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Yield of alarm features in predicting significant endoscopic findings among hospitalized patients with dyspepsia

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World Journal of Gastroenterology 2024年第26期30卷 3210-3220页

作者： lama Ibrahim Maamoun Basheer Tawfik Khoury Wisam Sbeit Department of Internal Medicine Galilee Medical CenterNahariya 22001Israel Department of Gastroenterology Galilee Medical CenterNahariya 22001Israel Azrieli Faculty of Medicine Bar-Ilan UniversitySafed 1311502Israel

BACKGROUND Dyspepsia is a very prevalent upper gastrointestinal tract symptoms *** of these symptoms might arise from serious underlying diseases,so the promotion of evidence-based guidelines could potentially better align evaluation and *** To determine the value of alarm features as a predictive factor for significant endoscopic findings(SEFs)among hospitalized patients presenting with *** We conducted a retrospective case-control study including information about 6208 endoscopic procedures performed for hospitalized *** were divided into two groups,with and without SEFs,and compared to elucidate the ability of the different alarm features to predict *** During the study,605 patients fulfilled the inclusion *** the demographics and clinical characteristics of the two groups were compared,tachycardia(P<0.05),normocytic anemia,(P<0.05),leukocytosis(P<0.05),and hypoalbuminemia(P<0.05)documented on admission prior to endoscopy were strong predictors of *** the alarm features,upper gastrointestinal bleeding,persistent vomiting,odynophagia[odds ratio(OR)=3.81,P<0.05;OR=1.75,P=0.03;and OR=7.81,P=0.07,respectively]were associated with *** weight loss was strongly associated with malignancy as an endoscopic finding(OR=2.05;P<0.05).In addition,long-term use of anti-aggregate medications other than aspirin(P<0.05)was correlated to *** Novel predictors of SEFs were elucidated in this *** parameters could be used as an adjunctive in decision making regarding performing upper endoscopy in hospitalized patients with dyspepsia.

关键词： Dyspepsia Endoscopy Weight loss Anti-aggregate medications Persistent vomiting Odynophagia

Management of hepatocellular carcinoma recurrence after liver surgery and thermal ablations:state of the art and future perspectives

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 71-88页

作者： Astrid Herrero Cyprien Toubert Jose Ursic bedoya Eric Assenat Boris Guiu Fabrizio Panaro Thomas Bardol Gianluca Cassese Department of HPB Surgery and Liver Transplantation Saint Eloi HospitalMontpellier UniversityMontpellierFrance Department of Hepatology and Liver Transplantation Saint Eloi HospitalMontpellier UniversityMontpellierFrance Department of Digestive Oncology Saint Eloi HospitalMontpellier UniversityMontpellierFrance Department of Radiology Saint Eloi HospitalMontpellier UniversityMontpellierFrance Laboratory of rare human Circulating Cells(LCCRH) University Medical Center of MontpellierMontpellierFrance Division of Minimally Invasive and Robotic HPB Surgery Department of Clinical Medicine and SurgeryFederico II University HospitalNaplesItaly

Despite the improvements in surgical and medical therapy for hepatocellular carcinoma(HCC),recurrence still represents a major *** to 70%of patients can experience HCC recurrence after liver resection(LR),as well as 20%of them even after liver transplantation(LT).The patterns of recurrence are different according to both the time and the ***,the risk factors and the management can change not only according to these patterns,but also according to the underlying liver condition and to the first treatment *** knowledge of such correlation is fundamental,since prevention and effective management of recurrence are undoubtedly the most important strategies to improve the outcomes of HCC *** adjuvant therapy,maintaining very close monitoring during the first 2 years in order to diagnose curable recurrence and continue this monitoring beyond 5 years because late recurrences exist,remains our only possibility *** represents the cornerstone treatment for HCC,including both LT and ***,new interesting therapeutic opportunities are coming from immunotherapy that has shown encouraging results also in the adjuvant *** such a complex and evolutionary scenario,the aim of this review is to summarize current strategies for the management of HCC recurrence,focusing on the different possible scenarios,as well as on future perspectives.

关键词： Hepatocellular carcinoma recurrence hepatocellular carcinoma management liver surgery liver transplantation thermal ablation(TA) survival after recurrence

Study of the Effectiveness of Papaver Sp. Alkaloids as Future Therapeutic Alternatives against Enterococcus Sp. Causing Hospital-Acquired Septicemic Infections

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Journal of Biosciences and Medicines 2024年第8期12卷 107-127页

作者： lama Mohammed Ayoub Shbibe Georgette Antranik Babojian Department of Plant Biology Faculty of Science Damascus University Damascus Syria

Background and Objective: In recent years, control of Enterococcus sp. It has been proven in the local medical environment to be a cause of acquired septicemia in various age groups, and medical instruments are considered an effective means of transmitting enterococcal septicemia, and catheters are at the forefront in terms of danger. Based on this risk, this study aimed to monitor the spread of Enterococcus sp., which causes blood poisoning acquired from catheters, and to compare its response to antibiotics with that of those isolated from clinical samples in children, as a first study locally. The effectiveness of alkaloids of different types of Papaver sp. In Syrian plants, they were tested against infection with this bacteria. Materials and Methods: The study dealt with two parts: The first part included collecting clinical samples from the University Children’s Hospital in Damascus/bacterial diagnostic laboratories/then isolating and diagnosing the bacteria by following a set of tests to identify the most prevalent genera and species and comparing their prevalence rate with Enterococcus. The second part;It included collecting plant samples, confirming the species taxonomically, then extracting alkaloids from plant parts (fruit, stem, Flowers), then comparing the extent of resistance of bacterial strains to antibiotics compared to the Enterococcus sp., and then confirming the antibacterial activity of the Papaver sp. alkaloids against Enterococcus sp. Result:In its first part, the study confirmed the significant contribution of the Enterococcus sp. to infections acquired from various sources, largely in catheter tip infections (9.09%) and to a lesser extent in other sources (3.7%), The second part was to confirm the effective-ness of the alkaloid extract of the Papaver sp., especially the two species Papaver syriacum, and Papaver dubium, against Enterococcus sp. with areole diameters that ranged between (15 - 26 mm) for the fruit extract and at a minimum inhibit

关键词： Catheters Skin Ulcers Acquired Infection Multi-Resistant Enterococcus Sp. Papaver Sp. Alkaloids Minimum Inhibitory and Lethal Concentration

Quantitative Assessment of Liver Fibrosis by Elastography in Patients with Chronic Liver Disease: A Cross-Sectional Study in Lomé (Togo)

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Open Journal of Radiology 2024年第2期14卷 42-54页

作者： Massaga Dagbe Bidamin N’timon Sonia Ekembe Rafiou El-Hadji Yakoubou Pihou Gbande Lantam Sonhaye lama Kegdigoma Agoda-Koussema Komlanvi Victor Adjenou Department of Radiology and Medical Imaging Kara University Hospital Kara Kara Togo Department of Radiology and Medical Imaging Lom University Hospital Lome Togo Department of Hpato-gastroenterology Kara University Hospital Kara Togo Department of Radiology and Medical Imaging Sokod Regional Hospital Sokode Togo Department of Internal Medicine Kara University Hospital Kara Togo

Aim: To describe the two-dimensional elastographic profile according to the Shearwave (2D-SWE) technique in patients with chronic liver disease in Lom. Materials and method: Cross-sectional, descriptive study conducted over seven month at the Autel dElie Clinic in Lom, from January to August 2022, on adult patients with chronic liver disease who underwent abdominal ultrasound coupled with two-dimensional elastography. Results: The sample size was 54 patients. The mean age of the patients was 33 12 years, with extremes of 18 and 66 years. Patients aged 30 years or less accounted for 48.1% (n = 26). All patients (n = 54) had at least one transaminase assay with a mean of 69.3 78.3 IU/l (AST) and 59.3 82.8 IU/l (ALT). There was no statistically significant association between the biological parameters and the presence of fibrosis. Viral liver disease was the main cause, accounting for 81.5% (n = 44) of cases, with no significant association with the degree of fibrosis. Ultrasound revealed a dysmorphic liver (57.4%;n = 31) and portal hypertension (18.5%, n = 10). Fibrosis stages F1, F2 and F4 accounted for (48.1%, n = 26), (24.1%, n = 13) and (13%, n = 7) of cases respectively. Liver dysmorphia was significantly associated with the presence of fibrosis (p = 0.012) and portal hypertension was significantly associated with the degree of fibrosis (p = 0.0063). Conclusion: Assessment of liver fibrosis in patients with chronic liver disease using 2D-SWE elastography is essential for patient follow-up.

关键词： Hepatic Fibrosis 2D-SWE Elastography Chronic Liver Disease Lomé

Conformity Assessment of Lead Aprons Used in Conventional Radiology: A Multi-Centre Survey in Togo

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Open Journal of Radiology 2024年第2期14卷 55-63页

作者： Massaga Dagbé Bidamin N’timon Ousmane Aminata Bah Pihou Gbandé Komi Awobanou Koku Adambounou Masamaesso Tchaou Abdoulatif Amadou Lantam Sonhaye lama Kegdigoma Agoda-koussema Komlanvi Victor Adjénou Radiology Department Kara University Hospital Kara Togo Armed Forces Reference Imaging Center (CIRA) Conakry Guinea Radiology Department Sokod Regional Hospital Sokod Togo Radiology Department Lom University Hospital Lom Togo Radiation Protection/Telemedicine Department Lom University Hospital Lom Togo Radiology Department Kara Regional Hospital Kara Togo

Aim: Lead aprons are used to protect against scattered radiation from the patient during interventional procedures and certain special conventional radiological examinations. Given the importance of the role lead aprons are supposed to play in radiation protection, we propose to assess their conformity in medical imaging departments in public and religious hospitals in Togo. Materials and method: A multi-centre survey conducted from 26 November to 06 December 2021 in the radiology departments of public and religious health facilities in Togo. All aprons in use were included. The evaluation criteria were physical (visual), quantitative (radiographic) and qualitative (dosimetric). Results: We had registred 43 aprons among wich 27 (62.79%) leaded aprons were labelled non-compliant and 16 (37.21%) were labelled compliant. Of the aprons judged to be non-compliant, 70.37% were more than 10 years old and 96.30% showed defects on the radiographic images. The most common defects were vampire marks (18.64%), multiple folds (16.96%), cracks (16.96%), multiple cracks (15.25%), tears (8.47%), absence of lead (5.08%), holes (3.39%) and lead corrosion (1.69%). Defective aprons (62.96%) had at least two defects. The defects were of thoraco-abdomino-pelvic (74.07%), thoracic (14.82%) and abdomino-pelvic (11.11%) topography. For indirect exposure at 50 and 70 kilovolts, all the aprons had an attenuation factor greater than 90%. After dosimetric measurement, 13.95% of aprons had attenuation factors below 90% for indirect exposure at 100 kilovolts. Conclusion: The compliance of the leaded decks is trifactorial (physical, radiographic and dosimetric). However, there is no significant difference in X-ray attenuation capacity between defective and normal decks.

关键词： Lead Apron Compliance Radiation Protection Radiology Togo

Performance evaluation of creep feed grinding ofγ-TiAl intermetallics with electroplated diamond wheels

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Chinese Journal of Aeronautics 2021年第6期34卷 100-109页

作者： Xinxin XI Wenfeng DING Zhixin WU lama ANGGEI College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenyang Liming Aero-Engine Co. Ltd.Aero-Engine Corporation of ChinaShenyang 110043China

This paper evaluates the performance of creep feed grindingγ-TiAl intermetallic(Ti-45 Al-2 Mn-2 Nb)using electroplated diamond ***,a comparative analysis with the grinding results by using electroplated CBN wheels was conducted,mainly involving abrasive wheel wear behavior and maximum material removal rate below surface burn *** was found that the diamond wheel would produce much better grinding results including lower wheel wear rate and higher maximum material removal *** the surface integrity obtained at different level of material removal rate was characterized with the utilization of the diamond *** poor ductility of thisγ-TiAl intermetallic material was found to have a marginal effect on the surface integrity,as no severe surface defects such as material pullout were generated during the stable wheel wear *** the involved operating parameters,a deformation layer was produced with~10μm or more in thickness depending on the material removal rate ***,a work-hardened layer extending to more than 100μm was produced with a maximum microhardness of above 520 HV0.05(bulk value 360 HV0.05).The residual stress remained compressive,with a value of above-100 MPa and even up to-500 MPa for an elevated material removal *** chip was the main chip type,indicating good wheel sharpness in the grinding process.

关键词： Creep feed grinding Electroplated abrasive wheels Surface integrity Wheel wear γ-TiAl intermetallic

Hepatocellular carcinoma chemoprevention in chronic hepatitis B patients:all-in on statins?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 676-678页

作者： JoséUrsic-bedoya Boris Guiu Department of Hepatology St-Eloi University HospitalMontpellierFrance Department of Radiology St-Eloi University HospitalMontpellierFrance

Chronic hepatitis B(CHB)affects approximately 257 million individuals worldwide,the highest prevalence being in Western Pacific WHO Region[6.2%(1)].In highly endemic CHB regions,the 5-year cumulative incidence of hepatocellular carcinoma(HCC)ranges from 3%to 17%,depending on the presence of cirrhosis(2).Antiviral treatment decreases the risk of HCC,without abolishing it completely(3).Paradoxically,by decreasing liver-related mortality,antiviral treatment in CHB patients causes an increase in HCC long-term incidence(4).

关键词： prevention patients mortality

Establishing a blueprint for successful liver transplantation for alcohol-related cirrhosis:the importance of a multidisciplinary team

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 150-152页

作者： JoséUrsic-bedoya Hélène Donnadieu-Rigole Department of Hepatogastroenterology Hepatology and Liver Transplantation UnitSaint Eloi HospitalUniversity of MontpellierMontpellierFrance Department of Addictology Saint Eloi HospitalUniversity of MontpellierMontpellierFrance

Liver transplantation(LT)for alcohol-related liver disease(ALD)has come a long way since the implementation of LT as a standard *** considered a contra-indication due to poor outcomes and moral issues(1,2),it is nowadays the most common indication for LT in Western countries(3,4).Patient and graft survival in this setting are excellent(5).However,relapse rates remain high(6),which jeopardizes long-term survival and the acceptance of the transplant team for these *** evaluation of the suitability to a LT for a potential candidate is therefore *** length of sobriety,namely over six months,has longtime been considered as the condition sine qua ***“6-month rule”is insufficient to predict the risk of relapse and is progressively being abandoned by learned societies recommendations(7,8).Moreover,situations in which a recent alcohol consumption is obvious,such as alcoholic hepatitis or positive blood and/or urine test before the procedure,are associated with good outcomes(9-11).

关键词： alcohol liver urine

Contribution to the understanding of the performance differences between commercial current collectors in Li–S batteries

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Journal of Energy Chemistry 2021年第11期30卷 295-306,I0007页

作者： A.Benitez F.Luna-lama ACaballero E.Rodriguez-Castellon J.Morales Dpto.Química Inorgánica e Ingeniería Química Instituto Universitario de Nanoquímica(IUNAN)Universidad de Córdoba14071 CórdobaSpain Dpto.de Química Inorgánica Cristalografía y MineralogíaFacultad de CienciasUniversidad de Málaga29071 MálagaSpain

Lithium–sulfur batteries have been recognised as highly promising next-generation batteries, due to their low cost and high theoretical energy density. Despite numerous advances in this technology over the last decade, its commercialisation is still a challenge that has not yet been achieved. Many efforts have been made to improve the problems that these batteries present, mainly by investigating different cathode manufacturing strategies, testing novel Li anodes, new additives in the electrolytes, and modified separators or interlayers. However, the characteristics of the current collectors used in the preparation of the electrodes have been rarely addressed. Three commercial collectors are commonly used in basic research on Li–S batteries: Al foil, carbon coated Al foil (Al-C), and carbon paper (gas diffusion layer, GDL). In this work, a detailed study of the electrochemical response of these commercial collectors has been carried out. The tests were carried out on two S composites formed by carbons of a different natures, commercial carbon black and synthetic N-doped graphene. In addition, the S impregnation method was different, using either melt diffusion at 155 ℃ or ethylenediamine as S solvent, respectively. In both systems, the results were similar – the electrodes supported on GDL delivered higher specific capacities than those supported on Al and Al-C, with minimal differences between the two. Of the different collector properties examined to explain this behaviour, namely Al corrosion, electrical conductivities, surface-level composition, and surface texture, only the latter had a significant effect in the performance of GDL-based electrodes. SEM images revealed a rough and cracked surface formed by the agglomerated carbon particles that give rise to a complex pore system, predominantly consisting of macropores. All of these features are beneficial for a better anchoring of the active material on the collector surface, in addition to enhancing the wettabi

关键词： Current collector Carbon paper Aluminum foil Lithium–sulfur battery