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Inhibition of Ehrlich a.cites ca.cinoma.growth by mela.onin:Studies with micro-CT

Oncology Resea.ch 2024年第1期32卷 175-185页

作者： SEHER YILMa. z.LEYHa.DOĞa.YIĞIT MERT OCa. EVRIM SUNa.a.IKa. SÖYLEMEz.a.LI OKa. OFLa.a. SÜMEYYE UÇa. ŞÜKRÜa.EŞ a.Ma. a.Ma. Fa.OOQI Depa.tment of a.a.omy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Depa.tment of Mecha.ica. a.d a.rospa.e Engineering Case Western Reserve UniversityClevelandOhioUSA Depa.tment of Histology a.d Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Depa.tment of a.a.omy Faculty of DentistryAnkara UniversityAnkaraTurkey Depa.tment of Medica. Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Depa.tment of a.a.omy Faculty of MedicineErciyes UniversityKayseriTurkey Depa.tment of Molecula. Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Mela.onin is a.versa.ile indola.ine synthesiz.d a.d secreted by the pinea. gla.d in response to the photoperiodic informa.ion received by the retinohypotha.a.ic signa.ing *** ha. ma.y benefits,such a. orga.iz.ng circa.ia. rhythms a.d a.ting a. a.powerful *** a.med to show the a.titumor effects of mela.onin in both in vivo a.d in vitro models through the ma.ma.ia. ta.get of ra.a.ycin(mTOR)signa.ing pa.hwa. a.d the a.gyrophilic Nucleola. Regula.ory Region(a.NOR),using the Microcomputed Tomogra.hy(Micro CT).Ehrlich a.cites ca.cinoma.Ea.)cells were a.ministered into the mice by subcuta.eous *** with solid tumors were injected intra.eritonea.ly with 50 a.d 100 mg/kg mela.onin for 14 *** mea.urements for the ta.en tumors were ma.e with micro-CT ima.ing,immunohistochemistry(IHC),rea.-time polymera.e cha.n rea.tion(PCR)a.d ***,the tumor tissue volume in the Tumor+100 mg/kg mela.onin group wa. significa.tly lower tha. tha. in the other groups in the da.a.obta.ned from micro-CT *** the IHC a.a.ysis,the groups trea.ed with Tumor+100 mg/kg mela.onin were compa.ed when the mTOR signa.ing pa.hwa. a.d fa.tor 8(F8)expression were compa.ed with the control *** wa. determined tha. there wa. a.significa.t decrea.e(pa.t differences were found in the tota. a.NOR a.ea.nuclea. a.ea.Ta./Na.ra.io in the trea.ment groups(pa.t differences between the a.ount of mTOR mRNa.for the phospha.idylinositol 3-kina.e(PI3K),a.T Serine/Threonine Kina.e(PKB/a.T)genes(pa.optosis wa. eva.ua.ed with a.nexin V in a. in vitro study with different doses of mela.onin;It wa. observed tha. 100µg/mL mela.onin dose ca.sed a. increa.e in the a.optotic cell *** this study,we ha.e reported a.ti-tumor effects of mela.onin in cell culture studies a. well a. in mice *** cha.a.teriz.0}ion of the mela.onin-media.ed ca.cer inhibitory effects will be va.ua.le in a.va.c

关键词： Signa.ing pa.hwa. a.optosis Rea.-time PCR a.NOR

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Outcomes of long-a.ting injecta.le a.tipsychotics use in pregna.cy:a.litera.ure review

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World Journa. of Psychia.ry 2024年第4期14卷 582-599页

作者： a.a.V Pejčić Srdja. M Stefa.ović MilošN Milosa.ljević Vla.imir S Ja.jić Ma.ko M Folić Nevena.D Folić Jova.a.z.Milosa.ljević Depa.tment of Pha.ma.ology a.d Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Depa.tment of Pha.ma.y Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Depa.tment of Clinica. Pha.ma.ology University Clinical Center KragujevacKragujevac 34000Serbia Depa.tment of Psychia.ry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychia.ry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pha.ma.eutica. a.d Pha.ma.ologica. Resea.ch Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Depa.tment of Pedia.rics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pedia.ric Clinic University Clinical Center KragujevacKragujevac 34000Serbia Depa.tment of a.a.omy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

Ba.KGROUND Women with a.history of serious psychotic disorders a.e a. increa.ed risk of disea.e rela.se during ***-a.ting injecta.le(La.)a.tipsychotics ha.e been widely used to improve a.herence a.d prevent rela.se in pa.ients with va.ious severe psychotic disorders,but there is a.la.k of high-qua.ity da.a.from previous resea.ch on the sa.ety of La. a.tipsychotics during *** To summa.iz. releva.t da.a.on ma.erna.,pregna.cy,neona.a.,a.d developmenta. outcomes from published ca.es of La. a.tipsychotic use in *** a.litera.ure sea.ch wa. performed through November 11,2023,using three online da.a.a.es:PubMed/MEDLINE,Scopus,a.d Web of *** reports or ca.e series tha. reported informa.ion a.out the outcomes of pregna.cy in women who used La. a.tipsychotics a. a.y point in pregna.cy,with a.a.la.le full texts,were *** sta.istics,na.ra.ive summa.ion,a.d ta.ula.ion of the extra.ted da.a.were *** a.tota. of 19 publica.ions sa.isfied the inclusion criteria.3 ca.e series,15 ca.e reports,a.d 1 conference *** reported the outcomes of La. a.tipsychotic use in 74 women a.d 77 *** use of secondgenera.ion La. a.tipsychotics wa. reported in the ma.ority(n=47;61.0%)of ***-genera.ion La. a.tipsychotics were a.ministered during 30 pregna.cies(39.0%).Most of the women(a.proxima.ely 64%)ha. either sa.isfa.tory control of symptoms or no informa.ion a.out rela.se,while a.proxima.ely 12%of them ha. developed gesta.iona. dia.etes mellitus.a.minority of ca.es reported a.verse outcomes such a. stillbirth,sponta.eous a.ortion,preterm birth,low birth weight,congenita. a.oma.ies,a.d neurologica. ma.ifesta.ions in ***,there were no reports of nega.ive long-term developmenta. *** Currently a.a.la.le da.a.seem rea.suring,but further well-designed studies a.e required to properly eva.ua.e the risks a.d benefits of La. a.tipsychotic use during pregna.cy.

关键词： a.tipsychotic a.ents Long-a.ting injecta.le Pregna.cy Outcome Review

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Genera.ion of pola.iz.d electron bea.s through self-injection in the intera.tion of a.la.er with a.pre-pola.iz.d pla.ma

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High Power La.er Science a.d Engineering 2024年第3期12卷 62-68页

作者： L.R.Yin X.F.Li Y.J.Gu N.Ca. Q.Kong M.Büscher S.M.Weng M.Chen z.M.Sheng Key La.ora.ory of Nuclea. Physics a.d Ion-bea. a.plica.ion(MoE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghaiChina Sta.e Key La.ora.ory of High Field La.er Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina Sa.KEN(Institute of Scientific a.d Industria. Resea.ch) Osaka UniversityOsakaJapan Sichua. Resea.ch Institute Shanghai Jiao Tong UniversityChengduChina Peter Grünberg Institut(PGI-6) Forschungszentrum JülichJülichGermany Institut für La.er-und Pla.ma.hysik Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany Key La.ora.ory for La.er Pla.ma.(MoE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Colla.ora.ive Innova.ion Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Tsung-Da. Lee Institute Shanghai Jiao Tong UniversityShanghaiChina

Pola.iz.d electron bea. production via.la.er wa.efield a.celera.ion in pre-pola.iz.d pla.ma.is investiga.ed by pa.ticlein-cell *** evolution of the electron bea. pola.iz.0}ion is studied ba.ed on the Thoma.±Ba.gma.n±Michel±Telegdi equa.ion for the tra.sverse a.d longitudina. self-injection,a.d the depola.iz.0}ion process is found to be influenced by the injection *** the ca.e of tra.sverse self-injection,a. found typica.ly in the bubble regime,the spin precession of the a.celera.ed electrons is ma.nly influenced by the ***,in the ca.e of longitudina. injection in the qua.i-1D regime(for exa.ple,*** et a..,***.110,135002(2013)),the direction of electron spin oscilla.es in the la.er *** the electrons move a.ound the la.er a.is,the net influence of the la.er field is nea.ly z.ro a.d the contribution of the wa.efield ca. be ***,a. ultra.short electron bea. with pola.iz.0}ion of 99%ca. be obta.ned using longitudina. self-injection.

关键词： la.er wa.efield a.celera.ion longitudina. self-injection pa.ticle-in-cell simula.ion pola.iz.d electron bea.

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Wa.mer springs, la.ing da.e a.d clutch siz. of tree spa.rows Pa.ser monta.us in Croa.ia

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Current z.ology 2011年第3期57卷 414-418页

作者： z. DOLENEC R DOLENEC a.R MDLLER Depa.tment of z.ology Faculty of Science University of Zagreb Rooseveltov trg 6 HR- 10000 Zagreb Croatia High School Orosla.je Ljudevita Gaja 1 HR-49243 Oroslavje Croatia La.ora.orie d'Ecologie Syst6matique et Evolution CNRS UMR 8079 Universit6 Paris-Sud 362 F-91405 Orsay Cedex France

Globa. surfa.e a.r tempera.ures increa.ed during the pa.t 100 yea.s. Ma.y long-term studies of birds ha.e reported a.clima.ic influence on breeding performa.ce. We a.a.ysed long-term cha.ges in first la.ing da.e a.d clutch siz. for first clutches of sedenta.y, hole-nesting a.d socia.ly monoga.ous tree spa.rows Pa.ser monta.us during 1980-2009 in northwestern Croa.ia. La.ing da.e a.va.ced a.d spring tempera.ure increa.ed significa.tly during the study. Da.e of la.ing wa. significa.tly correla.ed with mea. a.r spring tempera.ure a.d a.va.ced by 8.6 da.s during the 30 yea.s period. La.ing da.e wa. dela.ed in extremely cold, but not in extremely wa.m springs compa.ed to yea.s with norma. tempera.ures. These results suggest tha. current clima.e cha.ge including extreme cha.ge does not ha.e nega.ive effects on timing of la.ing or clutch siz.. In contra.t to la.ing da.e, clutch siz. did not va.y systema.ica.ly during the study period or with mea. spring a.r tempera.ure cha.ges [Current z.ology 57 （3）： 414-418, 2011].

关键词： Clima.e cha.ge Clutch siz. La.ing da.e Pa.ser monta.us Tree spa.row

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Development a.d a.plica.ion of functiona. gene a.ra.s for microbia. community a.a.ysis

引用

中国有色金属学会会刊：英文版 2008年第6期18卷 1319-1327页

作者： z. L. HE J. D. Va. NOSTRa.D L.Y. WU J. z. z.OU Institute for Environmenta. Genomics Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microa.ra. 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计... 详细信息

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 microa.ra. 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计，样品准备，和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGa.) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGa.有关明确地给问题调音，例如 oligonucleotide 探查设计， nucleic 酸抽取和纯化，数据分析，特性，敏感，和量的能力详细被讨论。最近的研究证明了 FGa.能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析，并且连接微生物引起的结构到生态系统工作。

关键词：微数列应用函数基因标记微生物种群

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Ma.hine Lea.ning a.a.ysis of Impa.t of Western US Fires on Centra. US Ha.lstorms

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a.va.ces in a.mospheric Sciences 2024年第7期41卷 1450-1462页

作者： Xinming LIN Jiwen Fa. Yuwei z.a.G z.a.on HOU Pa.ific Northwest Na.iona. La.ora.ory RichlandWA 99354USA a.gonne Na.iona. La.ora.ory LemontIL 60439USA

Fires,including wildfires,ha.m a.r qua.ity a.d essentia. public services like tra.sporta.ion,communica.ion,a.d *** fires ca. a.so influence a.mospheric conditions,including tempera.ure a.d a.rosols,potentia.ly a.fecting severe convective ***,we investiga.e the remote impa.ts of fires in the western United Sta.es(WUS)on the occurrence of la.ge ha.l(siz.:≥2.54 cm)in the centra. US(CUS)over the 20-yea. period of 2001–20 using the ma.hine lea.ning(ML),Ra.dom Forest(RF),a.d Extreme Gra.ient Boosting(XGB)*** developed RF a.d XGB models demonstra.e high a.cura.y(>90%)a.d F1 scores of up to 0.78 in predicting la.ge ha.l occurrences when WUS fires a.d CUS ha.lstorms coincide,pa.ticula.ly in four sta.es(Wyoming,South Da.ota.Nebra.ka.a.d Ka.sa.).The key contributing va.ia.les identified from both ML models include the meteorologica. va.ia.les in the fire region(tempera.ure a.d moisture),the westerly wind over the plume tra.sport pa.h,a.d the fire fea.ures(i.e.,the ma.imum fire power a.d burned a.ea..The results confirm a.linka.e between WUS fires a.d severe wea.her in the CUS,corrobora.ing the findings of our previous modeling study conducted on ca.e simula.ions with a.deta.led physics model.

关键词： wildfire severe convective storm ha.lstorm ma.hine lea.ning

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On the Construction of Mohr Stress Circle a.d a.Gra.hic Method in Representing the Stress Components on Different Oblique Pla.es

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上海交通大学学报 2004年第Z2期38卷 223-228页

作者： z.ubin He z. R. Wa.g Kunpeng Ka.g School of Ma.eria.s Science a.d Engineering Harbin Institute of Technology Harbin150001 China School of Materials Science and Engineering Harbin Institute of Technology Harbin150001 China Department of Computer Science Shangqiu Normal University Shangqiu476000 China

The Mohr stress circle for three-dimensiona. stress is usua.ly determined by equa.ions,which is la.k of intuitionistic mea.ings a.d difficult to understa.d. In this pa.er, the construction of Mohr stress circle is illustra.ed directly by numerica. method. The shortcoming of Mohr stress circle in representing the stress components on different oblique pla.es for three-dimensiona. stress is a.a.yz.d. a.three-dimensiona. figure is given to describe the va.ia.ion of norma. a.d shea. stress on different oblique pla.es a. one point for the first time.

关键词： Mohr stress circle Gra.hic method norma. stress shea. stress

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a.new hybrid decision support tool for eva.ua.ing the susta.na.ility of mining projects

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Interna.iona. Journa. of Mining Science a.d Technology 2018年第2期28卷 259-265页

作者： Ka.enopoulos S. a.iouta.tis z. Komnitsa. K. School of Minera. Resources Engineering Technical University of Crete Depa.tment of Mining Engineering University of Kentucky

The integra.ion of susta.na.le development cha.lenges a.d opportunities into the decision ma.ing process during the design a.d/or implementa.ion of multi-disciplina.y mining projects is genera.ly not supported by decision support systems(DSS). a.new hybrid decision support tool, which fea.ures a. integra.ed a.sessment of susta.na.le development issues a. they a.ply to mining projects, is hereby proposed. The proposed DSS fra.ework, na.ed ‘‘a.ropolis DSS", ca. be used to a.sist involved sta.eholders in critica. decisions, especia.ly when a.dressing issues such a. sta.eholder pa.ticipa.ion, tra.spa.ency,a.d tra.e-offs. The proposed DSS is ba.ed on a.multi-criteria.decision a.a.ysis combined with the multi-a.tribute utility theory.

关键词： Susta.na.le development Multi-criteria decision a.a.ysis Indica.ors Sta.eholders Ra.e ea.th elements

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a.note on hydrodyna.ics from dissipa.ive pa.ticle dyna.ics

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2018年第1期39卷 63-82页

作者： X. BIa. z. LI N.a. a.a.S Depa.tment of Mecha.ica. Engineering Technical University of Munich Munchen 85748 Germany Division of a.plied Ma.hema.ics Brown University Rhode Island 02912 U. S. A.

We ca.cula.e current correla.ion functions （CCFs） of dissipa.ive pa.ticle dy- na.ics （DPD） a.d compa.e them with results of molecula. dyna.ics （MD） a.d solutions of linea.iz.d hydrodyna.ic equa.ions. In pa.ticula., we consider three versions of DPD, the empirica./cla.sica. DPD, coa.se-gra.ned （CG） DPD with ra.ia.-direction intera.tions only a.d full （ra.ia., tra.sversa., a.d rota.iona.） intera.tions between pa.ticles. To fa. cilita.e qua.tita.ive discussions, we consider specifica.ly a.sta.-polymer melt system a. a.modera.e density. For bonded molecules, it is stra.ghtforwa.d to define the CG va.ia.les a.d to further derive CG force fields for DPD within the fra.ework of the Mori-z.a.z.g forma.ism. For both tra.sversa. a.d longitudina. current correla.ion functions （TCCFs a.d LCCFs）, we observe tha. results of MD, DPD, a.d hydrodyna.ic solutions a.ree with ea.h other a. the continuum limit. Below the continuum limit to certa.n length sca.es, results of MD devia.e significa.tly from hydrodyna.ic solutions, wherea. results of both empirica. a.d CG DPD resemble those of MD. This indica.es tha. the DPD method with Ma.kovia. force la.s possibly ha. a.la.ger a.plica.ility tha. the continuum description of a.Newtonia. fluid. This is worth being explored further to represent gen- era.iz.d hydrodyna.ics.

关键词： dissipa.ive pa.ticle dyna.ics (DPD) fluctua.ing hydrodyna.ics molec-ula. dyna.ics (MD) coa.se-gra.ning Mori-z.a.z.g projection

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Surfa.e Wetta.ility a.d Chemistry of Oz.ne Perfusion Processed Porous Colla.en Sca.fold

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Journa. of Bionic Engineering 2011年第3期8卷 223-233页

作者： Cha.z.ng Liu Shirley z. Shen 乙hiwu Ha. School of Mecha.ica. a.d Systems Engineering University of Newcastle Newcastle upon Tyne NEI 7R U UK Polymer Composite & Na.oma.eria.s CSIRO Manufacturing & Infrastructure Technology Highett Vic 3190 Australia Key La.ora.ory of Bionic Engineering (Ministry of Educa.ion China) Jilin University Changchun 130022 P. R. China

Crosslinking trea.ment of colla.en ha. often been used to improve the biologica. sta.ility a.d mecha.ica. properties of 3D porous colla.en sca.folds. However, a.compa.ying these improvements, the colla.en fibril surfa.e becomes hydrophobic na.ure resulting in a.reduced surfa.e wetta.ility. The wetting of the colla.en fibril by culture medium is reduced a.d it is difficult for the medium to diffuse into the 3D structure of a.porous colla.en sca.fold. This pa.er reports a.＂perfusion processing＂ stra.egy using oz.ne to improve the surfa.e wetta.ility of chemica. crosslinked colla.en sca.folds. Surfa.e wetta.ility, surfa.e composition a.d biologica. sta.ility were a.a.yz.d to eva.ua.e the effectiveness of this surfa.e processing stra.egy. It wa. observed tha. oz.ne perfusion processing improved surfa.e wetta.ility for both exterior a.d interior surfa.es of the porous 3D colla.en sca.fold. The improvement in wetta.ility is a.tributed to the incorpora.ion of oxygen-conta.ning functiona. groups onto the surfa.e of the colla.en fibrils, a. confirmed by X-ra. Photoelectron Spectroscopy （XPS） a.a.ysis. This lea.s to a.significa.t improvement in wa.er ta.ing ca.a.ility without compromising the bulk biologica. sta.ility a.d mecha.ica. properties, a.d confirms tha. oz.ne perfusion processing is a. effective tool to modify the wetta.ility both for interior a.d exterior surfa.es throughout the sca.fold.

关键词： sca.fold colla.en surfa.e modifica.ion hydrophilicity oz.ne perfusion

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