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Assessment of the July effect in post-endoscopic retrograde cholangiopancreatography pancreatitis:Nationwide Inpatient Sample

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World Journal of Gastrointestinal Endoscopy 2017年第7期9卷 296-303页

作者： Allison R Schulman Marwan S Abougergi christopher c Thompson Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical School catalyst Medical consulting LLC

To assess incidence of post-endoscopic retrograde cholangiopancreatography (post-ERcP) pancreatitis in the early (July/August/September) vs the late (April/May/June) academic year and evaluate in-hospital mortality, length of stay (LOS), and total hospitalization charge between these time periods. METHODSThis was a retrospective cohort study using the 2012 Nationwide Inpatient Sample (NIS). Patients with International classification of Diseases, 9th Revision, clinical Modification (IcD-9 cM) procedure codes for ERcP were included. Patients were excluded from the study if they had an IcD-9 cM code for a principal diagnosis of acute pancreatitis, if the ERcP was performed before or on the day of admission or if they were admitted to non-teaching hospitals. Post-ERcP pancreatitis was defined as an IcD-9 cM code for a secondary diagnosis of acute pancreatitis in patients who received an ERcP as delineated above. ERcPs performed during the months of July, August and September was compared to those performed in April, May and June in academic hospitals. ERcPs performed at academic hospitals during the early vs late year were compared. Primary outcome was incidence of post-ERcP pancreatitis. Secondary outcomes included in-hospital mortality, length LOS, and total hospitalization charge. Proportions were compared using fisher’s exact test and continuous variables using student t-test. Multivariable regression was performed. RESULTSFrom the 36480032 hospitalizations in 2012 in the United States, 6248 were included in the study (3065 in July/August/September and 3183 in April/May/June) in the 2012 academic year. compared with patients admitted in July/August/September, patients admitted in April/May/June had no statistical difference in all variables including mean age, percent female, charleston comorbidity index, race, median income, and hospital characteristics including region, bed size, and location. Incidence of post-ERcP pancreatitis in early vs late academi

关键词： Pancreatitis Academic training Endoscopic retrograde cholangiopancreatography Endoscopy July effect

南极Lambert,Mellor和fisher冰川的物质平衡及Amery冰架底部物质通量的估算

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中国科学（D辑） 2007年第9期37卷 1192-1204页

作者：温家洪 Kenneth c.Jezek Beata M.csathó Ute c.Herzfeld Katy L.Farness Philippe Huybrechts 上海师范大学地理系 Byrd Polar Research center The Ohio State UniversityColumbusOH 43210USA cIRES/NSIDc University of Colorado BoulderBoulderCO 80309-0449USA Departement Geografie Vrije Universiteit BrusselPleinlaan 2B-1050BrusselsBelgium Alfred-Wegener-Institut für Polarund MeeresforschungPostfach 120161D-27515 BremerhavenGermany

利用现场观测与遥感数据对Lambert,Mellor和fisher冰川的物质平衡及其在Amery冰架的底部融化与冻结状况进行了估算.结果表明,澳大利亚组织的Lambert冰川盆地(LGB)考察路线的上游地区,Lambert与Mellor冰川分别为(3.9±2.1)和(2.1±2.4)Gt... 详细信息

利用现场观测与遥感数据对Lambert,Mellor和fisher冰川的物质平衡及其在Amery冰架的底部融化与冻结状况进行了估算.结果表明,澳大利亚组织的Lambert冰川盆地(LGB)考察路线的上游地区,Lambert与Mellor冰川分别为(3.9±2.1)和(2.1±2.4)Gt·a-1的正平衡,而fisher冰川基本处于平衡状态.上游地区总的正平衡为(5.9±4.9)Gt·a-1.考察路线以下,3条冰川均处于负平衡,总的负平衡为(-8.5±5.8)Gt·a-1.整个Lambert,Mellor和fisher冰川均接近于平衡状态.3条冰川总净平衡为(-2.6±6.5)Gt·a-1.前人认为GL线(1970年代初澳大利亚在LGB建立的冰川运动观测点的连线)以上的内陆盆地处于显著正平衡,可能是因为过高地估算了总积累量,并低估了穿过GL线的冰通量.靠近Amery冰架南端着地线,冰架底部的平均融化速率为(-23.0±3.5)m冰·a-1,向下游方向快速减小,并在距冰架最南端约300km处过渡为底部冻结.沿3条冰川在Amery冰架的冰流带(flowband),冻结速率约介于(0.5±0.1)^(1.5±0.2)m冰·a-1.由于冰流带底部的融化,流入冰架的内陆冰损失了大约80%±5%.3条冰流带底部总融化和总冻结分别为(50.3±7.5)和(7.0±1.1)Gt冰·a-1,这要比前人通过模拟和海洋观测估算的整个Amery冰架底部总融化和总冻结还要大很多.

关键词：物质平衡底部融化与冻结 Lambert冰川盆地 Amery冰架南极

Prospective,multicentre study of screening,investigation and management of hyponatraemia after subarachnoid haemorrhage in the UK and Ireland

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Stroke & Vascular Neurology 2023年第3期8卷 207-216,I0028-I0059页

作者： James J M Loan Steven Tominey Kirun Baweja Julie Woodfield Thomas J G chambers Mark Haley Simran S Kundu H Y Josephine Tang Anthony N Wiggins Michael T c Poon Paul M Brennan Translational Neurosurgery The University of Edinburgh Centre for Clinical Brain SciencesEdinburghUK Neurosurgery NHS LothianEdinburghUK Neurosurgery Institute of Neurological SciencesGlasgowUK Department of Medicine School of MedicineDentisty and NuringUniversity of GlasgowGlasgowUK Internal Medicine Queen's UniversityKingstonOntarioCanada centre for Discovery Brain Sciences University of EdinburghEdinburghUK Edinburgh centre for Diabetes and Endocrinology NHS LothianEdinburghUK Radiology University Hospitals Plymouth NHS TrustPlymouthUK Department of Medicine Cork University HospitalUniversity College CorkCorkIreland

Background Hyponatraemia often occurs after subarachnoid haemorrhage(SAH).However,its clinical significance and optimal management are *** audited the screening,investigation and management of hyponatraemia after *** We prospectively identified consecutive patients with spontaneous SAH admitted to neurosurgical units in the United Kingdom or *** reviewed medical records daily from admission to discharge,21 days or death and extracted all measurements of serum sodium to identify hyponatraemia(comes were death/dependency at discharge or 21 days and admission duration>10 *** of hyponatraemia with outcome were assessed using logistic regression with adjustment for predictors of outcome after SAH and admission *** assessed hyponatraemia-free survival using multivariable cox *** 175/407(43%)patients admitted to 24 neurosurgical units developed hyponatraemia.5976 serum sodium measurements were *** osmolality,urine osmolality and urine sodium were measured in 30/166(18%)hyponatraemic patients with complete *** most frequently target daily fluid intake was>3 L and this did not differ during hyponatraemic or non-hyponatraemic episodes.26%(n/N=42/164)patients with hyponatraemia received sodium supplementation.133(35%)patients were dead or dependent within the study period and 240(68%)patients had hospital admission for over 10 *** the multivariable analyses,hyponatraemia was associated with less dependency(adjusted OR(aOR)=0.35(95%cI 0.17 to 0.69))but longer admissions(aOR=3.2(1.8 to 5.7)).World Federation of Neurosurgical Societies grade I-III,modified fisher 2-4 and posterior circulation aneurysms were associated with greater hazards of *** In this comprehensive multicentre prospective-adjusted analysis of patients with SAH,hyponatraemia was investigated inconsistently and,for most patients,was not associated with changes in management or clinical outcome.T

关键词： admitted urine centre

坝上地区不同海拔农田和恢复半自然生境下尺蛾多样性

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应用生态学报 2012年第3期23卷 785-790页

作者：段美春刘云慧王长柳 Jan c. Axmacher 李良涛宇振荣中国农业大学资源与环境学院北京100193 四川省成都市青白江区城乡规划管理局成都610306 英国伦敦大学学院地理系

为研究生境恢复及地形变化导致的景观异质性对退化景观中生物多样性的影响,于2006和2007年对河北坝上3个不同海拔村庄的农田生境与恢复中的禁牧草地或再造林等半自然生境的尺蛾群落采用灯诱法进行取样调查,比较不同生境的尺蛾多样性.结... 详细信息

为研究生境恢复及地形变化导致的景观异质性对退化景观中生物多样性的影响,于2006和2007年对河北坝上3个不同海拔村庄的农田生境与恢复中的禁牧草地或再造林等半自然生境的尺蛾群落采用灯诱法进行取样调查,比较不同生境的尺蛾多样性.结果表明:两种生境类型间物种数和个体数存在显著差异、不同海拔村庄物种数也存在显著差异,但不同海拔村庄间个体数差异不显著,不同海拔村庄间以及各村庄内农田和半自然生境稀疏标准化物种数和fisher α指数无显著差异;非度量多维标度法(NMDS)显示不同海拔的不同生境下尺蛾群落结构显著不同.地形变化导致的景观异质性对坝上地区尺蛾群落组成及多样性影响显著,而无论是恢复中的草地、再造林等半自然生境还是农田生境均是维持尺蛾多样性的重要生境.注重不同地形条件下农田生境和半自然生境景观镶嵌体的保护对维持尺蛾群落γ多样性具有重要意义,但生境恢复能否促进尺蛾群落多样性恢复尚需长期监测.

关键词：坝上海拔生境恢复半自然生境尺蛾生物多样性

Tetanus Toxin Antibody Levels in Pre-School Nigerian children after Three Doses of Diphtheria-Pertussis-Tetanus/Pentavalent Immunization: A cross-Sectional Study

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World Journal of Vaccines 2018年第2期8卷 39-52页

作者： Emmanuel E. Ekanem Helen O. Uket Henry c. Okpara Department of Paediatrics University of Calabar and University of Calabar Teaching Hospital Calabar Nigeria Department of Paediatrics University of Calabar Teaching Hospital Calabar Nigeria Department of chemical Pathology University of Calabar and University of Calabar Teaching Hospital Calabar Nigeria

Background: Post-neonatal tetanus is an important problem. Prevention of tetanus in Nigeria is via immunization with three doses of Diphtheria-Pertussis-Tetanus (DPT)/Pentavalent vaccine at 6, 10 and 14 weeks. The anti-tetanus antibody levels of these children are not known after they had received DPT3/Pentavalent vaccines. Aim: This work was to determine the anti-tetanus antibody (IgG) response in Nigerian children aged six months to five years who had received three doses of DPT vaccine in early infancy. Methods: children aged six months to five years who were attended to in the University of calabar Teaching Hospital for acute illnesses were recruited. Their anti-tetanus IgG levels were measured using Enzyme Linked Immunosorbent Assay (ELISA). The optimal cut-off level of ≥0.1 IU/ml was used as the protective level. Data was analysed using the Statistical Package for Social Sciences (SPSS) version 20.0 with simple proportions and percentages. Students’ “t” test and ANOVA were used to compare quantitative variables while chi-square and fisher’s exact test were used to compare categorical data. Results: Four hundred and eighteen children participated in the study. The mean IgG antibody level was 1.021 ± 0.9 IU/ml. Four hundred children (95.7%) had protective levels of antibodies. The highest proportion of subjects with protective levels was in infants, 6 - 11 months (99%) and lowest in children aged 36 - 47 months (92.2%). conclusion: The proportion of children with protective levels was above 90% in all age groups studied. The current national immunization schedule is adequate. Further studies in older age groups are needful.

关键词： DPT/Pentavalent Vaccine Antibodies Response

MGMT and MLH1 methylation in Helicobacter pylori-infected children and adults

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World Journal of Gastroenterology 2013年第20期19卷 3043-3051页

作者： Marisa c Alvarez Juliana c Santos Nathália Maniezzo Marcelo S Ladeira Artur Lc da Silva Isabel cA Scaletsky José Pedrazzoli Jr Marcelo L Ribeiro Unidade Integrada de Farmacologia e Gastroenterologia Universidade So FranciscoBragan a Paulista 12916-900SPBrazil Programa de Pós Gradua o em Genética e Biologia Molecular State University of CampinasCampinas 13083-970SPBrazil Departamento de clínica Médica UNESPBotucatu 18618-970SPBrazil Departamento de Genética Universidade Federal do ParáBelém 68400-000PABrazil Departamento de Microbiologia Imunologia e ParasitologiaUniversidade Federal de So PauloSo Paulo 04021-001SPBrazil

AIM:To evaluate the association between Helicobacter pylori(***) infection and MLH1 and MGMT methylation and its relationship with microsatellite instability(MSI).METHODS:The methylation status of the MLH1 and MGMT promoter region was analysed by methylation specific methylation-polymerase chain reaction(MSPPcR) in gastric biopsy samples from uninfected or ***-infected children(n = 50),from adults with chronic gastritis(n = 97) and from adults with gastric cancer(n = 92).MLH1 and MGMT mRNA expression were measured by real-time PcR and normalised to a constitutive gene(β actin).MSI analysis was performed by screening MSI markers at 4 loci(Bat-25,Bat-26,D17S250 and D2S123) with PcR;PcR products were analysed by single strand conformation polymorphism followed by silver *** analyses were performed with either the χ 2 test with Yates continuity correction or fisher's exact test,and statistical significance for expression analysis was assessed using an unpaired Student's ***:Methylation was not detected in the promoter regions of MLH1 and MGMT in gastric biopsy samples from children,regardless of *** infection *** MGMT promoter was methylated in 51% of chronic gastritis adult patients and was associated with *** infection(P c cancer patients,and the difference in the percentage of methylated samples between these patients and those from ***-infected chronic gastritis patients was statistically significant(P cies among ***-infected and non-infected chronic gastritis adult patients were 13% and 7%,*** observed methylation of the MLH1 promoter(39%) and increased MSI levels(68%) in samples from gastric cancer patients in comparison to samples from ***-infected adult chronic gastritis patients(P ctively).The frequency of promoter methylation for both genes was higher in gastric cancer sam

关键词： Helicobacter pylori Microsatellite instability Promoter methylation MLH1 MGMT Gastric cancer

Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes

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World Journal of Virology 2017年第3期6卷 53-58页

作者： Eyone Jones Pavel Mazirka Margaret A McNurlan Frank Darras Marie c Gelato Giuseppe caso Department of Surgery Rutgers Robert Wood Johnson Medical School Department of Surgery Stony Brook University Medical Center Department of Urology Stony Brook University Medical Center Department of Medicine Stony Brook Uni-versity Medical Center

AIM To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome. METHODS Preadipocytes from healthy donors were assessed for proliferation and differentiation in the presence of nucleoside reverse transcriptase inhibitors(NRTIs), nonnucleoside reverse transcriptase inhibitors(NNRTIs), and protease inhibitors(PIs) individually and in combination. Effects on proliferation were assessed with a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay and effects on differentiation were assessed from glycerol-3-phosphate dehydrogenase(GPDH) activity and quantitation of Oil Red O staining for intracellular lipid. Data were analyzed with a randomized block ANOVA with post-hoc fisher's Least Significant Difference test. RESULTS Preadipocyte proliferation was inhibited by a combination of NNRTI + NRTI(14% at 48 h, P combination of atazanavir(ATV) + RTV + emtricitabine(FTc) + tenofovir(TDF) had the greatest inhibitory effect on proliferation at 48 h. Preadipocyte differentiation was most significantly reduced by the efavirenz + FTc + TDF assessed either by GPDH activity(64%) or lipid accumulation(39%), P combining NRTIs with a PI(ATV + FTc + TDF) significantly suppressed differentiation(GPDH activity reduced 29%, lipid accumulation reduced by 19%, P ct was slightly greater when a boosting amount of RTV was added(ATV + FTc + TDF + RTV, P cONcLUSION Although combination antiretroviral therapy is clinically more efficacious than single drug regimens, it also has a much greater inhibitory effect on preadipocyte proliferation and differentiation.

关键词： Nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors Protease inhibitors Pre-adipocytes Highly active antiretroviral therapy Lipodystrophy

Development of a Fast and Facile Analytical Approach to Quantify Radiometabolites in Human Plasma Samples Using Ultra High Performance Liquid chromatography

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American Journal of Analytical chemistry 2019年第5期10卷 185-201页

作者： cé cile Malherbe Rudy Bidault claude Netter Denis Guilloteau Johnny Vercouillie Nicolas Arlicot UMR 1253 iBrain Universit&#233 de Tours Inserm Tours France cHRU de Tours Unit&#233 de Radiopharmacie Tours France Thermo fisher Scientific Waltham MA USA cHRU de Tours Service de M&#233 decine Nuclé aire in Vitro Tours France INSERM cIc 1415 University Hospital Tours France

Introduction: conventional metabolite analyses often require manual sample preparation, generating variability of measurements. This study describes a new method to quantify radiometabolites in blood, combining ultra high performance liquid chromatography (UHPLc) and turbulent flow chromatography, an alternative fully automated process allowing analyte’s extraction. Methods: A new radiotracer for dopamine transporter imaging, namely LBT-999, was used to demonstrate the method’s robustness. Matrix effect, Turboflow column loading, linearity, specificity and precision were evaluated with in vitro samples of LBT-999 in human plasma. Radiodetector sensitivity and preliminary evaluation were respectively determined by analysis of calibrated samples of [18F]LBT-999 and blood samples from 4 healthy subjects injected with [18F]LBT-999, withdrawn at 5, 15, 30 and 45 min pi. Results: With three sequential loadings (3 × 100 μL) of the Turboflow column, mean coefficients of variation were 1%, below 2%, 2% and 30.9% for matrix effect, specificity, repeatability and intermediate precision, respectively. correlation coefficients for linearity were superior to 0.97. Limits of detection and quantification of the radiodetector were fixed at 3 and 9 c/s. Retention times for [18F]LBT-999 and the two radiometabolites detected by radio-UHPLc were 6.5, 4.8 and 9.6 min. Forty-five min after the injection, parent fraction was still predominant with 57.8% ± 25% of the total radioactivity. conclusions: An innovative approach, allying UHPLc and Turboflow column, was developed and its sensitivity, linearity, specificity and repeatability validated. Preliminary results of the clinical trial are in accordance with literature data, demonstrating its efficiency in radiometabolites quantification.

关键词： Radiometabolite Ultra High Performance Liquid chromatography Turboflow Method Validation [18F]LBT-999

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基底细胞癌的不寻常组织学类型

世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 11-11页

作者： Hutcheson A.c.S. fisher A.H. Lang Jr. P.G. 冯义国 Department of Dermatology Medical University of SouthCarolina 135 Rutledge AveCharleston SC29425 United StatesDr.

Uncommon histologic variants of basal cell carcinoma (Bcc) can present a diagnostic challenge. In this case series, we describe 3 patients with unusual Bccs encountered in a dermatologic surgical unit over a 1- year period from September 2003 to September 2004. The formalin- fixed, paraffin- embedded histologic specimens were initially examined microscopically after staining with hematoxylin and eosin. Additional stains, including diastase periodic acid- Schiff, colloidal iron, carcinoembryonic antigen, and cytokeratin- 20, were subsequently performed as appropriate. Of the 3 lesions, one exhibited apocrine differentiation and two demonstrated a trabecular growth pattern. Although Bccs demonstrating apocrine differentiation have previously been described, a trabecular growth pattern, to our knowledge, has not been previously reported for Bcc.

关键词：基底细胞癌顶泌腺小梁癌胚抗原细胞角蛋白外科门诊胶体金生长方式