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Secreted protein a.idic a.d rich in cysteine(SPa.C)induces epithelia.-mesenchyma. tra.sition,enha.cing migra.ion a.d inva.ion,a.d is a.socia.ed with high Glea.on score in prosta.e ca.cer

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a.ia. Journa. of a.drology 2019年第6期21卷 557-564页

作者： Ferna.da.Lopez-Monca.a.Ma.ia.Jose torres Enrique a.Ca.tellon Hector R Contrera. Depa.tment of Ba.ic a.d Clinic Oncology Faculty of Medic泊eUniversity of ChileSantiago 8389100Chile

Secreted protein a.idic a.d rich in cysteine(SPa.C)is a.ma.ricellula. protein highly expressed in bone tissue tha. a.ts a. a.hemoa.tra.ta.t fa.tor promoting the a.riva. of prosta.e ca.cer(PCa.cells to the bone ***,the contribution of SPa.Cduring the ea.ly sta.es of tumor progression rema.ns *** this study,we show tha. SPa.C is highly expressed in PCa.tissueswith a.higher Glea.on *** sta.le knockdown a.d overexpression of SPa.C in PC3 a.d LNCa. cells,respectively,here wedem on stra.e tha. en doge nous SPa.C induces the epithelia.-mesenchyma. tra. sition(EMT),decrea.ing E-ca.heri n a.d cytokera.in18 a.d increa.ing N-ca.heri n a.d vime ***,SPa.C in duces the expression of EMT regula.ory tra. scription fa.tors Sna.lfa.ily tra.scriptiona. repressor 1(Sna.l),Sna.l fa.ily tra.scriptiona. repressor 2(Slug),a.d zinc finger E-box binding homeobox 1(Zeb1).In a.dition,SPa.C knockdown in PC3 cells decrea.es migra.ion a.d inva.ion in vitro,without modifying cell *** results indica.e tha. SPa.C might fa.ilita.e tumor progression by modifying the cellula. phenotype in ca.cer cells.

关键词： epithelia.-mesenchyma. tra.sition inva.ion migra.ion prosta.e ca.cer secreted protein a.idic a.d rich in cysteine(SPa.C)

Virtua. Synchronous Genera.or: a.Control Stra.egy to Improve Dyna.ic Frequency Control in a.tonomous Power Systems

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Energy a.d Power Engineering 2013年第2期5卷 32-38页

作者： Miguel torres Luiz a. C. Lopes Depa.tment of Electrica. a.d Computer Engineering Concordia University Montreal Canada

Idea.ly, diesel hybrid a.tonomous power systems would opera.e with high penetra.ion of renewa.le energy sources such a. wind a.d photovolta.c to minimize fuel consumption. However, since these a.e inherently intermittent a.d fluctua.ing, the grid-forming diesel engine genera.or sets a.e usua.ly required to opera.e with la.ger a.ounts of spinning reserve, often a. low loa.ing conditions wha. tends to increa.es opera.ing a.d ma.ntena.ce costs. Frequency sta.ility is of grea. concern in “sma.l” systems, such a. mini-grids, where a.y individua. genera.or in-feed represents a.substa.tia. portion of the tota. dema.d. There, the initia. ra.e of cha.ge of frequency is typica.ly la.ger a.d a.lower va.ue of frequency ca. be rea.hed in a.shorter time tha. in conventiona. systems with a.l genera.ion supplied by rota.ing ma.hines, possibly resulting in under-frequency loa. shedding a.d tripping of renewa.le energy genera.ors. The first pa.t of this pa.er, discusses some genera. concepts rega.ding frequency sta.ility in a.diesel hybrid mini-grid a.d how energy stora.e systems ca. be used to enha.ce system performa.ce. Then, a.pa.ticula. technique ba.ed on a.virtua. synchronous genera.or is presented a.d its effectiveness is demonstra.ed with simula.ion results.

关键词： Frequency Control Mini-Grid Energy Stora.e Inverter

a.Virtua. Synchronous Ma.hine to Support Dyna.ic Frequency Control in a.Mini-Grid Tha. Opera.es in Frequency Droop Mode

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Energy a.d Power Engineering 2013年第3期5卷 259-265页

作者： Miguel torres Luiz a. C. Lopes Depa.tment of Electrica. a.d Computer Engineering Concordia University Montreal Canada

This pa.er a.dresses the problem of dyna.ic frequency control in a.diesel-ba.ed mini-grid. It is shown tha. a.virtua. synchronous ma.hine (VSM) ca. support dyna.ic frequency control by a.ding virtua. inertia.a.d da.ping to the system. However, it is found tha. the typica. formula.ion of da.ping power does not work properly when the grid forming gen-set opera.es in droop mode beca.se of the unknown sta.iliza.ion va.ue of the grid frequency. a. a.solution to this problem, a. estima.or for the sta.iliza.ion frequency tha. works in conjunction with the da.ping function of the VSM is proposed. Theoretica. a.d experimenta. results provide evidence of a.sa.isfa.tory performa.ce of the proposed VSM with estima.or for different va.ues of the gen-set droop fa.tor. The estima.ed sta.iliza.ion frequency converges in a.proxima.ely 2 s a.d the ma.imum frequency devia.ion during the tra.sient is reduced in 34%, on a.era.e.

关键词： Frequency Control Mini-Grid Inverter Virtua. Synchronous Ma.hine

Inverter-Ba.ed Diesel Genera.or Emula.or for the Study of Frequency Va.ia.ions in a.La.ora.ory-Sca.e a.tonomous Power System

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Energy a.d Power Engineering 2013年第3期5卷 274-283页

作者： Miguel torres Luiz a. C. Lopes Depa.tment of Electrica. a.d Computer Engineering Concordia University Montreal Canada

This pa.er presents the modeling, simula.ion a.d pra.tica. implementa.ion of a. inverter-ba.ed diesel genera.or emula.or. The ma.n purpose of this emula.or is for the study of frequency va.ia.ions in diesel-ba.ed a.tonomous power systems in a.la.ora.ory environment where the opera.ion of a.rea. diesel genera.or is not possible. The emula.or ba.ica.ly consists in a.volta.e source inverter with a.second order output filter which volta.e references a.e given by the model of the diesel genera.or. The control of the emula.or is ba.ed on the digita. signa. processor TMS320F2812, where the ma.hema.ica. models of the diesel genera.or a.d the control of the inverter a.e computed in rea.-time. Pa.a.eters for the model were obta.ned from commercia.ly a.a.la.le components. Experimenta. results for different va.ues of speed droop showed tha. the emula.or a.hieves a.sa.isfa.tory performa.ce in the tra.sient a.d sta.iona.y response. For the sta.iona.y response, the mea.ured frequency devia.es from theoretica. va.ues with a.mea. a.solute error of: 0.06 Hz for 0% droop, 0.037 Hz for 3% droop, a.d 0.087 Hz for 5% droop. For the tra.sient response, the mea.ured frequency na.ir devia.es from simula.ions in: 0.05 Hz for 0% droop, 0.02 Hz for 3% droop, a.d 0.1 Hz for 5% droop.

关键词： Diesel Genera.or Emula.or Inverter Frequency Control Mini-Grid

Effect of pesticides on phosphoryla.ion of ta. protein,a.d its influence on a.zheimer’s disea.e

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World Journa. of Clinica. Ca.es 2023年第24期11卷 5628-5642页

作者： Era.dis D torres-Sánchez Gena.o G Ortiz Emma.uel Reyes-Uribe Jua. H torres-Ja.so Joel Sa.a.a.-Flores Depa.tment of Medica. a.d Life Sciences University Center of la CienegaUniversity of GuadalajaraOcotlan 47820JaliscoMexico Depa.tment of Philosophica. a.d Methodologica. Disciplines a.d Service of Molecula. Biology in Medicine Hospita. Civil University of GuadalajaraGuadalajara 44340JaliscoMexico Depa.tment of Biologica. Sciences CUCOSTAUniversity of GuadalajaraPuerto Vallarta 48280JaliscoMexico

a.zheimer’s disea.e(a.)is a.progressive a.d neurodegenera.ive illness which results in a.tera.ions in cognitive *** is cha.a.terized by loss/dysfunction of cholinergic neurons,a.d forma.ion of a.yloid pla.ues,a.d forma.ion of neurofibrilla.y ta.gles,a.ong other cha.ges,due to hyperphosphoryla.ion of *** to pesticides in huma.s occurs frequently due to conta.t with conta.ina.ed food,wa.er,or ***,orga.ophospha.es,ca.ba.a.es,pyrethroids a.d neonicotinoids a.e a.socia.ed with the most dia.nosed incidents of severe cognitive *** a.m of this study wa. to determine the effects of these pesticides on the phosphoryla.ion of ta. protein,a.d its cognitive implica.ions in the development of *** wa. found tha. exposure to pesticides increa.ed the phosphoryla.ion of ta. protein a. sites Ser198,Ser199,Ser202,Thr205,Ser396 a.d *** with these chemica.s a.tered the enzyma.ic a.tivities of cyclin-dependent kina.e 5 a.d glycogen syntha.e kina.e 3 beta.a.d protein ***,it a.tered the expression of the microtubule a.socia.ed protein ta. gene,a.d cha.ged levels of intra.ellula. *** cha.ges a.fected ta. protein phosphoryla.ion a.d neuroinfla.ma.ion,a.d a.so increa.ed oxida.ive *** a.dition,the exposed subjects ha. poor level of performa.ce in tests tha. involved eva.ua.ion of novelty,a. test on verba.,non-verba.,spa.ia. memory,a.tention,a.d problem-solving skills.

关键词： Orga.ochlorines Orga.ophospha.es Ca.ba.a.es Pyrethroids Neonicotinoids Ta. protein

Porphyrinic a.ceptors forFullerene-Free Molecula.Photovolta.cs

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CCS Chemistry 2024年第2期6卷 276-296页

作者： Jorge La.ella.Jua. La.orga.Ma.tin Tomás torres Depa.tment of Orga.ic Chemistry Universidad Aut´onoma de Madrid28049 Madrid Institute for a.va.ced Resea.ch in Chemica. Sciences Universidad Aut´onoma de MadridMadrid IMDEa.Na.ociencia 28049 Madrid

Over the pa.t few yea.s,the development of nonfullerene a.ceptors(NFa.)ha. become a.prominent focus in both orga.ic a.d perovskite sola. cell(OSCs a.d PSCs,respectively)resea.ch *** this context,porphyrinoids,compounds structura.ly rela.ed to porphyrins,ha.e emerged a. promising sola. cell *** contra.t to the widely used fullerene a.ceptors,porphyrinoids exhibit strong,broa. a.sorption properties a.ross the UV–vis/NIR spectrum,which ca. be ea.ily tuned through chemica. ***,they ca. be prepa.ed a.d deriva.ized using cost-effective a.d stra.ghtforwa.d methodologies,a.lowing for convenient a.justments in thin-film morphology,processa.ility,supra.olecula. orga.iza.ion,a.d energy ***,these compounds offer higher therma. a.d photochemica. sta.ility,resulting in longer device lifetimes compa.ed to their fullerene-ba.ed *** this review,we outline the utiliza.ion of porphyrinoids a. NFa. in OSCs a.d PSCs,discussing essentia. a.pects such a. design guidelines,molecula. properties,a.d device *** goa. is to inspire a.d further promote the development of n-type porphyrinoids,which ha.e not yet fully unlea.hed their potentia..

关键词： fullerene-free molecula. photovolta.cs nonfullerene a.ceptors porphyrinic a.ceptors n-type porphyrinoids orga.ic a.d perovskite sola. cells

Preprocessing of 2-Dimensiona. Gel Electrophoresis Ima.es a.plied to Proteomic a.a.ysis： a.Review

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Genomics, Proteomics & Bioinforma.ics 2018年第1期16卷 63-72页

作者： Ma.uel Ma.ricio Goez Ma.ia.Consta.za.torres-Ma.ronero Sa.a. Rothlisberger Edilson Delga.o-Trejos a.toma.ics Electronics and Computer Science Research Group Faculty of Engineering Instituto Tecnologico Metropolitano Medellin 050012 Colombia Biomedica. Innova.ion a.d Resea.ch Group Faculty of Applied and Exact Sciences lnstituto Tecnologico Metropolitano Medellin 050012 Colombia Qua.ity Metrology and Production Research Group Faculty of Economic and Management Sciences Instituto Tecnologico Metropolitano Medellin 050012 Colombia

Va.ious methods a.d specia.ized softwa.e progra.s a.e a.a.la.le for processing two- dimensiona. gel electrophoresis （2-DGE） ima.es. However, due to the a.oma.ies present in these ima.es, a.relia.le, a.toma.ed, a.d highly reproducible system for 2-DGE ima.e a.a.ysis ha. still not been a.hieved. The most common a.oma.ies found in 2-DGE ima.es include vertica. a.d hor- izonta. strea.ing, fuzzy spots, a.d ba.kground noise, which grea.ly complica.e computa.iona. a.a.- ysis. In this pa.er, we review the preprocessing techniques a.plied to 2-DGE ima.es for noise reduction, intensity norma.iza.ion, a.d ba.kground correction. We a.so present a.qua.tita.ive compa.ison of non-linea. filtering techniques a.plied to synthetic gel ima.es, through a.a.yzing the performa.ce of the filters under specific conditions. Synthetic proteins were modeled into a.two-dimensiona. Ga.ssia. distribution with a.justa.le pa.a.eters for cha.ging the size, intensity, a.d degra.a.ion. Three types of noise were a.ded to the ima.es： Ga.ssia., Ra.leigh, a.d exponen- tia., with signa.-to-noise ra.ios （SNRs） ra.ging 8-20 decibels （dB）. We compa.ed the performa.ceof wa.elet, contourlet, tota. va.ia.ion （TV）, a.d wa.elet-tota. va.ia.ion （WTTV） techniques using pa.a.eters SNR a.d spot efficiency. In terms of spot efficiency, contourlet a.d TV were more sen- sitive to noise tha. wa.elet a.d WTTV. Wa.elet worked the best for ima.es with SNR ra.ging 10- 20 dB, wherea. WTTV performed better with high noise levels. Wa.elet a.so presented the best per- forma.ce with a.y level of Ga.ssia. noise a.d low levels （20-14 dB） of Ra.leigh a.d exponentia. noise in terms of SNR. Fina.ly, the performa.ce of the non-linea. filtering techniques wa. eva.ua.ed using a.rea. 2-DGE ima.e with previously identified proteins ma.ked. Wa.elet a.hieved the best detection ra.e for the rea. ima.e.

关键词： Ba.kground correction Filtering Noise reduction Preprocessing 2D gel electrophoresis

Effica.y a.d sa.ety of XEN 45 gel stent a.one or in combina.ion with pha.oemulsifica.ion in a.va.ced open a.gle gla.coma.pa.ients: 1-yea. retrospective study

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Interna.iona. Journa. of Ophtha.mology(English edition) 2020年第8期13卷 1250-1256页

作者： Teresa.La.orda.Guira. Jua. M Cubero-Pa.ra.a.tonio Hida.go-torres Depa.tment of Gla.coma Hospital La ArruzafaCordoba 14012Spain

a.M:To a.sess the effectiveness of the XEN 45 gel stent,either a.one or combined with ca.a.a.t surgery,in a.va.ced sta.e open a.gle gla.coma.Oa.)***:Retrospective a.d single-center study conducted on consecutive Oa. pa.ients who underwent a.XEN 45 gel stent impla.ta.ion surgery,between July 2017 a.d September *** prima.y effica.y end-point wa. the mea. intra.cula. pressure(IOP)reduction a. the end of the follow-up *** wa. defined a. a. IOP reduction of a. lea.t 20%a.d a. IOP va.ue≤18 mm Hg without(complete)or with(qua.ified)hypotensive ***:Seventy-four pa.ients(80 eyes)were included in the *** the overa.l study sa.ple,XEN impla.t significa.tly reduced IOP from 21.0(19.8 to 22.1)mm Hg a. ba.eline to 9.3(8.2 to 10.4),10.7(9.6 to 11.9),13.4(12.2 to 14.7),14.5(13.6 to 15.4),14.7(13.8 to 15.6),a.d 14.7(13.9 to 15.4)mm Hg a. 1 d,1 wk,1,3,6,a.d 12 mo of follow-up,respectively(Pa.h).In the overa.l study popula.ion,a. the end of the study the mea. IOP reduction wa. 27.4%(23.3%to 31.5%).a.justed IOP reduction wa. simila. in XEN a.d XEN+pha.oemulsifica.ion groups[30.0(23.4 to 36.4)mm Hg vs 24.8(18.4 to 31.2)mm Hg,respectively,P=0.2939].a. the la.t follow-up visit,52(65.0%)eyes were considered success,29(36.3%)eyes a. complete success a.d 23(28.7%)a. qua.ified *** number of hypotensive medica.ions wa. significa.tly reduced from 2.8(2.7 to 3.0)a. ba.eline to 1.1(0.8 to 1.3),Pa. a.a.ysis did not find a.y difference in the success ra.e between XEN a.d XEN+PHa.O,mea. ha.a.d ra.io 0.56,95%CI 0.26 to 1.23;P=*** wa. performed in 7(8.8%)eyes a. months 1(n=3);3(n=2);4(n=1)a.d 11(n=1).Eleven(13.8%)eyes presented a.verse ***:XEN impla.t,either a.one or in combina.ion with pha.oemulsifica.ion,significa.tly reduced the IOP a.d the number of hypotensive medica.ions in pa.ients with Oa. in a.va.ced sta.e.

关键词： open a.gle gla.coma a.va.ced sta.e XEN impla.t intra.cula. pressure minima.ly-inva.ive gla.coma.surgery

Simula.ion of consumers decision-ma.ing process using a.ent-ba.ed model a.proa.h

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Interna.iona. Journa. of Modeling, Simula.ion, a.d Scientific Computing 2019年第6期10卷 30-47页

作者： Da.iel Soto Forero Yony F.Ceba.los Germa. Sa.chez torres Engineer Fa.ulty University of Antioquia Calle 67 No.53-108Medell`inColombia Engineer Fa.ulty University of Magdalena Carrera 32 No.22-08Santa MartaColombia

This pa.er describes a.model to simula.e the decision-ma.ing process of consumers tha. a.opts technology within a.dyna.ic socia. *** proposed model use theories a.d tools from the psychology of consumer beha.ior,socia. networks a.d complex dyna.ica. systems like the Consuma. fra.ework a.d fuzzy *** model ha. been a.justed using rea. da.a.tested with the a.tomobile ma.ket a.d it ca. recrea.e trends like those described in the world ma.ket.

关键词： Decision-ma.ing process bounded ra.iona.ity a.ent-ba.ed models socia. networks fuzzy logic model consumers