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Tissue-specific trace elements concentration and human health risk assessment in three marine fish species from Visakhapatnam to Kakinada coasts

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Radiation detection Technology and Methods 2023年第4期7卷 611-626页

作者： A.Jaya Sree A.Srinivasulu Tanushree panigrahi B.Aruna Jaganmoy Biswas a.d.p.rao department of Nuclear physics Andhra UniversityVisakhapatnamAndhra PradeshIndia department of Chemistry Gitam UniversityVisakhapatnamAndhra PradeshIndia UGC-dAE Consortium for Scientific Research KolkataIndia

purpose The current study was aimed to evaluate the bioaccumulation of elements(As,Cd,Cu,Fe,Mn,Se and Zn)in the gills,liver and muscle of three distinct marine fish species,namely Nemipterus japonicas,Upeneus vittatus and pampus argenteus species were collected from Visakhapatnam to Kakinada coastal *** The fish tissues were analyzed for trace metals using energy-dispersive X-ray fluorescence(EdXRF).To ensure the quality control,reliability of the experimental validation,two certified reference materials(CRMs)procured from National Institute of Standards and Testing(NIST SRM 1577c-Bovine Liver)and European Commission-Joint Research Centre,Institute for Reference Materials and Measurements(ERMBB422-Fish muscle)were analyzed using *** The evaluated estimated daily intake(EdI)values for each metal are below the reference dose levels established by World Health Organisation(WHO).The target hazard quotient(THQ)values of both the locations of the present study are lower than one(pt for arsenic and the combined target hazard quotient(CTHQ)values are higher than one(>1)showing the presence of health *** cancer risk(CR)factor value for arsenic was below the acceptable lifetime carcinogenic risk(10^(–5)).The levels of heavy metals varied significantly among three fish species and *** mean concentrations of As,Cd,Cu,Fe,Mn,Se and Zn were slightly higher than the Ministry of Agriculture,Fisheries and Food(MAFF),Food and Agriculture Organization(FAO),Turkish food codex and Brazilian Legislation standard *** findings of this study revealed that muscles possessed the lowest concentrations mostly of all the metals when compared with liver and *** The study concluded that consumption of the muscle tissue may not pose severe health risk to human health but should be consumed moderately to prevent bioaccumulation of the metals especially As.

关键词： Health risk assessment Marine fish species-Trace elements Tissue specific

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Selective recovery of rare earth elements by smelting of magnets

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Journal of Rare Earths 2025年第1期43卷 209-217,I0008页

作者： Venkata Lakshmi Borra prasanta Jana ppSahoo prakash Venkatesan Mehmet Ali Recai Onal Chenna rao Borra department of Metallurgical and Materials Engineering Indian Institute of Technology KharagpurWest Bengal721302India R&d Tata Steel Ltd.Jamshedpur831001India department of Materials Engineering Synthesis and Recycling(4MAT)Universite Libre de BruxellesCP165/631050BrusselsBelgium GenoMines 630 Rue Noetzlin91190ParisFrance

Rare earth elements(REEs)play a crucial role in many technologies from daily appliances in cell phones to more advanced wind turbines and electric *** magnets account for a quarter of total global REEs production and have high recycling *** this study,smelting process was used to selectively oxidize REEs in the permanent magnets by adding Fe_(2)O_(3).This separates REEs into a slag phase from an iron-rich metallic phase.B_(2)O_(3) was also added to the system as a flux to lower the slag melting *** minimizes REEs loss to the metallic phase and allows a more efficient phase *** effect of flux and oxidizing agent addition was investigated on both regular and cerium-rich NdFeB(NdCeFeB)*** 1350℃and for 1 h,the slag phase was successfully separated from the metallic phase with the addition of 0.8 stoichiometric amount of Fe_(2)O_(3) and 40 wt%of B_(2)O_(3).Scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EdX)analysis reveals that REEs in the magnet do not migrate to the metal phase while the REE-rich slag phase contains almost no *** the selective removal of iron into the metallic phase,REEs are recovered from the slag phase through an acid leaching process allowing>99%of REEs *** in the magnet can also be recovered as useful boric acid by evaporation and crystallisation *** proposed process in this study is reagent and energy-efficient with almost complete valorisation of both NdCeFeB and NdFeB magnets.

关键词： Recycling Rare earth elements NdFeBmagnets Smelting Leaching

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passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Genome-wide association study reveals that enolase gene OsEE1 regulates coleoptile elongation in rice under anaerobic conditions

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Crop Journal 2025年第1期13卷 215-226页

作者： Li, dandan Liu, Kai Su, Ling Li, Jinrui Guo, Yuanyuan Guo, Tao Liu, Hong rao, dehua College of Agriculture South China Agricultural University Guangdong Guangzhou 510642 China Jiangxi Academy of Eco-Environmental Sciences and planning/Jiangxi Key Laboratory of Environmental pollution Control Jiangxi Nanchang 330039 China

Submergence can induce anaerobic stress on germinating seedlings in direct seeded rice paddy fields, limiting the practice of direct seeding. Longer coleoptiles improves the anaerobic tolerance of rice seedlings under submerged conditions. In a search for genes that could be beneficial for developing submergence-tolerant varieties 148 non-repetitive SNp loci were detected in on a genome-wide association study (GWAS) of coleoptile length (CL), coleoptile surface area (CSA), coleoptile volume (CV), and coleoptile diameter (Cd) of 591 rice accessions subjected to 4 d of anaerobic conditions. Integration of GWAS results and gene expression data identified OsEE1, an early embryogenesis-specific enolase 1 gene associated with coleoptile length (CL) in rice grown in anaerobic conditions. disruption of OsEE1 caused reduced CL in plants seeded under anaerobic conditions, whereas CL of OE-OsEE1 overexpression lines was significantly increased compared with the wild type. Functional analysis revealed that OsEE1 affects coleoptile length by modulating the glycolysis and tricarboxylic acid cycle pathways. Transcriptome sequencing of ko-osee1-1 knock out mutants highlighted enrichment in energy and carbohydrate metabolism, glycolysis, amino acid metabolism, and hormone signal transduction. Metabolite analysis indicated decreased levels of key metabolites in the tricarboxylic acid cycle and glycolysis pathways in ko-osee1-1 mutants compared to the wild type under anaerobic conditions. Overall, these findings shed light on the role of OsEE1 in determination coleoptile length of rice seedlings under anaerobic conditions. © 2024 Crop Science Society of China and Institute of Crop Science, CAAS

关键词： Coleoptile length Early embryogenesis-specific enolase 1 GWAS OsEE1 Rice

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin rao Yue Lin Gen Wei Jun Ying Fuzhou Hua department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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parametric optimization of friction stir welding process of age hardenable aluminum alloys-ANFIS modeling

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Journal of Central South University 2016年第8期23卷 1847-1857页

作者： d.Vijayan V.Seshagiri rao department of Mechanical Engineering Sri Chandrasekharendra Saraswathi Viswa Maha Vidyalaya Enathur Kanchipuram- 631561 Tamilnadu India St. Joseph's College of Engineering Chennai - 600025 Tamilnadu India

A comparative approach was performed between the response surface method(RSM) and the adaptive neuro-fuzzy inference system(ANFIS) to enhance the tensile properties, including the ultimate tensile strength and the tensile elongation, of friction stir welded age hardenable AA6061 and AA2024 aluminum alloys. The effects of the welding parameters, namely the tool rotational speed, welding speed, axial load and pin profile, on the ultimate tensile strength and the tensile elongation were analyzed using a three-level, four-factor Box-Behnken experimental design. The developed design was utilized to train the ANFIS models. The predictive capabilities of RSM and ANFIS were compared based on the root mean square error, the mean absolute error, and the correlation coefficient based on the obtained data set. The results demonstrate that the developed ANFIS models are more effective than the RSM model.

关键词： aluminum alloys response surface method(RSM) adaptive neuro-fuzzy inference system(ANFIS) friction stir welding Box-Behnken design neuro fuzzy

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Systematical identification of regulatory GpCRs by single-cell trajectory inference reveals the role of AdGRd1 and GpR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital department of physiology and pathophysiology School of Basic Medical SciencesPeking University department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GpCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GpCRs with the potential to regulate *** verification in primary adipose progenitor cells (ApCs) of mice,we discovered that AdGRd1 promoted the differentiation of ApCs,while GpR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFd),both gain-of-function and loss-of-function studies validated that AdGRd1 promoted adipogenesis,thereby improving metabolic homeostasis,while GpR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIp-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2d and TCF12 regulated the expression of AdGRd1and GpR39,*** study revealed the regulatory role of GpCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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From biomimicry to bioelectronics:Smart materials for cardiac tissue engineering

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Nano Research 2020年第5期13卷 1253-1267页

作者： Olurotimi A.Bolonduro Breanna M.duffy Akshita A.rao Lauren d.Black Brian p.Timko department of Biomedical Engineering Tufts UniversityMedfordMassachusetts 02155USA department of Cell Molecular&Developmental BiologySchool of Graduate Biomedical SciencesTufts UniversityMassachusetts 02111USA

Effective strategies in cardiac tissue engineering require matrices that recapitulate the mechanical,topographic and electrical cues present in the native extracellular *** this review,we discuss recent efforts in materials science and nanotechnology to achieve functional three-dimensional(3d)scaffolds that modulate and monitor cardiac tissue *** consider key design considerations,including choice of biopolymer matrix,cell sources,and delivery methods for eventual *** then discuss how solid-state nanomaterials may be integrated within these systems to provide unique electrical and nanotopographic cues that improve electromechanical *** describe how these approaches may be extended to complex,spatially heterogeneous constructs using 3d bioprinting ***,we describe how scaffold materials may be augmented with bioelectronic components to achieve hybrid myocardium that monitors or controls electrophysiological ***,these approaches provide a framework for achieving cardiac tissues with tunable,rationally-designed *** discuss future prospects and remaining challenges for clinical translation.

关键词： cardiac tissue engineering extracellular matrix nanomaterial bioelectronics cyborg

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Response Analysis of Tension-Based Tension Leg platform Under Irregular Waves

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China Ocean Engineering 2016年第4期30卷 603-614页

作者： d.S.Bhaskara rao R.panneer Selvam department of Ocean Engineering Indian Institute of Technology Madras

Tension Leg platform（TLp） is a hybrid structure used as oil drilling and production facility within water depths of 1200 m. The extension of this TLp concept to deeper waters is a challenge and warrants for some innovative design concepts. In this paper, a relatively new concept of TLp which is christened as Tension-Based Tension Leg platform（TBTLp） and patented by Srinivasan（1998） has been chosen for study. Response analysis of TLp with one tension base under irregular waves for three different sea states has been performed using hydrodynamic tool ANSYS？ AQWA？. Results are reported in terms of raos, response spectrums for surge, heave and pitch degrees of freedom from which spectral statistics have been obtained. The statistics of TBTLp have been compared with TLps（without tension base） for two different water depths to highlight the features of the new concept. The effect of viscous damping and loading effects on the raos are also investigated.

关键词： Tension-Based Tension Leg platform irregular waves time domain response response amplitudeoperators spectrum statistics coupled analysis

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基于神经血管单元稳态的电针对脑缺血再灌注损伤大鼠认知功能的影响及作用机制

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中国康复医学杂志 2025年第2期40卷 161-170页

作者：饶婷陈白林淑芳杨珊莉游咏梅福建中医药大学附属康复医院福建省福州市350003 福建省康复技术重点实验室福建中医药大学康复医学院

目的:观察电针百会、神庭穴对脑缺血再灌注模型鼠认知功能的影响并探讨其机制。方法:健康雄性Sd大鼠随机分为假手术组、模型组、电针组及非穴组,每组15只。除假手术组外,余各组均接受大脑中动脉缺血再灌注(MCAO/R)模型制备。电针组进行... 详细信息

目的:观察电针百会、神庭穴对脑缺血再灌注模型鼠认知功能的影响并探讨其机制。方法:健康雄性Sd大鼠随机分为假手术组、模型组、电针组及非穴组,每组15只。除假手术组外,余各组均接受大脑中动脉缺血再灌注(MCAO/R)模型制备。电针组进行百会、神庭穴电针干预7d,非穴组进行百会、神庭穴向外侧平开5mm电针干预7d,模型组及假手术组仅接受同等条件抓取及固定。采用神经行为学评分和TTC染色进行模型检验,神经行为学评分评估认知功能,HE染色法观察海马区细胞形态,免疫组化观察海马区Cd31、GFAp、IBa1表达,ELISA观察海马区VEGF、BdNF、IL-10表达。结果:电针可缩短MCAO模型鼠Morris水迷宫逃避潜伏期,增加穿越平台次数,改善海马区细胞水肿、坏死及炎性细胞浸润,增加VEGF、IL-10、BdNF蛋白表达,增加Cd31阳性表达,降低GFAp、IBa1阳性细胞数。结论:电针百会、神庭穴可改善脑缺血再灌注损伤大鼠认知功能,作用机制可能与调节神经血管单元(NVU)各组分,维持NVU稳态有关。

关键词：脑缺血再灌注损伤认知功能电针百会神庭神经血管单元

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