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a.ma.hema.ica. model of circa.ia. rhythms synchroniza.ion using fra.tiona. differentia. equa.ions system of coupled va. der Pol oscilla.ors

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Interna.iona. Journa. of Bioma.hema.ics 2018年第1期11卷 313-336页

作者： J. E. Esca.a.te-Ma.tfnez J. F. Gomez-aguilar C. Ca.deron-Ra.on a. aguilar-melendez P. Pa.illa.Longoria Fa.ulta. de Ingenieria.Mecdnica.y Eldctrica Universidad Veracruzana Av. Venustiano Carranza S/N Col. Revolucidn C. P. 93390 Poza Riea Veracruz Mdxico CONa.yT-TecnolSgico Na.iona. de Mexico/CENIDET Interior Interna.o Pa.mira.S/N Col. Palmira C. P. 62490 Cuernavaca Morelos Mexico Fa.ulta. de Ingenier~a.Mecdnica.y Eldctrica Universidad Veracruzana Av. Venustiano Carranza S/ZN Col. Revolucidn C. P. 93390 Poza Rica Veracruz Mexico Fa.ul$a. de Ingenierd Civil Universidad Veracruzana Av. Venustiano Carranza S/N Col. Revolucion C. P. 93390 Poza Rica Veracruz Mexico Instituto de Investiga.iones en Ma.emdtica. a.lica.a. ySistema. (IIMa.) UNAM Circuito Escolar Cd. Universitaria Del. Coyoacan Mdxico D. F. C. P. 04510 Mexico

This pa.er presents a. a.terna.ive representa.ion of a.system of differentia. equa.ions qua.ita.ively showing the beha.ior of the biologica. rhythm of a.cra.fish during their tra.sition from juvenile to a.ult sta.es. The model focuses on the intera.tion of four cellula. oscilla.ors coupled by diffusion of a.hormone, a.pa.a.eter μ is used to simu- la.e the qua.ity of communica.ion a.ong the oscilla.ors, in biologica. terms, it mea. sures developmenta. ma.urity of the cra.fish. Since some quorum-sensing mecha.ism is a.sumed to be responsible for the synchroniza.ion of the biologica. oscilla.ors, it is na.- ura. to investiga.e the possibility tha. the underlying diffusion process is not sta.da.d, i.e. it ma. be a.so-ca.led a.oma.ous diffusion. In this ca.e, it is well understood tha. diffusion equa.ions with fra.tiona. deriva.ives describe these processes in a.more rea.is- tic wa.. The a.terna.ive formula.ion of these equa.ions conta.ns fra.tiona. opera.ors of Liouville-Ca.uto a.d Ca.uto-Fa.rizio type. The numerica. simula.ions of the equa.ions reflect synchroniza.ion of ultra.ia. rhythms lea.ing to a.circa.ia. rhythm. The cla.sica. beha.ior is recovered when the order of the fra.tiona. deriva.ive is V = 1. We discuss possible biologica. implica.ions.

关键词： Circa.ia. rhythm va. der Pol oscilla.ors Liouville-Ca.uto fra.tiona. oper-a.or Ca.ut^Fa.rizio fra.tiona. opera.or a.a.s Ba.hforth Moulton method syn-chronicity.

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Neuroprotection by resvera.rol-glucuronide a.d quercetin-glucuronide via.binding to polyphenol-a.d glycosa.inoglyca.-binding sites in the la.inin receptor

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 819-820页

作者： Ra.udu Gopa.a.rishna.Jennifer aguilar Emily Lee Willia. J.Ma.k Depa.tment of Integra.ive a.a.omica. Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Depa.tment of Neurologica. Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dieta.y polyphenolic compounds resvera.rol a.d quercetin prevent neurodegenera.ive disea.es in experimenta. models;however, they rea.h the bra.n only in na.omola. concentra.ions in the glucuronida.ed a.d sulfa.ed ... 详细信息

关键词： resvera.rol mola. da.ed

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Dendritic spine degenera.ion:a.prima.y mecha.ism in the a.ing process

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1696-1698页

作者： Gonza.o Flores Leona.do aguilar-Hernández Ferna.o Ga.cía.Dolores Humberto Nicolini a.drea.Judith Vázquez-Hernández Hira. Tendilla.Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencia. Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Na.iona. de Medicina.Genómica.INMEGEN) Mexico CityMexico

Recent reports suggest tha. a.ing is not solely a.physiologica. process in living beings;instea., it should be considered a.pa.hologica. process or disea.e(a.orim et a.., 2022). Consequently, this process involves a.wide ra.ge of fa.tors, spa.ning from genetic to environmenta. fa.tors, a.d even includes the gut microbiome(GM)(Ma.er et a.., 2022). a.l these processes coincide a. some point in the infla.ma.ory process, oxida.ive stress, a.d a.optosis, a. different degrees in va.ious orga.s a.d systems tha. constitute a.living orga.ism(Ma.er et a.., 2022;aguilarHernández et a.., 2023).

关键词： a.ing process stress

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The gluon ma.s genera.ion mecha.ism： a.concise primer

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Frontiers of physics 2016年第2期11卷 131-148页

作者： a. C. aguilar D. Binosi J. Pa.a.a.silioua University of Ca.pina. (UNICa.P) "Gleb Wataghin" Institute of Physics 13083-859 Campinas SP Brazil Europea. Centre for Theoretica. Studies in Nuclea. Physics a.d Rela.ed a.ea. (ECT^＊) a.d Fonda.ione Bruno Kessler Villa Tambosi Strada delle Tabarelle 286 1-38123 Villazzano (TN) Italy Depa.tment of Theoretica. Physics a.d IFIC University of Valencia and CSIC E-46100 Valencia Spain

We present a.peda.ogica. overview of the nonperturba.ive mecha.ism tha. endows gluons with a.dyna.ica. ma.s. This a.a.ysis is performed ba.ed on pure Ya.g-Mills theories in the La.da. ga.ge, within the theoretica. fra.ework tha. emerges from the combina.ion of the pinch technique with the ba.kground field method. In pa.ticula., we concentra.e on the Schwinger-Dyson equa.ion sa.isfied by the gluon propa.a.or a.d exa.ine the necessa.y conditions for obta.ning finite solutions within the infra.ed region. The role of sea.ull dia.ra.s receives pa.ticula. a.tention, a. do the identities tha. enforce the ca.cella.ion of a.l potentia. qua.ra.ic divergences. We stress the necessity of introducing nonperturba.ive ma.sless poles in the fully dressed vertices of the theory in order to trigger the Schwinger mecha.ism, a.d expla.n in deta.l the instrumenta. role of these poles in ma.nta.ning the Becchi-Rouet-Stora.Tyutin symmetry a. every step of the ma.s-genera.ing procedure. The dyna.ica. equa.ion governing the evolution of the gluon ma.s is derived, a.d its solutions a.e determined numerica.ly following implementa.ion of a.set of simplifying a.sumptions. The obta.ned ma.s function is positive definite, a.d exhibits a.power la. running tha. is consistent with genera. a.guments ba.ed on the opera.or product expa.sion in the ultra.iolet region. a.possible connection between confinement a.d the presence of a. inflection point in the gluon propa.a.or is briefly discussed.

关键词： nonperturba.ive physics Schwinger-Dyson equa.ions dyna.ica. ma.s genera.ion

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Cdk5 a.d a.erra.t cell cycle a.tiva.ion a. the core of neurodegenera.ion

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Neura. Regenera.ion Resea.ch 2023年第6期18卷 1186-1190页

作者： Ra.uel Requejo-aguilar Depa.tment of Biochemistry a.d Molecula. Biology University of CórdobaCórdobaSpain Ma.mónides Biomedica. Resea.ch Institute of Córdoba.IMIBIC) 14071 CórdobaSpain

Neurodegenera.ive disea.es a.e ca.sed by the progressive loss of specific *** exa.t mecha.isms of a.tion of these disea.es a.e unknown,a.d ma.y studies ha.e focused on pa.hwa.s rela.ed to a.norma. a.cumula.ion a.d processing of proteins,mitochondria. dysfunction,a.d oxida.ive stress lea.ing to a.optotic ***,a.growing body of evidence indica.es tha. a.erra.t cell cycle re-entry pla.s a.ma.or role in the pa.hogenesis of *** a.tiva.ion of the cell cycle in ma.ure neurons could be promoted by severa. signa.ing mecha.isms,including c-Jun N-termina. kina.es,p38 mitogen-a.tiva.ed protein kina.es,a.d mitogen-a.tiva.ed protein kina.e/extra.ellula. signa.-regula.ed kina.e ca.ca.es;post-tra.sla.iona. modifica.ions such a. Ta.-phosphoryla.ion;a.d DNa.da.a.e *** a.l these events,implica.ed Cdk5,a.proline-directed serine/threonine protein kina.e,seems to be responsible for severa. cellula. processes in neurons including a.on growth,neurotra.smission,syna.tic pla.ticity,neurona. migra.ion,a.d ma.ntena.ce of neurona. ***,under pa.hologica. conditions,Cdk5 dysregula.ion ma. lea. to cell cycle re-entry in post-mitotic ***,Cdk5 hypera.tiva.ion,by its physiologic a.tiva.or p25,hyper-phosphoryla.es downstrea. substra.es rela.ed to neurodegenera.ive *** review summa.izes fa.tors such a. oxida.ive stress,DNa.da.a.e response,signa.ing pa.hwa. disturba.ce,a.d Ubiquitin protea.ome ma.function contributing to cell cycle re-entry in post-mitotic *** a.so describes how a.l these fa.tors a.e linked to a.grea.er or lesser extent with ***,it offers a.globa. vision of the function of cell cycle-rela.ed proteins in ma.ure neurons with a.focus on Cdk5 a.d how this protein contributes to the development of a.zheimer’s disea.e,Pa.kinson’s disea.e,a.yotrophic la.era. sclerosis,a.d Huntington’s disea.e by cell cycle a.tiva.ion.

关键词： a.zheimer´s disea.e a.yotrophic la.era. sclerosis a.optosis Cdk5 cell cycle Huntington´s disea.e neurodegenera.ion neuron oxida.ive stress Pa.kinson´s disea.e signa.ing Ta. phosphoryla.ion

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On the role of endogenous neurotoxins a.d neuroprotection in Pa.kinson's disea.e

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Neura. Regenera.ion Resea.ch 2017年第6期12卷 897-901页

作者： Jua. Segura.aguilar Molecula. a.d Clinica. Pha.ma.ology ICBM Faculty of Medicine University of Chile

For 50 yea.s a.o wa. introduced L-3,4-dihydroxyphenyla.a.ine（L-dopa. in Pa.kinson＇s disea.e trea.ment a.d during this significa.t a.va.ces ha. been done but wha. trigger the degenera.ion of the nigrostria.a. system rema.n unknown. There is a.genera. a.reement in the scientific community tha. mitochondria. dysfunction, protein degra.a.ion dysfunction, a.pha.synuclein a.grega.ion to neurotoxic oligomers, neuroinfla.ma.ion, oxida.ive a.d endopla.mic reticulum stress a.e involved in the loss of dopa.inergic neurons conta.ning neuromela.in in Pa.kinson＇s disea.e. The question is wha. triggers these mecha.isms. The a.e of norma. onset in idiopa.hic Pa.kinson＇s disea.e suggests tha. environmenta. fa.tors such a. meta.s, polluta.ts or genetic muta.ions ca.not be involved beca.se these fa.tors a.e rela.ed to ea.ly onset of Pa.kinsonism. Therefore, we ha.e to sea.ch for endogenous neurotoxins a.d neuroprotection in order to understa.d wha. trigger the loss of dopa.inergic neurons. One importa.t fea.ure of Pa.kinson＇s disea.e is the ra.e of the degenera.ive process before the motor symptoms a.e evident a.d during the disea.e progression. The extremely slow ra.e of Pa.kinson＇s disea.e suggests tha. the neurotoxins a.d the neuroprotection ha.e to be rela.ed to dopa.ine meta.olism. Possible ca.dida.es for endogenous neurotoxins a.e a.pha.synuclein neurotoxic oligomers, 4-dihydroxyphenyla.eta.dehyde a.d ortho-quinones formed during dopa.ine oxida.ion to neuromela.in. Vesicula. monoa.ine tra.sporter-2, DT-dia.hora.e a.d gluta.hione tra.sfera.e M2-2 seems to be the most importa.t neuroprotective mecha.ism to prevent neurotoxic mecha.ism during dopa.ine oxida.ion.

关键词： dopa.ine endogenous endopla.mic degenera.ion reticulum extremely gluta.hione Dopa.ine tra.sporter meta.olism

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Single-neuron neurodegenera.ion a. a.degenera.ive model for Pa.kinson’s disea.e

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 529-535页

作者： Sa.dro Huenchugua.a.Jua. Segura.aguilar Escuela.de Tecnología.Médica Facultad de SaludUniversidad Santo TomásLos CarrerasOsornoChile Molecula.&Clinica. Pha.ma.ology Instituto de Ciencias Biomedicas(ICBM)Faculty of medicineUniversity of ChileIndependenciaSantiagoChile

The positive effect of levodopa.in the trea.ment of Pa.kinson’s disea.e,a.though it is limited in time a.d ha. severe side effects,ha. encoura.ed the scientific community to look for new drugs tha. ca. stop the neurodegenera.ive process or even regenera.e the neuromela.in-conta.ning dopa.inergic nigrostria.a. *** preclinica. studies with coenzyme Q10,mitoquinone,isra.ipine,nilotinib,TCH346,neurturin,zonisa.ide,deferiprone,pra.inezuma.,a.d cinpa.ema. prompted clinica. ***,these fa.led a.d a.ter more tha. 50 yea.s levodopa.continues to be the key drug in the trea.ment of the disea.e,despite its severe side effects a.ter 4–6 yea.s of chronic *** la.k of tra.sla.ed successful results obta.ned in preclinica. investiga.ions ba.ed on the use of neurotoxins tha. do not exist in the huma. body a. new drugs for Pa.kinson’s disea.e trea.ment is a.big *** our opinion,the ca.se of these fa.lures lies in the experimenta. a.ima. models involving neurotoxins tha. do not exist in the huma. body,such a. 1-methyl-4-phenyl-1,2,3,6-tetra.ydropyridine a.d 6-hydroxydopa.ine,tha. induce a.very fa.t,ma.sive a.d expa.sive neurodegenera.ive process,which contra.ts with the extremely slow one of neuromela.in-conta.ning dopa.inergic *** exceedingly slow progress of the neurodegenera.ive process of the nigrostria.a. neurons in idiopa.hic Pa.kinson’s pa.ients is due to(i)a.degenera.ive model in which the neurotoxic effect of a. endogenous neurotoxin a.fects a.single neuron,(ii)a.neurotoxic event tha. is not expa.sive a.d(iii)the fa.t tha. the neurotoxin tha. triggers the neurodegenera.ive process is produced inside the neuromela.in-conta.ning dopa.inergic *** endogenous neurotoxin tha. fits this degenera.ive model involving one single neuron a. a.time is a.inochrome,since it(i)is genera.ed within neuromela.in-conta.ning dopa.inergic neurons,(ii)does not ca.se a. expa.sive neurotoxic effect a.d(iii)triggers a.l the mecha.isms involved in t

关键词： 1-methyl-4-phenyl-1,2,3,6-tetra.ydropyridine 6-hydroxydopa.ine a.inochrome dopa.inergic neurons DT-dia.hora.e exogenous neurotoxins gluta.hione tra.sfera.e M2-2

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Sta.e a.d perspectives on fla.onoid neuroprotection a.a.nst a.inochrome-induced neurotoxicity

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Neura. Regenera.ion Resea.ch 2021年第9期16卷 1797-1798页

作者： Victor Silva.Jua. Segura.aguilar La.ora.ory of Neurochemistry a.d Cell Biology Department of Biochemistry and BiophysicsInstitute of Health SciencesFederal University of Bahia40110-100SalvadorBahiaBrazil Molecula. a.d Clinica. Pha.ma.ology ICBMFaculty of MedicineUniversity of ChileChile

Pa.kinson's disea.e(PD) motor symptoms a.e induced by the loss of dopa.inergic neurons conta.ning neuromela.in in the nigrostria.a. system. The exa.t mecha.ism tha. triggers the degenera.ion of the nigrostria.a. neurons is still unknown but there is genera. consensus in the scientific community tha. mitochondria. dysfunction, a.pha.synuclein a.grega.ion to neurotoxic oligomers, protein degra.a.ion dysfunction of both lysosoma. a.d protea.oma. systems, endopla.mic reticulum stress.

关键词： degenera.ion reticulum a.grega.ion

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a.new mecha.ism for protection of dopa.inergic neurons media.ed by a.trocytes

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Neura. Regenera.ion Resea.ch 2015年第8期10卷 1225-1227页

作者： Jua. Segura.aguilar Molecula. a.d Clinica. Pha.ma.ology ICBM Faculty of Medicine University of Chile

For a.long time,the question a.out the mecha.ism involved in the degenera.ive process of the nigrostria.a. system in Pa.kinson’s disea.e（PD）,resulting in the loss of dopa.inergic neurons conta.ning neuromela.in,ha.... 详细信息

关键词： dopa.ine fa.ilia. degenera.ive mitochondria.quinone Dopa.ine syna.tic reticulum endopla.mic gluta.hione

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Interfa.ia. Stra.egies for Sma.t Slippery Surfa.es

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Journa. of Bionic Engineering 2020年第4期17卷 633-643页

作者： Glen McHa.e Rodrigo Ledesma.aguilar Ga.y George Wells Sma.t Ma.eria.s&Surfa.es La.ora.ory Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon TyneNE18STUK

The problem of conta.t line pinning on surfa.es is perva.ive a.d contributes to problems from ring sta.ns to ice *** we provide a.single conceptua. fra.ework for interfa.ia. stra.egies encompa.sing five stra.egies for modifying the solid-liquid interfa.e to remove pinning a.d increa.e droplet *** biomimetic stra.egies a.e included,(i)reducing the liquid-solid interfa.ia. a.ea.inspired by the Lotus effect,(ii)converting the liquid-solid conta.t to a.solid-solid conta.t by the forma.ion of a.liquid ma.ble inspired by how ga.ling a.hids remove honeydew,a.d(iii)converting the liquid-solid interfa.e to a.liquid-lubrica.t conta.t by the use of a.lubrica.t impregna.ed surfa.e inspired by the Nepenthes Pitcher *** further stra.egies a.e,(iv)converting the liquid-solid conta.t to a.liquid-va.or conta.t by using the Leidenfrost effect,a.d(v)converting the conta.t to a.liquid-liquid-like conta.t using slippery omniphobic cova.ent a.ta.hment of a.liquid-like coa.ing(SOCa.).Using these a.proa.hes,we expla.n how surfa.es ca. be designed to ha.e sma.t functiona.ity whilst reta.ning the mobility of conta.t lines a.d ***,we show how droplets ca. eva.ora.e a. consta.t conta.t a.gle,be positioned using a.Cheerios effect,tra.sported by bounda.y reconfigura.ion in a. energy inva.ia.t ma.ner,a.d drive the rota.ion of solid components in a.Leidenfrost hea. *** conceptua. fra.ework ena.les the ra.iona.e design of surfa.es which a.e slippery to liquids a.d is releva.t to a.diverse ra.ge of a.plica.ions.

关键词： superhydrophobicity SLIPS liquid ma.bles leidenfrost SOCa.

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