State and perspectives on flavonoid neuroprotection against aminochrome-induced neurotoxicity

作     者：Victor Silva Juan Segura-Aguilar Victor Silva;Juan Segura-Aguilar

作者机构：Laboratory of Neurochemistry and Cell BiologyDepartment of Biochemistry and BiophysicsInstitute of Health SciencesFederal University of Bahia40110-100SalvadorBahiaBrazil Molecular and Clinical PharmacologyICBMFaculty of MedicineUniversity of ChileChile 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第9期

页      面：1797-1798页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by ANID-FONDECYT 1170033 JSA by Fundacao de ApoioàPesquisa do Estado da Bahia(FAPESB JCB0057/2016 to VS) 

主　　题：degeneration reticulum aggregation 

摘      要：Parkinson s disease(PD) motor symptoms are induced by the loss of dopaminergic neurons containing neuromelanin in the nigrostriatal system. The exact mechanism that triggers the degeneration of the nigrostriatal neurons is still unknown but there is general consensus in the scientific community that mitochondrial dysfunction, alpha-synuclein aggregation to neurotoxic oligomers, protein degradation dysfunction of both lysosomal and proteasomal systems, endoplasmic reticulum stress.