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MDC、超声心动图及两者联合检测肺动脉高压

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国际医学放射学杂志 2010年第2期 187-188页

作者： a.devaraj A.U.Wells M.G.Meister T.J.Corte S.J.Wort D.M.Hansell 范丽 Department of Radiology Royal Brompton HospitalSydney StreetLondonSW 36NPEngland

目的评价MDCT测量值检测肺动脉高压的可靠性,且进一步确定MDCT和超声心动图的联合应用对肺动脉高压的检测是否比两者单独检测更具有预测价值。材料与方法此项回

关键词：超声心动图相关性平均超声波诊断肺动脉压 MDC

使用体积法确定肺小结节生长：一项“跨时间一致性”CT研究结果，并对当前结节管理指南具有启示意义

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国际医学放射学杂志 2022年第3期 367-367页

作者： E.C.Bartlett S.V.Kemp B.Rawal a.devaraj 刘柱娜

摘要目的容积CT扫描肺结节体积的增加可能代表结节真实的生长或测量变化。在结节指南中，经常使用结节体积增加25%来确定其已经生长，这是基于肺转移性结节的重

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混合多维MR成像无创性评估前列腺组织成分来诊断前列腺癌的价值:一项可行性研究

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国际医学放射学杂志 2018年第4期 481-481页

作者： A.Chatterjee R.M.Bourne S.Wang a.devaraj A.J.Gallan T.Antic 郑娇凤 Department of Radiology University of Chicago

目的探讨混合多维MR成像的分区分析是否可应用于诊断前列腺癌并明确其侵袭性。材料与方法对22例前列腺癌病人行术前3.0 T MR成像。对不同回波时间（47、75、100 ms）和不同b值（0、750、1 500 s/mm2）分别进行组合,获得混合多维MR成像... 详细信息

目的探讨混合多维MR成像的分区分析是否可应用于诊断前列腺癌并明确其侵袭性。材料与方法对22例前列腺癌病人行术前3.0 T MR成像。对不同回波时间（47、75、100 ms）和不同b值（0、750、1 500 s/mm2）分别进行组合,获得混合多维MR成像横断面影像,并形成与每个体素相关的3×3阵列数据。将混合数据拟合到三区信号模型,计算各分区的表观扩散系数（ADC）和T2值,计算前列腺各区带组织间质、上皮和腺泡腔的体积。测量经前列腺切除术确诊的恶性肿瘤组织的兴趣区（n=28）和正常前列腺组织（n=71）的体积分数、常规ADC和T2值。采用受试者操作特征（ROC）曲线分析评估各种参数对前列腺癌和前列腺良性组织的鉴别价值。结果与正常组织相比较,混合多维MRI显示前列腺癌上皮组织的体积分数明显增加（分别为23.2%±7.1%∶48.8%±9.2%）,腺泡腔（26.4%±14.1%∶14.0%±5.2%）和基质（50.5%±15.7%∶37.2%±9.1%）的体积分数减小。前列腺各区带组织成分的体积分数显示,Gleason评分与Spearman评分相关系数较T2值（ρ=-0.292,P=0.132）和ADC值（ρ=-0.315,P=0.102）更高（上皮:ρ=0.652,P=0.000 1;基质:ρ=-0.439,P=0.20;腺泡腔:ρ=-0.390,P=0.040）。ROC曲线下面积显示区分前列腺癌与正常前列腺组织时,上皮体积分数（0.991）差异最高,其次为腺泡腔体积分数（0.800）和基质体积分数（0.789）。结论当前列腺癌存在时,前列腺腺泡腔、基质和上皮组织的体积分数显著改变。混合多维MR成像可对这些参数进行无创性测量,并可能有助于提高前列腺癌的诊断并明确其侵袭性。

关键词： MR 上皮组织前列腺癌体积分数无创性

COVID-19病人出院后3个月和1年后的CT肺部异常

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国际医学放射学杂志 2022年第4期 480-480页

作者： B.Vijayakumar J.Tonkin a.devaraj K.E.J.Philip C.M.Orton S.R.Desai P.L.Shah 刘雪丹

摘要目的在长达1年的随访中，评估出院新型冠状病毒肺炎（COVID-19）病人的症状、功能损害和在连续胸部CT扫描中显示的残余肺异常。资料与方法作为一项针对

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高分辨力CT与肺功能指标判断慢性过敏性肺炎的预后

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国际医学放射学杂志 2012年第5期 504-504页

作者： S.L.F.Walsh N.Sverzellati a.devaraj A.U.Wells D.M.Hansell 盛会雪 Department of Radiology Royal Brompton HospitalSydney StreetLondon SW3 6NPUK

摘要目的探讨高分辨力CT(HRCT)和肺功能指标(PFT)确定慢性纤维化过敏性肺炎(CHP)病人预后情况。材料与方法应用PFT(FEV1、FVC和DLco)与HRCT对92例慢性过敏性肺炎病人的病例记录进行评估。HRCT结果由两名观察者对病变范围、毛玻璃样改变... 详细信息

摘要目的探讨高分辨力CT(HRCT)和肺功能指标(PFT)确定慢性纤维化过敏性肺炎(CHP)病人预后情况。材料与方法应用PFT(FEV1、FVC和DLco)与HRCT对92例慢性过敏性肺炎病人的病例记录进行评估。HRCT结果由两名观察者对病变范围、毛玻璃样改变、细和粗网格状改变、微囊和大囊状的蜂窝样改变、小叶肺气肿和肺实变进行评分。对每种病变引起的支气管扩张进行分级。

关键词：过敏性肺炎预后结果研究 CT 肺功能检测

Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 315-322页

作者： devaraj Ezhilarasan Department of Pharmacology the Blue LabMolecular Medicine and Toxicology DivisionSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 600077Tamil NaduIndia

Background: Upon liver injury, quiescent hepatic stellate cells(q HSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells(MFBs). The q HSCs in the normal liver are less fibrogenic, migratory, and also have less proliferative potential. However, activated HSCs(a HSCs) are more fibrogenic and have a high migratory and proliferative MFBs phenotype. HSCs activation is a highly energetic process that needs abundant intracellular energy in the form of adenosine triphosphate(ATP) for the synthesis of extracellular matrix(ECM) in the injured liver to substantiate the injury. Data sources: The articles were collected through Pub Med and EMBASE using search terms "mitochondria and hepatic stellate cells", "mitochondria and HSCs", "mitochondria and hepatic fibrosis", "mitochondria and liver diseases", and "mitochondria and chronic liver disease", and relevant publications published before September 31, 2020 were included in this review. Results: Mitochondria homeostasis is affected during HSCs activation. Mitochondria in a HSCs are highly energetic and are in a high metabolically active state exhibiting increased activity such as glycolysis and respiration. a HSCs have high glycolytic enzymes expression and glycolytic activity induced by Hedgehog(Hh) signaling from injured hepatocytes. Increased glycolysis and aerobic glycolysis(Warburg effect) endproducts in a HSCs consequently activate the ECM-related gene expressions. Increased Hh signaling from injured hepatocytes downregulates peroxisome proliferator-activated receptor-γ expression and decreases lipogenesis in a HSCs. Glutaminolysis and tricarboxylic acid cycle liberate ATPs that fuel HSCs to proliferate and produce ECM during their activation. Conclusions: Available studies suggest that mitochondria functions can increase in parallel with HSCs activation. Therefore, mitochondrial modulators should be tested in an elaborate manner to control or prevent the HSCs activation

关键词： Hepatic stellate cells Glutaminolysis Glycolysis Hedgehog Myofibroblasts

Critical role of estrogen in the progression of chronic liver diseases

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 429-434页

作者： devaraj Ezhilarasan Department of Pharmacology Biomedical Research Unit and Laboratory Animal CentreSaveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077Tamil NaduIndia

Background:Estrogens regulate sexual function and also have a significant role in various pathophysiological *** have a non-reproductive role as the modulators of the immune system,growth,neuronal function,and *** receptors are expressed in the liver and their impaired expression and function are implicated with obesity and liver associated metabolic *** purpose of the current review is to discuss the disparity role of estrogens on several forms of liver *** sources:A comprehensive search in PubMed and EMBASE was conducted using the keywords“estrogens and liver diseases”,“estradiol and liver diseases”,“hormones and liver diseases”,“endocrine function in liver diseases”,and“female hormones in liver diseases”.Relevant papers published before September 30,2019 were ***:The present review confirms the imperative role of estrogen in various forms of chronic liver *** play a key role in maintaining homeostasis and make the liver less susceptible to several forms of chronic liver diseases in healthy premenopausal *** contrast,clinical studies also showed increased estrogen levels with chronic liver ***:Several studies reported the protective role of estrogens in chronic liver diseases and this has been widely accepted and confirmed in experimental studies using ovariectomized rat ***,in a few clinical studies,increased estrogen levels are also implicated in chronic liver ***,further studies are warranted at molecular level to explore the role of estrogen in various forms of chronic liver diseases.

关键词： Estrogen Hepatic fibrosis Chronic liver diseases Hepatic stellate cells

Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats

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Chinese Journal of Natural Medicines 2016年第1期14卷 40-47页

作者： devaraj Ezhilarasan Slvanesan Karthikeyan Food and Hepatotoxicology Laboratory Department of Pharmacology and Environmental Toxicology University of MadrasTaramani Chennai 600113 India

The present study was designed to evaluate the hepatoprotective and antioxidant potentials of silibinin(SBN)against N-nitrosodimethylamine(DMN)-induced toxic insults in the rat *** liver damage was induced in Wistar albino rats by repeated administration of DMN(10 mg·kg-1 b.w.,i.p.)on 3 consecutive days per week for 3 ***(100 mg·kg-1 b.w.,p.o.)was given daily to the DMN treated rats for two *** marker enzymes of liver toxicity and second-line enzymic and non-enzymic antioxidants were evaluated in serum and liver tissues before and after SBN *** of the liver was evaluated by H & E *** DMN treatment produced a progressive increase in all the serum marker enzymes(AST,ALT,ALP,LDH,and γ-GT),peaking on Day *** treatment produced highly significant decreases in all the second-line antioxidant parameters(GSH,GST,GR,GPx,and vitamins C and E).The SBN treatment significantly reversed the DMN-induced damages,towards *** studies confirmed the development of liver toxicity in DMN-treated rats,which was reversed by SBN treatment in corroboration with the aforementioned biochemical results,indicating the hepatoprotective and antioxidant properties of *** conclusion,the DMN-induced degenerative changes in the liver were alleviated by SBN treatment and this protective ability may be attributed to its antioxidant,free radical scavenging,and membrane stabilizing properties.

关键词： Dimethylnitrosamine Silibinin Oxidative stress Hepatotoxicity Glutathione dysregulation

Wnt/beta-catenin signaling and its modulators in nonalcoholic fatty liver diseases

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 333-345页

作者： Karthik Shree Harini devaraj Ezhilarasan Department of Pharmacology Molecular Medicine and Toxicology LabSaveetha Dental CollegeSaveetha Institute of Medical and Technical Sciences(SIMATS)ChennaiTamil Nadu 600077India

Nonalcoholic fatty liver disease(NAFLD)is a global health concern associated with significant morbidity and *** is a spectrum of diseases originating from simple steatosis,progressing through nonalcoholic steatohepatitis(NASH),fibrosis,and cirrhosis that may lead to hepatocellular carcinoma(HCC).The pathogenesis of NAFLD is mediated by the triglyceride accumulation followed by proinflam-matory cytokines expression leading to inflammation,oxidative stress,and mitochondrial dysfunction de-noted as“two-hit hypothesis”,advancing with a“third hit”of insufficient hepatocyte proliferation,lead-ing to the increase in hepatic progenitor cells contributing to fibrosis and ***/β-catenin signaling is responsible for normal liver development,regeneration,hepatic metabolic zonation,ammonia and drug detoxification,hepatobiliary development,etc.,maintaining the overall liver *** key regula-tors of canonical Wnt signaling such as LRP6,Wnt1,Wnt3a,β-catenin,GSK-3β,and APC are abnormally regulated in *** experimental studies have shown the aberrated Wnt/β-catenin signaling dur-ing the NAFLD progression and NASH to hepatic fibrosis and ***,in this review,we have em-phasized the role of Wnt/β-catenin signaling and its modulators that can potentially aid in the inhibition of NAFLD.

关键词： Steatosis Fatty liver Oxidative stress Chronic liver diseases Fibrosis Wnt/β-catenin