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Chinese Business Review 2009年第9期8卷 49-53页

作者： Werner frese Vitali Altholz Department of Economics Technische Universitat Dortmund Dortmund 44227 Germany International Graduate School Zittau Zittau 02763 Germany

Case Studies on Acupuncture Principles in Headaches

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Chinese Medicine and Culture 2021年第2期4卷 93-98页

作者： Saroj Kumar Pradhan Andreas Rudolf Gantenbein Yi-Ming Li Sebastian frese Susanne Lehmann Felix Angst Department of Traditional Chinese Medicine Zurzach Care/TCM-Klinik Ming DaoBad Zurzach 5330Switzerland Department of Research Swiss TCM AcademyBad ZurzachSwitzerland in Collaboration with Department of ResearchNanjing University of Chinese MedicineNanjing 210029JiangsuChina Department of Neurology and Neurorehabilitation Zurzach CareBad Zurzach 5330Switzerland Department of Prevention Zurzach CareBad Zurzach 5330Switzerland Department of Research Zurzach CareBad Zurzach 5330Switzerland

Objective:This observational cohort pilot study aimed to evaluate the effects of the acupuncture methods,Jiu Cang Zhen(JCZ)and Huang Guan(HG),on changes in headache intensity in an inpatient,multimodal Zurzach Headache Programme(ZHP).Methods:Study participants consisted of patients diagnosed with chronic headache disorder(headache ds,30 days per month)or daily persistent *** patients received conventional therapies with active and passive *** patient group was treated with JCZ and HG acupuncture methods,receiving a total of six to eight acupuncture sessions of 50 to 60 minutes each,during a 3–4-week multimodal ZHP at the RehaClinic Bad *** intensity was quantified using a Numerical Rating Scale(NRS)before and after each acupuncture therapy ***:Ten patients were recruited,six women and four men,with a mean age of 41.7(standard deviation,[SD]=13.9).A reduction in headache intensity was reported by all patients in each of the *** average NRS for pain was 4.21(SD=1.44)before acupuncture and 1.24(SD=0.93)after acupuncture(means first by number of sessions,then per n=10 patients).This resulted in a mean difference of 2.97(SD=1.04),corresponding to a standardized response mean of 2.85(95%confidence interval:2.11–3.60,one-tailed P<0.001),meaning there was a large ***:This pilot study shows that JCZ and HG are suitable acupuncture methods for reducing headache intensity in the treatment of headaches.A comparison with the conventional classical acupuncture methods from the acupuncture textbook for traditional Chinese medicine students in China,exploration with a larger patient group,and prolonged monitoring of pain behavior could be foci of follow-up investigations.

关键词： Acupuncture headache migraine medication-overuse headache neurology

The Role of Quality Control in Targeted Next-generation Sequencing Library Preparation

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 200-206页

作者： Rouven Nietsch Jan Haas Alan Lai Daniel Oehler Stefan Mester Karen S. frese Farbod Sedaghat-Hamedani Elham Kayvanpour Andreas Keller Benjamin Meder Institute for Cardiomyopathies Department of Internal Medicine IIIUniversity of Heidelberg69120 HeidelbergGermany German Centre for Cardiovascular Research(DZHK) Heidelberg/MannheimGermany Chair for Clinical Bioinformatics Medical FacultySaarland University66123 SaarbruckenGermany

Next-generation sequencing （NGS） is getting routinely used in the diagnosis of hereditary diseases, such as human cardiomyopathies. Hence. it is of utter importance to secure high quality sequencing data, enabling the identification of disease-relevant mutations or the conclusion of negative test results. During the process of sample preparation, each protocol for target enrichment library preparation has its own requirements for quality control （QC）; however, there is little evi- dence on the actual impact of these guidelines on resulting data quality. In this study, we analyzed the impact of QC during the diverse library preparation steps of Agilent SureSelect XT target enrichment and lllumina sequencing. We quantified the parameters for a cohort of around 600 samples, which include starting amount of DNA, amount of sheared DNA, smallest and largest fragment size of the starting DNA; amount of DNA after the pre-PCR, and smallest and largest fragment size of the resulting DNA; as well as the amount of the final library, the corresponding smallest and largest fragment size, and the number of detected variants. Intriguingly, there is a high tolerance for variations in all QC steps, meaning that within the boundaries proposed in the current study, a considerable variance at each step of QC can be well tolerated without compromising NGS quality.

关键词： Next-generation sequencing Quality control Library preparation Target enrichment Sequence variants

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创业者差错取向的绩效作用及其跨文化比较

心理学报 2008年第11期40卷 1203-1211页

作者：王重鸣郭维维 Michael frese Andreas Rauch 浙江大学管理学院杭州310027 基盛大学心理学系德国

创业企业是创业者的延伸,但创业者对创业企业的影响究竟是怎样的,当前的研究进展还不能很好的解释这点。研究采用跨文化比较的方法,首先分析中国和德国的创业者差错取向对创业企业差错气氛的影响模式,然后检验中国样本和德国样本的跨文... 详细信息

创业企业是创业者的延伸,但创业者对创业企业的影响究竟是怎样的,当前的研究进展还不能很好的解释这点。研究采用跨文化比较的方法,首先分析中国和德国的创业者差错取向对创业企业差错气氛的影响模式,然后检验中国样本和德国样本的跨文化测量等同性,之后对比并综合分析两组样本模型的异同。研究发现在中国样本模型中,创业企业差错气氛在创业者差错取向的绩效影响中不起中介作用,而在德国样本模型中正相反。此外,研究还发现创业者个性特质对企业组织气氛存在一种"投影"影响。

关键词：差错管理创业领导跨文化

Comparison of the Colonization Ability of Autochthonous and Allochthonous Strains of Lactobacilli in the Human Gastrointestinal Tract

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Advances in Microbiology 2012年第3期2卷 399-409页

作者： Steven A. frese Robert W. Hutkins Jens Walter Department of Food Science and Technology University of Nebraska Lincoln USA

Bacteria of the genus Lactobacillus are widely used as oral probiotics due to their putative health benefits. In this study, we compared the colonization ability of two Lactobacillus strains that were identified as autochthonous to the human gastrointestinal tract (Lactobacillus reuteri ATCC PTA 6475 (MM4-1a) and (Lactobacillus mucosae FSL-04) with that of an allochthonous strain (Lactobacillus acidophilus DDS-1). Colonization ability was tested in a single-blinded, cross-over study, with twelve human subjects. The test strains were quantified in fecal samples by two independent methods, selective plating and molecular typing and quantitative real time PCR. The study revealed that the two autochthonous strains (L. reuteri ATCC PTA 6475 and L. mucosae FSL-04) reached higher population levels in fecal samples and were recovered more frequently from subjects compared to the allochthonous strain (L. acidophilus DDS-1). All three strains became undetectable 8 days after the end of consumption with one exception, showing that persistence of all three strains remains short term in most individuals. In conclusion, this study showed that autochthonous Lactobacillus strains can be established more efficiently, albeit temporarily, in the human gastrointestinal tract, suggesting that evolutionary and ecological characteristics could be valuable criteria for the selection of probiotic strains.

关键词： Lactobacillus Probiotic Lactobacillus reuteri Lactobacillus mucosae Lactobacillus acidophilus Gut Microbiology Microbial Ecology Colonization Resistance

Fastest and most reproducible optical contact angle determination using the novel liquid needle

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Fastest and most reproducible optical contact angle determin...

中国化学会第十七届全国胶体与界面化学学术会议

作者： K.Oetjen M.Jin D.frese C.Scheithauer R.Sanedrin P.R.Waghmare T.Willers KRüSS GmbH2. KRüSS USA University of Alberta

＜正＞Generally, the optical determination of static and advancing contact angle （CA） is made on drops applied or extended, respectively, onto a substrate through the use of solid needles. Although this method is used extensively, this way of dosing can be time consuming, cumbersome and if not performed meticulously can lead to erroneous results. Recently, we established a novel "liquid needle" dosing as promising and advantageous alternative （compare figure and [1]）.

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创业者差错取向的绩效作用及其跨文化比较

心理学 2009年第4期 1203-1211页

作者：王重鸣郭维维 Michael frese Andreas Rauch

创业企业是创业者的延伸，但创业者对创业企业的影响究竟是怎样的，当前的研究进展还不能很好的解释这点。研究采用跨文化比较的方法，首先分析中国和德国的创业者差错取向对创业企业差错气氛的影响模式，然后检验中国样本和德国样本的... 详细信息

创业企业是创业者的延伸，但创业者对创业企业的影响究竟是怎样的，当前的研究进展还不能很好的解释这点。研究采用跨文化比较的方法，首先分析中国和德国的创业者差错取向对创业企业差错气氛的影响模式，然后检验中国样本和德国样本的跨文化测量等同性，之后对比并综合分析两组样本模型的异同。研究发现在中国样本模型中，创业企业差错气氛在创业者差错取向的绩效影响中不起中介作用，而在德国样本模型中正相反。此外，研究还发现创业者个性特质对企业组织气氛存在一种“投影”影响。

关键词：差错管理创业领导跨文化 error management entrepreneurial leadership cross-culture

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降钙素基因相关肽与颈源性头痛

世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 28-29页

作者： frese A. Schilgen M. Edvinsson L. 李一明 Dr.Department of Neurology University of Münster Albert-Schweitzer-Str. 33 D-48129 Münster Germany

Trigeminovascular activation is involved in the pathophysiology of migraine and cluster headache. The marker evaluated best for trigeminovascular activation is calcitonin gene-related peptide (CGRP) in the cranial circulation. It is unknown whether trigeminovascular activation plays any role in cervicogenic headache (CEH). The objective of this study was to investigate CGRP plasma levels in CEH patients in relation to headache state. To compare plasma CGRP levels between the peripheral and the cranial circulation. Blood from both external jugular veins and from the antecubital vein was drawn from 11 patients with CEH. Plasma CGRP levels were measured by radioimmunoassay. No difference was found between CGRP levels assessed on days with and without headache. There was no difference beween CGRP levels from the symptomatic and the asymptomatic external jugular vein and the antecubital vein. There is no evidence for an activation of the trigeminovascular system in CEH. In certain cases, clinical differentiation between CEH and migraine without aura is difficult. Plasma CGRP levels might serve as a biological marker to distinguish the two headache entities.

关键词：颈源性头痛 CGRP 头痛程度放射免疫测定法肘前静脉丛集性头痛脑循环周和病理生理无症状

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北美区域重磁相关异常

世界地质 1985年第1期 73-87页

作者： R.R.B.Von frese W.J.Hinze L.W.Braile 张曼珠

重磁异常结合其他地质、地球物理资料进行相关分析,有利于提高位场异常地质解释的质量。利用等效点源反演绘制的图件,来研究北美及相邻海域的地面自由空间重力异常、POGO(线轨道地球物理观测)卫星磁异常,以及区域热流和构造信息间的视... 详细信息

重磁异常结合其他地质、地球物理资料进行相关分析,有利于提高位场异常地质解释的质量。利用等效点源反演绘制的图件,来研究北美及相邻海域的地面自由空间重力异常、POGO(线轨道地球物理观测)卫星磁异常,以及区域热流和构造信息间的视一空间相关关系。在卫星高度上相关异常的区域位场,也用泊松理论在重、磁场导数异常之间,移动窗口线性回归作定量分析。在大陆地区观测到长波长重磁异常之间的一种反相关关系。重力异常为负、磁力异常为正的地区,其特点是地壳相对较厚,磁化强度较高。例如:一个突出的磁力高与爱那达科盆地向辛辛那堤穹窿延伸的重力低相对应。磁力异常为负、重力异常为正的地区,其特征是地壳较薄,区域热流值较高。如:北美和中美洲的科迪勒拉地区,以及黄石地热区。虽然,海洋区域的重磁异常显示弱相关,但统计相关的符号一般为正。

关键词：重磁异常正异常反相关磁力高自由空间重力异常北美