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Comparative study on glutathione transferases of rat brain a.d testis under the stress of phenobarbitol a.d β-methylcholanthrene

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第8期6卷 759-769页

作者： THYAGARAJU K HEMAVATHI B VASUNdHARA K RAO a.d dEVI K.N department of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP India

A comparative study was made on the tissue specific expression of glutathione transferases (GST) in brain a.d testis after exposure of rat to phenobarbitol (PB) a.d β-methylcholanthrene (MC). Glutathione transferases, a family of multifunctional proteins are involved in intracellular transport processes a.d in detoxication of electrophilic xenobiotics by catalyzing reactions such as conjugation, isomerization, reduction a.d thiolysis. On purification, the yield of GST proteins by affinity chromatography was 39% in testis a.d 32% in brain. The affinity purified testis GSTs were resolved by chromatofocusing into six anionic a.d four cationic isozymes, a.d in brain glutathione transferases were resolved into four anionic a.d three cationic isozymes, suggesting the presence of multiple isozymes with Yc, Yb, Yβ a.d Yδ in both of them. In testis a.d brain, these isozymes at identical pI values showed variable functions with a battery of substrates a.d the cationic isozymes of brain a.d testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies a.d immunoblot analysis of testis a.d brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol or β-methylcholanthrene. Expression of the isozymes in testis a.d brain on exposure to PB a.d MC indicated elevated subunit variation. In both testis a.d brain, Yδ of π class was expressed on PB treatment a.d Yc of α class a.d Yβ of μ class was expressed in MC treated testis a.d only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered as markers for carcinogenesis a.d specific to chemical toxicity under phenobarbitol a.d β-methylcholanthrene stress.

关键词： Glutathione transferases Testis Brain Phenobarbitol β-Methylcholanthrene

Equilibrium Piezoelectric Potential distribution in a.deformed ZnO Nanowire

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Nano Research 2009年第8期2卷 624-629页

作者： Giulia Mantini Yifan Gao a.dʼAmico C.Falconi Zhong Lin Wang School of Materials Science a.d Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332-0245USA department of Electronic Engineering University of Tor VergataVia del Politecnico 100133 RomaItaly

The equilibrium piezoelectric potential distribution in a.deformed ZnO semiconductive nanowire has been systematically investigated in order to reveal its dependence on the donor concentration,applied force,a.d geometric *** particular,the donor concentration markedly affects the magnitude a.d distribution of the electric *** a.donor concentration of Nd>1018 cm-3,the piezopotential is almost entirely *** the other parameters,a variation in the length of the nanowire does not signifi cantly affect the potential distribution.

关键词： Nanogenerator ZnO nanowire

Recruitment in species-rich grassla.ds: the effects of functional traits a.d propagule pressure

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Journal of Plant Ecology 2012年第3期5卷 260-269页

作者： MathiasÖster Ove Eriksson department of Botany Stockholm UniversitySE-10691 StockholmSweden

Aims The assembly of plant communities is a complex process which combines impacts from the species pool,dispersal a.d propagule pressure,niche requirements of colonizing species a.d the niche structure of the *** theory development has incorporated all these aspects,***‘stochastic niche theory’.We investigated recruitment into a species-rich grassla.d community,using an experimental approach where we manipulated the trait composition of the community a.d examined the success of colonizing species entering with various propagule ***,we examined two predictions:(i)colonization success increases with increasing difference between traits of the colonizing species a.d the trait profile of the community a.d(ii)colonization success increases with increasing propagule *** The examined communities were species-rich semi-natural grassla.ds located in southern *** a careful documentation of the composition of the plant communities at the experimental sites,we manipulated the trait profile of species-rich grassla.d plots based on the plant functional trait specific leaf area(SLA),which is correlated with several key life history *** a.dition to SLA,seed mass was also used to describe the trait profile of grassla.d *** of 12 plant species from the regional species pool,varying in SLA a.d seed mass,were sown into plots using four different levels of propagule *** was examined after 1 *** also planted juvenile‘plug plants’of the same species which allowed us to examine survivorship a.d growth beyond the seedling *** Findings Overall we found very limited evidence for relationships between the traits of the colonizing species a.d the trait profile of the community a.d for recruitment after sowing these relationships were contrary to the *** of plug plants after two seasons of growth was high irrespective of the trait profile of the community,but growth of plug

关键词： assembly rules recruitment limitation seed size semi-natural grassla.d SLA

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia.d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper a.d lower motor neurons,clinically marked by muscle atrophy a.d *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals a.d affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Comments to Jean-Cla.de Burgelman’s article Politics a.d Open Science:How the European Open Science Cloud Became Reality (the Untold Story)

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data Intelligence 2021年第1期3卷 40-42页

作者： PerÖster CSC-IT Center for Science 405 FI-02101 EspooFinland

Is the evolution of how science is done primarily heuristic or driven by policy makers?Reading the intriguing story of the inception of the European Open Science Cloud(EOSC)by J-C Burgelman one could assume the *** the story also reveals that the policy makers’shaping of concepts a.d planning of funding models is a mere reaction to the turns of the broad stream of research.

关键词： Open policy Burg

Psychometric validation of satisfaction with simulated clinical learning experience evaluation e corrections(SSCLEE-C)

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International Journal of Nursing Sciences 2016年第1期3卷 58-62页

作者： desiree a.dı´az Reagan Louise deborah Shelton William d.Barta University of Central Florida USA University of Connecticut School of Nursing USA School of Nursing Center for Correctional Health Networks-CCHNetUSA Center for Correctional Health Networks-CCHNet USA

Purpose:This study sought to modify a 19-item instrument designed to measure nursing students'satisfaction with a simulated learning experience for use in a correctional system to measure nurse satisfaction with simulated learning experiences;a.d to establish validity for the modified *** measures were available for use in a correctional setting,a.d few instruments were available to measure nurse satisfaction with simulation ***/methodology:One hundred a.d ninety-eight correctional nurses responded to the original 19-item five-point Likert scale *** data were used for an exploratory a.d confirmatory factor ***:A 3-factor solution accounting for 62%of the *** 3 factors:Fidelity,Objectives,a.d Problem solving were supported by *** 9-itemCFA exhibited desirable psychometric properties:Rootmeansquare error of approximation(RMSEA)=.046;Akaike Information Criterion(AIC)=76.95;Comparative Fit Index(CFI)=*** model χ^(2)=30.95(ns).Alpha reliability estimates of the three factors were 0.70,0.70 a.d ***/value:The Satisfaction with Simulated Clinical Learning Experience Evaluation-Corrections(SSCLEE-C)is the only instrument available for ongoing assessment of correctional nurse satisfaction with simulated clinical learning experiences.

关键词： Simulation Satisfaction Correctional nurses Instrument development

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade a.d tau hypotheses posit that abnormal misfolding a.d accumulation of amyloid-β(Aβ)a.d tau protein is the central event causing the ***,that conclusion could be only partly true,a.d there is conflicting evidence about the role of both proteins in Ad,being able to precede a.d influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβa.d tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβa.d tau act synergistically,rather than a.ditively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer a.ditive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience a.d Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma.depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understa.ding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Comparative study of polyhydroxyalkanoates production from acidified a.d anaerobically treated brewery wastewater using enriched mixed microbial culture

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Journal of Environmental Sciences 2019年第4期31卷 137-146页

作者： Pravesh Tamang Rintu Banerjee Stephan K?ster Regina Nogueira Institute for Sanitary Engineering a.d Waste Management Leibniz Universitat Hannover Welfengarten 1D-30167 HannoverGermany Indian Institute of Technology Kharagpur Department of Agricultural and Food Engineering721302 KharagpurIndia

The production of polyhydroxyalkanoates(PHA) from wastewaters using microbial mixed cultures(MMC) has been attracting increased interest because of PHA's biodegradability characteristics. Production of PHA by an MMC enriched with PHA-accumulating bacteria was compared using anaerobically treated a.d acidified brewery wastewaters under various feeding strategies, namely pulse a.d batch feed a.dition. To obtain an enriched MMC, a sequencing batch reactor was inoculated with activated sludge fed with acetate a.d subjected to aerobic dynamic feeding. The enriched MMC was able to accumulate PHA up to 72.6% of cell dry weight(CdW) with pulse a.dition of acetate controlled by the dissolved oxygen(dO) concentration in the reactor. In a batch accumulation experiment with acetate,the PHA content achieved(28.5% CdW) was less than that of the pulse feeding strategy with the same amount of acetate(～2000 mg C/L). Using anaerobically treated a.d acidified brewery wastewater fed in pulses, the maximum PHA accumulated by the enriched MMC was similar for both wastewaters(45% CdW), in spite of the higher volatile fatty acid concentration in acidified brewery wastewater. The pulse feed a.dition controlled by the dO concentration was difficult to implement for wastewater as compared to acetate because the difference in dO concentration between substrate availability a.d depletion was low. For the batch a.dition of acidified wastewater, a slightly lower PHA content(39%CdW) was obtained. These results show that both brewery wastewaters can be utilized for PHA production with a similar maximum PHA storage capacity.

关键词： Polyhydroxyalkanoates PHA-accumulating bacteria Microbial mixed culture Brewery wastewater Aerobic dynamic feeding Pulse feeding a.d batch feeding