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Living in a Condominium Regime:Neighborhood Conflicts in Low-Income Housing,Tijuana,Baja California-A Secondary Publication

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journal of World Architecture 2024年第2期8卷 96-107页

作者： M.Zárate López a.alm.jo ornelas M.Sahagún Valenzuela Autonomous University of Baja California Mexico

This paper analyzes neighborhood conflicts arising from the condominium property regime,under which social housing promoted by Mexican government institutions and private developers is *** regime has facilitated access to housing for the salaried population,but it is far from contributing to the attainment of the right to *** research takes as case studies housing complexes located in the city of Tijuana,Baja California,*** analysis included a mixed ***,similar case studies were analyzed;secondly,a review of the Condominium Property Regime Law was carried out in order to understand its *** view of the pandemic situation,a virtual survey was applied to the inhabitants of these areas,as well as interviews with presidents of neighborhood committees of these *** the above,it was found that this form of ownership generates conflicts,reflected in the dissatisfaction of the inhabitants with their housing,disagreements and controversies in their organization and *** inhabitants have to collectively solve the problems they face,related to the maintenance and use of common areas,insecurity,and cleanliness,among *** addition,there is a lack of support from local *** this,it is concluded that although the inhabitants have a space that solves their housing problem,it does not manage to be a space that adequately guarantees their right to housing.

关键词： Neighborhood conflicts Right to housing Condominium property Social interest Affordable housing

Dexamethasone intravitreal implant(Ozurdex) in diabetic macular edema: real-world data versus clinical trials outcomes

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International journal of Ophthalmology(English edition) 2021年第10期14卷 1571-1580页

作者： Pedro Neves Mário ornelas Inês Matias joão Rodrigues Margarida Santos Marco DutraMedeiros David Martins Department of Ophthalmology Centro Hospitalar de SetúbalSetúbal 2910-549Portugal Department of Ophthalmology Hospital BeatrizÂngeloLoures 2674-514Portugal Department of Ophthalmology Hospital da Luz SetúbalSetúbal 2900-722Portugal Department of Ophthalmology Centro Hospitalar Lisboa CentralFaculdade de Ciências MédicasNOVA University of LisbonLisbon 1990-237Portugal

AIM: To investigate the safety and efficacy of intravitreal dexamethasone implants(Ozurdex?/DEX) in patients with diabetic macular edema(DME) either na?ve or nonna?ve to anti-VEGF therapies who switched to DEX implant independent of response to anti-vascular endothelial growth factors(anti-VEGFs).METHODS: This was an audit retrospective review of medical records of patients with DME who switched to the DEX intravitreal implant. Patients were divided into 2 groups: patients na?ve to antiangiogenic therapy and patients who were previously treated with anti-VEGFs. Data regarding demographics, changes in mean best-corrected visual acuity(BCVA), central macular thickness(CMT), and intraocular pressure(IOP) was collected over 6 mo. The demographic data mean changes in BCVA, CMT, and IOP were compared. Six-month follow-up data of 47 patients(57 eyes), who either switched to DEX implant irrespective of response to previous treatments or were treatment na?ve before receiving DEX implant, was ***: Improvement in mean BCVA was observed from 1-4 mo after injection with a decreased effect at month 6 as expected, with better outcomes in na?ve compared to non-na?ve patients. A statistically relevant decrease in mean CMT was observed during the follow-up period. An increase in mean IOP was observed in the first 2 mo after DEX therapy. The mean number of injections of the overall population during the 6 mo was 1.3. A subgroup analysis showed no relevant difference between phakic versus pseudophakic patients relative to measured outcomes. There was no cataract progression during the follow-up period and no adverse events ***: This real-life setting study shows that intravitreal DEX implant is effective and safe. The timings of greater therapeutic impact are concordant with previous studies and suggest that earlier treatment with corticosteroids may have an additional benefit in na?ve patients.

关键词： anti-VEGF therapy diabetic macular edema dexamethasone intravitreal implant na?ve eyes steroids

Unravelling host-mediated effects on hemiparasitic Mexican mistletoe Psittacanthus calyculatus(DC.)*** traits linked to mutualisms with pollinators and seed dispersers

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journal of Plant Ecology 2018年第6期11卷 827-842页

作者： Sandra Rodríguez-Mendieta Carlos Lara Juan Francisco ornelas Centro de Investigación en Ciencias Biológicas Universidad Autónoma de Tlaxcalakm 10.5 Carretera San Martín Texmelucan-TolucaSan Felipe IxtacuixtlaTlaxcala 90120Mexico Departamento de Biología Evolutiva Instituto de EcologíaA.C.(INECOL)Carretera antigua a Coatepec 351XalapaVeracruz 91080Mexico

Aims While the influence of mistletoe-host interactions on each other’s evolution is well-recognized,the role of interactions between mis-tletoes and its mutualistic pollinators and seed dispersers mediated by host species is relatively *** Here,we examine the effects of host species(Mexican hawthorn Crataegus mexicana DC,black cherry Prunus serotina Ehrh.,leather-leaf Mexican oak Quercus crassipes Bonpl.)on flower morphology,nectar production,pollinator visitation rate and female reproduct-ive fitness in hemiparasitic Mexican mistletoe Psittacanthus caly-culatus(DC.)***(Loranthaceae)populations at three different *** first measured the lengths of corolla,style,stamen,exerted stamen and anther,the length and width of the ovary and nectar availability for mistletoe flowers in natural ***,we evaluated flower visitation and measured(length and width)and weighed the fruits and its seeds of mistletoes growing on each of the three host ***,we evaluated the effects of host species,location and flower traits on fruit or seed size variation(both as proxies of reproductive fitness).Important Findings We found mistletoes growing on natural hosts *** and *** produced larger flowers,fruits and seeds than mistle-toes on cultivated ***,these differences varied across *** amount of available nectar and hummingbird vis-itation rates in flowers of mistletoes on *** was higher at the three sites than in flowers of mistletoes on *** or *** effects of host species,study site and floral trait covariates affected significantly all fitness measures,indicating that mistletoes’reproductive fitness is affected differently depending on the host species and their site of *** host-associated differ-ences in reproduction might have implications for interactions with mutualistic vectors.

关键词： floral and fruit traits hosts hummingbirds local host adaptation mistletoes nectar parasitic plants pollination Psittacanthus

Host-parasite interactions in perpetual darkness:Macroparasite diversity in the cavefish Astyanax mexicanus

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Zoological Research 2023年第4期44卷 782-792页

作者： Ana Santacruz David Hernández-Mena Ramses Miranda-Gamboa Gerardo Pérez-Ponce De León Claudia Patricia ornelas-García Departamento de Zoología Instituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico City CP 04510México Departamento de Sistemas y Procesos Naturales Escuela Nacional de Estudios Superiores Unidad MéridaUcúYucatán CP 97357México Instituto de Energías Renovables Universidad Nacional Autónoma de MéxicoTemixcoMorelos CP 62580México Colección Nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico City CP 04510México Stowers Institute for Medical Research Kansas CityMO 64110USA

Astyanax mexicanus has repeatedly colonized cave environments,displaying evolutionary parallelisms in many troglobitic *** being a model system for the study of adaptation to life in perpetual darkness,the parasites that infect cavefish are practically *** this study,we investigated the macroparasite communities in 18 cavefish populations from independent lineages and compared them with the parasite diversity found in their sister surface fish populations,with the aim of better understanding the role that parasites play in the colonization of new *** the cavefish populations,we identified 13 parasite taxa,including a subset of 10 of the 27 parasite taxa known for the surface *** infecting the cavefish belong to five taxonomic groups,including trematodes,monogeneans,nematodes,copepods,and *** are the most dominant group,found in 14 *** macroparasites include species with direct life cycles and trophic transmission,including invasive ***,paired comparisons indicate higher parasite richness in the cavefish than in the surface *** variation in parasite composition across the caves suggests historical and geographical contingencies in the host-parasite colonization process and potential evolution of local *** base-line data on parasite diversity in cavefish populations of *** provides a foundation to explore the role of divergent parasite infections under contrasting ecological pressures(cave *** environments)in the evolution of cave adaptive traits.

关键词： Adaptation Metazoan parasites Niche change Parasite assemblage Prevalence

The changes on intimate partner violence against women in the health system in Portugal

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Health 2013年第7期5卷 65-70页

作者： Raquel Cardoso josé ornelas Instituto Superior de Psicologia Aplicada Instituto Universitário Lisbon Portugal Instituto Superior de Psicologia Aplicada Instituto Universitário Lisbon Portugal

In Portugal, over the last 20 years, we have seen great strides in addressing intimate partner violence against women by their male partners. Measuring and understanding progress, and achieving sustainable systems change is a major challenge and to achieve this aim we need to identify events, persons and settings that contribute for the critical factors that create long term transformations in the systems and the creation of new resources [1]. Since the healthcare system is one of the main actors of intervention with survivors, the goal of this project was to interview key stakeholders from the healthcare system in order to understand the main changes they perceive have happened over the past two decades. Based on interviews with key stakeholders, our study explores the evidences of the changes that occurred in the healthcare system, the intersections with other systems and their visions for the future.

关键词： Social Change Intimate Partner Violence against Women Health System

Effect of structure and function of paraoxonase-1(PON-1)on organophosphate pesticides metabolism

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BIOCELL 2020年第3期44卷 363-370页

作者： HAZAEL RAMIRO CEJA-GÁLVEZ ERANDIS DHENI TORRES-SÁNCHEZ JUAN HERIBERTO TORRES-JASSO ARTURO VILLALOBOS ornelas joEL SALAZAR-FLORES Department of Medical and Life Sciences University Center of La CiénegaUniversity of Guadalajara(CUCI-UdeG)OcotlánCP 47810Mexico Department of Biological Sciences University Center of the CoastUniversity of Guadalajara(CUCosta-UdeG)Puerto VallartaCP 48280Mexico

Paraoxonase-1(PON1)is an important enzyme in various pathologies such as pesticide poisoning,diabetes,atherosclerosis,neuronal disorders,and cancer,due to its multifunctional activity since it acts on different ***,one of its main functions is the hydrolysis of organophosphate(OP)compounds from pesticides that cause fatal poisoning at the level of the central nervous system(CNS).The objective of this review was to investigate whether the structure,genetics,and function of PON1 affect the metabolism of organophosphate pesticides or other *** was selected from articles in the database PubMed–NCBI(https://***/pubmed/)with a publication date between 2011 and *** enzymatic activity of PON1 can be modified depending on its chemical structure since there are different genetic polymorphisms that change PONI morphologies or the levels of expression in the *** leads to differences in susceptibilities to organophosphate pesticide *** results of this review reveal that phenotypic variants of PON1 have differences in affinities for OP substrates.

关键词： PON1 Pesticides Organophosphorus toxicity

Thinking outside the black box:are the brain endothelial cells the new main target in Alzheimer's disease?

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Neural Regeneration Research 2023年第12期18卷 2592-2598页

作者： Enrique Estudillo Adolfo López-ornelas Alejandro Rodríguez-Oviedo Neptali Gutiérrez de la Cruz Marco Antonio Vargas-Hernández Adriana Jiménez Laboratorio de Reprogramación Celular Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezMexico CityMexico División de Investigación Hospital Juárez de MéxicoMexico CityMexico Hospital Nacional Homeopático Hospitales Federales de ReferenciaMexico CityMexico Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Morfología Escuela Militar de Graduados de SanidadSecretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico Escuela Militar de Graduados de Sanidad Secretaría de la Defensa NacionalBatalla de CelayaLomas de SoteloMiguel HidalgoMexico CityMexico

The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain through multiple mechanisms of *** brain endothelial cell function is crucial for brain homeostasis,their role in neurodegenerative diseases has historically not been considered with the same importance as other brain cells such as microglia,astroglia,neurons,or even molecules such as amyloid beta,Tau,or ***'s disease is the most common neurodegenerative disease,and brain endothelial cell dysfunction has been reported by several ***,its impairment has barely been considered as a potential therapeutic *** we review the most recent advances in the relationship between Alzheimer's disease and brain endothelial cells commitment and analyze the possible mechanisms through which their alterations contribute to this neurodegenerative disease,highlighting their inflammatory phenotype and the possibility of an impaired secretory pattern of brain endothelial cells that could contribute to the progression of this ***,we discuss why shall brain endothelial cells be appreciated as a therapeutic target instead of solely an obstacle for delivering treatments to the injured brain in Alzheimer's disease.

关键词： dementia endothelial cells neurodegeneration neuroinflammation neuronal death paracellular transport transcellular transport

Mitochondrial phylogeography and molecular evolution of the rhodopsin visual pigment in troglobitic populations of Astyanax mexicanus(De Filippi,1853)

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Zoological Research 2023年第4期44卷 761-775页

作者： Marco A.A.Garduño-Sánchez Vladimir de Jesus-Bonilla Silvia Perea Ramses Miranda-Gamboa Andrea Herrera-García Mauricio de la Maza Benignos Claudia Patricia ornelas-García Colección Nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoC.P.04510México Posgrado en Ciencias Biológicas Colección Nacional de PecesDepartamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoC.P.04510México Licenciatura en Ciencias Forenses Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCiudad UniversitariaCoyoacánMéxico CityC.P.04510México Instituto de Energías Renovables Universidad Nacional Autónoma de MéxicoTemixcoMorelos C.P.62580Mexico Facultad de Ciencias Biológicas Universidad Autónoma de Nuevo LeónCiudad UniversitariaSan Nicolás de los GarzaNuevo LeónC.P.66450México

Cave-adapted animals provide a unique opportunity to study the evolutionary mechanisms underlying phenotypic,metabolic,behavioral,and genetic evolution in response to cave *** Mexican tetra(Astyanax mexicanus)is considered a unique model system as it shows both surface and cave-dwelling *** date,at least 33 different cave populations have been identified,with phylogenetic studies suggesting an origin from at least two independent surface lineages,thereby providing a unique opportunity to study parallel *** the present study,we carried out the most exhaustive phylogeographic study of *** to date,including cave and surface localities,using two mitochondrial markers(cytochrome b(cyt b)and cytochrome c oxidase subunit I(COI))and nuclear rhodopsin visual pigment(rho).Additionally,we inferred the molecular evolution of rho within the two contrasting environments(cave and surface)and across three geographic regions(Sierra de El Abra,Sierra de Guatemala,and Micos).In total,267 individuals were sequenced for the two mitochondrial fragments and 268 individuals were sequenced for the rho visual pigment from 22 cave and 46 surface *** results based on the mitochondrial data supported the two-lineage hypothesis,except for the Pachón and Chica caves,whose introgression has been largely *** Sierra de El Abra region depicted the largest genetic diversity,followed by the Sierra de Guatemala *** the phylogeographic patterns of rho,we recovered exclusive haplogroups for the Sierra de El Abra(Haplogroup I)and Sierra de Guatemala regions(Haplogroup IV).Moreover,a 544 bp deletion in the rho gene was observed in the Escondido cave population from Sierra de Guatemala,reducing the protein from seven to three intramembrane *** change may produce a loss-of-function(LOF)but requires further *** nonsynonymous(dN)and synonymous(dS)substitution rates(omega valuesω),our results revealed

关键词： Visual pigments Selection Cavefish Vision loss Loss of function

Phenotypic Variation among and within Three Peppers Species(Capsicum)from Mexico

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Phyton-International journal of Experimental Botany 2021年第1期90卷 259-275页

作者： Carlos Eduardo ornelas-Ramírez Sergio Hernández-Verdugo Jesús Enrique Retes-Manjarrez Angel Valdez-Ortiz Antonio Pacheco-Olvera Tomás Osuna-Enciso Flor Porras Facultad de Agronomía Universidad Autónoma de SinaloaCuliacánSinaloa80000México Programa Regional de Posgrado en Biotecnología Facultad de Ciencias Químico-BiológicasUniversidad Autónoma de SinaloaCuliacánSinaloa80030México Centro de Investigación en Alimentación y Desarrollo A.C.Unidad Culiacán CuliacánSinaloa80110México

The phenotypic variation and its distribution among species,morphotypes,and among and within populations was estimated in 71 populations pertaining to 15 morphotypes of three domesticated species of Capsicum from *** were made in the states of Sinaloa,Nayarit,Oaxaca,Tabasco,and Yucatán in two agroecosystems:Backyard-garden and *** phenotypic characteristics were analyzed through one-way variance analysis and multivariate analyses of principal components analysis(PCA)and hierarchical clustering using Ward’s *** study was performed in a uniform greenhouse experiment.A high variation was found among and within populations in all the measured *** the total variation,13.0%was distributed among species,27.9%among morphotypes,8.1%among populations,and 51.0%within *** plants grew in a uniform environment,these results indicate that the differences observed among and within species,morphotypes,and populations have a genetic *** and multivariate analyses clearly differentiated morphotypes,suggesting that the category of morphotypes must be used to nominate the infraspecific variation in the domesticated *** principal components analysis identified a total of 15 principal components that contributed to explain the total *** first two components explained 59.64%of the total variation and seven components explained more than 90%of the total *** the measured characteristics,number of seed per fruit,weight of the fruit,width of the fruit,length of the fruit,stem diameter,days to flowering,and height of the plant contributed to component 1 variation,whereas width of the leaf,length of the leaf,and number of locules,number of fruits and number of seeds per plant contributed to component *** hierarchical clustering separated the populations and the morphotypes in two large different *** group consisted of populations collected in monoculture conditions and the oth

关键词： Phenotypic variation Capsicum annuum Capsicum chinense Capsicum frutescens morphotype