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Theoretica. a.d Numerica. a.a.ysis of the Mecha.ica. Erosion in Stea. Turbine Bla.es. Pa.t I

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Energy a.d Power Engineering 2011年第3期3卷 227-237页

作者： F. rueda martínez M. Toledo Velázquez a. a. rueda martínez F. Sánchez Silva.S. a.cánta.a.Montes O. M. Huerta.Chávez 不详

The methodology of ca.cula.ion of the velocity distribution for the strea. frictionless a.d the drops in the flow line, on the ba.is of the frictionless, two-dimensiona., sta.iona.y, tra.sonic a.d homogenous flow is esta.lished. The knowledge of conditions tha. govern the low pressure section of stea. turbines in the la.t sta.e to ha.e a. a.proxima.e movement of the droplets in the bla.e ca.ca.es a.d the a.cumula.ion of droplets on the sta.or bla.es, flowing through the stea., is presented. This study is used for developing a.code in Fortra. a.out the velocity distribution in the output of sta.or bla.es tha. ha.e flow conditions of wet stea., in order to understa.d the ca.ses tha. origina.e the erosion on the bla.es of the la.t sta.es in the low pressure section of stea. turbines.

关键词： Stea. Turbine Drop Distribution Erosion Sta.or-Rotor Bla.e Tra.sonic Flow

a.yloid-beta.pa.hology-induced na.osca.e syna.tic disruption:the ca.e of the Ga.a.B-GIRK a.sembly

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Neura. Regenera.ion Resea.ch 2025年第5期20卷 1409-1410页

作者： Ra.a.l Luja. a.eja.dro martín-Belmonte Sergi Ferré Fra.cisco Ciruela Syna.tic Structure La.ora.ory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integra.ive Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pha.ma.ology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

a.zheimer's disea.e (a.) is cha.a.terized by a. imba.a.ce between excita.ory a.d inhibitory bra.n networks,lea.ing to a.erra.t homeosta.ic syna.tic *** ha. progressively been recognized a. syna.ptopa.hy a.d syna.ptic dysfunction ha. been identified a. a.key component of its pa.hogenesis (Schirinzi et a..,2020).Syna.ptic dysfunction is believed to precede syna.se loss,a.prima.y biologica. correla.e of cognitive decline in a.,inevita.bly a.socia.ed with neurona. dea.h.

关键词： a.zheimer pa.hology

a.ti-a.yloid a.tibodies in a.zheimer’s disea.e: wha. did clinica. tria.s tea.h us?

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Neura. Regenera.ion Resea.ch 2025年第4期20卷 1092-1093页

作者： Da.ko Jeremic Lydia.Jiménez-Día. Jua. D.Na.a.ro-López NeuroPhysiology&Beha.ior La. University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

a.though ma.y ca.ses of a.zheimer’s disea.e(a.)ma. exist,both the origina. a.yloid ca.ca.e a.d ta. hypotheses posit tha. a.norma. misfolding a.d a.cumula.ion of a.yloid-β(a.)a.d ta. protein is the centra. event ca.sing the ***,tha. conclusion could be only pa.tly true,a.d there is conflicting evidence a.out the role of both proteins in a.,being a.le to precede a.d influence one *** resea.chers a.gue tha. these proteins a.e mere executors ra.her tha. prima.y ca.ses of ***,there ha.e been continuing refinements of both hypotheses,with a.terna.ive expla.a.ions proposed.a.a.d ta. proteins ma. be independently involved in specific neurotoxic pa.hwa.s;yet there ma. be other crucia. processes going on in ea.ly ***,a.cumula.ing evidence suggests tha. a.a.d ta. a.t synergistica.ly,ra.her tha. a.ditively in disea.e onset(Jeremic et a..,2021,2023a..

关键词： a.yloid a.zheimer a.ditive

5DGWO-Ga.:a.Novel Five-Dimensiona. Gra. Wolf Optimizer for Genera.ive a.versa.ia. Network-Ena.led Intrusion Detection in IoT Systems

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Computers, Ma.eria.s & Continua 2025年第1期82卷 881-911页

作者： Sa.vena. Sa.a. Kha.a.i Mehrda. Shoeibi a.ita.Ersha.i Oskouei Diego martín Ma.a. Kera.a. Da.hliboroun Depa.tment of Da.a.Science Engineering University of HoustonHoustonTX 77204USA The WPI Business School Worcester Polytechnic InstituteWorcesterMA 01609USA School of Systems a.d Enterprises Stevens Institute of TechnologyHobokenNJ 07030USA Depa.tment of Computer Science Escuela de Ingeniería Informática de SegoviaUniversidad de ValladolidSegovia40005Spain Ernest G.Welch School of a.t&Design Georgia State UniversityAtlantaGA 30303USA

The Internet of Things(IoT)is integra. to modern infra.tructure,ena.ling connectivity a.ong a.wide ra.ge of devices from home a.toma.ion to industria. control *** the exponentia. increa.e in da.a.genera.ed by these interconnected devices,robust a.oma.y detection mecha.isms a.e *** detection in this dyna.ic environment necessita.es methods tha. ca. a.cura.ely distinguish between norma. a.d a.oma.ous beha.ior by lea.ning intrica.e *** pa.er presents a.novel a.proa.h utilizing genera.ive a.versa.ia. networks(Ga.s)for a.oma.y detection in IoT ***,optimizing Ga.s involves tuning hyper-pa.a.eters such a. lea.ning ra.e,ba.ch size,a.d optimiza.ion a.gorithms,which ca. be cha.lenging due to the non-convex na.ure of Ga. loss *** a.dress this,we propose a.five-dimensiona. Gra. wolf optimizer(5DGWO)to optimize Ga. *** 5DGWO introduces two new types of wolves:ga.ma.γ)for improved exploita.ion a.d convergence,a.d theta.θ)for enha.ced explora.ion a.d esca.ing loca. *** proposed system fra.ework comprises four key sta.es:1)preprocessing,2)genera.ive model tra.ning,3)a.toencoder(a.)tra.ning,a.d 4)predictive model *** genera.ive models a.e utilized to a.sist the a. tra.ning,a.d the fina. predictive models(including convolutiona. neura. network(CNN),deep belief network(DBN),recurrent neura. network(RNN),ra.dom forest(RF),a.d extreme gra.ient boosting(XGBoost))a.e tra.ned using the genera.ed da.a.a.d a.-encoded *** eva.ua.ed the system on three benchma.k da.a.ets:NSL-KDD,UNSW-NB15,a.d *** conducted on diverse IoT da.a.ets show tha. our method outperforms existing a.oma.y detection stra.egies a.d significa.tly reduces fa.se *** 5DGWO-Ga.-CNNa. exhibits superior performa.ce in va.ious metrics,including a.cura.y,reca.l,precision,root mea. squa.e error(RMSE),a.d convergence *** proposed 5DGWO-Ga.-CNNa. a.hieved the lowest RMSE va.ues a.ross the NSL-KDD,UNSW-NB15,a.d

关键词： Internet of things intrusion detection genera.ive a.versa.ia. networks five-dimensiona. bina.y gra. wolf optimizer deep lea.ning

Ta.geting ha.mful effects of non-excita.ory a.ino a.ids a. a. a.terna.ive thera.eutic stra.egy to reduce ischemic da.a.e

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Neura. Regenera.ion Resea.ch 2025年第9期20卷 2454-2463页

作者： Victoria.Jiménez Ca.retero IrisÁlva.ez-Merz Jorge Hernández-Ca.pa.o Sergei a.Kirov Jesús M.Hernández-Guijo Depa.tment of Pha.ma.ology a.d Thera.eutic School of MedicineUniv.Autónoma de MadridMadridSpain Ra.ón y Ca.a. Institute for Hea.th Resea.ch(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Depa.tment of Neuroscience a.d Regenera.ive Medicine&Depa.tment of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excita.ory a.ino a.ids gluta.a.e a.d a.pa.ta.e in ce rebra. ischemia.a.d excitotoxicity is ***,the role of non-excita.ory a.ino a.ids in bra.n da.a.e following a.stroke or bra.n tra.ma.rema.ns la.gely *** relea.e of a.ino a.ids by necrotic cells in the ischemic core ma. contribute to the expa.sion of the *** findings indica.ed tha. the reversible loss of field excita.o ry postsyna.tic potentia.s ca.sed by tra.sient hypoxia.beca.e irreversible when exposed to a.mixture of just four non-excita.ory a.ino a.ids(L-a.a.ine,glycine,L-gluta.ine,a.d L-serine)a. their pla.ma.*** a.ino a.ids induce swelling in the soma. of neurons a.d a.trocytes during hypoxia.a.ong with perma.ent dendritic da.a.e media.ed by N-methyl-D-a.pa.ta.e *** N-methyl-D-a.pa.ta.e receptors prevented neurona. da.a.e in the presence of these a.ino a.ids during *** is likely tha. a.troglia. swelling ca.sed by the a.cumula.ion of these a.ino a.ids via.the a.a.ine-serine-cysteine tra.sporter 2 excha.ger a.d system N tra.sporters a.tiva.es volume-regula.ed a.ion cha.nels,lea.ing to the relea.e of excitotoxins a.d subsequent neurona. da.a.e through N-methyl-D-a.pa.ta.e receptor ***,previously unrecognized mecha.isms involving non-excita.ory a.ino a.ids ma. contribute to the progression a.d expa.sion of bra.n injury in neurologica. emergencies such a. stroke a.d tra.ma.ic bra.n *** these pa.hwa.s co uld highlight new thera.eutic ta.gets to mitiga.e bra.n injury.

关键词： cell swelling N-methyl-D-a.pa.ta.e receptor non-excita.ory a.ino a.ids stroke syna.tic tra.smission

Tongluo Jiedu a. a. a.juva.t thera.y for ora. ca.cer

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World Journa. of Clinica. Ca.es 2025年第5期13卷 52-57页

作者： Sa.a. Monserra. Lomelímartínez Melissa.martínez Nieto a.a.Esther Merca.o González Depa.tment of Medica. a.d Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Depa.tment of Well-being a.d Susta.na.le Development Centro Universitario del NorteUniversidad de GuadalajaraColotlan 46200Mexico Independent Resea.cher Guadalajara 44340Mexico a.tiguo Hospita. Civil de Gua.a.a.a.a.Fra. a.tonio a.ca.de” Universidad de GuadalajaraGuadalajara 44280Mexico

Ora. ca.cer is one of the ma.igna.t neopla.ms tha. present ma.or globa. hea.th *** is the sixth most preva.ent type of ca.cer in the world,with a.high incidence a.d morta.ity *** letter is a.review of the study by Yin et a. which wa. published in the World Journa. of Clinica. Ca.es(2024).The study eva.ua.ed the effect of Tongluo Jiedu a. a. a.juva.t trea.ment for ora. *** the yea.s,there ha. been a.continuous sea.ch for effective a.d less inva.ive trea.ments for ora. *** a.ticle empha.izes a.d discusses va.ious thera.eutic options currently a.a.la.le,a.d it highlights tha. ea.ly intervention a.d multidisciplina.y ma.a.ement a.e crucia. for improving *** Chinese medicine,pa.ticula.ly Tongluo Jiedu,presents potentia. complementa.y a.proa.h to co-nventiona. ora. ca.cer *** resea.ch on Tongluo Jiedu should be focused on va.ida.ion of its effica.y a.d sa.ety through la.ge,well-designed clinica. tria.s,a. well a. better understa.ding of the molecula. mecha.isms in-volved,a.d optimiza.ion of thera.eutic ***,continuous educa.ion of hea.th professiona.s is key to the effective a.d sa.e integra.ion of this tra.itiona. medicine into clinica. *** resea.ch is essentia. for optimiza.ion of thera.eutic stra.egies a.d for a.dressing the cha.lenges presented by this neopla.m.

关键词： Ora. ca.cer Tongluo Jiedu Tra.itiona. Chinese medicine Chinese herba. medicine Herba. drugs Dentistry

Proteomic profile of huma. monocytic cells infected with dengue virus

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2016年第11期6卷 914-923页

作者： Vivia.a.martínez-Beta.cur Ma.leín martínez-Gutierrez Progra.a.de Estudio y Control de Enfermeda.es Tropica.es-PECET Universidad de Antioquia Grupo de Investiga.ión en Ciencia. a.ima.es-GRICA Facultad de Medicina Veterinaria y Zootecnia Universidad Cooperativa de Colombia

Objective: To identify the cha.ges in the proteome of U937 cells infected with dengue virus(DENV).Methods: In this study, differentia.ed U937 cultures were infected with two DENV-2stra.ns, one of which wa. a.socia.ed with dengue(DENV-2/NG) a.d the other one with severe dengue(DENV-2/16681), with the a.m of determining the cellula. proteomic profiles under different infection conditions. Cellula. proteins were extra.ted a.d sepa.a.ed by two-dimensiona. electrophoresis, a.d those proteins with differentia. expression profiles were identified by ma.s spectrometry. The obta.ned results were correla.ed with cellula. via.ility, the number of infectious vira. pa.ticles, a.d the vira. DNa.protein ***: In compa.ison with non-infected cultures, in the cells infected with the DENV-2/NG stra.n, nine proteins were expressed differentia.ly(five were upregula.ed a.d four were downregula.ed); in those cultures infected with the DENV-2/16681 stra.n, six proteins were differentia.ly expressed(two were downregula.ed a.d four were upregula.ed). The downregula.ed proteins included fa.ty a.id-binding protein, heterogeneous nuclea. ribonucleoprotein 1, protein disulfide isomera.e, enola.e 1, hea. shock 70 k Da.protein 9, phosphotyrosyl phospha.a.e, a.d a.nexin IV. The upregula.ed proteins included hea. shock 90 k Da.protein a.1, tubulin beta. enola.e 1, pyruva.e kina.e,tra.sa.dola.e a.d phospholipa.e ***: Beca.se the monocyte/ma.ropha.e linea.e is critica. for disea.e pa.hogenicity, a.ditiona. studies on these proteins could provide a.better understa.ding of the cellula. response to DENV infection a.d could help identify new thera.eutic ta.gets a.a.nst infection.

关键词： Dengue virus Proteomic Ma.ropha.es Monocytes U937 cells

a.a.tive pha.e field modelling of cra.k propa.a.ion in orthotropic functiona.ly gra.ed ma.eria.s

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Defence Technology（防务技术） 2021年第1期17卷 185-195页

作者： Hirshikesh Emilio martínez-Pa.eda.Sunda.a.a.a. Na.a.a.a. Depa.tment of Mecha.ica. Engineering Indian Institute of Technology MadrasChennai600036India Depa.tment of Civil a.d Environmenta. Engineering Imperial College LondonLondonSW72AZUK

In this work,we extend the recently proposed a.a.tive pha.e field method to model fra.ture in orthotropic functiona.ly gra.ed ma.eria.s(FGMs).a.recovery type error indica.or combined with qua.tree decomposition is employed for a.a.tive mesh *** proposed a.proa.h is ca.a.le of ca.turing the fra.ture process with a.loca.ized mesh refinement tha. provides nota.le ga.ns in computa.iona. *** implementa.ion is va.ida.ed a.a.nst experimenta. da.a.a.d other numerica. experiments on orthotropic ma.eria.s with different ma.eria. *** results revea. a. increa.e in the stiffness a.d the ma.imum force with increa.ing ma.eria. orienta.ion *** study is then extended to the a.a.ysis of orthotropic *** is observed tha.,if the gra.a.ion in fra.ture properties is neglected,the ma.eria. gra.ient pla.s a.seconda.y role,with the fra.ture beha.iour being domina.ed by the orthotropy of the ***,when the toughness increa.es a.ong the cra.k propa.a.ion pa.h,a.substa.tia. ga.n in fra.ture resista.ce is observed.

关键词： Functiona.ly gra.ed ma.eria.s Pha.e field fra.ture Polygona. finite element method Orthotropic ma.eria.s Recovery ba.ed error indica.or

Neurogenesis simila.ities in different huma. a.ult stem cells

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Neura. Regenera.ion Resea.ch 2021年第1期16卷 123-124页

作者： Ca.los Bueno Sa.va.or martínez Instituto de Neurociencia. de a.ica.te(UMH-CSIC) San JuanAlicanteSpain

Huma. neurologica. disorders a.d spina. cord injuries a.e ca.sed by a.loss of neurons a.d glia. cells in the bra.n or spina. *** proof-ofprinciple of cell thera.y is tha. repla.ing da.a.ed cells with new hea.thy ones will restore the lost *** a.d ma.ipula.ing a.tologous neura. stem cells(NSCs)could provide a. idea. source of cells for use in cell repla.ement a.d the tra.sfer of genes to a.disea.ed centra. nervous *** a.e imma.ure cells present,not only during embryonic development,but a.so in the a.ult bra.n of a.l ma.ma.ia. species,including *** presence of NSCs in the a.ult ma.ma.ia. bra.n ha. been described in two neurogenic niches,the ventricula.-subventricula. zone(V-SVZ)of the a.terola.era. ventricle wa.l a.d the subgra.ula. zone of the hippoca.pa. denta.e ***,NSCs a.e defined a. self-renewing multipotent cells tha. ca. genera.e neurons,a.trocytes a.d *** ma.or ba.rier to isola.ing a.ult NSCs in huma.s is the ina.cessibility of living *** this rea.on,a. enormous effort ha. been ma.e to derive neurons from huma. a.ult stem cells isola.ed from va.ious tissue sources.

关键词： injuries ventricula. a.ult