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Hepatocellular carcinoma review:Current treatment,and evidence-based medicine

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World Journal of Gastroenterology 2014年第15期20卷 4115-4127页

作者： Ali Raza Gagan k sood Department of Internal Medicine St. Luke’s Episcopal HospitalBaylor College of MedicineHoustonTX 77030United States Division of Gastroenterology and Hepatology Baylor College of MedicineSt. Luke’s Liver CenterHoustonTX 77030United States

Hepatocellular carcinoma(HCC)is the fifth most common tumor *** treatment options are available for HCC including curative resection,liver transplantation,radiofrequency ablation,trans-arterial chemoembolization,radioembolization and systemic targeted agent like *** treatment of HCC depends on the tumor stage,patient performance status and liver function reserve and requires a multidisciplinary *** the past few years with significant advances in surgical treatments and locoregional therapies,the short-term survival of HCC has improved but the recurrent disease remains a big *** pathogenesis of HCC is a multistep and complex process,wherein angiogenesis plays an important *** patients with advanced disease,sorafenib is the only approved therapy,but novel systemic molecular targeted agents and their combinations are *** article provides an overview of treatment of early and advanced stage HCC based on our extensive review of relevant literature.

关键词： Hepatocellular carcinoma Trans-arterial chemoembolization Drug-eluting beads Radiofrequency ablation Liver transplantation Chemotherapy Sorafenib Radioembolization

Hepatitis C Associated B-cell Non-Hodgkin Lymphoma:Clinical Features and the Role of Antiviral Therapy

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Journal of Clinical and Translational Hepatology 2015年第2期3卷 134-139页

作者： Syed Tasleem Gagan k sood Department of Surgery St.Luke's Center for Liver Disease Baylor College of Medicine Houston Texas USA Department of Surgery St.Luke's Center for Liver Disease Baylor College of Medicine Houston Texas USA Department of Gastroenterology and Hepatology Baylor College of Medicine Houston Texas USA

The link between chronic hepatitis C virus (HCV) infection and a subset of B-cell non-Hodgkin lymphomas (B-NHL) is strongly supported by epidemiological *** demonstrating complete regression of lymphoma after antiviral treatments suggests possible chronic antigenic stimulation for the origin of B-NHL and provides evidence for a virus-mediated lymphomagenesis.B-NHL is a heterogeneous group of lymphomas with varied clinical presentation and may be indolent or *** optimal management of HCV related B-NHL is not *** treatment may be sufficient for low-grade lymphomas,but chemotherapy is necessary in patients with high grade *** (IFN)-based antiviral treatment regimens for HCV infection are limited by poor tolerance and suboptimal antiviral *** approved novel direct acting antiviral (DAA) drugs are highly effective and *** has opened a new era for the treatment of HCV related B-NHL alone or in conjunction with *** of HCV associated B-NHL should be performed in an interdisciplinary approach in close consultation with hematologist and *** this review,we summarize data regarding clinical features and epidemiology of B-NHL and discuss novel therapeutic approaches,including DAAs,that may prove to be effective in the treatment of HCV associated lymphomas.

关键词： Hepatitis C Non-Hodgkin lymphoma Mixed cryoglobulinemia Rituximab

Advancing frontiers in anaesthesiology with laparoscopy

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World Journal of Gastroenterology 2014年第39期20卷 14308-14314页

作者： Jayashree sood Department of Anaesthesiology Pain and Perioperative Medicine Sir Ganga Ram Hospital Old Rajinder Nagar New Delhi 110060 India

The introduction of laparoscopy in the surgeon’s armamentarium was in fact a “revolution in the history of surgery”. Since this technique involves insufflation of carbon dioxide it produces several pathophysiological changes which have to be understood by the anaesthesiologist who can modify the anaesthesia technique accordingly. Advantages of laparoscopy include reduced pain, small scars and early return to work. Certain complications specific to laparoscopic surgery are due to carboperitoneum and increased intra-abdominal pressure. Venous air embolism, although very rare, can be lethal if not managed promptly. Other complications include subcutaneous emphysema, haemodynamic compromise and arrhythmias. Although associated with minimal postoperative morbidity, postoperative pain, nausea and vomiting can be quite problematic. The limitations of laparoscopy have been overcome by the introduction of robotic surgery. There are important implications for the anaesthesiologist during robotic surgeries which have to be practiced accordingly. Robotic surgery has a learning curve for both the surgeon and the anaesthesiologist. The robot is bulky, and cannot be disengaged after docking. Therefore it is important that the anaesthetized patient remains immobile throughout surgery and anaesthesia is reversed only after the robot has been disengaged at the end of surgery. Advances in laparoscopy and robotic surgery have modified anaesthetic techniques too.

关键词： Laparoscopy Anaesthesia Robotic Advances Pathophysiological changes Complications

Fragment emission and critical behavior in light and heavy charged systems

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Chinese Physics C 2021年第1期45卷 215-225页

作者： Samiksha sood Rohit kumar Arun Sharma Sakshi Gautam Rajeev k.Puri Department of Physics Panjab UniversityChandigarh 160014India Department of Physics G.D.College.BillawarJammu 185204India

We study the emission of fragments in central collisions of light and heavily charged systems of^4+Ar+^45 Sc and^s4kr+^197 Au,respectively,using the Quantum Molecular Dynamics(QMD)model as the primary *** fragments are identified using an energy based clusterization algorithm,i.e.,the Simulated Annealing Clusterization Algorithm(SACA).The charge distributions of intermediate mass fragments[3≤Zf≤12]are fitted with power-law(∝Zf^-τ)and exp on ential(∝e^-λZf)fits in order to extract the parametersτandλ,whose minimum values are also sometimes linked with the onset of fragmentation or the critical point for a liquid-gas phase *** parameters such as the normalized second moment,,average size of the second largest cluster,phase separation parameter(Sp),bimodal parameter(P),information entropy(H),and Zipfs law are also analyzed to find the exact energy of the onset of *** detailed analysis predicts that an energy point exists between 20-23.1 MeV/nucleon,which is very close to the experimentally observed value of 23.9 MeV/nucleon for the^40Ar+^45Sc *** also find that the critical energy deduced using Zipfs law is higher than those predicted from other critical ***,no minimum is found for t values of the highly charged system of^84kr+^197Au,in agreement with experimental findings and various theoretical *** observe that the QMD+SACA model calculations are in agreement with the experimental *** agreement supports our results regarding the energy point of the liquid-gas phase transition and the onset of fragmentation.

关键词： heavy-ion collisions transport model clusterization algorithm Monte-Carlo technique li・quid-gas phase transition

Tribological response of waste tire rubber as micro-fillers in automotive brake lining materials

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Friction 2020年第6期8卷 1153-1168页

作者： Anand PAI Sayikumar SUBRAMANIAN Tribhuvan sood Department of Aeronautical and Automobile Engineering Manipal Institute of TechnologyManipal Academy of Higher Education ManipalKarnataka 576104lIndia Cranfield University CranfieldMilton KeynesBedfordshire MK430ALUK

Elastomeric materials show promise as potential micro-fillers in brake *** can provide vibration damping and acoustic advantages in intermittent and abrupt impact applications such as *** elastomeric material can be salvaged from non-biodegradable automotive tires,thereby providing an opportunity to reuse materials that will otherwise be discarded in *** tribological and thermomechanical performances of the waste tire rubber were assessed to determine their potential for use as micro-fillers in the brake linings of commercial vehicles with a gross weight less than 16 ***,the brake lining materials were fabricated with fine waste tire rubber particulates(WTRPs)as the micro-fillers,phenolic-R resin as the binder,graphite as the dry lubricant,laterite as the co-filler,and coconut coir for natural fiber *** effects of increasing the WTRP weight fraction on the brake response of the linings were analyzed,and the different compositions were benchmarked against a commercial brake *** characterization comprising compressive strength,hardness,density,and porosity studies were carried *** and wear characteristics of the linings were analyzed using a rotary tribometer with simultaneous thermal *** manufactured lining with 15 wt%WTRPs exhibited a mean friction coefficient of^0.38,a specific volumetric loss rate of 1,662μm3/(N?m),and improved thermal *** optical microscopy and scanning electron microscopy(SEM)with energy dispersive spectroscopy(EDS),wear surface morphology studies compared the relative development of primary and secondary plateaus and revealed the redistribution of wear debris,leading to the stability of the coefficient of friction.

关键词： automotive brakes elastomers graphite energy dispersive spectroscopy(EDS) scanning electron microscopy(SEM) wear mechanisms

Long term results of use of azathioprine in patients with ulcerative colitis in India

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World Journal of Gastroenterology 2006年第45期12卷 7332-7336页

作者： Ajit sood Vandana Midha Neena sood Manu Bansal Departments of Gastroenterology Dayanand Medical College and Hospital Ludhiana 141001 Punjab India Departments of Medicine Dayanand Medical College and Hospital Ludhiana 141001 Punjab India Departments of Pathology Dayanand MedicalCollege and Hospital Ludhiana 141001 Punjab India

AIM： To evaluate the role of azathioprine （AZA） in Indian patients with ulcerative colitis over longer duration of time. METHODS： One hundred fifty six patients with ulcerative colitis who were treated with AZA from January 1995 to December 2003 were reviewed. The indications for its use were as follows：（1） steroid dependent and steroid refractory disease; （2） Azathioprine monotherapy for na＇fve patients with severe disease; and （3） combination therapy （AZA ＋ sulfasalazine or 5-aminosalicylates） for naive patients with severe disease. The data included patient and disease demographics, efficacy and toxicity profile of AZA. Patients with a minimum duration of 6 mo use of AZA were included in this report. RESULTS： Of a total of 156 patients treated with AZA, 45 were excluded from analysis for the following reasons- （follow up less than 6 mo, n = 9; poor follow up, n = 18; adverse affects, n = 18）. In steroid refractory/dependent group the mean number of relapses prior to and post initiation of AZA therapy were 3.28 （± 0.81） and 0.94 （± 0.29） respectively. Discontinuation of steroids could be accomplished in 12 of the 15 steroid dependent patients. The proportion of patients with sustained remission of 1, 2, 3, 4 and 5 years duration were calculated. Eighteen patients experienced adverse effects necessitating withdrawal of AZA （pancreatitis, n = 7; hepatitis, n = 3; gastrointestinal intolerance, n = 2; alopecia, n = 2; and hematological, n = 4） while 13 patients needed dose reduction or temporary withdrawal of the drug. CONCLUSION： Azathioprine is well tolerated and has therapeutic benefits lasting as long as 4 years. Adverse effects such as pancreatitis, hepatitis, cytopenias and gastrointestinal symptoms do occur but are controlled by drug withdrawal only.

关键词： Ulcerative colitis Azathioprine Immunosuppressive

Electrochemical and electronic properties of nitrogen doped fullerene and its derivatives for lithium-ion battery applications

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Journal of Energy Chemistry 2018年第2期27卷 528-534页

作者： Parveen sood ki Chul kim Seung Soon Jang School of Materials Science and Engineering Georgia Institute of Technology Atlanta CA 30332-0245. USA Department of Chemical Engineering Konkuk University Seoul 05029 Republic of Korea Institute for Electronics and Nonotechnology Georgia Institute of Technology Atlanta GA 30332-0245 USA Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA 30332-0245 USA

We have studied the redox potentials and electronic properties of C60 and C59N using density functional theory method. It is found that doping C60 with one nitrogen atom results in a slight increase in redox potential. Next, we have also studied C59N functionalized with various redox-active oxygen containing functional groups and strongly electron withdrawing functional groups. It is found that the intrinsic electronic structure of the molecule is the major determinant of the redox potential. Our DFT calculations show that the electron affinity to redox potential of functionalized C59N is correlated with the LUMO of the systems very well. This is the first systematic study on the redox properties and electronic structures of N-doped C60 systems.

关键词： DFT Redox potential C60 Doping Li-ion battery

Barnyard millet global core collection evaluation in the submontane Himalayan region of India using multivariate analysis

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The Crop Journal 2015年第6期3卷 517-525页

作者： Salej sood Rajesh k.khulbe Arun kumar R. Pawan k. Agrawal Hari D.Upadhyaya Indian Council of Agricultural Research-Vivekananda Institute of Hill Agriculture International Crop Research Institute for the Semi-Arid Tropics (ICRISAT)

Barnyard millet(Echinochloa spp.) is one of the most underresearched crops with respect to characterization of genetic resources and genetic enhancement. A total of 95 germplasm lines representing global collection were evaluated in two rainy seasons at Almora,Uttarakhand, India for qualitative and quantitative traits and the data were subjected to multivariate analysis. High variation was observed for days to maturity, five-ear grain weight, and yield components. The first three principal component axes explained 73% of the total multivariate variation. Three major groups were detected by projection of the accessions on the first two principal components. The separation of accessions was based mainly on trait morphology. Almost all Indian and origin-unknown accessions grouped together to form an Echinochloa frumentacea group. Japanese accessions grouped together except for a few outliers to form an Echinochloa esculenta group. The third group contained accessions from Russia, Japan, Cameroon, and Egypt. They formed a separate group on the scatterplot and represented accessions with lower values for all traits except basal tiller number. The interrelationships between the traits indicated that accessions with tall plants, long and broad leaves, longer inflorescences, and greater numbers of racemes should be given priority as donors or parents in varietal development initiatives. Cluster analysis identified two main clusters based on agro-morphological characters.

关键词： Agro-morphological variation Barnyard millet core germplasm Cluster analysis Echinochloa spp Principal component analysis

Security and QoS issues in blockchain enabled next-generation smart logistic networks:A tutorial

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Blockchain(Research and Applications) 2022年第3期3卷 46-59页

作者： Anjali Vaghani keshav sood Shui Yu Deakin University GeelongVIC3220Australia University of Technology SydneyNSW2007Australia

The blockchain-enabled smart logistics market is expected to grow worth USD 1620 billion and at a compound annual growth rate of 62.4%.Smart logistics ensures intelligence infrastructure,logistics automation,real-time analysis of supply chain data synchronization of the logistics process,cost transparency,unbroken shipment tracking all the way down to the transportation route,*** the smart logistics domain,significant advancement and growth of the Internet of Things(IoT)sensors are ***,the connectivity of IoT systems,including Tactile Internet,without proper safeguards creates vulnerabilities that can still be deliberately or inadvertently cause *** view of this,we primarily notice two key ***,the logistics domain can be compromised by a variety of natural or man-made activities,which eventually affect the overall network ***,there are thousands of entities in the supply chain network that use extensive machine-learning algorithms in many scenarios,and they require high-power computational *** these two challenges,we note that the first concern can be addressed by adding blockchain to IoT logistic *** second issue can be addressed using *** will support 1-μs latency communications,support seamless computing at the edges of networks,and autonomously predict the best optimal location for edge *** by this,we have highlighted motivational examples to show the necessity to integrate 6G and blockchain in smart logistic ***,we have proposed a 6G and blockchain-enabled smart logistic high-level *** have presented the key intrinsic issues of this framework mainly from the security and resource management *** this paper,recent state-of-the-art advances in blockchain enabled next-generation smart logistic networks are *** have also examined why 6G and not 5G would be compatible with the smart *** have introduced five different use cases of blockcha

关键词： Blockchain Internet of Things 5G 6G Security Smart logistics