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Neural Regeneration Research 2022年第9期17卷 1965-1966页

作者： Celia Herrera-Rincon Julia Murciano-brea Stefano Geuna Department of Biodiversity Ecology&Evolutionand ModelingData Analysis&Computational Tools for Biology Research GroupBiomathematics UnitComplutense University of MadridMadridSpain Department of Clinical and Biological Sciences and Cavalieri Ottolenghi Neuroscience InstituteUniversity of TurinTurinItaly

The human body is populated by a large number of microbial colonies,with an estimated 10-100 trillion *** total genome size of human microbial colonies by far overwhelms the size of the host’s *** heterogenous group of microbial colonies(primarily bacteria,but also archaea,eukaryotes and viruses)is referred to with the term microbiota,and although most of them populate the gut,microbes are also detectable in many other organs of the body,especially in the distal tracts of the genitourinary system and the *** the last years,an increasing amount of evidence has been accumulated on how the microbiota exerts a significant influence on the development and physiology of the human body.

关键词： neural organs size

The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

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Bone Research 2023年第2期11卷 273-291页

作者： Hengwei Zhang Jane LLiesveld Laura MCalvi brea CLipe Lianping Xing Michael WBecker Edward MSchwarz Shu-Chi A.Yeh Center for Musculoskeletal Research University of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Wilmot Cancer Center University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of Orthopaedics University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical Engineering University of RochesterNYUSA Department of Physiology/Pharmacology University of Rochester Medical CenterRochesterNYUSA

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HSCs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.

关键词： remodeling homeostasis likely

Polarization conversion using customized subwavelength laser-induced periodic surface structures on stainless steel

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Photonics Research 2022年第9期10卷 2024-2031页

作者： MAHMOUD H.ELSHORBAGY LUIS MIGUEL SÁNCHEZ-brea JERÓNIMO BUENCUERPO JESÚS DEL HOYO ÁNGELA SORIA-GARCÍA VERÓNICA PASTOR-VILLARRUBIA ALEJANDRO SAN-BLAS AINARA RODRÍGUEZ SANTIAGO MIGUEL OLAIZOLA JAVIER ALDA Grupo Complutense deÓptica Aplicada Departamento deÓpticaFacultad de Ciencias FıÂsicasUniversidad Complutense de MadridPlaza de las Ciencias S.N.28040 MadridSpain Physics Department Faculty of ScienceMinia University61519 El-MinyaEgypt L’Institut Photovoltaïque d’Île-de-France(IPVF) 18 Bd Thomas Gobert91120 PalaiseauFrance Ceit-Basque Research and Technology Alliance(BRTA) Manuel Lardizabal 1520018 Donostia/San SebastiánSpain Universidad de Navarra TecnunManuel Lardizabal 1320018 Donostia/San SebastiánSpain

Stainless steel is a basic raw material used in many *** can be customized by generating laser-induced periodic surface structure(LIPSS)as subwavelength ***,we present the capabilities of an LIPSS on stainless steel to modify the polarization state of the reflected radiation at the IR *** structures have been modeled using the finite element method and fabricated by femtosecond laser *** Stokes parameters have been obtained experimentally and a model for the shape has been used to fit the simulated Stokes values to the experimental *** birefringence of the LIPSS is analyzed to explain how they modify the polarization state of the incoming *** find the geometry of the subwavelength grating that makes it work as an optical retarder that transforms a linearly polarized light into a circularly polarized *** addition,the geometrical parameters of the LIPSS are tuned to selectively absorb one of the components of the incoming light,becoming a linear axial *** selecting the geometrical parameters and orientation of the fabricated LIPSS makes it possible to obtain an arbitrary pure polarization state when illuminated by a pure linearly polarized state oriented at an azimuth of 45°.The overall reflectance of these transformations reaches values close to 60%with respect to the incident intensity,which is the same reflectivity obtained for non-nanostructured stainless steel flat surfaces.

关键词： steel laser polarization

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三维后方交会

国外地质与勘测 1995年第1期 52-57页

作者： brea.,MC 徐惠莲

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物质进化论

商业周刊（中文版） 2016年第13期 79-83页

作者： Caroline Winter brea Souders

Thyroid Cartilage Chondrosarcoma Review: Management and Prognosis of a Rare Tumor

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第2期3卷 57-65页

作者： Antonio Rodríguez-Valiente Amaya Roldán-Fidalgo Jose Ramón García-Berrocal Isabel Salas Beatriz brea Department of Neuroradiology University Hospital Puerta de Hierro Majadahonda Madrid Spain Department of Otorhinolaryngology University Hospital Puerta de Hierro Majadahonda Madrid Spain Department of Pathology University Hospital Puerta de Hierro Majadahonda Madrid Spain

Objective: This article is a critical review of the literature concerning thyroid cartilage chondrosarcoma and is particularly focused on the management and prognosis of this rare entity. Study Design: A review of all the cases of thyroid cartilage chondrosarcoma reported in the literature up to January 2013. Methods: The search was carried out through the introduction of the MeSH terms: Chondrosarcoma, Laryngeal Cartilages, Thyroid Cartilage, Therapeutics. All the studies related to thyroid cartilage chondrosarcoma were selected together with a newly presented case. Results: A total of 47 cases have been described in the literature, and 35 of these include sufficient data for statistical analysis. The age of patients ranged from 40 to 77 years, with a male predilection (88.6%). The main symptoms were neck mass and hoarseness. Grade I and II tumors were most frequent. A total of 13 cases described an extension of the tumor beyond the thyroid cartilage. The most common treatment was partial laryngectomy (50%). All patients who died were male, with grade II or II-III tumor or associated sarcoma, had metastases and received radiotherapy in addition to total laryngectomy. Conclusion: Patient age and tumor size does not influence the prognosis. Tumor grade I and I-II have good prognoses, whereas the prognosis is unpredictable in tumors between grade II and III. Patients with associated sarcoma, or metastasis, have a worse prognosis. Partial laryngectomy is a good therapeutic option, although total laryngectomy is sometimes required in order to ensure complete resection.

关键词： Chondrosarcoma Laryngeal Cartilages Thyroid Cartilage Therapeutics

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请用细菌洗手

商业周刊（中文版） 2019年第10期 64-69页

作者： CAROLINE WINTON brea SOUDERS(摄影) 杨飞(译) 不详

2009年2月的一天,外面连下了一周的雪,54岁的戴维.惠特洛克(David Whitlock)在他位于马萨诸塞州坎布里奇附近的三居室公寓里打点完行装,将东西搬进他的面包车里。为了在全球范围内给他新发现的一种令他痴迷的东西申请专利,这位发明家花... 详细信息

2009年2月的一天,外面连下了一周的雪,54岁的戴维.惠特洛克(David Whitlock)在他位于马萨诸塞州坎布里奇附近的三居室公寓里打点完行装,将东西搬进他的面包车里。为了在全球范围内给他新发现的一种令他痴迷的东西申请专利,这位发明家花光了自己所有的钱一将近50万美元。这是从土壤样品中采集的一种细菌,他认为这种细菌能改善皮肤病、高血压和其他健康问题。惠特洛克说:“这是我能做的最重要的事情。但是我知道我需要取得专利,否则就无法让任何人感兴趣。”

关键词：细菌洗手申请专利 2009年马萨诸塞州健康问题面包车发明家

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三维后方交会

本钢译丛 1996年第1期 48-52页

作者： brea.,MC 法维刚

传统的测量后方交会是二维交会。或者已知三个测站的坐标，观测两个水平角，或者已知两点的坐标和在待求坐标的测站上观测一个水平角和一个方位角，即可求得第四个点的坐标，本文叙述了观测一个水平角和到两已知点的竖直角，即可求得一... 详细信息

传统的测量后方交会是二维交会。或者已知三个测站的坐标，观测两个水平角，或者已知两点的坐标和在待求坐标的测站上观测一个水平角和一个方位角，即可求得第四个点的坐标，本文叙述了观测一个水平角和到两已知点的竖直角，即可求得一个点的三维坐标的几何图形和计算过程，提出迭代和直接解算两种方法。

关键词：测量后方交会三维交会

Vascular Loops and Neuro-Otologic Symptoms: Is There Any Correlation?

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第6期2卷 245-247页

作者： Amaya Roldán-Fidalgo Antonio Rodríguez-Valiente Francisco Martín González Mayte Pinilla Almudena Trinidad Beatriz brea álvarez Department of Otorhinolaryngology and Neuroradiology Puerta de Hierro University Hospital Madrid Spain

Objective: To determine the relationship between vascular loops in the internal auditory canal and otologic symptoms. Methods: We performed a retrospective study, with a systematic review of the literature and analyzed the magnetic resonances imaging (MRI) of 91 patients attended in the ENT department since April to June 2013, in order to correlate radiological findings with otologic symptoms. Results: Vascular loops were seen in the internal auditory canal of patients without clinical symptoms;however an association was found between the presence of vascular compression of the eighth nerve displayed on MRI and the presence of sensorineural hearing loss and tinnitus. No association was found between vertigo and vascular loops. Conclusion: The presence of vascular loops in the internal auditory canal may be an incidental finding in MRIs of patients without clinical symptoms. However, in patients with tinnitus or sensorineural hearing loss that is unexplained by other clinical pathologies, these may be correlated with the existence of vascular loops which compress the eighth cranial nerve or contact the bone wall of the internal auditory canal. Further studies involving a larger number of patients are required to accurately evaluate the association between these symptoms and vascular loops.

关键词： Vascular Loop Arterial Loop Internal Auditory Canal Tinnitus Deafness Vertigo

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Death of Death Note？

China International Business 2007年第6期 46-46页

作者： Jennifer brea