检索结果-南通市图书馆

维普期刊数据库

TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Yuan Dong Li Su Sin Man lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

关键词：

Mehler's formula and functional calculus Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2019年第6期62卷 1143-1166页

作者： Nicolas lerner Department of Mathematics Sorbonne Université

We show that Mehler's formula can be used to handle several formulas involving the quantization of singular Hamiltonians. In particular, we diagonalize in the Hermite basis the Weyl quantization of the characteristic ... 详细信息

关键词： Mehler’s formula quantization rough Hamiltonians

维普期刊数据库

Answering Reachability Queries on Incrementally Updated Graphs by Hierarchical Labeling Schema

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2016年第2期31卷 381-399页

作者： Tak-lam Wong Department of Mathematics and Information Technology The Hong Kong Institute of Education Hong Kong China

We proposed a novel solution schema called the Hierarchical Labeling Schema （HLS） to answer reachability queries in directed graphs. Different from many existing approaches that focus on static directed acyclic graphs （DAGs）, our schema focuses on directed cyclic graphs （DCGs） where vertices or arcs could be added to a graph incrementally. Unlike many of the traditional approaches, HLS does not require the graph to be acyclic in constructing its index. Therefore, it could, in fact, be applied to both DAGs and DCGs. When vertices or arcs are added to a graph, the HLS is capable of updating the index incrementally instead of re-computing the index from the scratch each time, making it more efficient than many other approaches in the practice. The basic idea of HLS is to create a tree for each vertex in a graph and link the trees together so that whenever two vertices are given, we can immediately know whether there is a path between them by referring to the appropriate trees. We conducted extensive experiments on both real-world datasets and synthesized datasets. We compared the performance of HLS, in terms of index construction time, query processing time and space consumption, with two state-of-the-art methodologies, the path-tree method and the 3-hop method. We also conducted simulations to model the situation when a graph is updated incrementally. The performance comparison of different algorithms against HLS on static graphs has also been studied. Our results show that HLS is highly competitive in the practice and is particularly useful in the cases where the graphs are updated frequently.

关键词： graph indexing reachability query Hierarchical Labeling Schema (HLS) incremental update directed cyclic graph

Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in synthetic juxtacrine circuits

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2023年第4期8卷 654-672页

作者： Calvin lam Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE68198USA.

The ability to control mammalian cells such that they self-organize or enact therapeutic effects as desired has incredible *** only would it further our understanding of native processes such as development and the immune response,but it would also have powerful applications in medical fields such as regenerative medicine and *** control is typically obtained by synthetic circuits that use synthetic receptors,but control remains *** synthetic juxtacrine receptors(SJRs)are widely used as they are fully modular and enable spatial control,but they have limited gene expression amplification and temporal *** these are integral facets to cell control,I therefore designed transcription factor based amplifiers that amplify gene expression and enable unidirectional temporal control by prolonging duration of target gene *** a validated in silico framework for SJR signaling,I combined these amplifiers with SJRs and show that these SJR amplifier circuits can direct spatiotemporal patterning and improve the quality of self-organization.I then show that these circuits can improve chimeric antigen receptor(CAR)T cell tumor killing against various heterogenous antigen expression *** amplifiers are flexible tools that improve control over SJR based circuits with both basic and therapeutic applications.

关键词： Synthetic biology Synthetic development Synthetic immunotherapy synNotch SNIPR Amplifiers Self-organization Temporal control Spatiotemporal control CAR T cell Synthetic receptors

Foot reflexology in autoimmune diseases:Effectiveness and mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第7期13卷 1-5页

作者： Jozélio Freire de Carvalho Aaron lerner Carina Benzvi Núcleo de Pesquisa em Doenças Crônicas não Transmissíveis Federal University of BahiaSalvador 40231-300BahiaBrazil Department of Research Chaim Sheba Medical CenterThe Zabludowicz Research Center for Autoimmune DiseasesRamat Gan 52621Israel

Foot reflexology(FR)is a Chinese-originated and non-invasive complementary therapy increasingly used by functional,alternative and para-medical *** attempts are made to study FR in non-functional organic *** present invited Editorial discusses the application of FR in autoimmune diseases(AD),highlighting a few successful studies demonstrating symptomatic relief and objective *** promising results,the FR domain remains under-investigated and an urgent need to confirm and understand the effect of FR in chronic diseases,including AD,is highly recommended.

关键词： Reflexology Foot reflexology Sensorineural hearing loss Autoimmune diseases Autoimmunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phase change memory

Science China(Information Sciences) 2011年第5期54卷 1061-1072页

作者： lam Chung IBM Research T.J. Watson Research Center Yorktown Heights New York 10598 USA

Phase change memory (PCM) is a non-volatile solid-state memory technology based on the large resistivity contrast between the amorphous and crystalline states in phase change materials. We present the physics behind this large resistivity contrast and describe how it is being exploited to create high density PCM. We address the challenges facing this technology, including the design of PCM cells, fabrication, device variability, thermal cross-talk and write disturb. We discuss the scalability, assess the performance, and examine the reliability of PCM including data retention, multi-bit storage and endurance.

关键词： solid state memory non-volatile DRAM flash phase change resistive memory data retention write endurance solid-state drive computer memory

Nutritional deficiencies in the pediatric age group in a multicultural developed country,Israel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2014年第5期2卷 120-125页

作者： Motti Haimi Aaron lerner Children’s Health Center Clalit Health ServicesBruce and Ruth Rappaport School of MedicineTechnion-Israel Institute of Technology34369 HaifaIsrael Pediatric Gastroenterology and Nutrition Unit Carmel Medical CenterBruce and Ruth Rappaport School of MedicineTechnion- Israel Institute of Technology34369 HaifaIsrael

Nutrient deficiencies are prevalent *** and morbid conditions have been described to result from nutritional *** is essential to address nutrient deficiencies as these may lead to chronic longterm health problems such as rickets,iron deficiency anemia,goiter,obesity,coronary heart disease,type2 diabetes,stroke,cancer and *** the present review we surveyed the extent and severity of nutritional deficiencies in Israel through a selective and comprehensive Medline review of previous reports and studies performed during the last 40 *** populations have multiple nutritional deficiencies,including iron,calcium,zinc,folic acid,and vitamins B12,C,D and E,spanning all age groups,several minorities,and specific *** Israel,some of the nutrients are mandatorily implemented and many of them are implemented voluntarily by local *** suggest ways to prevent and treat the nutritional deficiencies,as a step to promote food fortification in Israel.

关键词： Nutrient deficiencies Type 2 diabetes Obesity Israel

Schistosomal appendicitis:A serious and often misdiagnosed condition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第10期13卷 62-64页

作者： Phi Duong Nguyen Thanh Kien lam Orthopaedic-Burn-Plastic Surgery City Children’s HospitalHo Chi Minh City 71815Viet Nam The Faculty of Medical Technology Van Lang UniversityHo Chi Minh City 700000Viet Nam

Schistosomal appendicitis(SA)is a rare but serious complication of schistosomiasis,a parasitic disease affecting over 250 million people worldwide.A recent retrospective study by Wang et al provides important insights into the clinicopathological characteristics of *** study compared 136 cases of SA to 5418 cases of non-SA over a ten-year *** findings include a higher average age of SA patients(61.73 years vs 35.8 years for non-SA),a higher proportion of acute on chronic appendicitis(33.1%vs 16%),and a significantly higher incidence of colorectal cancer(11.7%vs 2.2%).Despite these differences,SA remains a diagnostic challenge due to its nonspecific clinical presentation and lack of specific laboratory *** study also highlights the persistent prevalence of SA,accounting for 1.6%-3.4%of all appendicitis cases each year from 2013 to *** findings underscore the need for enhanced awareness,early detection,and prompt treatment of SA in endemic *** the association with colorectal cancer,patients with SA require thorough screening and *** research into the pathogenesis and diagnostic markers of SA is *** the global battle against schistosomiasis continues,targeted efforts to diagnose and manage SA can significantly improve patient outcomes.

关键词： Schistosomal appendicitis Schistosomiasis Colorectal cancer Misdiagnosis Clinicopathological characteristics

Conditional Coverage Estimation for High-Quality Prediction Intervals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2023年第3期32卷 289-319页

作者： Ziyi Huang Henry lam Haofeng Zhang School of Engineering and Applied Science Columbia UniversityNew YorkNY 10027USA

Deep learning has been recently studied to generate high-quality prediction intervals(PIs)for uncertainty quantification in regression tasks,including recent applications in simulation *** high-quality criterion requires PIs to be as narrow as possible,whilst maintaining a pre-specified level of data(marginal)***,most existing works for high-quality PIs lack accurate information on conditional coverage,which may cause unreliable predictions if it is significantly smaller than the marginal *** address this problem,we propose an end-to-end framework which could output high-quality PIs and simultaneously provide their conditional coverage *** doing so,we design a new loss function that is both easy-to-implement and theoretically justified via an exponential concentration *** evaluation on real-world benchmark datasets and synthetic examples shows that our approach not only achieves competitive results on high-quality PIs in terms of average PI width,but also accurately estimates conditional coverage information that is useful in assessing model uncertainty.

关键词： Uncertainty quantification prediction intervals conditional coverage neural networks calibrationerror