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Insights of the brain damage response using antibodies identifying surface antigens on neural stem cells and neuroblasts

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Neural Regeneration Research 2015年第10期10卷 1574-1575页

作者： Silvia Santamaria Jose a.garcia-Sanz Department of Cellular and Molecular Medicine Centro de Investigaciones Biologicas (CIB-CSIC)

Similarly to other adult tissues,a hierarchical structure has been established for the brain,where the differentiated cell types（neurons,oligodendrocytes and astrocytes）are generated from primary progenitor cells,known as type B astrocytes or neural stem cells （NSC）, through one or multiple stages of amplification （transient amplifying cells） that generate precursor cells （iPC） with more restricted potential nlPCs （neural）, alPCs （astrocytes）, olPC （oligodendrocytes）（Kriegstein and Alvarez-Buvlla, 2009）.

关键词： NSCs stem

A GIS-based methodology for the appraisal of historical,architectural,and social values in historic urban cores

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Frontiers of Architectural Research 2020年第4期9卷 900-913页

作者： Juan a.garcia-Esparza Pablo Altaba Tena Department of Mechanical Engineering and Construction Universitot Jaume I12071Castello de la PlanaSpain

Historic environments represent the evolution of materials and techniques that have been used for the construction these environments over the *** into the study of this field entails working not only on the crafts that have constructed these environ ments but also on the people who made,used,and reinterpreted them by learning about the craftsmen and the idiosyncrasies of the *** study has adopted several methodologies as referenee to examine the material and cultural reality of the rural region of Valencia,*** the adaptation of in ter national methodologies,researchers have carried out a digital database that compiles and maps out the results of the Local Character Assessment of ten Histotiric Urban Cores by incorporating the historical,architectural,and social values to reinforce the Territorial Heritage Action *** of the critical innovations adopted by this form of assessment is the compulsory integration of tangible and intangible heritage through the active involvement of users and *** innovation is to understand the values behind the dynamism and transformation of historic ***,this study advances theory and practice on the transmission of knowledge among artisans,researchers,and the population and how con temporary practices help acquire new meani ngs that overlap the past ones.

关键词： Historic environment Local Character Assessme nt Digital heritage GIS for heritage Heritage values

Estimates of voluntary activation in individuals with anterior cruciate ligament reconstruction:Effects of type of stimulator,number of stimuli,and quantification technique

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Journal of Sport and Health Science 2022年第1期11卷 85-93页

作者： Steven a.garcia Kazandra M.Rodriguez Scott R.Brown Riann M.Palmieri-Smith Chandramouli Krishnan School of Kinesiology University of MichiganAnn ArborMI 48109USA Neuromuscular and Rehabilitation Robotics Laboratory(NeuRRo Lab) Department of Physical Medicine and RehabilitationUniversity of MichiganAnn ArborMI 48108USA Department of Orthopaedic Surgery Michigan MedicineUniversity of MichiganAnn ArborMI 48109USA Robotics Institute University of MichiganAnn ArborMI 48109USA

Background:Accurate quantification of voluntary activation is important for understanding the extent of quadriceps dysfunction in individuals with anterior cruciate ligament reconstruction(ACLR).Voluntary activation has been quantified using both percent activation derived from the interpolated twitch technique and central activation ratio(CAR)derived from the burst superimposition technique,as well as by using different types of electrical stimulators and pulse train ***,it is unclear how these parameters affect voluntary activation estimates in individuals with *** study was performed to fill this important knowledge gap in the anterior cruciate ligament ***:Quadriceps strength and voluntary activation were examined in 18 ACLR participants(12 quadriceps/patellartendon graft,6 hamstring tendon graft;time since ACLR:1.06±0.82 years,mean±SD)at 90°of knee flexion using 2 stimulators(Digitimer and Grass)and pulse train conditions(3-pulse and 10-pulse).Voluntary activation was quantified by calculating both CAR and percent ***:Results indicated that voluntary activation was significantly overestimated by CAR when compared with percent activation(p0.05);however,the Digitimer evoked greater torque at rest than the Grass(p<0.001).Conclusion:These results indicate that percent activation derived from the interpolated twitch technique provides superior estimates of voluntary activation than CAR derived from burst superimposition and is less affected by pulse train conditions or stimulators in individuals with ACLR.

关键词： Anterior cruciate ligament Central activation Inhibition Knee strength Triplet Twitch interpolation

Generic sensor platform based on electro- responsive molecularly imprinted polymer nanoparticles (e-NanoMIPs)

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Microsystems & Nanoengineering 2020年第1期6卷 266-274页

作者： a.garcia-Cruz O.S.Ahmad K.Alanazi E.Piletska S.A.Piletsky School of Chemistry University of LeicesterLeicesterUK

The present research describes the design of robust electrochemical sensors based on electro-responsive molecularly imprinted polymer nanoparticles(e-MIPs).The e-MIPs,tagged with a redox probe,combine both recognition and reporting *** system replaces enzyme-mediator pairs used in traditional *** analyte recognition process relies on the generic actuation phenomenon when the polymer conformation of e-MIPs is changing in response to the presence of the template *** analyte concentration is measured using voltammetric *** an exemplification of this technology,electrochemical sensors were developed for the determination of concentrations of trypsin,glucose,paracetamol,C4-homoserine lactone,and *** present technology allows for the possibility of producing generic,inexpensive,and robust disposable sensors for clinical,environmental,and forensic applications.

关键词： functions. methods. polymer

Thin films of binary amorphous Zn-Zr alloys developed by magnetron co-sputtering for the production of degradable coronary stents:A preliminary study

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Bioactive Materials 2018年第4期3卷 385-388页

作者： Nathalie Annonay Fatiha Challali Marie-Noelle Labour Valerie Bockelee a.garcia-Sanchez Florent Tetard Marie-Paule Besland Philippe Djemia Frederic Chaubet Laboratoire de Science des Materiaux et des Procedes UPR CNRS 3407Universite Paris 13Sorbonne-Paris-CiteInstitut Galilee99 av J.B.Clement93430VilletaneuseFrance Laboratory for Vascular Translational Science Inserm U1148Universite Paris 13Universite Paris-DiderotSorbonne-Paris-CiteInstitut Galilee99 av J.B.Clement93430VilletaneuseFrance Institut des Materiaux Jean Rouxel(IMN)UMR CNRS 6502 Universite de Nantes2rue de la HoussiniereB.P.3222944322Nantes Cedex 3France

*** Vascular stents are endo-prostheses that allow the restoration of blood flow in case of obstruction of a vessel.A stent usually consists of a corrosion-resistant metal such as Nitinol,316L steel or a CoCr alloy[1].Many studies have been undertaken for the production of polymer degradable stents[2,3]or metallic stents[4,5]and,among these,devices made of pure zinc or crystallized alloy based on zinc obtained by molding and extrusion are promising in terms of biodegradability,biocompatibility and mechanical properties[6],but also concerning the degradation rate of the stent which should to be effective until arterial remodeling and tissue healing are complete[5].The objective of this preliminary study is the comparison of the degradation in simulated biological medium and the endothelial cytotoxicity of amorphous and crystallized thin ZnZr films according to their composition and *** this work,the thin layers were deposited on silicon substrates by magnetron *** technology is already used to make metal stents[7,8].

关键词： alloy alloys corrosion

高温超导体中磁通涡旋的量子隧道效应——TlBaCaCuO化合物磁弛豫的实验研究

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物理学进展 1996年第2期16卷 215-228页

作者：张西祥白海力 a.garcia 姜恩永 T.Tejada

本文报道了ＴｌＢａＣａＣｕＯ超导体（２２１２，２２２３单相，多晶及薄膜材料）中磁弛豫现象的实验结果。从实验上证实了通量运动由热激活到非热激活机制的转变。实验中得到的与温度无关的磁弛豫速率与由通量运动量子隧道效应理论计... 详细信息

本文报道了ＴｌＢａＣａＣｕＯ超导体（２２１２，２２２３单相，多晶及薄膜材料）中磁弛豫现象的实验结果。从实验上证实了通量运动由热激活到非热激活机制的转变。实验中得到的与温度无关的磁弛豫速率与由通量运动量子隧道效应理论计算结果相一致。

关键词：高温超导体量子隧道效应 TBCCO 磁弛豫

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荧光素眼底血管造影术

眼科学报 1986年第3期2卷 198-204页

作者： Robert P.Murphy 荘时 Charles a.garcia 美国霍普金斯大学医学院眼科美国霍普金斯大学医学院眼科美国德克萨斯州休斯敦市德克萨斯大学医学院眼科赫曼眼科研究所威尔玛眼科研究所视网膜血管中心威尔玛眼科研究所视网膜血管中心中国内蒙古自治区乌兰察布盟医院留美访问学者

荧光素眼底血管造影术 1871年Von Bayer合成荧光素染料。十年后,Paul Ehrlich观察到注药后前房很快显示一垂直的染色线条,在眼内有炎症的情况下,染色形状有所改变,以此作为鉴别眼部血管渗透性正常或异常的指

关键词：脉络膜炎脉络膜疾病荧光素眼底血管造影术荧光素充盈色素上皮眼底荧光素血管造影窗样缺损透见荧光

Land-use change and windstorms legacies drove the recolonization dynamics of laurel forests in Tenerife, Canary islands

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Forest Ecosystems 2023年第1期10卷 113-124页

作者： Vicente Rozas Maria a.garcia-Lopez Jose M.Olano Gabriel Sanguesa-Barreda Miguel garcia-Hidalgo Susana Gomez-Gonzalez Roberto Lopez-Rubio Jose M.Fernandez-Palacios Ignacio garcia-Gonzalez Laura Lozano-Lopez Paula.garcia-Gonzalez Ana I.garcia-Cervigon EiFAB-iuFOR Universidad de ValladolidCampus Duques de Soria42004SoriaSpain Departamento de Biologia-IVAGRO Universidad de CadizCampus Rio San Pedro11510Puerto RealSpain Center for Climate and Resilience Research(CR)2 Blanco Encalada 20028370449SantiagoChile Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n28933MostolesSpain Grupo de Ecologia y Biogeografia Insular Universidad de La Laguna38206La LagunaTenerifeSpain BIOAPLIC Departamento de BotanicaEscola Politecnica Superior de EnxenariaCampus TerraUniversidade de Santiago de CompostelaLugo27002Spain

Laurel forests are quite relevant for biodiversity conservation and are among the island ecosystems most severely damaged by human *** the past,Canary laurel forests have been greatly altered by logging,livestock and *** remains of laurel forests are currently protected in the Canary Islands(Spain).However,we miss basic information needed for their restoration and adaptive management,such as tree longevity,growth potential and responsiveness to natural and anthropogenic *** dendrochronological methods,we studied how forest dynamic is related to land-use change and windstorms in two well-preserved laurel forests on Tenerife *** cores were collected from over 80 trees per stand at three stands per *** used ring-width series to estimate tree ages and calculate annual basal area increments(BAI),cumulative diameter increases,and changes indicative of released and suppressed *** tree species were found in all stands,with Laurus novocanariensis,Ilex canariensis and Morella faya being the most common *** some individuals were over 100 years old,61.8%-88.9% of the trees per stand established between 1940 and 1970,coinciding with a post-war period of land abandonment,rural exodus and the onset of a tourism *** trees have shown growth rates larger than 1 cm diameter per year and most species have had increasing BAI trends over the past *** growth releases occurred after windstorms at both sites,but the effects of windstorms were site-dependent,with the 1958 storm affecting mainly the eastern tip of the island(Anaga massif)and the 1991 storm the western tip(Teno massif).Given the great ability of laurel forest trees to establish after land use cessation and to increase growth after local disturbances such as windstorms,passive restoration may be sufficient to regenerate this habitat in currently degraded areas.

关键词： Canary islands Dendroecology Disturbance Forest structure Macaronesia Management cessation Tree rings

Cellular/dendritic transition,dendritic growth and microhardness in directionally solidified monophasic Sn-2%Sb alloy

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Transactions of Nonferrous Metals Society of China 2018年第8期28卷 1679-1686页

作者： O.L.ROCHA T.A.COSTA M.DIAS a.garcia Federal hlstitute of Education Science and technology of Para - IFPA 66093-020 Belem-Para Brazil Faculty of mechanical Engineering Federal University of Para - UFPA 66075-110 Belem-Para Brazil Department of Manufacturing and Materials Engineering University of Campinas-UNICAMP 13083-860 Campinas-Sao Paulo Brazil

Horizontal directional solidification experiments were carried out with a monophasic Sn-2%Sb（mass fraction） alloy to analyze the influence of solidification thermal parameters on the morphology and length scale of the microstructure. Continuous temperature measurements were made during solidification at different positions along the length of the casting and these temperature data were used to determine solidification thermal parameters, including the growth rate（VL） and the cooling rate（TR）. High cooling rate cells and dendrites are shown to characterize the microstructure in different regions of the casting, with a reverse dendrite-to-cell transition occurring for TR5.0 K/s. Cellular（λc） and primary dendrite arm spacings（λ1） are determined along the length of the directionally-solidified casting. Experimental growth laws relating λc and λ1 to VL and TR are proposed, and a comparative analysis with results from a vertical upward directional solidification experiment is carried out. The influence of morphology and length scale of the microstructure on microhardness is also analyzed.

关键词： Sn-Sb monophasic alloy directional solidification thermal paIameters inicrostructure reverse cellular/dendritictransition