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Phloroglucinol, a nutraceutical for IR-induced cardiac damage in diabetic rats

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Animal Models and Experimental Medicine 2019年第3期2卷 210-216页

作者： B.Pranav nayak K.R.Ganesha Nathani Minaz Rema Razdan Sumanta Kumar Goswami department of Pharmacology Al‐Ameen College of PharmacyBengaluruKarnatakaIndia department of Pharmaceutical sciences Northeastern UniversityBostonMAUSA

Background:Myocardial injury due to ischemia‐reperfusion(IR)is aggravated in diabetes which is associated with oxidative *** oxidative stress via use of antioxidants has been shown to be effective at minimizing myocardial cell death and improving cardiac *** aim of the present study was to evaluate the cardioprotective effect of phloroglucinol against myocardial reperfusion injury(MRI)in diabetic ***:diabetes was induced in female rats with streptozotocin(50 mg/kg).The diabetic rats were orally treated with phloroglucinol(100 and 200 mg/kg daily for 28 days).After treatment the hearts were isolated and mounted on a Langendorff *** hearts were subjected to 15 minutes of IR to induce myocardial *** functions including heart rate(HR),resting and developed tension,and rate of change of contraction(+dP/dtmax)were *** injury biomarkers lactate dehydrogenase(LdH)and creatine kinase(CK‐MB)were measured in the heart *** of the antioxidant enzymes reduced glutathione(GSH)and malondialdehyde(MdA)were *** and eosin(H&E)staining was also ***:After IR injury,a decrease in HR and+dP/dtmax in hearts from diabetic rat was seen compared to healthy rat hearts,which was reversed by phloroglucinol *** infarct size,measured by H&E staining,was increased in diabetic rats compared to healthy rats and an increase in the activity of LdH and CK‐MB in the heart perfusate in diabetic rats was decreased by phloroglucinol *** increase in MdA levels and a decrease in levels of antioxidant enzymes were observed in diabetic rats,which was reversed with phloroglucinol ***:Phloroglucinol treatment has potential therapeutic promise in the treatment of MRI in diabetes.

关键词： Langendroff apparatus myocardial reperfusion injury phloroglucinol streptozotocin

discovery method for distributed denial-of-service attack behavior in SdNs using a feature-pattern graph model

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Frontiers of Information Technology & Electronic Engineering 2019年第9期20卷 1195-1208页

作者： Ya XIAO Zhi-jie FAN Amiya nayak Cheng-xiang TAN College of Electronics and Information Engineering Tongji UniversityShanghai 201804China School of Electrical Engineering and Computer Science University of OttawaOttawa K1N 6N5Canada The Third Research Institute of the Ministry of Public Security Shanghai 200120China

The security threats to software-defined networks(SdNs)have become a significant problem,generally because of the open framework of *** all the threats,distributed denial-of-service(ddoS)attacks can have a devastating impact on the *** propose a method to discover ddoS attack behaviors in SdNs using a feature-pattern graph *** feature-pattern graph model presented employs network patterns as nodes and similarity as weighted links;it can demonstrate not only the traffc header information but also the relationships among all the network *** similarity between nodes is modeled by metric learning and the Mahalanobis *** proposed method can discover ddoS attacks using a graph-based neighborhood classification method;it is capable of automatically finding unknown attacks and is scalable by inserting new nodes to the graph model via local or global *** on two datasets prove the feasibility of the proposed method for attack behavior discovery and graph update tasks,and demonstrate that the graph-based method to discover ddoS attack behaviors substantially outperforms the methods compared herein.

关键词： Software-defined network distributed denial-of-service(ddoS) Behavior discovery distance metric learning Feature-pattern graph

Modification of structural and dielectric properties of polycrystalline Gd-doped BFO–PZO

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Journal of Advanced dielectrics 2018年第5期8卷 1-21页

作者： Ambika Ray Banarji Behera Tanmoy Basuy Saumitra Vajandar Santosh Kumar Satpathy Pratibindhya nayak Material Research Laboratory School of Physics Sambalpur UniversityJyoti Vihar BurlaOdisha 768019India Centre for Advanced 2d Materials National University of Singapore Singapore 117546Singapore Centre for Ion Beam Applications National University of Singapore Singapore 117542Singapore department of Physics School of Applied Science Centurion University of Technology and Management BhubaneswarOdisha 752050India

(1-y)(BiFe_(1-x)GdxO_(3))–y(PbZrO3)composites(y=0:5),having four different Gd concentrations(x=0:05,0.1,0.15,and 0.2),were synthesized and their structural,dielectric,and ferroelectric properties have been studied using different characterization *** addition,to investigate the effect of ion implantation on the microstructure and dielectric properties,these composites were exposed to 2 MeV He+-*** of the structure,surface morphology and electrical properties of the samples before and after ion exposure were demonstrated using powder X-ray diffraction(XRd),scanning electron microscopy(SEM)technique,and LCR *** compositional analysis was carried out using energy dispersive X-ray spectrometry(EdS).XRd results demonstrated a decrease in the intensity profile of the dominant peak by a factor of 6 showing a degradation of the ***–Hall(WH)plots reveal reduction in the grain size after irradiation along with an increase in strain and dislocation density.A decrease in the dielectric constant and loss has been recorded after ion beam exposure with reduction in ac conductivity *** contribution of grain and grain boundary effect in conduction mechanism has been addressed using Nyquist *** the samples demonstrate a lossy ferroelectric loop which shows a clear modification upon *** role of structural defects modifying the physical properties of the composite materials is discussed in this work.

关键词： Ion beam irradiation defects dielectric properties ferroelectricity.

Annona muricata fruit extract protects against diethylnitrosamine-induced hepatocellular cancer in rats

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Asian Pacific Journal of Tropical Medicine 2019年第6期12卷 272-282页

作者： Subin Varghese Thomas John Paul Akhila Hosur Shrungeswara Subhankar Biswas Aarti Abhishek Shah Chandrashekar Kodangala Subraya Yogendra nayak department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalIndia department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalIndia department of Pharmacognosy Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalIndia

Objective: To evaluate the anticancer potentials of Annona muricata fruit by in vitro and in vivo methods. Methods: The ethanolic extract of Annona muricata fruit was prepared by Soxhlet extraction method and further fractionated with petroleum ether, ethyl acetate and chloroform. The fractions were tested for cytotoxicity, apoptosis, scratch wound assay, and cell cycle analysis. IC50, apoptotic index and percentage cell migration were determined using HepG2 cells. For the in vivo studies, hepatocellular carcinoma was induced by administering 0.01% diethylnitrosamine(dEN) in drinking water in Wistar rats. In pre-treatment, rats were co-administered 200 mg/kg of fruit extract with dEN for 14 weeks. In post-treatment, the extract was co-administered after 8-weeks of dEN-induction for 14 weeks. Liver function test, haematological test, oxidative stress markers, relative liver weight, number of cancer nodules and histopathological parameters were ***: Annona muricata fruit extract =significantly lowered cell proliferation counts. The chloroform-fraction possessed higher activity (IC50=(53.7±4.3) μg/mL)The chloroform fraction inhibited cell migration, which was significant compared to curcumin. Further investigations regarding the mode of anticancer activity revealed that the chloroform fraction induced apoptosis. The cell cycle analysis indicated that cells were being arrested at G0/G1. In the in vivo studies, the dEN-control group showed a significant decrease in body weights with increased mortality rate, hepatic nodules, and impairment of liver function compared to normal rats. The rats pre-treated and post-treated with the extract showed positive results with significant improvement in the parameters that were adversely affected by dEN. In addition, other adverse effects of dEN, such as blood dyscrasias and hepatic endogenous antioxidant, were significantly attenuated by Annona muricata fruit ***: The Annona muricata fruit extract has

关键词： HepG2-cells Apoptosis Liver cancer Acetogenins Rat liver cancer Scratch wound assay

Beaconless Position-based Routing with Guaranteed delivery for Wireless Ad hoc and Sensor Networks

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自动化学报 2006年第6期32卷 846-855页

作者： CHAWLA Mohit GOEL Nishith KALAICHELVAN Kalai nayak Amiya STOJMENOVIC Ivan department of Computer Science & Engineering IIT GuwahatiGuwahati 781039India Cistel Technology Inc OttawaOntario K2E 7V7Canada EION Technology Inc OttawaOntario K1Y 2X5Canada SITE University of OttawaOttawaOntario K1N 6N5Canada

Existing position-based routing algorithms, where packets are forwarded in the geographic direction of the destination, normally require that the forwarding node should know the positions of all neighbors in its transmission range. This information on direct neighbors is gained by observing beacon messages that each node sends out periodically. Several beaconless greedy routing schemes have been proposed recently. However, none of the existing beaconless schemes guarantee the delivery of packets. Moreover, they incur communication overhead by sending excessive control messages or by broadcasting data packets. In this paper, we describe how existing localized position based routing schemes that guarantee delivery can be made beaconless, while preserving the same routes. In our guaranteed delivery beaconless routing scheme, the next hop is selected through the use of control RTS/CTS messages and biased timeouts. In greedy mode, the neighbor closest to destination responds first. In recovery mode, nodes closer to the source will select shorter timeouts, so that other neighbors, overhearing CTS packets, can eliminate their own CTS packets if they realize that their link to the source is not part of Gabriel graph. Nodes also cancel their packets after receiving data message sent by source to the selected neighbor. We analyze the behavior of our scheme on our simulation environment assuming ideal MAC, following GOAFR+ and GFG routing schemes. Our results demonstrate low communication overhead in addition to guaranteed delivery.

关键词： Beaconless routing geometric routing guaranteed delivery sensor networks

Exogenous gonadotropin releasing hormone (GnRH) modulates scrotal and testicular biometrics, libido, endocrinological and heamatological profiles in Ganjam goat under humid tropical coastal ecosystem of Odisha

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Asian pacific Journal of Reproduction 2022年第6期11卷 285-291页

作者： Jibanjyoti nayak Anil Kumar Nahak Purna Chandra Mishra dillip Kumar Karna Chinmoy Mishra Perumal Ponraj OUAT-College of Veterinary Science and Animal Husbandry BhubaneswarOdishaIndia ICAR-Central Island Agricultural Research Institute Port Blair-744105Andaman and Nicobar IslandsIndia

Objective:To assess the effect of exogenous gonadotropin releasing hormone(GnRH)in libido,scrotal and testicular biometrics,endocrinological and heamatological profiles of Ganjam goat buck during winter and pre-monsoon ***:Forty eight healty Ganjam goat bucks of 3-4 years old were equally divided into the control and treatment *** control group received distilled water as placebo,while the treatment group received GnRH injection(4μg Buserelin acetate/mL)once a week for four *** weight,scrotal circumference and testicular parameters(testicular volume,testicular weight and testis index),endocrinological profiles[follicle stimulating hormone(FSH),luteinizing hormone(LH),and testosterone],sex behavioural profiles(libido score,mating ability score,and sex behavioural score)and heamatological profiles(red blood cells,white blood cells,haemoglobin,and packed cell volume)were ***:The libido,scrotal and testicular biometrics,and endocrinological profiles significantly differed between the control and GnRH-treated bucks within and between the seasons within the two groups(Pdy weight,scrotal circumference,testicular volume,testicular weight,testis index,FSH,LH,testosterone,libido score,mating ability score,sex behavioural score,red blood cells,haemoglobin and packed cell volume were significantly higher in the GnRH-treated bucks compared to the control bucks in pre-monsoon and winter seasons(Pdy weight,scrotal circumference,testicular volume,testicular weight,testis index,FSH,LH,testosterone,libido score,mating ability score,sex behavioural score,red blood cell counts(in treatment),and haemoglobin were significantly higher in pre-monsoon compared to winter season in the experimental groups(Pd cell counts neither differed between seasons nor between the two ***:Exogenous GnRH supplementation and pre-monsoon season have higher beneficial effects in improvement of endocrinological profi

关键词： Hormone GnRH Ganjam goat Libido Scrotal parameters Testicular parameters

Comment on “Integrated Mineralogical Characterization of Banded Iron Ores of Orissa and Its Implications on Beneficiation” by Mohanty <i>et al</i>. (2012), Journal of Minerals and Materials Characterization and Engineering, 11, 1133-1142

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Journal of Minerals and Materials Characterization and Engineering 2013年第5期1卷 280-283页

作者： Pranaba K. nayak Tata Institute of Fundamental Research Mumbai India

Mohanty et al. (2012) have wrongly analyzed M?ssbauer spectra obtained from various iron ore samples. We criticized their approach suggesting suitable methodology, and suggested to refer earlier work carried out by Na... 详细信息

关键词： Mossbauer Spectroscopy Banded Iron Formation Goethite Magnetite Hematite

Grafting Vinyl Monomers onto Chitosan:IV:Graft Copolymerized of Acrylicacid onto Chitosan Using Ceric Ammonium Nitrate as the Initiator— Characterization and Antimicrobial Activities

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Materials Sciences and Applications 2011年第12期2卷 1741-1748页

作者： Manoj Kumar Pati Padmalochan nayak 不详

Acrylicacid was grafted onto chitosan by using the ceric ammonium nitrate as the initiator. The effect of initiator concentration, monomer concentration, time & temperature on % G and % GE were studied. The grafted samples were characterized using FTIR, TGA, SEM and XRd methods. From the FTIR data it was ascertained that grafting has occurred considerably. The morphology of the grafted polymer was observed from the SEM picture. The thermal analysis indicated the different stages of degradation of the grafted copolymer. Evidence of grafting was obtained from comparison of SEM, XRd, and FTIR of the grafted and nongrafted chitosan as well as solubility characteristics of the products. The antibacterial and antifungal activities of the grafted polymer have also been investigated.

关键词： Chitosan Acrylicacid Graftcopolymerization Antifungal Antibactarial

Measurement of(n,α)and(n,2n)reaction cross sections at a neutron energy of 14.92±0.02 MeV for potassium and copper with uncertainty propagation

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Chinese Physics C 2022年第1期46卷 110-117页

作者： A.Gandhi Aman Sharma Rebecca Pachuau1 Namrata Singh L.S.danu S.V.Suryanarayana B.K.nayak A.Kumar department of Physics Banaras Hindu UniversityVaranasi 221005India Nuclear Physics division Bhabha Atomic Research CentreMumbai 400085India

Experimentally measured neutron activation cross sections are presented for the ^(65)Cu(n,0)^(62m)Cu,^(41) K(n,a)^(38C)l,and ^(65)Cu(n.2n)^(64)Cu reactions with detailed uncertainty *** neutron cross secions were measured at an incident energy of 14.92±0.02 MeV,and the neutrons were based on the(d,n)a fusion *** ^(27) Al(n,a)^(24)Na reaction was used as a reference reaction for the normalization of the neutron *** pre-calib-rated lead-shielded HPGe detector was used to detect the residues'γ-ray *** data from the measured cross sections are compared to the previously measured cross sections from the EXFOR database,theoretically calculated cross sections using the TALYS and EMPIRE codes,and evaluated nuclear data.

关键词： nuclear reactions (n,a)and(n,2n)reactions t(c/,n)a neutron source uncertainty propagation covariance analysis TALYS-1.9 and EMPIRE-3.2 code