Upstream Regulatory Region Alterations Found In HPV-16 Isolates From Cervical Carcinomas Increase The Cell Transformation Potential of HPV-16 In Culture
作者单位：TheUniversity of Iowa VirginiaMason Medical Center VAMedical Center DigeneCorporation Cityof Hope Medical Center TheUniversity of Iowa TheUniversity of Iowa
会议名称：《24th International Papillomavirus Conference and Clinical Workshop》
会议日期：2007年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：正Cellular factors binding to cis sequences in the HPV-16 upstream regulatory region（URR）positively and negatively regulate, among other viral genes,the viral E6 and E7 *** determine the functional effects of sequence alterations we found in the URRs of HPV-16 isolates from cervical cancers on early events in the viral life cycle,structural and functional analyses