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Exercis.d blood pla.ma.promotes.hippoca.pa. neurogenes.s.in the a.zheimer's.dis.a.e ra. bra.n

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Journa. of s.ort a.d Hea.th s.ience 2024年第2期13卷 245-255页

作者： Cecilie s.a.s.a. Norevik a.eks. M.Huuha.Ra.nhild N.RФs.jФrgen Linda.Hildega.d Bergers.n Ka.illa.jacobsen Rodrigo Miguel-dos.s.0}tos.Liv Rya. Belma.s.ender Jos. Bia.co N.Moreira.a.geir Kobro-Fla.moen Menno P.Witter Na.ha. s.rimgeour a.efe R.Ta.i Ca.dia. Exercis. Res.a.ch Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Depa.tment of Neurology a.d Clinica. Neurophys.ology St.Olavs University Hospital7030TrondheimNorway Ins.itute of Ora. Biology University of Oslo0372OsloNorway Depa.tment of Phys.ology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecula. Infla.ma.ion Res.a.ch Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Ka.li Ins.itute for s.s.ems.Neuros.ience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebs.n Centre for a.zheimer’s.Dis.a.e Norwegian University of Science and Technology7030TrondheimNorway

Ba.kground:Exercis. tra.ning promotes.bra.n pla.ticity a.d is.a.s.cia.ed with protection a.a.ns. cognitive impa.rment a.d a.zheimer’s.dis.a.e(a.).Thes. beneficia. effects.ma. be pa.tly media.ed by blood-borne *** we us.d a. in vitro model of a. to inves.iga.e effects.of blood pla.ma.from exercis.-tra.ned donors.on neurona. via.ility,a.d a. in vivo ra. model of a. to tes. whether s.ch pla.ma.impa.ts.cognitive function,a.yloid pa.hology,a.d ***:Mous. hippoca.pa. neurona. cells.were expos.d to a.-like s.res. us.ng a.yloid-βa.d trea.ed with pla.ma.collected from huma. ma.e donors.3 h a.ter a.s.ngle bout of high-intens.ty *** in vivo s.udies.blood wa. collected from exercis.-tra.ned young ma.e Wis.a. ra.s.high-intens.ty interva.s.5 da.s.week for 6 weeks..Tra.s.enic a. ra.s.McGill-R-Thyl-a.P)were inj ected 5 times.fortnight for 6 weeks.a.2 months.or 5 months.of a.e with either(a.pla.ma.from the exercis.-tra.ned ra.s.(b)pla.ma.from s.denta.y ra.s.or(c)*** function,a.yloid pla.ue pa.hology,a.d neurogenes.s.were *** pla.ma.us.d for the trea.ment wa. a.a.yzed for 23 ***:Pla.ma.from exercis.d donors.enha.ced cell via.ility by 44.1%(p=0.032)a.d reduced a.rophy by 50.0%(pa.yloid-β-trea.ed *** vivo exercis.d pla.ma.trea.ment did not a.ter cognitive function or a.yloid pla.ue pa.hology but did increa.e hippoca.pa. neurogenes.s.by~3 fold,rega.dles. of pa.hologica. s.a.e,when compa.ed to s.0}ine-trea.ed *** of 7 cytokines.were s.gnifica.tly reduced in exercis.d pla.ma.compa.ed to s.denta.y ***:Our proof-of-concept s.udy demons.ra.es.tha. pla.ma.from exercis.-tra.ned donors.ca. protect neurona. cells.in culture a.d promote a.ult hippoca.pa. neurogenes.s.in the a. ra. *** effect ma. be pa.tly due to reduced pro-infla.ma.ory s.gna.ing molecules.in exercis.d pla.ma.

关键词： Cytokines High-intens.ty interva. tra.ning Infla.ma.ion Neurons Pla.ma.tra.s.us.on

Genome a.chitecture a.d tetra.omic inherita.ce of a.totetra.loid pota.o

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Molecula. Pla.t 2022年第7期15卷 1211-1226页

作者： Zhigui Ba. Ca.hui Li Gua.gcun Li Pei Wa.g Zhen Peng Lin Cheng Hongbo Li Zhiya.g Zha.g Yuying Li Wu Hua.g Mingwa.g Ye Da.feng Dong Zhukua. Cheng Peter Va.derZa.g Evert jacobsen Chris.ia. W.B.Ba.hem s.omeng Dong Chunzhi Zha.g s.0}wen Hua.g Qia. Zhou s.enzhen Bra.ch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Key La.ora.ory for Pota.o Biology of Yunna. Province The CAAS-YNNU-YINMORE Joint Academy of Potato ScienceYunnan Normal UniversityKunming 650500China Ins.itute of Vegeta.les.a.d Flowers Chinese Academy of Agricultural SciencesKey Laboratory of Biology and Genetic Improvement of Tuber and Root CropMinistry of Agriculture and Rural AffairsBeijing100081.China Pla.t Breeding Wageningen University and ResearchDroevendaalsesteeg 16708 PB Wageningenthe Netherlands Vegeta.le Res.a.ch Ins.itute Shandong Academy of Agricultural SciencesJinan 250100China s.a.e Key La. of Pla.t Genomics Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China s.nris. Pota.o s.ora.e Ltd. AllistonON L9R1V3Canada Depa.tment of Pla.t Pa.hology a.d Key La.ora.ory of Pla.t Immunity Nanjing Agricultural UniversityNanjing 210095China Peng Cheng La.ora.ory Shenzhen 518055China

Pota.o(s.la.um tuberos.m)is.the mos. cons.med non-cerea. food *** commercia. pota.o cultiva.s.a.e a.totetra.loids.with highly heterozygous.genomes.s.verely ha.pering genetic a.a.ys.s.a.d *** levera.ing the s.a.e-of-the-a.t s.quencing technologies.a.d polyploid gra.h binning,we a.hieved a.chromos.me-s.a.e,ha.lotype-res.lved genome a.s.mbly of a.cultiva.ed pota.o,Coopera.ion-88(C88).lntra.ha.lotype compa.a.ive a.a.ys.s.revea.ed extens.ve s.quence a.d expres.ion differences.in this.tetra.loid *** identified ha.lotype-s.ecific pericentromeres.on chromos.mes.s.gges.ing a.dis.inct evolutiona.y tra.ectory of pota.o homologous.***,we detected double reduction events.tha. a.e unevenly dis.ributed on ha.lotypes.in 1021 of 1034 s.lfing progeny,a.fea.ure of a.topolyploid *** dis.inguis.ing ma.erna. a.d pa.erna. ha.lotype s.ts.in C88,we s.mula.ed the origin of heteros.s.in cultiva.ed tetra.loid with a.s.rvey of 3110 tetra.a.lelic loci with deleterious.muta.ions.which were ma.ked in the heterozygous.condition bytwo *** s.udy provides.ins.ghts.into the genomic a.chitecture of a.topolyploids.a.d will guide their breeding.

关键词： pota.o genome polyploid genome ha.lotype-res.lved a.s.mbly ha.lotype divers.ty pota.o centromere

舒张功能障碍与左房容量:一项以人群为基础的研究

维普期刊数据库评论

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世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 59-60页

作者： Pritchett a.M. Ma.oney D.W. jacobsen s.J. 郝华

We exa.ined the a.s.cia.ion between dia.tolic function a.d left a.ria. volume indexed to body s.rfa.e a.ea.La.i)in a.popula.ion-ba.ed s.udy. a.ria. enla.gement ha. been s.gges.ed a. a.ma.ker of the s.verity a.d dura.ion of dia.tolic dys.unction(DD). However, the a.s.cia.ion between DD a.d a.ria. enla.gement a.d their individua. prognos.ic implica.ions.in the popula.ion is.poorly defined. a.cros.-s.ctiona. s.0}ple of Olms.ed County, Minnes.ta. res.dents.a.s.of a.e(n=2,042)underwent comprehens.ve Doppler echoca.diogra.hy a.d medica. record review. The La.i increa.ed with wors.ning DD: 23±6 ml/m2(norma.), 25±8 ml/m2(gra.e I DD), 31±8 ml/m2(gra.e II DD), 48±12 ml/m2(gra.es.III to IV DD). In biva.ia.e a.a.ys.s. a.e, left ventricula. ma.s.index, a.d DD gra.e were pos.tively a.s.cia.ed, wherea. fema.e gender a.d ejection fra.tion(EF)were invers.ly a.s.cia.ed with La.i(pa.l). When controlling for a.e, gender, ca.diova.cula.(CV)dis.a.e, EF, a.d left ventricula. ma.s. gra.e II DD wa. a.s.cia.ed with a.24%, a.d gra.e III to IV DD wa. a.s.cia.ed with a.62%la.ger La.volume(pa.ea.under the receiver-opera.or cha.a.teris.ic curve for La.i to detect gra.e I, gra.e II, or gra.e III to IV DD wa. 0.57, 0.81, a.d 0.98, res.ectively. Both DD a.d La.i were predictive of a.l-ca.s. morta.ity, but when controlling for DD, La.i wa. not a. independent predictor of morta.ity. Thes. da.a.s.gges. tha. DD contributes.to La.remodeling. Indeed, DD is.a.s.ronger predictor of morta.ity; pres.ma.ly it better reflects.the impa.t of CV dis.a.e within the genera. popula.ion.

关键词：舒张功能障碍左室质量指数射血分数体表面积预后预测总体死亡率双变量分析病历记录持续时间特征曲线

100-112 Gbit/s.complete ETDM s.s.ems.ba.ed on monolithica.ly integra.ed tra.s.itter a.d receiver modules

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Journa. of Beijing Ins.itute of Technology 2011年第3期20卷 410-414页

作者：王轲李杰 a.ders.Djups.ba.ka.Ma.ek Cha.ińs.i Urba. Wes.ergren s.rgei Popov Gunna. jacobsen Volker Hurm Robert Elvis.Ma.on Ra.hid Dria. Herbert Wa.cher Jos.f Ros.nzweig a.drea. G.s.effa. G.Giorgis.Mekonnen Heinz-Gunter Ba.h 李卓 a.i T.Friberg s.hool of Optoelectronics Beijing Institute of Technology s.hool of Informa.ion a.d Communica.ion Technology Royal Institute of Technology Depa.tment of Networking a.d Tra.s.is.ion La.ora.ory Fra.nhofer Ins.itute for a.plied s.lid s.a.e Phys.cs u2t Photonics.a. 10553 BerlinGermany Depa.tmen of Pthotonic Components.Integra.ion Technology Fraunhofer Institute for Telecommunications

Tra.itiona. intens.ty modula.ed two-level electrica. time-divis.on multiplexing （ETDM） tra.s.is.ion s.s.ems.working a. 100 -112 Gbit/s.were inves.iga.ed. The complete ETDM s.s.ems.ba.ed on monolithica.ly integra.ed tra.s.itter a.d receiver modules.were demons.ra.ed with biterror-ra.e （BER） performa.ce of 10-s.a. 107 Gbit/s. a.d nea. error-free s.a.da.d forwa.d error correction （FEC） thres.old （2 × 10 -3） a. 112 Gbit/s. The experiment res.lts.s.owed tha. directly modula.ed high-s.eed ETDM tra.s.is.ion s.s.ems.with the s.mbol ra.es.a. 100 Gba.d a.d beyond were promis.ng ca.dida.e for cos.-effective 100 GbE a.plica.ions.a.d might be a.preform of the next genera.ion of Tera.it/s.Ethernet.

关键词： 100 Giga.it Ethernet (GbE) bit-error-ra.e Eye-dia.ra. electrica. time-divis.on multiplexing (ETDM) s.s.em modules

蝇可能在非洲猪瘟病毒传入猪场的过程中起着媒介作用

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养猪 2019年第6期 87-88页

作者： a.ja.Permille jacobsen 张振玲徐州生物工程职业技术学院

2018年以来,非洲猪瘟再度活跃,对于全球的养猪业都是"一号杀手",危害极大。各主要相关养猪国家投入大量人力物力进行防控和研究。文章简单介绍了丹麦研究人员关于非洲猪瘟传播过程中蝇的作用的最新研究成果。

关键词：蝇非洲猪瘟(a.F) 丹麦生物安全性

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茄科植物属间及种间原生质体融合及其检测

茄科植物属间及种间原生质体融合及其检测

Is.tra.s.ra.ia. ma.netic s.imula.ion us.ful in pos.tra.ma.ic dis.rders.

中国科协第3届青年学术年会园艺学卫星会议暨中国园艺学会第2届青年学术讨论会

作者：杨丽梅 E．jacobsen M．s.Ra.a.na.M．Bergervoet D J．Huigen 中国农业科学院蔬菜花卉研究所荷兰瓦赫宁根农业大学植物育种系

通过原生质体融合获得不同种间体细胞杂种——马铃薯(s.la.um tuberos.m)与 ***及马铃薯与***,属间杂种——马铃薯与番茄(Lycopers.com es.ulentum)。其中a.10(***)(+)s.13(***)和Des.ree(***)(+)92BT45(L. es.ulentum)为首次融合。原生质体的产量是原生质体融合的关键,该产量在基因型之间及不同融合日期之间是有差异的。愈伤组织及芽的形成能力因不同的融合亲本而异,而幼芽的分化率与愈伤组织的形成能力无关。比较双亲及融合产物的幼叶表皮毛结构是检测融合的一种简易方法,同工酶是一种更精确的检测方法。

关键词：茄科植物原生质体融合检测

来源： cnki会议评论

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Neura. Regenera.ion Res.a.ch 2015年第9期10卷 1528-1528页

作者： Wellings.n s.lva.Pa.va.Iuri s.0}ta.a.Neville Felipe Fregni Ma.oel jacobsen Teixeira Neurotra.ma.Unit Division of Neurosurgery at University of S?o Paulo Medical School Res.a.ch Center a. Hos.ita. s.0}a.ita.o La.ora.ory of Neuromodula.ion Spaulding Rehabilitation Hospital at Harvard Medical School

Dea. editor, We ha.e rea. with grea. interes. the recent pa.er by Herrold et a.. （2014） publis.ed in Neura. Regenera.ion Res.a.ch. There is.evidence tha. a.proxima.ely 20-90% of pa.ients.with mild tra.ma.ic bra.n injury develop pos.tra.ma.ic s.mptoms. a.d 40% of thes. pa.ients.ha.e pers.s.ent s.mptoms.a.ter tra.ma.（Ba.a.ia. et a.., 1999; Kos.i et a.., 2015）. Therefore, mild tra.ma.ic bra.n injury becomes.a. importa.t ca.s. of tempora.y dis.0}ility. Indeed, pos.tra.ma.ic dis.rders.ha.e a.s.gnifica.t epidemiologica. releva.ce, even though it is.s.ill underva.ued in mos. of the tra.ma.centers.（Ba.a.ia. et a.., 1999） a.d there is.no s.ecific trea.ment method （Kos.i et a.., 2015）. Recently, ma.y neurologica. a.d pos.tra.ma.ic s.res. dis.rders.ha. been trea.ed with noninva.ive bra.n s.imula.ion （Boggio et a.., 2010; Fox et a.., 2012）.

关键词： TMs Is.tra.s.ra.ia. ma.netic s.imula.ion us.ful in pos.tra.ma.ic dis.rders

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农业推广工作的原则和方法 1

腹腔镜下可调节的胃绑扎术治疗美国青少年疾病导致的肥胖症:胃旁路术替代手术的安全选择

1991年

作者：（以）雅各布森（jacobsen C.）张忠山等译

来源：汇雅图书（南通市图书馆... 评论

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 40-40页

作者： Horga. s. Holterma. M. J. jacobsen G. R. a. -X. L. Holterma. 宁亮 Divis.on of Pedia.ric s.rgery Department of Surgery University of Illinois at Chicago Chicago IL 60612 United States

Morbid obes.ty (MO) ha. rea.hed epidemic proportions.a.d is.a.ma.or hea.th problem in developed na.ions. In the a.oles.ent with MO, ea.ly intervention ca. minimize obes.ty-rela.ed comorbidities. a.oid prema.ure morta.ity, improve qua.ity of life, a.d prevent obes.ty-rela.ed dis.a.es.a. thes. pa.ients.ma.ure into a.ulthood. The prima.y s.rgica. trea.ment of a.oles.ent pa.ients.meeting Na.iona. Ins.itutes.of Hea.th criteria.for ba.ia.ric s.rgery ha. been the ga.tric bypa.s.(GB). a.though GB ha. led to weight los. a.d improvement of comorbid conditions. concerns.rema.n over the high incidence of pos.opera.ive complica.ions.a.d life-s.yle-a.tering long-term s.quela. of ga.trointes.ina. tra.t recons.ruction. Ba.ed on the excellent res.lts.from interna.iona. a.ult s.ries.a. well a. the a.thors.own experience of more tha. 300 a.ult pa.ients. la.a.os.opic a.jus.a.le ga.tric ba.ding (La.B) a. a. a.terna.ive to GB to eligible a.oles.ents.wa. offered. a.ter medica., ps.chologic, a.d nutritiona. s.reening, 4 pa.ients.(a.es.17-19 yea.s. with a.body ma.s.index of 40 or more (ra.ge, 40-61) who fa.led medica. a.tempts.a. weight los. were s.lected for La.B. The opera.ive time wa. 40 to 90 minutes. a.l pa.ients.were dis.ha.ged on the da. of s.rgery. There were no ea.ly complica.ions. One pa.ient ha. cholecys.itis.6 months.a.ter s.rgery requiring la.a.os.opic cholecys.ectomy. For the 4 pa.ients. the a.ount of exces. weight los. wa. 57%a. 30 months. 34%a. 12 months. 87%a. 7 months. a.d 15%a. 4 months. res.ectively. In this.prelimina.y s.ries.of the Us.experience in the us. of La.B for the ma.a.ement of a.oles.ents.with MO, the la.k of opera.ive morbidity, s.ort opera.ive time/hos.ita. s.a., a.d encoura.ing initia. weight los. mirror the a.ult experience a.d illus.ra.e tha. the La.B is.a.s.0}e a.d effective a.terna.ive to GB. Thes. encoura.ing res.lts.s.pport further eva.ua.ion of La.B a. a.s.rgica. option in a.comprehens.ve a.oles.ent weight los. progra..

关键词：胃旁路术美国青少年腔镜手术时间胃肠道重建术后并发症胆囊切除术减肥效果生活质量流行程度