4期 35-38页

作者： Jim lorincz 常家辉耿琼

卧式、立式以及通用加工中心的相关技术一直在飞速发展。不论它是面向单一合约制造商还是生产型的原始设备制造商。控制装置、切削刀具和自动化设备等已经延伸到了加工中心的范畴。

关键词：加工中心切削刀具自动化设备控制装置高精度加工相关技术五轴数控五轴联动自动换刀原始设

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

脑腱黄瘤病的患病率可能高于以往认识

世界核心医学期刊文摘(神经病学分册) 2006年第1期 16-17页

作者： lorincz M.T. Rainier S. Thomas D. Fink J.K. 高中宝 5214 CCGCB Box 0940 1500 E Medical Center Dr Ann Arbor MI 48109-0940 United States Dr.

Background: Cerebrotendinous xanthomatosis (CTX) is a rare but treatable neurodegenerative disorder caused by 27-sterol hydroxylase (CYP27) deficiency. Objective: To describe clinical features and results of genetic analysis in a family with CTX. Design: Case report. Setting: University hospital. Subjects: A 54-year-old woman with CTX, her family members, and 115 white control subjects. Main Outcome Measures: Results of clinical evaluation and magnetic resonance imaging of the brain in the affected subject; results of mutation analysis of the CYP27 coding sequence in the patient, her parents, and the control subjects. Results: The proband and her affected sibling had classic features of CTX, including presenile cataracts, tendon xanthomas, diarrhea, and a complex neurodegenerative disorder. They were somewhat atypical, however, because their cataracts were congenital, cognitive impairment had been noted in childhood, and the white matter involvement was more severe than usual. The proband was shown to be homozygous for CYP27 mutation R362C. Similar analysis of 115 control subjects identified 1 subject who was a heterozygous carrier for this same CYP27 mutation. Conclusions: The prevalence of CTX due to CYP27 mutation R362C alone is approximately 1 per 50 000 among white individuals. Although the disorder is rare, this incidence is substantially greater than previously recognized. Greater awareness of CTX is important because specific treatment is available.

关键词：脑腱黄瘤病患病率神经变性

山西省襄垣县妇女人乳头状瘤病毒感染与宫颈癌关系的研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华流行病学杂志 2001年第5期22卷 375-378页

作者：赵方辉李楠马俊飞张洵吴令英戎寿德 lorincz A Belinson J 乔友林中国医学科学院肿瘤研究所肿瘤医院流行病室北京100021 中国医学科学院肿瘤研究所肿瘤医院妇瘤科北京100021 山西省襄垣县妇幼保健院中国医学科学院肿瘤研究所肿瘤医院病理科北京100021 Digene Corporation Cleveland Clinic Foundation

目的　了解我国宫颈癌高发区妇女生殖道人乳头状瘤病毒 (humanpapillomavirus ,HPV)感染状况 ,研究高危型HPV感染与宫颈癌的关系。方法　应用第二代杂交捕获试验对山西省襄垣县 1997名 35～ 45岁已婚妇女自己采集的阴道细胞和医生采集... 详细信息

目的　了解我国宫颈癌高发区妇女生殖道人乳头状瘤病毒 (humanpapillomavirus ,HPV)感染状况 ,研究高危型HPV感染与宫颈癌的关系。方法　应用第二代杂交捕获试验对山西省襄垣县 1997名 35～ 45岁已婚妇女自己采集的阴道细胞和医生采集的宫颈细胞 ,检测 13种高危型HPV脱氧核糖核酸 (DNA)。采用多因素的非条件logistic回归模型分析HPV感染与宫颈癌及宫颈上皮内瘤变 (CIN)的关系。用卡帕 (kappa)系数衡量两种标本HPV检测的符合度。结果　该人群的高危型HPVDNA总检出率为 2 0 .8%。HPVDNA检出率随病变程度加重呈趋势性增高 (χ2 =44 4.0 4,P =0 .0 0 0 )。两年龄组 (35～ 39岁和 40～ 45岁 )妇女的宫颈HPVDNA检出率几乎一样(2 0 .9%∶2 0 .6 %,χ2 =0 .0 3,P =0 .86 )。非条件logistic回归分析显示 ,HPV感染与宫颈上皮内高度病变及癌症 (≥CINⅡ )和低度病变 (CINⅠ )的发生高度相关 (OR =2 5 4.2和OR =2 6 .4) ,归因危险百分比 (ARP)分别为 98.1%和 83.6 %。自我取样HPV检测的灵敏度低于医生取样HPV检测 (84%∶98%,χ2 =5 .92 ,P =0 .0 15 ) ,特异度差异无显著性 (86 %∶85 %,χ2 =0 .0 0 ,P =0 .997) ,但两种标本HPV检测的符合度较好 (kappa =0 .74)。结论　女性生殖道高危型HPV感染是当地宫颈癌及CIN流?

关键词：宫颈肿瘤人乳头状瘤病毒盲法

维普期刊数据库