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Heterogeneous Multiscale Methods: A Review

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Communications in Computational Physics 2007年第3期2卷 367-450页

作者： Weinan e Bjorn engquist Xiantao Li Weiqing Ren eric Vanden-eijnden Department of Mathematics and Program in Applied and Computational Mathematics Princeton UniversityPrincetonNJ 08544USA Department of Mathematics The University of Texas at AustinAustinTX 78712USA Department of Mathematics Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Mathematics Courant Institute of Mathematical SciencesNew York UniversityNew YorkNY 10012USA.

This paper gives a systematic introduction to HMM,the heterogeneous multiscale methods,including the fundamental design principles behind the HMM philosophy and the main obstacles that have to be overcome when using HMM for a particular *** is illustrated by examples from several application areas,including complex fluids,micro-fluidics,solids,interface problems,stochastic problems,and statistically self-similar *** is given to the technical tools,such as the various constrained molecular dynamics,that have been developed,in order to apply HMM to these *** of mathematical results on the error analysis of HMM are *** review ends with a discussion on some of the problems that have to be solved in order to make HMM a more powerful tool.

关键词： Multi-scale modeling heterogeneous multi-scale method multi-physics models constrained micro-scale solver data estimation.

The protection of Thymus vulgaris leaves alcoholic extract against hepatotoxicity of alcohol in rats

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 341-351页

作者： Samah A.el-Newary Nermeen M.Shaffie e.A.Omer Medicinal and Aromatic Plants Research Department Pharmaceutical Industries Research DivisionNational Research Center Pathology Department Medical Researches DivisionNational Research CentreGiza Egypt

Objective:This study was performed to investigate the protective effect of Thymus vulgaris(***) leaves 70%alcoholic extract against alcohol-mediate hepatotoxicity ***:The protective effect of extract was investigated at dose of 500 mg/kg/day orally against alcohol-mediate hepatotoxicity using adult male Wister albino rats during 21 *** effect of *** extract was evaluated comparing with silymarin standard drug al recommended dose(25 mg/kg/day) orally for 21 ***:Alcohol-mediate hepatotoxicity rats(alcohol-control) showed hepatocytes distortion represented as marked increment on liver biomarkers;alkaline phosphatase(ALP),aspartate transaminase(AST) and alanine transaminase(ALT) activities,as well as pronounced reduction on total protein and its fractions albumin and globulin corresponding to normal *** to oxidative stress status as depletion on glutathione concentration,catalase(CAT),superoxide dismutase(SOD),glutathione reductase(GR),glutathione-S-transferase(GST) and glutathione peroxidase(GPx)activities,concurrence with augmentation oxidative stress parameters;malondyaldchydc(MDA) and hydrogen peroxide(H_2O_2) concentrations comparing to normal *** administration elevated total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) comparing to normal ***-administration *** extract with alcohol showed protective effect on hepatocytes manifested as minimizing on *** and ALT activities and increment on total protein,albumin and globulin production compared to *** enzymes activities;***,GST and GPx were significantly magnified,while MDA and H_2O_2 concentration were lessened corresponding to ***,lipid profile was markedly improved and risk ratio was lowered compared to *** results were confirmed by normalization of degenerated and fibrotic liver tissue as of alcohol-cont

关键词： Thymus vulgaris Alcohol-mediate hepatotoxicity Polyphenols Flavonoids Antioxidants enzymes activities Oxidative stress Histopathology

essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography examination for Chinese anesthesiologists

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Frontiers of Medicine 2015年第1期9卷 123-128页

作者： Yong G. Peng Haibo Song e. Wang Weipeng Wang Jin Liu Department of Anesthesiology College of Medicine University of Florida Shands Hospital Gainesville FL 32610 USA Department of Anesthesiology West China Hospital of Sichuan University Chengdu 610041 China Department of Anesthesiology Xiangya Hospital of Central South University Changsha 410008 China Department of Anesthesiology Fuwai Hospital and Cardiovascular Institute Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Guidelines for the intraoperative transesophageal echocardiography （Tee） examination have defined a detailed standard for medical professionals, particularly anesthesiologists, on how a Tee exam should proceed. Over the years, Tee has gained substantial popularity and emerged as a preferred monitoring modality to aid in perioperative management and decision making during hemodynamic instability situations or critical care settings. Tee training pathways and practice guidelines have been well established in western countries and many regions of the world. However, Tee training and practice information for anesthesiologists are lacking in China. As innovative technologies develop, other educational models have emerged to aid in obtaining competency in basic Tee exam. Hence, establishing a consensus on the ideal Tee training approach for anesthesiologists in China is urgently needed. Developing an effective curriculum that can be incorporated into an anesthesiology resident＇s overall training is also necessary to provide knowledge and skills toward competency in basic Tee exam. With evolving medical system reforms and increasing demands for intraoperative hemodynamic monitoring to accommodate surgical innovations, anesthesiology professionals are increasingly obliged to perform intraoperative Tee exams in their current and future practices. To overcome obstacles and achieve significant progress in using the Tee modality to help in intraoperative management and surgical decision making, publishing basic Tee training guidelines for China＇s anesthesiologists is an important endeavor.

关键词： transesophageal echocardiography guidelines training competency

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Leader-follower Formation Control Based on Logic Control Networks Approach 25th

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Leader-follower Formation Control Based on Logic Control Net...

Iridium-catalyzed direct ortho-C–H amidation of benzoic acids with sulfonylazides

第25届中国控制与决策会议

作者： Lequn Zhang Jun-e Feng Hongli Lv School of Mathematics Shandong University School of Information and electrical engineering Shandong Jianzhu University

ISBN: (纸本)9781467355339

The formation control （FC） problem is investigated via mix-valued logic approach. First, a trajectory tracking algorithm of mix-valued logic control networks （MLCN） is proposed. A new formulation of FC problems is established and a feedback control is designed to solve FC problems. The mathematical description of partial-formation control （PFC） problems is then designed as a structure of logical networks. An interesting practical example of PFC is also presented and discussed in detail.

关键词： leader-follower formation control mix-valued logic control networks semi-tensor product

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Chinese Chemical Letters 2015年第11期26卷 1336-1340页

作者： Ming-e Wei Lian-Hui Wang Yu-Dong Li Xiu-Ling Cui engineering Research Center of Molecular Medicine Ministry of Educationthe Key Laboratory of Xiamen Marine and Gene Drugs Institute of Molecular Medicine and School of Biomedical Sciences Huaqiao University

A mild and efficient iridium-catalyzed ortho-C-H amidation with sulfonyl azides by weakly coordinating carboxylic acid was demonstrated, which provided a novel approach to anthranilic acid derivatives.

关键词： lr-catalysisBenzoic acidSulfonyl azidesC-H bond amination

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Cell Wall Biology： Perspectives from Cell Wall Imaging

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Molecular Plant 2011年第2期4卷 212-219页

作者： Kieran J.D. Lee Susan e. Marcus J. Paul Knox Centre for Plant Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK

Polysaccharide-rich plant cell walls are important biomaterials that underpin plant growth, are major repositories for photosynthetically accumulated carbon, and, in addition, impact greatly on the human use of plants. Land plant cell walls contain in the region of a dozen major polysaccharide structures that are mostly encompassed by cellulose, hemicelluloses, and pectic polysaccharides. During the evolution of land plants, polysaccharide diversification appears to have largely involved structural elaboration and diversification within these polysaccharide groups. Cell wall chemistry is well advanced and a current phase of cell wall science is aimed at placing the complex polysaccharide chemistry in cellular contexts and developing a detailed understanding of cell wall biology. Imaging cell wall glycomes is a challenging area but recent developments in the establishment of cell wall molecular probe panels and their use in high throughput procedures are leading to rapid advances in the molecular understanding of the spatial heterogeneity of individual cell walls and also cell wall differences at taxonomic levels. The challenge now is to integrate this knowledge of cell wall heterogeneity with an understanding of the molecular and physiological mechanisms that underpin cell wall properties and functions.

关键词： Cell structure cell walls fluorescence imaging development cell wall imaging polysaccharides

Development of Cell Lines Stably expressing Staphylococcal Nuclease Fused to Dengue 2 Virus Capsid Protein for CTVI

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Acta Biochimica et Biophysica Sinica 2004年第8期36卷 577-582页

作者： Cheng-Feng QIN and e-De QIN Institute of Microbiology and epidemiology, Academy of Military Medical Sciences, Beijing 100071, China Institute of Microbiology and epidemiology Academy of Military Medical SciencesBeijing 100071 China

To explore the potential application of capsid-targeted viral inactivation (CTVI) strategy in prophylactic model against dengue virus (DV) infection, here we fused a Ca2+-dependent nuclease, staphylococcal nuclease (SN), to the capsid protein of dengue 2 virus (D2C) at the carboxyl terminal, and constructed the desired expression plasmid pc/D2C-SN and control plasmids pc/D2C-SN* and pc/D2C. A mammalian cell line BHK-21 was transfected by electroporation with those plasmids and thereafter selected by 5 μg/ml blasticidin. The resistant cell clones were then expanding cultured and screened by RT-PCR and Western Blot assays. The nuclease activity of the expressed fusion protein D2C-SN was analyzed by in vitro DNA digestion assay. It was confirmed cell lines stably expressing D2C-SN and control constructs were obtained. The intracellular expressed fusion protein D2C-SN had ideal nuclease activity and no cytotoxicity on mammalian cells. Those engineered cell lines provided the experimental system for CTVI application in prophylactic model and paved the new road for combating DV infection with CTVI.

关键词： dengue 2 virus capsid protein staphylococcal nuclease CTVI stable expression

Output tracking of Periodically Time-Variant Boolean Control Networks

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Output tracking of Periodically Time-Variant Boolean Control...

Male-killer dynamics in the tropical butterfly, Acraea encedana （Lepidoptera： Nymphalidae）

第36届中国控制会议

作者： Biao Wang Jun-e Feng Min Meng School of Mathematics Shandong University

ISBN: (纸本)9781538629185

This paper investigates the output tracking problem of periodically time-variant Boolean control networks. First, by semi-tensor product, output reachability of system is analyzed, which is the one of the key issues. Secondly, via the property of output reachability, a necessary and sufficient condition for the existence of a control for output tracking problem is ***, two design algorithms of a free control sequence and a state feedback control are established. Finally, one practical example is shown to demonstrate the effectiveness of the theoretical results.

关键词： Periodically time-variant Boolean networks output tracking semi-tensor product of matrices

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Insect Science 2013年第6期20卷 717-722页

作者： Sami Saeed M. Hassan eihab Idris Michael e. N. Majerus Department of Biology Faculty of Science University of Hail Hail Kingdom of Saudi Arabia Department of Zoology Faculty of Science University of Khartoum P.O. Box 321 Khartoum 11115 Sudan Department of Genetics University of Cambridge Deceased Department of Genetics University of Cambridge Cambridge CB2 3EH United Kingdom

Sex ratio distortion in the tropical butterfly Acraea encedana is caused by infection with a male-killing bacterium of the genus Wolbachia. Previous research on this species has reported extreme female bias, high bacterial prevalences, and full sex role reversal. In this paper, we provide an assessment for the dynamics of the male-killer, based on a survey for sex ratios and Wolbachia prevalences among wild populations of A. encedana in Uganda. The study reveals that Wolbachia infection showed considerable variation over both spatial and temporal scales.

关键词： female bias PCR population dynamics prevalence Wolbachia Uganda