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Immunotherapy of gastric cancer:Present status and future perspectives

World Journal of Gastroenterology 2024年第8期30卷 779-793页

作者： John k Triantafillidis manousos m konstadoulakis Apostolos E Papalois Inflammatory Bowel Disease Unit “Metropolitan General”HospitalHolargos 15562AtticaGreece.Hellenic Society for Gastrointestinal Oncology354 Iera OdosChaidari 12461AtticaGreece Second Department of Surgery University of Athens School of MedicineAretaieion HospitalAthens 11528AtticaGreece Unit of Surgical Research and Training Second Department of SurgeryUniversity of AthensSchool of MedicineAretaieion HospitalAthens 11528AtticaGreece

In this editorial,we comment on the article entitled“Advances and key focus areas in gastric cancer immunotherapy:A comprehensive scientometric and clinical trial review(1999-2023),”which was published in the recent issue of the World Journal of *** focused on the results of the authors’bibliometric analysis concerning gastric cancer immunotherapy,which they analyzed in depth by compiling the relevant publications of the last 20 *** that,we briefly describe the most recent data concerning the epidemiological parameters of gastric cancer(GC)in different countries,attempting to give an interpretation based on the etiological factors involved in the etiopathogenesis of the *** then briefly discuss the conservative treatment(chemotherapy)of the various forms of this malignant *** describe the treatment of resectable tumors,locally advanced neoplasms,and unresectable(advanced)*** attention is given to modern therapeutic approaches with emphasis on immunotherapy,which seems to be the future of GC treatment,especially in combination with *** is also a thorough analysis of the results of the study under review in terms of the number of scientific publications,the countries in which the studies were conducted,the authors,and the scientific centers of origin,as well as the clinical studies in ***,an attempt is made to draw some conclusions and to point out possible future directions.

关键词： Gastric cancer Chemotherapy Immunotherapy Immune checkpoint inhibitors Bibliometrics Scientometrics

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The asymptotic behavior for a binary alloy in energy and material science:The unified method and its applications

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Journal of Ocean Engineering and Science 2024年第4期9卷 373-378页

作者： m.Adel k.Aldwoah F.Alahmadi m.S.Osman Department of mathematics Faculty of ScienceIslamic University of MadinahMedinaSaudi Arabia Department of mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt

The Cahn-Hilliard system was proposed to the first time by Chan and Hilliard in *** model(or system of equations)has intrinsic participation energy and materials sciences and depicts significant characteristics of two phase systems relating to the procedures of phase separation when the temperature is *** instance,it can be noticed when a binary alloy(“Aluminum+Zinc”or“Iron+Chromium”)is cooled down *** this case,partially or totally nucleation(nucleation means the appearance of nuclides in the material)is observed:the homogeneous material in the initial state gradually turns into inhomogeneous,giving rise to a very accurate dispersive ***,when the time scale is slower the microstructure becomes *** this work,to the first time,the unified method is presented to investigate some physical interpretations for the solutions of the Cahn-Hilliard system when its coefficients varying with time,and to show how phase separation of one or two components and their concentrations occurs dynamically in the ***,2D and 3D plots are introduced to add more comprehensive study which help to understand the physical phenomena of this *** technique applied in this analysis is powerful and efficient,as evidenced by the computational work and *** technique can also solve a large number of higher-order evolution equations.

关键词： Cahn-Hilliard system Traveling wave solutions The unified method Variable coefficients

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中巴经济走廊是巴基斯坦的中国债务陷阱吗？

中巴经济走廊是巴基斯坦的中国债务陷阱吗？

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作者： kALEEm ullah kHAN 山东财经大学

学位级别：硕士

中巴经济走廊(CPEC)是中国“一带一路”倡议(BRI)下的旗舰项目,引发了对其经济影响和对巴基斯坦债务可持续性潜在影响的广泛讨论。本研究对中巴经济走廊(CPEC)进行了全面分析,探讨了其多方面的维度,包括基础设施发展、能源项目、经济增... 详细信息

中巴经济走廊(CPEC)是中国“一带一路”倡议(BRI)下的旗舰项目,引发了对其经济影响和对巴基斯坦债务可持续性潜在影响的广泛讨论。本研究对中巴经济走廊(CPEC)进行了全面分析,探讨了其多方面的维度,包括基础设施发展、能源项目、经济增长潜力和地缘政治意义。通过对经验证据、金融机制??和项目成果的审查,该研究批判性地评估了中巴经济走廊(CPEC)作为巴基斯坦潜在“债务陷阱”的普遍说法,为该走廊对巴基斯坦经济的影响提供了细致入微的视角。调查结果显示,中巴经济走廊是巴基斯坦经济转型、加强能源安全、基础设施发展和区域互联互通的重要催化剂。中巴经济走廊(CPEC)下的战略投资具有促进长期经济增长、提高出口竞争力并吸引大量外国直接投资的潜力。然而,这些好处的实现取决于有效的债务管理、经济政策改革和资金来源的多元化。该研究强调了透明财务规划和实施全面改革的重要性,以确保中巴经济走廊的经济红利有助于可持续发展和债务可持续性。与简化的“债务陷阱”叙述相反,本研究认为,通过战略性金融管理和结构性改革,中巴经济走廊可以在增强巴基斯坦经济主权和促进可持续发展方面发挥关键作用。该研究的结论是,尽管面临挑战,中巴经济走廊仍为经济振兴和区域一体化提供了前所未有的机遇,标志着巴中关系进入了新时代,并为“一带一路”的更广泛目标做出了贡献。

关键词：中巴经济走廊(CPEC) 一带一路倡议(BRI) 债务可持续性

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Supposition of graphene stacks to estimate the contact resistance and conductivity of nanocomposites

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Applied mathematics and mechanics(English Edition) 2024年第4期45卷 663-676页

作者： Y.ZARE m.T.mUNIR G.J.WENG k.Y.RHEE Biomaterials and Tissue Engineering Research Group Department of Interdisciplinary TechnologiesBreast Cancer Research CenterMotamed Cancer InstituteTehran ***Iran College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait Department of mechanical and Aerospace Engineering Rutgers UniversityNew BrunswickNJ 08903U.S.A. Department of mechanical Engineering(Bk21 Four) College of EngineeringKyung Hee UniversityYongin 446701Republic of Korea

In this study,the effects of stacked nanosheets and the surrounding interphase zone on the resistance of the contact region between nanosheets and the tunneling conductivity of samples are evaluated with developed equations superior to those previously *** contact resistance and nanocomposite conductivity are modeled by several influencing factors,including stack properties,interphase depth,tunneling size,and contact *** developed model's accuracy is verified through numerous experimental *** further validate the models and establish correlations between parameters,the effects of all the variables on contact resistance and nanocomposite conductivity are ***,the contact resistance is primarily dependent on the polymer tunnel resistivity,contact area,and tunneling *** dimensions of the graphene nanosheets significantly influence the conductivity,which ranges from 0 S/m to90 S/*** increased number of nanosheets in stacks and a larger gap between them enhance the nanocomposite's ***,the thicker interphase and smaller tunneling size can lead to higher sample conductivity due to their optimistic effects on the percolation threshold and network efficacy.

关键词： graphene polymer composite stacked nanosheet tunneling conductivity contact resistance interphase

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Ovule number as a rising star for regulating seed yield: Hope or hype

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Journal of Integrative Agriculture 2024年第11期23卷 3623-3640页

作者： Shahid ullah khan Ahmad Ali Sumbul Saeed Yonghai Fan Ali Shehazd Hameed Gul Shah Fahad kun Lu Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City and Southwest University College of Agronomy and BiotechnologySouthwest University Engineering Research Center of South Upland Agriculture Ministry of Education Women medical and Dental College Khyber Medical University National key Laboratory of Crop Genetic Improvement Huazhong Agricultural University School of Environment and Science Griffith University College of Agronomy and Biotechnology Southwest University Department of Agronomy Abdul Wali Khan University Mardan Department of Natural Sciences Lebanese American University

Rapeseed(Brassica napus L.) is the second most widely grown premium oilseed crop globally, mainly for its vegetable oil and protein meal. One of the main goals of breeders is producing high-yield rapeseed cultivars with sustainable production to meet the requirements of the fast-growing population. Besides the pod number, seeds per silique(SS), and thousand-seed weight(TSW), the ovule number(ON) is a decisive yield determining factor of individual plants and the final seed yield. In recent years, tremendous efforts have been made to dissect the genetic and molecular basis of these complex traits, but relatively few genes or loci controlling these traits have been reported thus far. This review highlights the updated information on the hormonal and molecular basis of ON and development in model plants(Arabidopsis thaliana). It also presents what is known about the hormonal, molecular, and genetic mechanism of ovule development and number, and bridges our understanding between the model plant species(A. thaliana) and cultivated species(B. napus). This report will open new pathways for primary and applied research in plant biology and benefit rapeseed breeding programs. This synopsis will stimulate research interest to further understand ovule number determination, its role in yield improvement, and its possible utilization in breeding programs.

关键词： Brassica napus ovule number genetics ovule development hormonal signaling

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Physical properties and maximum allowable mass-radius relation of complexity-free compact stellar objects within modified f(R,T)gravity formalism

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Chinese Physics C 2024年第7期48卷 273-288页

作者： m.k.Jasim S.k.maurya Abdelghani Errehymy Ali khalid Jassim kottakkaran Sooppy Nisar Abdel-Haleem Abdel-Aty Department of mathematical and Physical Sciences College of Arts and SciencesUniversity of NizwaNizwa 616Sultanate of Oman Astrophysics Research Centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa Electrical Engineering Department College of EngineeringMustansiriyah UniversityBaghdadIraq Department of mathematics College of Science and Humanities in AlkharjPrince Sattam bin Abdulaziz UniversityAl KharjSaudi Arabia Department of Physics College of SciencesUniversity of BishaP.O.Box 344Bisha 61922Saudi Arabia

This paper investigates the physical properties and predicted radii of compact stars generated by the Tolman-IV complexity-free model within the background of modified gravity theory,particularly the f(R,T)-gravity theory,under complexity formalism for a spherically symmetric spacetime proposed by ***[Phys Rev D 97:044010,2018].By solving the resulting set of differential equations,we obtain the explicit forms of the energy-momentum(Em)tensor components,including the density,radial pressure,and tangential *** influence of the parameterχon various physical properties of the star is thoroughly *** model undergoes a series of rigorous tests to determine its physical *** findings indicate that the model exhibits regularity,stability,and a surface with vanishing *** boundary of this surface is determined by carefully selecting the parameter *** complexity method employed in f(R,T)gravity offers an interesting approach for developing astrophysical models that are consistent with observable events as demonstrated by recent *** this regard,we use observational data from the GW190814 event,detected by the LIGO and Virgo observatories,to investigate the validity of the Tolman-IV model in f(R,T)*** analysis includes comparing the model's predictions with the observed characteristics of the compact object involved in the *** addition,data from two-millisecond pulsars,PSR J1614-2230 and PSR J0952-0607,are incorporated to further constrain the theoretical ***,we present a diagram depicting the relationship between the total mass and radius of the compact object candidates for different values ofχ.

关键词： complexity modified gravity compact Stars

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Defect Engineering in Earth-Abundant Cu_(2)ZnSnSe_(4) Absorber Using Efficient Alkali Doping for Flexible and Tandem Solar Cell Applications

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Energy & Environmental materials 2024年第2期7卷 249-256页

作者： muhammad Rehan Ara Cho Inyoung Jeong kihwan kim Asmat ullah Jun-Sik Cho Joo Hyung Park Yunae Jo Sung Jun Hong Seung kyu Ahn SeJin Ahn Jae Ho Yun Jihye Gwak Donghyeop Shin Photovoltaics Research Department Korea Institute of Energy Research(KIER)152-Gajeong-roYuseong-guDaejeon 34129Korea Department of Renewable Energy Engineering University of Science and Technology(UST)217-Gajeong-roYuseong-guDaejeon 34113Korea korea Institute of Energy Technology(kENTECH) 50772 Ujeong-roNaju Jeonnam 58217Korea

To demonstrate flexible and tandem device applications,a low-temperature Cu_(2)ZnSnSe_(4)(CZTSe)deposition process,combined with efficient alkali doping,was ***,high-quality CZTSe films were grown at 480℃by a single co-evaporation,which is applicable to polyimide(PI)*** of the alkali-free substrate,Na and k alkali doping were systematically studied and optimized to precisely control the alkali distribution in *** bulk defect density was significantly reduced by suppression of deep acceptor states after the(NaF+kF)*** the low-temperature deposition with(NaF+kF)PDTs,the CZTSe device on glass yields the best efficiency of 8.1%with an improved Voc deficit of 646 *** developed deposition technologies have been applied to *** the first time,we report the highest efficiency of 6.92%for flexible CZTSe solar cells on ***,CZTSe devices were utilized as bottom cells to fabricate four-terminal CZTSe/perovskite tandem cells because of a low bandgap of CZTSe(~1.0 eV)so that the tandem cell yielded an efficiency of 20%.The obtained results show that CZTSe solar cells prepared by a low-temperature process with in-situ alkali doping can be utilized for flexible thin-film solar cells as well as tandem device applications.

关键词： alkali doping Earth-abundant Cu_(2)ZnSnSe_(4) flexible solar cells four-terminal tandem cells low-temperature process

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Assessment of spermatogenesis in camels via seminiferous tubule staging and testosterone profiling

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Asian pacific Journal of Reproduction 2024年第3期13卷 133-142页

作者： Saif ullah Abdul Quddus Quanwei Wei Wael Ennab Sheeraz mustafa Jiahao Sun Rahmani mohammad malyar Abdul Baseer Dagan mao Fangxiong Shi College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China Faculty of Veterinary and Animal Sciences Lasbela University of Agriculture Water and Marine SciencesBalochistanPakistan Faculty of Veterinary and Animal Sciences Ziaddin University karachi Pakistan

Objective:To investigate the successive morphological stages of spermatogenesis,hormonal regulation,and testosterone profile in dromedary camel ***:Testicular tissue samples were obtained from 12 dromedary bull camels aged 7 to 8 at a local *** histological assessment involved tissue processing,hematoxylin and eosin(H&E)staining,and examination under a *** analysis,germ cell identification,and assessment of seminiferous tubules and maturation were *** assay was performed by radioimmunoassay using blood samples collected at regular ***:The study revealed 12 phases of the dromedary camel's seminiferous epithelium cycle,highlighting distinct morphological characteristics and cellular *** migration,maturation,cap formation,and the Golgi-mediated synthesis of proacrosomal vesicles were also explained in dimension,as were the steps of acrosome *** and mature sperm cells were present when spermatogenesis phases were *** analysis of the dimensions of seminiferous tubules revealed specific measures for diameter,area,and epithelial height about luminal ***,there were noticeable variations in the serum testosterone concentrations during the study period,indicating temporal ***:This study outlines the spermatogenesis process in dromedary camels across 12 stages,emphasizing cellular dynamics and acrosomal *** also provides seminiferous tubule measurements and observes seasonal testosterone fluctuations,offering insights into reproductive regulation and potential strategies for camel breeding conservation.

关键词： Spermatogenesis Camel Testosterone profile morphological staging

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A new technique for fault diagnosis in transformer insulating oil based on infrared spectroscopy measurements

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High Voltage 2024年第2期9卷 319-335页

作者： mohamed m.F.Darwish mohamed H.A.Hassan Nagat m.k.Abdel-Gawad matti Lehtonen Diaa-Eldin A.mansour Department of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical Engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland Department of Electrical Power Engineering Egypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityEgypt Department of Electrical Power and machines Engineering Faculty of EngineeringTanta UniversityTantaEgypt

Condition monitoring of the insulating system within power transformers has a massive importance according to the electrical *** gas analysis(DGA)is frequently used for this ***,DGA lacks the necessary level of accuracy to identify all equipment faults,particularly in their initial stages of ***,it does not have the capability for real-time monitoring and relies on manual sampling and laboratory testing,causing potential delays in fault ***,the interpretation of DGA data necessitates specialised expertise,which may pose difficulties for smaller entities that have limited access to ***,the contribution of this research is to use infrared spectroscopy measurements as a new effective technique substituting the DGA method for fault diagnosis in insulating *** inception faults that were considered in this study were the electrical fault(discharges of high energy)and the thermal fault(300°Cmperaturemulation processes inside the laboratory for both types of inception ***,six samples of pure paraffinic mineral oil were taken to be degraded in the *** that,all of them besides another sample that were not subjected to any kind of faults were taken to be examined by Fourier transform infrared(FTIR)spectroscopy to obtain an overview of the oil's behaviour in each fault *** that,the FTIR analysis was initially verified utilising the DGA ***,for further affirmation,the dielectric dissipation factor(DDF)for all samples was *** the final analysis,the verification tests provide experimental evidence about the outperformance of this new optical technique in detecting the transformer's inception faults in addition to proving its potential for being a superior alternative to the well-known traditional diagnostic techniques.

关键词： fault diagnosis spectroscopy

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mechanical sensor PDLIm5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations

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Genes & Diseases 2024年第3期11卷 136-139页

作者： Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat ullah khan You Pan Wenqing Liu Jinhui Zhu muhammad Akram khan Chujiang Xu Jingxing Dai Jun Ouyang Guangdong Provincial key Laboratory of medical Biomechanics&National key Discipline of Human Anatomy Schoolof BasicMedical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Laboratory medicine Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of Pathology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510080China Department of Breast Surgery Guangxi Medical University Cancer HospitalNanningGuangxi 530000China Department of Veterinary Pathology Faculty of Veterinary and Animal SciencesPMAS Arid Agriculture UniversityRawalpindi 46300Pakistan Department of Orthopedics TCM-Integrated HospitalSouthern Medical UniversityGuangzhouGuangdong 510000China

Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout ***,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations.

关键词： alterations injuries massive

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