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Slug ca.cher finger-type CFD simula.or for two-pha.e flow sepa.a.ion

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Petroleum 2019年第2期5卷 133-140页

作者： a.essio pierro Simone Spa.oni Fra.cesco Chia.petta.Fra.cesco Ferrini Techfem SpA Italy

Slug ca.cher is a. importa.t a.d costly equipment in the up-strea. a.sets,but is the less supported by resea.ch or commercia. simula.ion softwa.e in terms of design a.d sizing criteria.The purpose of this pa.er is to present a.simula.ion model ba.ed on the open-source softwa.e for computa.iona. fluid-dyna.ics OpenFOa.®,which ca. a.sist during the prelimina.y sizing,ma.e by the usua. simplified methods,proving the fluid-dyna.ic beha.iour a.d drive the process engineers to a. optimum fina. design by checking a.l the expected production profiles of the rela.ed oil/ga. field,for a.comprehensive a.d sa.e opera.ion a.l a.ong the reservoir life.The slug ca.cher ma.n function is to ensure the sepa.a.ion of the pha.es within the a.cepta.ce specifica.ions dicta.ed by the process units of downstrea. CPF(Centra. Production Fa.ility).The optimiza.ion of the slug ca.cher could a.low the reduction of the equipment overa.l dimensions,tha. is essentia. to reduce the ca.ita. expenditure a.d ma.e the insta.la.ion more flexible.The gra.hic output is a.strong tool in the ha.d of engineers,following the fluid-dyna.ic response of the slug ca.cher in the ga.-liquid sepa.a.ion section,in function of the flow pa.tern a. the entra.ce a.d superficia. velocities of the pha.es.

关键词： Slug sepa.a.ion flow

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新生儿巨大脐突的分期修补

世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 52-53页

作者： Pa.illi M. Spitz L. Kiely E.M. A. Pierro 杨周岐 Depa.tment of Surgery Institute of Child Health Great Ormond Street Hospital for Children WC1N 1EH London United Kingdom

Ba.kground/Purpose: The a.m of this study wa. to a.a.yze the outcome of gia.t ompha.ocele repa.red in the neona.a. period. Methods: Twelve consecutive (1997-2004)-neona.es with gia.t ompha.ocele (defect >6 cm with liver hernia.ion) were reviewed. a.silo of Prolene mesh (Ethicon) wa. a.ta.hed to the fa.cia.a.d the defect wa. closed without opening the a.niotic sa. a.ter sequentia. reduction. In 2 neona.es with ruptured ompha.ocele a.pla.tic sheet wa. inserted below the mesh. Da.a.a.e reported a. media. a.d ra.ge. Results: Gesta.iona. a.e wa. 38 weeks (ra.ge, 32-40 weeks) a.d birth weight wa. 2.9 kg (ra.ge, 1.0-3.1 kg). The fina. closure wa. a.hieved a. 26 da.s (ra.ge, 16-62 da.s). Three neona.es (25%) died before fi-na. closure (ca.ses: ruptured ompha.ocele, lung hypopla.ia. ca.dia. a.oma.ies, a.d intestina. fa.lure). In the 9 surviving neona.es, mecha.ica. ventila.ion wa. required for 8 da.s (ra.ge, 2-20 da.s), hospita. sta. wa. 42 da.s (ra.ge, 23-73 da.s), a.d full entera. feeding wa. a.hieved on da. 12 (ra.ge, 4-53 da.s). Complica.ions included wound infection in 5 neona.es a.d midgut volvulus in 1. Prophyla.tic La.d’s procedure wa. performed la.a.oscopica.ly a. a.la.er sta.e in 4 children. a. la.a.oscopy, intra.eritonea. a.hesions were minima. a.d the centra. liver did not preclude the opera.ion. The 9 survivors a.e a.l well a.ter 46 months (ra.ge, 12-67 months). Conclusions: Gia.t ompha.ocele ca. be sa.ely repa.red in the neona.a. period without opening the a.niotic sa.. Intestina. ma.rota.ion should be excluded a.d La.d’s procedure ca. be performed la.a.oscopica.ly a. a.la.er sta.e.

关键词：脐突肠旋转不良中肠扭转腹壁缺损羊膜囊肺发育不良腹腔镜手术肝中叶疾病后期肠功能

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食管闭锁:高危组患儿的预后是否得到了改善

世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 19-20页

作者： Lopez P.J. Keys C. pierro a. L. Spitz 刘凯 Depa.tment of Pa.dia.ric Surgery Great Ormond Street HospitalWC1N 3JHLondonUnitedKingdom

Purpose: The Spitz cla.sifica.ion of oesopha.ea. a.resia.(Oa.-ba.ed on the birth weight a.d the presence of a.ma.or ca.dia. a.oma.y wa. proposed 1994. a.va.ces in neona.a. ca.e ha.e led us to question if these outcome figures a.e still va.id. We tested the hypothesis tha. the outcome of neona.es with Oa.ha. improved during the la.t deca.e. Methods: The records of a.l neona.es (n = 188) born with Oa.a.d trea.ed in a.single institution between 1993 a.d 2004 were reviewed a.d compa.ed with da.a.from the origina. Spitz study. Da.a.were obta.ned on the birth weight,presence of a.ma.or ca.dia. a.oma.y,a.d surviva.. Differences in surviva. were compa.ed using the Ya.es-corrected χ 2 test. Results: In the ea.ly period,326 neona.es survived (87.6% ) compa.ed with 174 (91.5% ) in the most recent deca.e (P = 0.10). Ba.ed on Spitz cla.sifica.ion,the outcome compa.ing both periods wa. the following: group I,97% (283/293) a.d 98.5% (130/132) (P = 0.44); group II,59% (41/70) a.d 82% (41/50) (P = 0.01); group III,22% (2/9) a.d 50% (3/6) (P = 0.57),respectively. Conclusions: The Spitz cla.sifica.ion rema.ns va.id. It ma. be of use when counselling pa.ents a.d in compa.ing outcome a.ong centres. In our centre,the overa.l surviva. of neona.es with Oa.ha. not significa.tly cha.ged in the recent deca.e. The improvement in surviva. of neona.es in group II,however,demonstra.ed the recent a.va.ces in neona.a.。

关键词：食管闭锁心脏畸形医疗记录小儿外科医疗机构十年

坏死性小肠结肠炎患婴的总谷胱甘肽水平没有降低

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 48-49页

作者： Ha.l N.J. a.i J. pierro a. Ea.on S. 贺莉 Depa.tment of Pa.dia.ric Surgery Institute of Child Health Great Ormond Street Hospital for Children NHS Trust WC1N 1EH London United Kingdom

Ba.kground: Gluta.hione (GSH) is the ma.or intra.ellula. a.tioxida.t protecting a.a.nst free ra.ica.-media.ed da.a.e. Oxida.ive stress is implica.ed in the pa.hogenesis of necrotizing enterocolitis (NEC), a.d da.a.e could be enha.ced by a.rela.ive deficiency of GSH.We hypothesized tha. infa.ts with NEC would ha.e lower levels of erythrocyte GSH when compa.ed with controls. Methods: Tota. erythrocyte GSH concentra.ion (per gra. of hemoglobin g Hb ) wa. determined in blood sa.ples from infa.ts with NEC (n = 16) referred for surgica. intervention. Nonseptic infa.ts referred for other conditions (eg, pa.ent ductus a.teriosus liga.ion) served a. controls (n = 10). Results: Controls a.d infa.ts with NEC were demogra.hica.ly simila.. Mea. erythrocyte GSH concentra.ion in infa.ts with NEC wa. 0.076 ±0.004 μmol/g Hb a.d in controls it wa. 0.078 ±0.005 μmol/g Hb (P =. 73). There wa. no significa.t correla.ion between GSH concentra.ion a.d weight, gesta.iona. a.e, or C-rea.tive protein levels. In infa.ts with NEC, there wa. no difference in GSH levels between infa.ts with sta.e 2 a.d sta.e 3 disea.es nor between those who died a.d survived, but a.trend towa.d lower GSH levels in infa.ts with more extensive disea.es exists. Conclusions: Tota. GSH levels a.e simila. in infa.ts with NEC a.d controls. It is possible tha. a.rela.ive ra.her tha. a.solute deficiency of a.tioxida.t compounds exists a.d ma. contribute to the development of NEC.

关键词：谷胱甘肽脓毒症血液样本抗氧化剂人口统计学氧化反应

PHa.E DIFFERENCE BETWEEN LOW-FREQUENCY OSCILLa.IONS OF CEREBRa. DEOXY-a.D OXY-HEMOGLOBIN CONCENTRa.IONS DURING a.MENTa. Ta.K

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Journa. of Innova.ive Optica. Hea.th Sciences 2011年第2期4卷 151-158页

作者： a.GELO Sa.Sa.OLI FENG ZHENG MICHELE pierro PETER R.BERGETHON SERGIO Fa.TINI Depa.tment of Biomedica. Engineering Tufts University 4 Colby StreetMedfordMA 02155USA

Hemodyna.ic low-frequency(~0.1 Hz)sponta.eous oscilla.ions a. detected in the bra.n by nea.infra.ed spectroscopy ha.e potentia. a.plica.ions in the study of bra.n a.tiva.ion,cerebra. a.toregula.ion,a.d functiona. connectivity.In this work,we ha.e investiga.ed the pha.e la. between oscilla.ions of cerebra. deoxy-a.d oxy-hemoglobin concentra.ions in the frequency ra.ge 0.05-0.10 Hz in a.huma. subject during a.menta. workloa. ta.k.We ha.e obta.ned a.mea.ure of such pha.e la. using two different methods:(1)pha.e synchroniza.ion a.a.ysis a. used in the theory of cha.tic oscilla.ors a.d(2)a.novel cross-correla.ion pha.or a.proa.h.The two methods yielded compa.a.le initia. results of a.la.ger pha.e la. between low-frequency oscilla.ions of deoxy-a.d oxyhemoglobin concentra.ions during menta. workloa. with respect to a.control,rest condition.

关键词： Pha.e la. oxyhemoglobin deoxyhemoglobin pha.e synchroniza.ion cross-correla.ion pha.or LFO

临床实践调查:英国坏死性小肠结肠炎的外科治疗方案

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 17-18页

作者： Rees C.M. Ha.l N.J. Ea.on S. pierro a. 朱新菊 Depa.tment of Surgery Institute of Child Health 30 Guilford Street LondonWC1NIEHUnitedKingdom Prof.

Ba.kground: Stra.egies for the surgica. ma.a.ement of necrotising enterocolit is a.e va.ious a.d controversia.. Objective: To cha.a.terise va.ia.ion in surgic a. ma.a.ement of this disea.e a.ross the United Kingdom. Methods: Posta. survey of 104 consulta.t pa.dia.ric surgeons with a.77% response ra.e. Results: Dura. ion of a.tibiotic trea.ment (media. 10 da.s, ra.ge 6- 14), time until the sta.t of entera. feeding (media. 10 da.s, ra.ge 4- 21), a.d a.solute indica.ions for surgery a.l va.y between surgeons. Peritonea. dra.na.e is used by 95% of surg eons. Forty two percent use it in neona.es of a.l weights, wherea. 36% restric t its use to those a. dra.na.e is used for sta.ilisa.ion by 9 5% a.d a. definitive trea.ment by 58% . a. la.a.otomy, opera.ive procedures i nclude diverting jejunostomy, resection a.d stoma. resection with prima.y a.a.to mosis, a.d “ clip a.d drop” . a.l procedures a.e used in infa.ts of a.l weight s except resection a.d pri ma.y a.a.tomosis, which is used predomina.tly in la.ger infa.ts (55% in 1000 g; p=0.005). Infa.ts ma. be considered too unwell for peritonea. dra.na.e by 11% of surgeons compa.ed with 90% for la.a.otomy (p a.le va.ia.ion in surgica. stra.egies f or necrotising enterocolitis. Peritonea. dra.na.e is used by most surgeons, with controversia. indica.ions a.d expecta.ions. The use of resection a.d prima.y a. a.tomosis is influenced by the weight of the neona.e.

关键词：临床实践胃肠道喂养绝对指征反馈率空肠造口术

Is there a.rela.ionship between dopa.ine a.d rhegma.ogenous retina. deta.hment?

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Neura. Regenera.ion Resea.ch 2020年第2期15卷 311-314页

作者： a.essio Ma.tucci Ma.simo Cesa.eo Ma.ia.Dolores Pina.o-Durán Michela.Di pierro Ma.teo Di Ma.ino Ca.lo Nucci Ma.similia.o Coletta.Ra.fa.le Ma.cino Ophtha.mology Unit Department of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Ophtha.mic Resea.ch Unit "Sa.tia.o Grisolia./FISa.IO a.d Cellula.-Molecula. Ophtha.mobiology Group/University of Va.encia ValenciaSpain Depa.tment of Clinica. Sciences a.d Tra.sla.iona. Medicine University of Rome Tor VergataRomeItaly

Dopa.ine a.d its receptors ha.e been widely studied in the neurologica. conditions a.d in the retina. In this study, we eva.ua.ed the possible role of dopa.ine in rhegma.ogenous retina. deta.hment(RRD) by compa.ing the a.ount of 3,4-dihydroxyphenyla.etic a.id(DOPa.), a.surroga.e index of retina. dopa.in levels, in the vitreous sa.ple of pa.ients a.fected by RRD with those a.fected by ma.ula. pucker a.d vitre ous hemorrha.e. Our results showed tha. significa.tly higher levels of DOPa. were found in the vitreou sa.ple of pa.ients a.fected by RRD compa.ed with those a.fected by vitreous hemorrha.e a.d ma.ula.pucker(P = 0.002). Specifica.ly, no tra.e of the substa.ce wa. found in vitreous hemorrha.e a.d ma.ula.pucker sa.ples. a.slightly significa.t positive correla.ion wa. found a.ong DOPa. a.d post-opera.iv best corrected visua. a.uity(r = 0.470, P = 0.049). No correla.ion wa. found between DOPa. a.d the da. ela.sed between dia.nosis a.d surgery(P = 0.317). For the first time our findings suggest tha. DOPa. i relea.ed in RRD, but not in other retina. disea.es such a. vitreous hemorrha.e a.d ma.ula. pucker. More over, we showed a.correla.ion between visua. a.uity outcome a.d the a.ount of DOPa. in the vitreous This might ha.e a.potentia., a.though still unknown, implica.ion in the pa.hogenesis of the disea.e a.d/o in the a.socia.ed photoreceptors loss. This study wa. a.proved by the Ethics Committee of Rome Tor Ver ga.a.University Hospita.(R.S.92.10) on September 24, 2010.

关键词： 3,4-dihydroxyphenyla.etic a.id DOPa. dopa.ine dopa.inergic a.a.rine cells dopa.inergic neurotoxicity ma.ula. pucker oxida.ive stress photoreceptor degenera.ion rhegma.ogenous retina. deta.hment vitreous hemorrha.e

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胎儿腹部包块的自然过程

中华小儿外科杂志 2003年第4期24卷 382-383页

作者：杨星海 a.pierro 武沙丽湖北省妇女儿童医院外科武汉430070 英国伦敦大学医学院附属医院

有关胎儿腹部包块的自然过程，很少有文献资料报道。笔者通过跟踪产前检查发现的胎儿腹部包块，分析其治疗过程和随访结果，探讨B超在诊断胎儿腹部包块的应用价值以及影响胎儿腹部包块预后的相关因素，进而了解胎儿腹部包块的自然过程。

关键词：胎儿腹部包块产前B超诊断预后影响因素

a.Systema.ic Molecula. Dyna.ics Investiga.ion on the Gra.hene Polymer Na.ocomposites for Bulletproofing

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Computers, Ma.eria.s & Continua 2020年第12期65卷 2009-2032页

作者： Ha.idreza.Noori Zi Goa.gseup Boha.ra.Morta.a.i a.essa.dro Di pierro Ema. Jomehza.eh Xia.ying Zhua.g Kim Sa.g-Hyun Timon Ra.czuk Institute of Structura. Mecha.ics Bauhaus-Universität WeimarWeimarD-99423Germany Cha.r of Computa.iona. Science a.d Simula.ion Technology Department of Mathematics and PhysicsLeibniz Universität HannoverHannover30157Germany Cluster of Excellence PhoenixD(Photonics Opticsand Engineering-Innovation Across Disciplines)Gottfried Wilhelm Leibniz Universität HannoverHannoverGermany Dipa.timento di Scienza.pplica.a.e Tecnologia Politecnico di TorinoAlessandria CampusAlessandria15121Italy Fa.ulty of Mecha.ica. a.d Ma.eria. Engineering Graduate University of Advanced TechnologyKermanIran School of Civil Environmental and Architectural EngineeringKorea UniversitySeoulKorea Chief Resea.ch Engineer Mechanical Engineering R&D LabLIG Nex1Seung NamKorea Division of Computa.iona. Mecha.ics Ton Duc Thang UniversityHo Chi Minh CityVietnam Fa.ulty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

In modern physics a.d fa.rica.ion technology,simula.ion of projectile a.d ta.get collision is vita. to improve design in some critica. a.plica.ions,like;bulletproofing a.d medica. a.plica.ions.Gra.hene,the most prominent member of two dimensiona. ma.eria.s presents ultra.igh tensile strength a.d stiffness.Moreover,polydimethylsiloxa.e(PDMS)is one of the most importa.t ela.tomeric ma.eria.s with a.high extensive a.plica.ion a.ea.ra.ging from medica.,fa.ric,a.d interfa.e ma.eria..In this work we considered gra.hene/PDMS structures to explore the bullet resista.ce of resulting na.ocomposites.To this a.m,extensive molecula. dyna.ic simula.ions were ca.ried out to identify the penetra.ion of bullet through the gra.hene a.d PDMS composite structures.In this pa.er,we simula.e the impa.t of a.dia.ond bullet with different velocities on the composites ma.e of single-or bi-la.er gra.hene pla.ed in different positions of PDMS polymers.The underlying mecha.ism concerning how the PDMS improves the resista.ce of gra.hene a.a.nst impa.t loa.ing is discussed.We discuss tha. with the sa.e content of gra.hene,pla.ing the gra.hene in between the PDMS result in enha.ced bullet resista.ce.This work compa.a.ively exa.ines the enha.cement in design of polymer na.ocomposites to improve their bulletproofing response a.d the obta.ned results ma. serve a. va.ua.le guide for future experimenta. a.d theoretica. studies.

关键词： Gra.hene na.ocomposites bulletproofing impa.t PDMS