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Ma.erna. beta.ne suppresses a.rena. expression of cholesterol tra.ficking genes a.d decrea.es pla.ma.corticosterone concentra.ion in offspring pullets

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Journa. of a.ima. Science a.d Biotechnology 2020年第1期11卷 241-250页

作者： Ha.ima.a.oba.er Yun Hu Na.meldin a.omer Zhen Hou a.dulra.ma. a.Idriss Ruqia. Zha. MOE Joint Interna.iona. Resea.ch La.ora.ory of a.ima. Hea.th&Food Sa.ety Nanjing Agricultural UniversityNanjing 210095People’s Republic of China Key La.ora.ory of a.ima. Physiology&Biochemistry Nanjing Agricultural UniversityNanjing 210095People’s Republic of China College of a.lied Medica. Sciences University of Nyala155 NyalaSudan.

Ba.kground:La.ing hens supplemented with beta.ne demonstra.e a.tiva.ed a.rena. steroidogenesis a.d deposit higher corticosterone(CORT)in the egg *** we further investiga.e the effect of ma.erna. beta.ne on the pla.ma.CORT concentra.ion a.d a.rena. expression of steroidogenic genes in offspring ***:Ma.erna. beta.ne significa.tly reduced(Pa.ma.CORT concentra.ion a.d the a.rena. expression of vimentin tha. is involved in tra.ficking cholesterol to the mitochondria.for utiliza.ion in offspring ***,volta.e-dependent a.ion cha.nel 1 a.d steroidogenic a.ute regula.ory protein,the two mitochondria. proteins involved in cholesterol influx,were both down-regula.ed a. m RNa.a.d protein ***,enzymes responsible for steroid syntheses,such a. cytochrome P450 fa.ily 11 subfa.ily a.member 1 a.d cytochrome P450 fa.ily 21 subfa.ily a.member 2,were significa.tly(Pa.ed a. m RNa.or protein levels in the a.rena. gla.d of pullets derived from beta.ne-supplemented ***,expression of tra.scription fa.tors,such a. steroidogenic fa.tor-1,sterol regula.ory element-binding protein 1 a.d c a.P response element-binding protein,wa. significa.tly(Pa.ced,together with their downstrea. ta.get genes,such a. 3-hydroxy-3-methyl-gluta.yl-coenzyme a.reducta.e,LDL receptor a.d sterol regula.ory element-binding protein clea.a.e-a.tiva.ing *** promoter regions of most steroidogenic genes were significa.tly(Pa.ed,a.though methyl tra.sfer enzymes,such a. a.CYL,GNMT1 a.d BHMT were ***:These results indica.e tha. the reduced pla.ma.CORT in beta.ne-supplemented offspring pullets is linked to suppressed cholesterol tra.ficking into the mitochondria.despite the a.tiva.ion of cholesterol a.d corticosteroid synthetic genes a.socia.ed with promoter hypomethyla.ion.

关键词： a.rena. gla.d Chicken Cholesterol Corticosterone Ma.erna. beta.ne Steroidogenesis

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New a.proa.h to Solve Cubic Objective Function Progra.ming Problem

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a.erica. Journa. of Opera.ions Resea.ch 2022年第3期12卷 83-93页

作者： Media.a. omer Nejma.din a. Sula.ma. Depa.tment of Ma.hema.ics College of Education Salahaddin University Erbil Iraq

In this pa.er, a.cubic objective progra.ming problem (COPP) is defined. Introduced a.new modifica.ion to solve a.cubic objective progra.ming problem. Suggested a. a.gorithm for its solution. a.so reported the a.gorithm of the usua. simplex method. a.plica.ion ta.ks a.out how the developed a.gorithm ca. be used to unra.el non-linea.. The proposed technique, modifica.ion simplex technique, ca. be used with the constructed numerica. exa.ples a. illustra.ive numerica. problems a.e given to demonstra.e the a.gorithms.

关键词： New a.proa.h Cubic Objective Progra.ming Problem Simplex Method

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Pa.tia. Qua.ity a.sessment of <sup>60</sup>Co-Telethera.y Ma.hine Performa.ce

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Open Journa. of Ra.iology 2015年第4期5卷 235-242页

作者： Moha.med a. a.i omer College of Medica. Ra.iologic Science Sudan University of Science and Technology Khartoum Sudan Depa.tment of Ra.iologic Technology College of Applied Medical Science Qassim University Buraidah Saudi Arabia

The a.m of this study wa. to a.sess the performa.ce of 60Co-telethera.y unit a. Ra.ia.ion a.d Isotopes Center in Kha.toum, using the common tools used for qua.ity control (Front pointer, Gra.hic pa.er, Pin, Non-screen film, meter a.d Check pla.e). The collected a.d a.a.yzed da.a.revea.ed tha.: there wa. a.difference between the ca.cula.ed theoretica. field size (FS) a.d the mea.ured one rela.ive to the cha.ge of SSD;a.d the a.era.e FS shift wa. 0.9 cm rela.ive to the sta.da.d one, while the ma.hine isocenter wa. a.most fixed a. 0° with a.shift of 0.003 cm, which wa. within the sta.da.d limit (0.2 cm). The dia.hra.m isocenter showed a.shift of ±0.36 cm (i.e. in clock a.d a.ti clock wise) in a.era.e rela.ive to sta.da.d limit (±0.3 cm) a.d the couch vertica. isocenter (CVI) rela.ive to the SSD cha.ges wa. exceeded the sta.da.d limit (0.2 cm) by a.fa.tor of 0.9 cm. a.so the SSD determined by the optica. dista.ce indica.or wa. grea.er tha. the a.tua. SSD (determined by Front pointer a.d mea.ured by sca.e meter) by a. a.era.e of 0.8 cm;which exceeded the limit (0.3 cm) by a. a.era.e fa.tor of 0.5 cm. The study a.so showed tha. the penumbra.profile (1.5 cm) wa. less tha. the a.tua. specified for 60Co-telethera.y ma.hine, while the ra.ia.ion bea. wa. so homogeneous a.ross the field size.

关键词： 60Co-Qua.ity Control Telethera.y Ra.iothera.y a.sura.ce

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Response surfa.e methodology-ba.ed optimiza.ion of ultra.ound-a.sisted extra.tion of β-sitosterol a.d lupeol from a.tra.a.us a.ropilosus(roots) a.d va.ida.ion by HPTLC method

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2020年第6期10卷 281-292页

作者： Perwez a.a. Na.ir a.Siddiqui a.i S.a.qa.ta.i a.za.ul Ha.ue omer a.Ba.uda. Sa.eh I.a.qa.oumi M.U.Kha. Depa.tment of Pha.ma.ognosy College of PharmacyKing Saud UniversityP.O.Box-2457Riyadh-11451Saudi Arabia Depa.tment of Pha.ma.ognosy College of PharmacyPrince Sattam bin Abdulaziz UniversityAl-KharjKSA Depa.tment of Pha.ma.eutica. Chemistry&Pha.ma.ognosy Unaizah College of PharmacyQassim UniversityAl QassimSaudi Arabia

Objective:To optimize the ultra.onica.ion method for efficient extra.tion ofβ-sitosterol a.d lupeol from the roots of a.tra.a.us a.ropilosus using Box-Behnken design of response surfa.e methodology(RSM),a.d its va.ida.ion by high performa.ce thin la.er chroma.ogra.hy(HPTLC)***:Ultra.onica.ion method wa. used to extra.tβ-sitosterol a.d lupeol from a.tra.a.us a.ropilosus(roots).RSM wa. used to optimize the different extra.tion pa.a.eters *** to solid ra.io(10–14 m L/g),tempera.ure(60-80℃)a.d time(40–60 min)to ma.imize the yield ofβ-sitosterol a.d *** qua.tita.ive estima.ion ofβ-sitosterol a.d lupeol wa. done in chloroform extra.t of a.tra.a.us a.ropilosus by va.ida.ed HPTLC method on 10 cm×20 cm gla.s-ba.ked silica.gel 60 F254 pla.e using hexa.e a.d ethyl a.eta.e(8:2,v/v)a. mobile ***:a.qua.ra.ic polynomia. model wa. found to be most a.propria.e with rega.d to R1(yield of tota. extra.tion;R2/%CV=0.9948/0.28),R2(β-sitosterol yield;R2/%CV=0.9923/0.39)a.d R3(lupeol yield;R2/%CV=0.9942/0.97).The va.ues of a.justed R2/predicted R2/signa. to noise ra.io for R1,R2,a.d R3 were 0.9782/0.9551/48.77,0.9904/0.9110/31.33,a.d 0.9927/0.9401/36.08,respectively,indica.ing a.high degree of correla.ion a.d a.equa.e *** linea. correla.ion plot between the predicted a.d experimenta. va.ues for R1,R2,a.d R3 showed high va.ues of R2 ra.ging from 0.9905-0.9973.β-sitosterol a.d lupeol in chloroform extra.t of a.tra.a.us a.ropilosus were detected a. Rf va.ues of 0.22 a.d 0.34,respectively,a.λma.=518 *** optimized ultra.onic extra.tion produced 8.462%w/w of R1,0.451%w/w of R2 a.d 0.172%w/w of R3 a. 13.5 m L/g liquid to solid ra.io,78℃of tempera.ure a.d 60 min of ***:The experimenta. findings of RSM optimized extra.tion a.d HPTLC a.a.ysis ca. be further a.plied for the efficient extra.tion ofβ-sitosterol a.d lupeol in other species of a.tra.a.us.

关键词： β-sitosterol Lupeol Box-Behnken design a.tra.a.us High performa.ce thin la.er chroma.ogra.hy

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Ca.na.is Use a.ong People with Menta. Illness: Clinica. a.d Socio-Demogra.hic Cha.a.teristics

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Open Journa. of Psychia.ry 2018年第3期8卷 244-252页

作者： Sumia.a. a. a.izi a.dela.iz a. omer a.ir a. Mufa.del Suda. Medica. Specia.iza.ion Boa.d Khartoum Sudan Depa.tment of Psychia.ry University of Khartoum Sudan Depa.tment of Psychia.ry Mediclinic Al Jawhara Hospital Al Ain United Arab Emirates

Ba.kground: Ca.na.is ca. be a.socia.ed with short-term a.d long-term a.verse effects such a. psychotic sta.es, risk of dependence, provoking rela.se a.d a.gra.a.ing existing psychotic symptoms. a.m: The current study is a.descriptive cross-sectiona. hospita. ba.ed study tha. a.ms to identify the preva.ence a.d correla.es of ca.na.is use a.ong pa.ients with menta. illness. Methods: The study wa. conducted in two outpa.ient psychia.ry clinics in Kha.toum (Suda.). The sa.ple size wa. 348 consecutive pa.ients over 2 months’ study period. Clinica. a.d sociodemogra.hic cha.a.teristics were documented. Descriptive sta.istics wa. used to describe the da.a.va.ia.les, a.d ta.ula.ed ta.les were used to ca.cula.e chi-squa.e test for ca.egorica. da.a.a.d the significa.ce wa. set a. p Results: a.tota. of 96 pa.ticipa.ts (27.6%) ha. history of ca.na.is a.use;a.l of them were ma.e pa.ients. The ma.ority (51%) sta.ted to use ca.na.is between 10 - 19 yea.s of a.e, a.d most of them (86.6%) ha. a.dura.ion of less tha. five yea.s of using ca.na.is. Psychia.ric symptoms occurred a.ter sta.ting ca.na.is use in 17.7% of ca.es. We found a.sta.istica.ly significa.t difference rela.ed to a.e when compa.ing the a.e of ca.na.is users a.d non-users (p = 0.0239). The ma.ority of pa.ients with comorbid menta. illness a.d ca.na.is a.use (89.5%) were below the a.e of 40 yea.s. There wa. a.so sta.istica.ly significa.t a.socia.ion between educa.iona. level a.hieved a.d history of using ca.na.is (p = 0.00001). Those with history of ca.na.is a.e more likely to be ma.ua. la.orers (46.9%), a.d those with no history of ca.na.is were mostly unemployed (44%), indica.ing significa.t influence of employment history (p = 0.0064). The rela.ion between using ca.na.is a.d the clinica. psychia.ric dia.nosis wa. not sta.ica.ly significa.t (p = 0.125). Conclusion: Ca.na.is use is highly preva.ent a.ong people with menta. illness. It is rela.ed to a.e, educa.iona. level a.d type of work.

关键词： Ca.na.is Sociodemogra.hic Psychia.ric Disorders Schizophrenia Mood Disorders

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Psychia.ric a.pects of Infectious Disea.es

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Open Journa. of Psychia.ry 2014年第3期4卷 202-217页

作者： a.ir Mufa.del a.dela.iz a. omer Moha.ed Oma. Sa.em a.-a.li Hospita. Doha Qatar Community Menta. Hea.th Services Behavioural Sciences Institute Al Ain Hospital UAE University of Kha.toum Khartoum Sudan

Psychia.ric symptoms ca. be a.socia.ed with severa. systemic a.d centra. nervous system infections a.d they ca. be the initia. presenting symptoms, occurring in the a.sence of neurologica. symptoms in some disorders a. in some ca.es of vira. encepha.itis. They could a.so be pa.t of the clinica. picture in other ca.es such a. psychosis or mood symptoms seconda.y to brucellosis or toxopla.mosis. La.e-onset neuropsychia.ric complica.ions ma. a.so occur severa. yea.s following the infection such a. in the ca.e of suba.ute sclerosing pa.encepha.itis due to mea.les. Some Infectious disea.es ma. ha.e possible etiologica. role for ma.or psychia.ric disorders, ba.ed on yet unconfirmed reports for vira. infectious disea.es (e.g. Influenza.virus a.d HSV-1) which a.e thought to ha.e risk for developing schizophrenia.a.d psychosis. Neuropsychia.ric a.verse effects ca. occur due to drugs (e.g. mefloquine, interferon-a.pha. tha. a.e used for trea.ment of infectious disea.es. Psychia.ric symptoms ca. a.so be rea.tiva.ed resulting from chronic, complica.ed a.d serious infections such a. HIV tha. ca. lea. to depression, a.xiety or a.justment disorders, a.though CNS involvement ca. a.so be a.possible etiologica. fa.tor. Pa.ients suffering from prima.y a.d severe psychia.ric disorders a.e a. increa.ed risk of contra.ting infection;tha. is ma.nly rela.ed to high risk beha.iors in pa.ients with ma.ia.or schizophrenia. It is a.so importa.t to consider tha. the co-occurrence of psychia.ric symptoms a.d infection ca. be incidenta. (i.e. infectious disea.es ca. occur in psychia.ric pa.ients rega.dless of the a.ove mentioned fa.tors). Ea.ly identifica.ion of the underlying etiology for orga.ic/seconda.y psychia.ric symptoms is essentia. for a.propria.e intervention a.d ea.ly trea.ment of the prima.y condition tha. could be the etiology of psychia.ric symptoms so a. to a.oid unnecessa.y long-term psychia.ric trea.ment a.d to a.oid complica.ions of possible misdia.nosis or dela.ed dia.nosis of

关键词： Ba.teria. Infections Vira. Infections Pa.a.itic Infections Psychia.ric Symptoms Neuropsychia.ric Fea.ures

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Trea.ment of Swine Slurry by a. Ozone Trea.ment System to Reduce Odor

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Journa. of Environmenta. Protection 2011年第7期2卷 867-872页

作者： a. R. omer Pa.l M. Wa.ker 不详

Development of a.technology tha. ca. reduce the odor of liquid swine ma.ure during a.ita.ion a.d la.d a.plica.ion could prove beneficia. to the swine industry. The purpose of this study wa. to eva.ua.e a.commercia. ozone trea.ment system for swine slurry under production sca.e conditions. The fa.ility used for this study wa. a.curta.n sided finishing building housing 500 grow–finish ma.ket hogs loca.ed over a.ma.ure pit mea.uring 12.2 m wide × 25.9 m long × 2.4 m deep with a.tota. pit ca.a.ity of 770,142 l, conta.ning 577,607 l. The system eva.ua.ed exposes a.r to ultra.violet light crea.ing O3. The O3 is then injected into slurry a. a.ra.e of 851.6 l/min. trea.ing 51,097 l/h. In this study the entire pit contents were trea.ed every 11.3 h. a. 0, 24, 48, a.d 96 h two slurry sa.ples were collected with a.3.05 m probe a.d six a.r sa.ple ba.s were collected via.a.va.uum pump. No significa.t differences were detected in slurry sa.ples between time periods. Mea. slurry va.ues were 13.6 ± 4.6% solids dry wt., 850 ± 70 mg/l setta.le solids, 54,200 ± 4384 mg/l tota. suspended solids, 61,050 ± 12,657 mg/l chemica. oxygen dema.d, 0.86 ± 0.14%N, 0.49 ± 0.27%P, 0.45 ± 0.01%K a.d dissolved oxygen below detection limits. a.monia.concentra.ions decrea.ed (P = 0.004) from 0 to 96 h. Odor pa.elists a.a.yzed a.r sa.ples for intensity a. recognition (IR), offensiveness a. recognition (OR), intensity a. full strength (IFS) a.d offensiveness a. full strength (OFS). Pa.elists found OR, IFS a.d OFS were reduced (P a. 48 h a.d 96 h compa.ed to 0 h a.d IR wa. reduced (P a. 24 h a.d 48 h a.d not a. 96 h but trended lower (P = 0.12) a. 96 h. The system eva.ua.ed significa.tly improved a.r qua.ity within the building suggesting tha. odor ema.a.ing from swine buildings a.d odor genera.ed during la.d a.plica.ion of slurry should be reduced.

关键词： Swine Slurry Odor Trea.ment Ozone

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The Impa.t of Obesity on the Left Ventricula. Ejection Fra.tion Using Echoca.diogra.hy

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Open Journa. of Medica. Ima.ing 2014年第4期4卷 172-177页

作者： Ba.a.edin a. Elkha.er a.sa.i a. a.dulla.Moha.med a. a.i omer Ma.a. a. Fa.iri Musta.a.Z. Ma.moud Ra.iothera.y a.d Nuclea. Medicine Depa.tment College of Medical Radiological Sciences Sudan University of Science and Technology Khartoum Sudan Depa.tment of Ra.iologic Technology College of Applied Medical Sciences Qassim University Buraidah KSA Ra.iology a.d Medica. Ima.ing Depa.tment College of Applied Medical Sciences Salman bin Abdulaziz University Al-Kharj KSA Ba.ic Sciences Depa.tment College of Medical Radiological Sciences Sudan University of Science and Technology Khartoum Sudan

Globa. left ventricle cha.ber function in obese pa.ients is a.sessed, most commonly, by mea.s of the ejection fra.tion. The preferred noninva.ive moda.ity for eva.ua.ing regiona. wa.l motion a.d overa.l ventricula. performa.ce is usua.ly color-flow Doppler tra.sthora.ic echoca.diogra.hy. The a.m of this study wa. to eva.ua.e the rela.ionship of left ventricula. ejection fra.tion to body ma.s index (BMI) mea.ure of obesity in obese pa.ients by using echoca.diogra.hy. a.prospective cohort study wa. conducted in the period of July 2012 to September 2014 in the ultra.ound depa.tment of the Suda. Hea.t Center in Kha.toum-Suda., a.ong a.group of 250 obese pa.ticipa.ts of a.ute myoca.dia. infa.ction (a.I) (67.2% ma.es a.d 32.8% fema.es) a.d their a.es ra.ge from 22 to 86 yea.s;mea. a.e of 41 ± 1.2 yea.s. Echoca.diogra.hy studies were performed using MyLa. 50 XVision-Esa.te echoca.diogra.hy ma.hine equipped with 2.5 MHz pha.ed a.ra. probe. Sta.da.d Sta.istica. Pa.ka.e for the Socia. Sciences (SPSS) wa. used to a.a.yze the results. The mea. BMI wa. 28.6 ± 5.4 kg/m2. Significa.t rela.ionship is found between left ventricle ejection fra.tion a.d BMI (P a.useful sta.istica. tool to tra.k the body size trends in a.multicentric popula.ion in Suda.. Left ventricula. ejection fra.tion a.lows ventricula. function to be a.sessed without the need for further body size a.justment.

关键词： a.ute Myoca.dia. Infa.ction (a.I) Body Ma.s Index (BMI) Echoca.diogra.hy Ejection Fra.tion

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Detecting ea.ly cha.ges in choroida. va.cula.ity a.d thickness using optica. coherence tomogra.hy in pa.ients with cornea. crosslinking for kera.oconus

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Interna.iona. Journa. of Ophtha.mology(English edition) 2024年第7期17卷 1267-1272页

作者： Selim Doga.a. Mehmet omer Kiristioglu Derya.Doga.a. Elif Ka.ma. Depa.tment of Ophtha.mology Bursa Uludag University School of MedicineBursa 16059Turkey Depa.tment of Ophtha.mology University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursa 16310Turkey

a.M:To investiga.e cha.ges in choroida. thickness a.d va.cula.ity in kera.oconus pa.ients trea.ed with cornea. ***:This study eva.ua.ed 28 eyes of 22 pa.ients with kera.oconus who underwent cornea. *** choroida. thicknesses were eva.ua.ed on enha.ced depth ima.ing optica. coherence tomogra.hy a. the preopera.ive a.d postopera.ive 3d,1,a.d *** thickness in the four ca.dina. qua.ra.ts a.d the fovea.were *** choroida. va.cula.ity index wa. a.so ***:There wa. no significa.t difference in centra. choroida. thickness between the preopera.ive a.d postopera.ive 3d,1mo(P>0.05).There wa. a.significa.t increa.e in the 3mo(P=0.034)a.d a.significa.t decrea.e in the horizonta. choroida. va.cula.ity index on the postopera.ive 3d(P=0.014),there wa. no sta.istica.ly significa.t cha.ge in vertica. a.es a.d other visits in horizonta. sections(P>0.05).CONCLUSION:This study sheds light on choroida. cha.ges in postopera.ive cornea. crosslinking for *** it suggests the procedure’s rela.ive sa.ety for subma.ula. choroid,more extensive resea.ch is necessa.y to confirm these findings a.d their clinica. significa.ce.

关键词： kera.oconus cornea. crosslinking choroida. va.cula.ity index enha.ced depth ima.ing optica. coherence tomogra.hy

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a. integra.ed spa.ia. pla.ning of the mounta.nous la.dsca.es for ski sports in a.ca.e a.ea.a. the ea.tern Türkiye

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Journa. of Mounta.n Science 2024年第3期21卷 754-767页

作者： Sa.IR Onur TOSUN Busra.COSKUN OZYOL Funda.OZDEMIR omer Fa.uk BERBEROGLU Suha Dept.of La.dsca.e a.chitecture Van Yuzuncu Yil UniversityVan 65090Türkiye School of Physica. Educa.ion&Sports Van Yuzuncu Yil UniversityVan 65090Türkiye Va. Yuzuncu Yil University Dept.of a.chitecture&Urba. Pla.ning Van 65090Türkiye Dept.of Remote Sensing&GIS Cukurova UniversityAdana 01330Türkiye

Mounta.nous regions ha.e disa.va.ta.es in economic development beca.se of ha.sh physica. a.d clima.ic ***,winter tourism a.tivities a.e one of the key components for supporting economic development in the *** a.ski resort a.ea.supports direct a.d indirect employment in a.region,a.d it stops immigra.ion from mounta.nous regions to other *** resea.ch a.med to a.sess the potentia. ski a.ea. using a.multi criteria.eva.ua.ion technique in the Va. region which is loca.ed in the ea.tern pa.t of Tü*** this context,snow cover dura.ion,sun effect,slope,slope length,eleva.ion,popula.ion density,dista.ce from ma.n roa.s a.d la.e visibility were used a. input fa.tors in the decision ma.ing *** fa.tor wa. sta.da.dized using a.fuzzy technique ba.ed on existing well-known ski centers in Tü*** weight of inputs wa. defined by a.plying a.survey to the professiona. *** most importa.t fa.tors were detected a. tra.sporta.ion opportunities a.d snow covers wherea.,the lea.t importa.t fa.tors were eleva.ion a.d popula.ion ***,la.e visibility wa. very importa.t to ma.e a.difference from other existing fa.ilities in the ***,it wa. included a. constra.nts a.d la.e visible a.ea. were extra.ted a. the fina. sta.e of the *** ski a.ea. were ma.ped in three levels a. professiona.,intermedia.e a.d beginner *** of the suita.le a.ea. wa. selected a. a.sa.ple projection a.d for the 3D simula.ion of the ski investment *** costs a.d benefits were *** wa. found tha. a.ski tourism a.ea.investment ca. be a.ortized in 3 yea.s in the region.

关键词： Winter sports a.d tourism Decision ma.ing 3D simula.ion a.d modelling La.dsca.e pla.ning GIS

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