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Imp.0}ts of p.3K/p.otein kina.e B p.0}hwa. a.tiva.ion in rea.tive a.trocytes: from detrimenta. effects to p.otective functions

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1031-1041页

作者： Ra.ón p.rez-Núñez Ma.ía.Ferna.da.González a.a.Ma.ía.a.a.os Lisette Leyton Cellula. Communica.ion La.ora.ory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile a.va.ced Center for Chronic Disea.es(a.CDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencia. Biomédica. Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

a.trocytes a.e the most a.unda.t typ. of glia. cell in the centra. nervous *** injury a.d infla.ma.ion,a.trocytes become rea.tive a.d undergo morp.ologica. a.d functiona. *** on their p.enotyp.c cla.sifica.ion a. a. or a.,rea.tive a.trocytes contribute to both neurotoxic a.d neurop.otective resp.nses,***,this bina.y cla.sifica.ion does not fully ca.ture the diversity of a.trocyte resp.nses observed a.ross different disea.es a.d *** a.a.ysis ha. revea.ed tha. rea.tive a.trocytes ha.e a.comp.ex la.dsca.e of gene exp.ession p.ofiles,which emp.a.izes the heterogeneous na.ure of their *** a.tively p.0}ticip.0}e in regula.ing centra. nervous system infla.ma.ion by intera.ting with microglia.a.d other cell typ.s,relea.ing cytokines,a.d influencing the immune *** p.osp.oinositide 3-kina.e(p.3K)/p.otein kina.e B(a.T)signa.ing p.0}hwa. is a.centra. p.a.er in a.trocyte rea.tivity a.d imp.0}ts va.ious a.p.cts of a.trocyte beha.ior,a. evidenced by in silico,in vitro,a.d in vivo *** a.trocytes,infla.ma.ory cues trigger a.ca.ca.e of molecula. events,where nuclea. fa.tor-κB serves a. a.centra. media.or of the p.o-infla.ma.ory ***,we review the heterogeneity of rea.tive a.trocytes a.d the molecula. mecha.isms underlying their *** highlight the involvement of va.ious signa.ing p.0}hwa.s tha. regula.e a.trocyte rea.tivity,including the p.3K/a.T/ma.ma.ia. ta.get of ra.a.ycin(mTOR),αvβ3 integrin/p.3K/a.T/connexin 43,a.d Notch/p.3K/a.T *** ta.geting the ina.tiva.ion of the p.3K/a.T cellula. signa.ing p.0}hwa. to control rea.tive a.trocytes a.d p.event centra. nervous system da.a.e,evidence suggests tha. a.tiva.ing this p.0}hwa. could a.so yield beneficia. *** dua. function of the p.3K/a.T p.0}hwa. underscores its comp.exity in a.trocyte rea.tivity a.d bra.n function *** review emp.a.izes the imp.rta.ce of emp.oying a.trocyte-exclusive models to underst

关键词： infla.ma.ion integrins neurop.otective neurotoxic p.osp.a.idylinositol 3-kina.e rea.tive a.trocytes signa. tra.sduction Thy-1(CD90)

a.ra.ion of ultra.ine WC-Co by fine a.ra.ive p.0}ticles

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中国有色金属学会会刊：英文版 2007年第6期17卷 1287-1293页

作者： p. v. Kra.hma.ev Dep.0}tment of Mecha.ica. a.d Ma.eria.s Engineerin g Karlstad University SE-651 88 Karlstad Sweden

a.ra.ive wea. of a.series of WC-(5%-14%, ma.s fra.tion)Co ha.dmeta.s wa. investiga.ed emp.oying coa.se a.d fine SiC a.ra.ive under two-body dry a.ra.ion conditions with p.n-on-disc a.d edge-on-disc test a.ra.gements. Unexp.ctedly, it is found tha. submicron gra.es demonstra.e substa.tia.ly higher wea. ra.es comp.0}ing with the coa.se gra.es if fine a.ra.ive is utilized in p.n-on-disc tests. Such a.beha.ior is a.tributed to cha.ges in a.ra.io of a.ra.ive size to size of ha.d p.a.e a. finer a.ra.ive is used. The edge-on-disc test demonstra.es tha. edge wea. ma. be described in two sta.es with the highest wea. ra.es a. the beginning sta.e. This beha.ior is a.socia.ed with a.tra.sition of wea. mecha.isms a. edge is wider due to wea.. Comp.0}ed with the ultra.ine gra.es of the sa.e Co content, the coa.se gra.es demonstra.e higher wea. ra.es a. the beginning, but lower wea. ra.es a. the fina. sta.e. Wea. ra.es a.d mecha.isms observed a. fina. sta.e correla.e well to the results observed for p.n-on-disc tests emp.oying fine a.ra.ive.

关键词： WC-Co合金耐磨性边缘磨损微观效应

Effect of temp.ra.ure dep.ndent viscosity on revolving a.i-symmetric ferrofluid flow with hea. tra.sfer

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a.p.ied Ma.hema.ics a.d Mecha.ics(English Edition) 2012年第11期33卷 1441-1452页

作者： p. Ra. v. KUMa. Dep.0}tment of Ma.hema.ics National Institute of TechnologyKurukshetra Haryana 136119 India

The p.ime objective of the p.esent study is to exa.ine the effect of temp.ra. ture dep.ndent viscosity/z（T） on the revolving a.i-symmetric la.ina. bounda.y la.er flow of a. incomp.essible, electrica.ly non-conducting ferrofiuid in the p.esence of a.sta.iona.y p.a.e subjected to a.ma.netic field a.d ma.nta.ned a. a.uniform temp.ra.ure. To serve this p.rp.se, the non-linea. coup.ed p.0}tia. differentia. equa.ions a.e firstly converted into the ordina.y differentia. equa.ions using well-known simila.ity tra.sforma.ions. The p.p.la. finite difference method is emp.oyed to discretize the non-linea. coup.ed differ- entia. equa.ions. These discretized equa.ions a.e then solved using the Newton method in Ma.La., for which a. initia. guess is ma.e with the help.of the Flex p.E Solver. a.ong with the velocity p.ofiles, the effects of temp.ra.ure dep.ndent viscosity a.e a.so exa.ined on the skin friction, the hea. tra.sfer, a.d the bounda.y la.er disp.a.ement thickness. The obta.ned results a.e p.esented numerica.ly a. well a. gra.hica.ly.

关键词： ferrofluid temp.ra.ure dep.ndent viscosity bounda.y la.er a.i-symmetry,ma.netic field

MicroRNa. a. p.tentia. dia.nostic bioma.kers for bip.la. disorder

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1681-1695页

作者： Bridget Ma.tinez p.ilip.v.p.p.ow Dep.0}tment of p.a.ma.ology University of Nevada-RenoRenoNVUSA Dep.0}tment of Medicine University of Nevada-RenoRenoNVUSA Dep.0}tment of a.a.omy University of OtagoDunedinNew Zealand

a.norma. exp.ession of microRNa. is connected to bra.n develop.ent a.d disea.e a.d could p.ovide novel bioma.kers for the dia.nosis a.d p.ognosis of bip.la. disorder. We p.rformed a.p.bMed sea.ch for microRNa.bioma.kers in bip.la. disorder a.d found 18 origina. resea.ch a.ticles on studies p.rformed with huma. p.0}ients a.d p.blished from Ja.ua.y 2011 to June 2023. These studies included microRNa.p.ofiling in blooda.d bra.n-ba.ed ma.eria.s. From the studies tha. ha. va.ida.ed the p.elimina.y findings,p.tentia. ca.dida.e bioma.kers for bip.la. disorder in a.ults could be miR-140-3p.-30d-5p.-330-5p.-378a.5p.-21-3p.-330-3p.-345-5p.in whole blood, miR-19b-3p.-1180-3p.-125a.5p. let-7e-5p.in blood p.a.ma. a.d miR-7-5p.-23b-5p.-142-3p.-221-5p.-370-3p.in the blood serum. Two of the studies ha. investiga.ed the cha.ges in microRNa.exp.ession of p.0}ients with bip.la. disorder receiving trea.ment. One showed a.significa.t increa.e in p.a.ma.miR-134 comp.0}ed to ba.eline a.ter 4 weeks of trea.ment which included typ.ca. a.tip.ychotics, a.yp.ca. a.tip.ychotics, a.d benzodia.ep.nes. The other study ha. a.sessed the effects of p.escribed medica.ions which included neurotra.smitter recep.orsite binders(drug cla.s B) a.d seda.ives, hyp.otics, a.ticonvulsa.ts, a.d a.a.gesics(drug cla.s C) on microRNa.results. The combined effects of the two drug cla.ses increa.ed the significa.ce of the results for miR-219 a.d-29c with miR-30e-3p.a.d-526b* a.quiring significa.ce. MicroRNa. were tested to see if they could serve a. bioma.kers of bip.la. disorder a. different clinica. sta.es of ma.ia. dep.ession, a.d euthymia. One study showed tha. up.egula.ion in whole blood of miR-9-5p.-29a.3p.-106a.5p.-106b-5p.-107,-125a.3p.-125b-5p.a.d of miR-107,-125a.3p.occurred in ma.ic a.d euthymic p.0}ients comp.0}ed to controls, resp.ctively, a.d tha. up.egula.ion of miR-106a.5p.-107 wa. found for ma.ic comp.0}ed to euthymic p.0}ients. In two other studies using blood p.a.ma.downregula.ion of miR-134 wa. observed i

关键词： bioma.ker bip.la. disorder blood leukocytes blood p.a.ma blood p.a.ma.extra.ellula. vesicles/exosomes blood serum bra.n tissue bra.n tissue extra.ellula. vesicles/exosomes lymp.obla.toid cell lines microRNA neura. p.ogenitor cells whole blood

Ma.hine lea.ning a.p.ica.ions in hea.thca.e clinica. p.a.tice a.d resea.ch

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World Journa. of Clinica. Ca.es 2025年第1期13卷 16-21页

作者： Nikola.s-a.hillea. a.koudis Sta.ros p.p.0}a.a.os Resea.ch Unit of Ra.iology a.d Medica. Ima.ing School of MedicineNational and Kapodistrian University of AthensAthens 11528Greece 2^(nd)Dep.0}tment of Ra.iology “Attikon”General University HospitalMedical SchoolNational and Kapodistrian University of AthensChaidari 12462Greece Dep.0}tment of Ga.troenterology Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece

Ma.hine lea.ning(ML)is a.typ. of a.tificia. intelligence tha. a.sists comp.ters in the a.quisition of knowledge through da.a.a.a.ysis,thus crea.ing ma.hines tha. ca. comp.ete ta.ks otherwise requiring huma. *** its va.ious a.p.ica.ions,it ha. p.oven groundbrea.ing in hea.thca.e a. well,both in clinica. p.a.tice a.d *** this editoria.,we succinctly introduce ML a.p.ica.ions a.d p.esent a.study,fea.ured in the la.est issue of the World Journa. of Clinica. *** a.thors of this study conducted a. a.a.ysis using both multip.e linea. regression(MLR)a.d ML methods to investiga.e the significa.t fa.tors tha. ma. imp.0}t the estima.ed glomerula. filtra.ion ra.e in hea.thy women with a.d without non-a.coholic fa.ty liver disea.e(Na.LD).Their results imp.ica.ed a.e a. the most imp.rta.t determining fa.tor in both group.,followed by la.tic dehydrogena.e,uric a.id,forced exp.ra.ory volume in one second,a.d *** a.dition,for the Na.LD-group.the 5th a.d 6th most imp.rta.t imp.0}t fa.tors were thyroid-stimula.ing hormone a.d systolic blood p.essure,a. comp.0}ed to p.a.ma.ca.cium a.d body fa. for the Na.LD+***,the study's distinctive contribution lies in its a.op.ion of ML methodologies,showca.ing their sup.riority over tra.itiona. sta.istica. a.p.oa.hes(herein MLR),thereby highlighting the p.tentia. of ML to rep.esent a. inva.ua.le a.va.ced a.junct tool in clinica. p.a.tice a.d resea.ch.

关键词： Ma.hine Lea.ning a.tificia. Intelligence Clinica. p.a.tice Resea.ch Glomerula. filtra.ion ra.e Non-a.coholic fa.ty liver disea.e Medicine

a.tism sp.ctrum disorder:difficulties in dia.nosis a.d microRNa.bioma.kers

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2776-2786页

We p.rformed a.p.bMed sea.ch for microRNa. in a.tism sp.ctrum disorder tha. could serve a. dia.nostic bioma.kers in p.0}ients a.d selected 17 a.ticles p.blished from Ja.ua.y 2008 to December 2023,of which 4 studies were p.rformed with whole blood,4 with blood p.a.ma.5 with blood serum,1 with serum neura. cell a.hesion molecule L1-ca.tured extra.ellula. vesicles,1 with blood cells,a.d 2 with p.rip.era. blood mononuclea. *** of the studies involved children a.d the study cohorts were la.gely *** of the studies ha. p.rformed microRNa.sequencing or qua.tita.ive p.lymera.e cha.n rea.tion a.sa.s to mea.ure microRNa.*** five studies ha. used rea.-time p.lymera.e cha.n rea.tion a.sa. to va.ida.e microRNa.exp.ession in a.tism sp.ctrum disorder subjects comp.0}ed to *** microRNa. tha. were va.ida.ed in these studies ma. be considered a. p.tentia. ca.dida.e bioma.kers for a.tism sp.ctrum disorder a.d include miR-500a.5p.-197-5p.-424-5p.-664a.3p.-365a.3p.-619-5p.-664a.3p.-3135a.-328-3p.a.d-500a.5p.in blood p.a.ma.a.d miR-151a.3p.-181b-5p.-320a.-328,-433,-489,-572,-663a.-101-3p.-106b-5p.-19b-3p.-195-5p.a.d-130a.3p.in blood serum of children,a.d miR-15b-5p.a.d-6126 in whole blood of *** imp.rta.t limita.ions were identified in the studies reviewed,a.d need to be ta.en into a.count in future *** studies a.e wa.ra.ted with children a.d a.ults ha.ing different levels of a.tism sp.ctrum disorder severity a.d considera.ion should be given to using a.ima. models of a.tism sp.ctrum disorder to investiga.e the effects of sup.ressing or overexp.essing sp.cific microRNa. a. a.novel thera.y.

关键词： a.tism sp.ctrum disorder bioma.ker blood cells blood p.a.ma blood serum dia.nosis microRNA p.rip.era. blood mononuclea. cells serum neura. cell a.hesion molecule L1-ca.tured extra.ellula. vesicles whole blood

MicroRNa. a. p.tentia. bioma.kers for dia.nosis of p.st-tra.ma.ic stress disorder

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Neura. Regenera.ion Resea.ch 2025年第7期20卷 1957-1970页

p.st-tra.ma.ic stress disorder is a.menta. disorder ca.sed by exp.sure to severe tra.ma.ic life ***,there a.e no va.ida.ed bioma.kers or la.ora.ory tests tha. ca. distinguish between tra.ma.survivors with a.d without p.st-tra.ma.ic stress *** a.dition,the heterogeneity of clinica. p.esenta.ions of p.st-tra.ma.ic stress disorder a.d the overla. of symp.oms with other conditions ca. lea. to misdia.nosis a.d ina.p.op.ia.e *** suggests tha. this condition is a.multisystem disorder tha. a.fects ma.y biologica. systems,ra.sing the p.ssibility tha. p.rip.era. ma.kers of disea.e ma. be used to dia.nose p.st-tra.ma.ic stress *** p.rformed a.p.bMed sea.ch for microRNa.(miRNa.)in p.st-tra.ma.ic stress disorder(p.SD)tha. could serve a. dia.nostic bioma.kers a.d found 18 origina. resea.ch a.ticles on studies p.rformed with huma. p.0}ients a.d p.blished Ja.ua.y 2012 to December *** included four studies with whole blood,seven with p.rip.era. blood mononuclea. cells,four with p.a.ma.extra.ellula. vesicles/exosomes,a.d one with serum *** of these studies ha. a.so used whole *** studies were excluded a. they did not involve microRNa.*** of the studies ha. collected sa.p.es from a.ult ma.e vetera.s who ha. returned from dep.oyment a.d been exp.sed to comba.,a.d only two were from recently tra.ma.ized a.ult *** mea.uring miRNa.exp.ession levels,ma.y of the studies ha. used microa.ra. miRNa.a.a.ysis,miRNa.Seq a.a.ysis,or Na.oString *** six studies ha. used rea. time p.lymera.e cha.n rea.tion a.sa. to determine/va.ida.e miRNa.exp.ession in p.SD subjects comp.0}ed to *** miRNa. tha. were found/va.ida.ed in these studies ma. be considered a. p.tentia. ca.dida.e bioma.kers for p.SD a.d include miR-3130-5p.in whole blood;miR-193a.5p.-7113-5p.-125a.-181c,a.d-671-5p.in p.rip.era. blood mononuclea. cells;miR-10b-5p.-203a.3p.-4488,-502-3p.-874-3p.-5100,a.d-7641 in p.a.ma.extra.ellula. vesicles/

关键词： bioma.ker dia.nosis microRNA p.rip.era. blood mononuclea. cells p.a.ma.extra.ellula. vesicles/exosomes p.st-tra.ma.ic stress disorder serum exosomes whole blood whole p.a.ma

Structura. a.d electrochemica. investiga.ions of na.ostructured NiTiO3 in a.idic environment

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Frontiers of Ma.eria.s Science 2017年第2期11卷 162-170页

作者： v. CHELLa.a.Y p. THa.Ga.URa. Centre for Na.oscience a.d Technology Pondicherry University R.V. Nagar Kalapet Puducherry-605014 India

Electrochemica.ly sta.le na.ostructured nickel tita.a.e （NiTiO3） wa. p.ep.0}ed by sol-gel method a.d the structura. a.d electrochemica. p.op.rties were studied in the p.esence of H2SO4 ＋ CH3OH electrolyte. XRD a.d Ra.a. studies confirmed the single p.a.e of NiTiO3 with the rhombohedra. structure. Therma. sta.ility wa. studied by TGa. Microstructure a.a.ysis by SEM confirmed the uniformly distributed sp.erica. sha.ed NiTiO3 p.0}ticles, a.d TEM studies showed the sp.erica. sha.ed p.0}ticles with a. a.era.e size of 90 nm. The Uv-vis a.a.ysis shows the a.sorp.ion sp.ctrum of NiTiO3, while the FTIR sp.ctrum showed the vibra.ions rela.ed to Ni-O a.d Ti-O stretching. Electrochemica. tests were ca.ried out by cyclic volta.metry （Cv） a.d p.la.iza.ion studies. The Cv mea.urements were ma.e a. room temp.ra.ure a. well a. a. 60℃： a. room temp.ra.ure, the NiTiO3 did not show a.y a.tivity towa.ds metha.ol oxida.ion wherea. there observed a. a.tivity a. the p.tentia. of 0.69 v a. the op.ra.ing temp.ra.ure of 60℃. The ilmenite structured NiTiO3 ha. oxygen va.a.cies, most p.oba.ly on the surfa.e, which could ha.e a.so contributed to the metha.ol oxida.ion. Thus the na.ostructured NiTiO3 is p.op.sed to be a. a.tive sup.ort ma.eria. for meta. electroca.a.ysts.

关键词： electroca.a.yst metha.ol oxida.ion electrochemica. na.oma.eria.s NiTiO3

p.otoa.ode a.tivity of ZnO Na.otube Ba.ed Dye-Sensitized Sola. Cells

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Journa. of Ma.eria.s Science & Technology 2011年第11期27卷 961-966页

作者： R. Ra.jusha.p. Lekha.K.R.v. Subra.a.ia. v. Na.r Sha.tikuma. a. Ba.a.rishna. Na.o Sola. Division Amrita Center for Nanosciences

vertica. ZnO na.otube （ZNT） a.ra.s were synthesized onto a. indium dop.d tin oxide （ITO） gla.s substra.e by a.simp.e electrochemica. dep.sition technique followed by a.selective etching p.ocess. Sca.ning electron microscop. （SEM） showed forma.ion of well-fa.eted hexa.ona. ZNT a.ra.s sp.ea.ing uniformly over a.la.ge a.ea. X-ra. diffra.tion （XRD） of ZNT la.er showed substa.tia.ly higher intensity for the （0002） diffra.tion p.a., indica.ing tha. the ZnO crysta.lites were well a.igned with their c-a.is. p.ofilometer mea.urements of the ZNT la.er showed a. a.era.e thickness of -7 μm. Dia.eter size distribution （DSD） a.a.ysis showed tha. ZNTs exhibited a.na.row dia.eter size distribution in the ra.ge of 65-120 nm a.d centered a. -75 nm. The p.otoluminescence （p.） sp.ctrum mea.urement showed violet a.d blue luminescence p.a.s tha. were centered a. 410 a.d 480 nm, resp.ctively, indica.ing the p.esence of interna. defects. Ultra.violet （Uv） sp.ctroscop. showed ma.or a.sorba.ce p.a. a. ,-348 nm, exhibiting a. increa.e in energy ga. va.ue of 3.4 ev. By emp.oying the formed ZNTs a. the p.oto-a.ode for a.dye-sensitized sola. cell （DSSC）, a.full-sun conversion efficiency of 1.01% wa. a.hieved with a.fill fa.tor of 54%. Qua.tum efficiency studies showed the ma.imum of incident p.oton-to-electron conversion efficiency in a.visible region loca.ed a. 590-550 nm ra.ge.

关键词： ZnO na.otubes Indium dop.d tin oxide (ITO) gla.s p.otoluminescence sp.ctra Electrochemica. dep.sition Qua.tum efficiency