坏死性小肠结肠炎患婴的总谷胱甘肽水平没有降低

作     者：Hall N.J. Ali J. Pierro A. Eaton S. 贺莉 

作者机构：Department of Paediatric Surgery Institute of Child Health Great Ormond Street Hospital for Children NHS Trust WC1N 1EH London United Kingdom 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第11期

页      面：48-49页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：谷胱甘肽 脓毒症 血液样本 抗氧化剂 人口统计学 氧化反应 

摘      要：Background: Glutathione (GSH) is the major intracellular antioxidant protecting against free radical-mediated damage. Oxidative stress is implicated in the pathogenesis of necrotizing enterocolitis (NEC), and damage could be enhanced by a relative deficiency of GSH.We hypothesized that infants with NEC would have lower levels of erythrocyte GSH when compared with controls. Methods: Total erythrocyte GSH concentration (per gram of hemoglobin g Hb ) was determined in blood samples from infants with NEC (n = 16) referred for surgical intervention. Nonseptic infants referred for other conditions (eg, patent ductus arteriosus ligation) served as controls (n = 10). Results: Controls and infants with NEC were demographically similar. Mean erythrocyte GSH concentration in infants with NEC was 0.076 ±0.004 μmol/g Hb and in controls it was 0.078 ±0.005 μmol/g Hb (P =. 73). There was no significant correlation between GSH concentration and weight, gestational age, or C-reactive protein levels. In infants with NEC, there was no difference in GSH levels between infants with stage 2 and stage 3 diseases nor between those who died and survived, but a trend toward lower GSH levels in infants with more extensive diseases exists. Conclusions: Total GSH levels are similar in infants with NEC and controls. It is possible that a relative rather than absolute deficiency of antioxidant compounds exists and may contribute to the development of NEC.