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Lights for epilepsy:ca. photobiomodula.ion reduce seizures a.d offer neuroprotection?

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Neura. Regenera.ion Resea.ch 2023年第7期18卷 1423-1426页

作者： Na.oleon torres-martinez Stepha. Cha.a.des John Mitrofa.is University of Grenoble a.pes FDD and CEA-LETIClinatecGrenobleFrance

Epilepsy is synonymous with individua.s suffering repea.ed“fits”or *** seizures a.e triggered by bursts of a.norma. neurona. a.tivity,a.ross either the cerebra. cortex a.d/or the *** a.dition,the seizure sites a.e cha.a.terized by considera.le neurona. *** the fa.tors tha. genera.e this a.norma. a.tivity a.d dea.h a.e not entirely clea.,recent evidence indica.es tha. mitochondria. dysfunction pla.s a.centra. *** trea.ment options include drug thera.y,which a.ms to suppress the a.norma. neurona. a.tivity,or surgica. intervention,which involves the remova. of the bra.n region genera.ing the seizure ***,~30%of pa.ients a.e unresponsive to the drugs,while the surgery option is inva.ive a.d ha. a.morbidity ***,there is a.need for the development of a. effective non-pha.ma.ologica. a.d non-inva.ive trea.ment for this disorder,one tha. ha. few side *** this review,we consider the effectiveness of a.potentia. new trea.ment for epilepsy,known a. photobiomodula.ion,the use of red to nea.-infra.ed light on body *** studies in a.ima. models ha.e shown tha. photobiomodula.ion reduces seizure-like a.tivity a.d improves neurona. ***,it ha. a. excellent sa.ety record,with little or no evidence of side effects,a.d it is *** a.l together,this trea.ment a.pea.s to be a. idea. trea.ment option for pa.ients suffering from epilepsy,which is certa.nly worthy of further considera.ion.

关键词： cell dea.h gliosis infla.ma.ion infra.ed mitochondria non-pha.ma.ologica. red seizure

Two mitochondria. ha.lotypes in Pterochloroides persica. （Hemiptera. a.hidida.： La.hnina.） a.socia.ed with different feeding sites

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Insect Science 2013年第5期20卷 637-642页

作者： Mdellel La.sa.d Da.id martinez-torres Ben Ha.ima.Ka.el Monia Hight Institute of a.ronomy Chott Mariem 4042 Sousse Tunisia Institut Ca.a.illes de Biodiversita. i Biologia.Evolutiva Universitat de Valencia Apdo. Correos 22085 46071 Valencia Spain

Pterochloroides persica. （Cholodkovsky） is a. a.hid species belonging to the subfa.ily La.hnina. tha. uses different members of Rosa.ea. （specia.ly Prunus spp.） a. hosts. Pa.tia. sequences from the mitochondria. cytochrome c oxida.e 1 （COI） a.d the nuclea. long-wa.e opsin genes were obta.ned for a.proxima.ely 100 P. persica. a.hid individua.s sa.pled from 34 colonies collected ma.nly in Tunisia.a.d other Mediterra.ea. loca.ions. The va.ia.ility found a. the mitochondria. locus revea.ed the presence of two ma.erna. ha.lotypes in the studied a.ea.tha. differed in a.single nucleotide. The nuclea. gene a.a.yzed, however, fa.led to revea. a.y va.ia.ility in this species. The va.ia.ility found a. the COI locus wa. rela.ed to the sea.on of a.hid sa.pling a.d with the site of feeding, with ha.lotype I mostly detected in sa.ples collected in spring a.d summer on trunks a.d bra.ches a.d ha.lotype II only detected in a.hids collected in a.tumn on roots. The observed pa.tern of molecula. va.ia.ion suggests the presence of two clona. ra.es of P. persica. coexisting in the studied a.ea.differentia.ly a.a.ted to conditions preva.ent in the a.terna.ive sea.ons a.d/or to different feeding sites.

关键词： a.hids COI La.hnina. life cycle Pterochloroides va.ia.ility

Novel stra.egies to ta.lor the photoca.a.ytic a.tivity of meta.–orga.ic fra.eworks for hydrogen genera.ion: a.mini-review

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Frontiers in Energy 2022年第5期16卷 734-746页

作者： Luis a.a.FONSO-HERRERa.Leticia.M.torres-martinez J.Ma.uel MORa.HERNa.DEZ Universida. a.tónoma.de Nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México Centro de Investiga.ión en Ma.eria.es a.a.za.os S.C.(CIMAV)Miguel de Cervantes No.120.Complejo Ind.ChihuahuaChihuahuaChih 31136México CONa.YT-Universida. a.tónoma.de Nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México

This review provides a.recompila.ion of the most importa.t a.d recent stra.egies employed to increa.e the efficiency of meta.-orga.ic fra.ework(MOF)-ba.ed systems towa.d the photoca.a.ytic hydrogen evolution(PHE)rea.tion through specific stra.egies:ta.loring the photoca.a.ytic a.tivity of ba.e MOFs a.d guest@MOF composites,forma.ion of heterojunctions ba.ed on MOFs a.d va.ious photoca.a.ysts,a.d inorga.ic photoca.a.ysts derived from *** to the da.a.reported in this mini-review,the most effective stra.egy to improve the PHE of MOFs relies on modifying the linkers with new seconda.y building units(SBUs).a.though severa. reviews ha.e investiga.ed the photoca.a.ytic a.tivity of MOFs from a.genera. point of view,ma.y of these studies rela.e this a.tivity to the physicochemica. a.d ca.a.ytic properties of ***,they did not consider the intera.tions between the components of the photoca.a.ytic *** study highlights the effects of strength of the supra.olecula. intera.tions on the photoca.a.ytic performa.ce of ba.e a.d MOF-ba.ed ma.eria.s during PHE.a.thorough review a.d compa.ison of the results esta.lished tha. meta.-na.opa.ticle@MOF composites ha.e wea. va. der Wa.ls forces between components,wherea. heterostructures only intera.t with MOFs a. the surfa.e of ba.e *** ma.eria. deriva.ives from MOFs,we found tha. pyrolysis destroyed some beneficia. properties of MOFs for ***,we conclude tha. a.ding SBUs to orga.ic linkers is the most efficient stra.egy to perform the PHE beca.se the SBUs a.ded to the MOFs promote synergy between the two ma.eria.s through strong coordina.ion bonds.

关键词： meta.-orga.ic fra.eworks(MOFs) photoca.a.ytic hydrogen evolution MOF heterojunctions ma.eria.s derived from MOFs ba.dga. recombina.ion

Mela.onin in the sea.ona. response of the a.hid a.yrthosiphon pisum

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Insect Science 2020年第2期27卷 224-238页

作者： Miquel Ba.bera.La.ra.Escriva.Jorge Ma.ia.o Colla.tes-a.egre Giuseppe Meca.Ezio Rosa.o Da.id martinez-torres Institut de Biologia.Integra.iva.de Sistemes&Institut Ca.a.illes de Biodiversita.i Biologia.Evolutiva Parc Cientific Universitat de ValenciaC/Catedmtico Jose Beltran n°246980PaternaValenciaSpain La.ora.ory of Food Chemistry a.d Toxicology Faculty of PharmacyUniversitat de ValenciaBurjassotSpain Depa.tment of Genetics University of LeicesterLeicesterLE17RHUK

a.hids displa. life cycles la.gely determined by the *** the wa.m long-da. *** a.hid species reproduce by vivipa.ous *** shortening of the photoperiod in a.tumn induces a.switch to sexua. *** a.d sexua. fema.es ma.e to produce overwintering resista.t *** a.dition to this full life cycle(holocycle),there a.e a.holocyelic linea.es tha. do not respond to cha.ges in photoperiod a.d reproduce continuously by *** molecula. or hormona. events tha. trigger the sca.ona. response(i.c,induction of the sexua. phenotypes)a.e still *** circa.ia. synthesis of mela.onin is known to pla. a.key role in vertebra.e photoperiodism,the involvement of the circa.ia. clock a.d/or of the hor-mone mela.onin in insect sea.ona. responses is not so well *** we show tha. mela.onin levels in the a.hid a.yrthosiphon pisum a.e significa.tly higher in holocyclice a.hids rea.ed under short da.s tha. under long da.s,while no differences were found between a.holoeyelic a.hids under the sa.e *** a.so found tha. mela.onin is loca.ized in the a.hid suboesopha.ea. ga.glion(SOG)a.d in the thora.ic ga.glionic ma.s(TGM).In a.a.ogy to vertcbra.es,insect-type a.yla.kxyla.ine N-a.etyltra.sfera.es(i-a.Na.s)a.e thought to pla. a.key role in mela.onin *** mea.ured the expression of four I-a.Na. genes identified in *** a.d loca.ized two of them in situ in the insect centra. nervous systems(CNS).Levels of expression of these genes were compa.ible with the qua.tities of mela.onin ***,like mela.onin,expression of these genes wa. found in the SOG a.d the TGM.

关键词： a.Na. a.hid in situ hybridiza.ion mela.onin photoperiodism qua.tifica.ion

How do we ma.a.e post-OLT redunda.t bile duct?

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World Journa. of Ga.troenterology 2013年第16期19卷 2501-2506页

作者： Victor torres Nichola. martinez Ga.riel Lee Jose a.meda.Glenn Gross Sa.deep Pa.el La.ra.Rosenkra.z Division of Ga.troenterology a.d Nutrition Department of Medicine University of Texas Health Science Center at San Antonio Depa.tment of Pa.crea.ic a.d Hepa.obilia.y Surgery University of Texas Health Science Center at San Antonio

a.M: To a.dress endoscopic outcomes of post-Orthotopic liver tra.spla.ta.ion (OLT) pa.ients dia.nosed with a."redunda.t bile duct" (RBD). METHODS: Medica. records of pa.ients who underwent OLT a. the Liver Tra.spla.t Center, University Texa. Hea.th Science Center a. Sa. a.tonio Texa. were retrospectively a.a.yzed. Pa.ients with suspected bilia.y tra.t complica.ions (BTC) underwent endoscopic retrogra.e chola.giopa.crea.ogra.hy (ERCP). a.l ERCP were performed by experienced bilia.y endoscopist. RBD wa. defined a. a.looped, sigmoid-sha.ed bile duct on chola.giogra. with a.socia.ed cholesta.ic liver bioma.kers. Pa.ients with bilia.y T-tube pla.ement, bilia.y a.a.tomotic strictures, bile lea.s, bile-duct stonessludge a.d suspected sphincter of oddi dysfunction were excluded. Thera.y included single or multiple bilia.y stents with or without sphincterotomy. The incidence of RBD, the number of ERCP corrective sessions, a.d the type of endoscopic interventions were recorded. Successful response to endoscopic thera.y wa. defined a. resolution of RBD with norma.iza.ion of a.socia.ed cholesta.is. La.ora.ory da.a.a.d pertinent ra.iogra.hic ima.ing noted included the pre-ERCP period a.d a.follow up period of 6-12 mo a.ter the la.t ERCP intervention. RESULTS: One thousa.d two hundred a.d eighty-two pa.ient records who received OLT from 1992 through 2011 were reviewed. Two hundred a.d twenty-four pa.ients underwent ERCP for suspected BTC. RBD wa. reported in ea.h of the initia. chola.giogra.s. Twentyone out of 1282 (1.6%) were identified a. ha.ing RBD. There were 12 men a.d 9 women, a.era.e a.e of 59.6 yea.s. Prima.y indica.ion for ERCP wa. cholesta.ic pa.tern of liver a.socia.ed bioma.kers. Nineteen out of 21 pa.ients underwent endoscopic thera.y a.d 2/21 required immedia.e surgica. intervention. In the endoscopica.ly ma.a.ed group: 65 ERCP procedures were performed with a. a.era.e of 3.4 per pa.ient a.d 1.1 stent per session. Fifteen out of 19 (78.9%) pa.ients were successfully

关键词： Redunda.t bile duct Orthotopic liver tra.spla.ta.ion Bilia.y complica.ions Bilia.y stent Endoscopic retrogra.e chola.giopa.crea.ogra.hy

Immunologic, meta.olic a.d genetic fa.tors in hepa.itis C virus infection

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World Journa. of Ga.troenterology 2014年第13期20卷 3443-3456页

作者： Nora.a.Fierro Ka.ina.Gonza.ez-a.da.o Ra.a.l torres-Va.a.ez Erika.martinez-Lopez Sonia.Roma. a.turo Pa.duro Depa.tment of Molecula. Biology in Medicine Civil Hospital of Guadalajara"Fray Antonio Alcalde" and Health Sciences CenterUniversity of GuadalajaraGuadalajara 44280JaliscoMexico

The mecha.isms tha. regula.e disea.e progression during hepa.itis C virus(HCV)infection a.d the response to trea.ment a.e not clea.ly *** studies ha.e demonstra.ed tha. a.strong host immune response a.a.nst HCV fa.ors HCV *** a.dition,genetic fa.tors a.d meta.olic ma.hinery,pa.ticula.ly cholesterol modula.ion,a.e involved in HCV *** is likely tha. the interpla. between a.l of these fa.tors contributes to the outcome of HCV *** recent yea.s,the world ha. experienced its la.gest epidemic of *** a.d the United Sta.es a.e the lea.ing sufferers from this epidemic a. the globa. *** is a.socia.ed with the development ofnumerous pa.hologies including hypercholesterolemia.which is one of the eight most importa.t risk fa.tors for morta.ity in *** ma. be rela.ed to the course of HCV infection in this ***,we focus on the urgent need to study the progression of HCV infection in rela.ion to ethnic *** a.e discussed tha. hold promise in identifying immune,meta.olic a.d genetic fa.tors tha.,in conjunction,could be thera.eutic ta.gets or predictors of the progression of HCV infection.

关键词： Hepa.itis C virus Immune response Lipids Meta.olism Genetics

Ora. a.lopurinol to prevent hypera.yla.emia.a.d a.ute pa.crea.itis a.ter endoscopic retrogra.e chola.giopa.crea.ogra.hy

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World Journa. of Ga.troenterology 2009年第13期15卷 1600-1606页

作者： Hector martinez-torres Xochilt Rodriguez-Lomeli Ca.lo Da.a.os-Cobia. Jesus Ga.cia.Correa.Jua. Ma.ue Ma.dona.o-martinez Fa.iola.Medra.o-Muoz Clotilde Fuentes-Orozco a.eja.dr Gonza.ez-Ojeda Depa.tment of Ga.troenterology a. Endoscopy UMAE-Hospital de Especialidades del Centr Medico Nacional de Occidente-IMSS Resea.ch Unit in Clinica. Epidemiology UMa.-Hospita. de Especia.ida.es del Centro Medico Na.iona.de Occidente-IMSS

a.M:To a.sess the effica.y of a.lopurinol to prevent hypera.yla.emia.a.d pa.crea.itis a.ter endoscopic retrogra.e chola.giopa.crea.ogra.hy(PEP).METHODS:One hundred a.d seventy pa.ients were enrolled a.d ra.domized to two groups:a.study group(n=85)who received 300 mg of ora. a.lopurinol a. 15 h a.d 3 h before endoscopic retrogra.e chola.giopa.crea.ogra.hy(ERCP)a.d a.control group(n=85)receiving a. ora. pla.ebo a. the sa.e *** Outcome Mea.urements included serum a.yla.e levels a.d the number severity of the episodes of *** a.yla.e levels were cla.sified a. norma.(a.yla.emia.>151 IU/L).Episodes of PEP were cla.sified following Ra.son's criteria.a.d CT severity ***:Gender distribution wa. simila. between *** a.e wa. 53.5±18.9 yea.s for study group a.d 52.8±19.8 yea.s for ***,the distribution of benign pa.hology wa. simila. between *** wa. more common in the control group(P=0.003).Mild PEP developed in two pa.ients from the study group(2.3%)a.d eight(9.4%) from control group(P=0.04),seven episodes were observed in high-risk pa.ients of the control group(25%) a.d one in the a.lopurinol group(3.3%,P=0.02).Risk fa.tors for PEP were precut sphincterotomy(P=0.02),pa.crea.ic duct ma.ipula.ion(P=0.002)a.d multiple procedures(P=0.000).There were no dea.hs or side ***:Ora. a.lopurinol before ERCP decrea.ed the incidences of hypera.yla.emia.a.d pa.crea.itis in pa.ients submitted to high-risk procedures.

关键词： Endoscopic retrogra.e chola.giopa.crea.ogra.hy Hypera.yla.emia a.ute pa.crea.itis Ora.a.lopurinol Risk fa.tors

Ra.S simula.ions of the U a.d V grooves effect in the subcritica. flow over four rota.ed circula. cylinders

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Journa. of Hydrodyna.ics 2015年第4期27卷 569-578页

作者： a.ONZO-Ga.CIa.a. GUTIERREZ-torres C.del C. JIMENEZ BERNa. J.a. MOLLINEDO-PONCE de LEON H.R. martinez-DELGa.ILLO S.a. Ba.BOSa.Sa.Da.a.J.G. Instituto Politécnico Na.iona. SEPI ESIME ZacatencoLABINTHAP U.P.Adolfo López Mateos Edif.5 3er.PisoMéxicoD.F.México Instituto Politécnico Na.iona. UPIITAAv.IPN 2580C.P.07340MéxicoD.F.México Universida. a.tónoma.Metropolita.a.a.ca.otza.co Depto.Ciencias BásicasAv.San Pablo 180Azcapotzalco C.P 07740MéxicoD.F.México

This pa.er presents a.CFD study a.out the effect of the V a.d U grooves in the flow over four cylinders in dia.ond sha.e configura.ion a. subcritica. flow conditions（Re= 41 000）. The k- ε Rea.iza.le turbulence model wa. implemented to fully structured hexa.edra. grids with nea.-wa.l refinements. Results showed tha. the numerica. model wa. a.le to reproduce the impinging flow pa.tern a.d the repulsive forces present in the la.era. cylinders of the smooth cylinder a.ra.. a. a.consequence of the flow a.ignment induced by the grooves, a.jet-flow is formed between the la.era. cylinders, which could ca.se a. importa.t vortex induced vibra.ion effect especia.ly in the rea. cylinder. The ma.nitudes of the shea. stresses a. the va.leys a.d pea.s for the V grooved cylinders were lower tha. those of the U grooved cylinders, but the sepa.a.ion points were dela.ed due the U grooves presence. It is discussed the presence of a.blowing effect ca.sed by counter-rota.ing eddies loca.ed nea. the grooves pea.s tha. ca.se a.decrea.e of the shea. stresses in the va.leys, a.d promote them a. the pea.s.

关键词： Ra.S model grooved cylinder four cylinders subcritica. flow impinging flow

Liquid biopsy a.proa.h to pa.crea.ic ca.cer

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World Journa. of Ga.trointestina. Oncology 2021年第10期13卷 1263-1287页

作者： Sonia.Pera.es Ca.olina.torres Cristina.Jimenez-Luna.Jose Pra.os Joa.uina.martinez-Ga.a. Jose Ma.uel Sa.chez-Ma.a. Octa.io Ca.a Depa.tment of Biochemistry a.d Molecula. Biology I Faculty of SciencesUniversity of GranadaGranada 18071Spain Depa.tment of Biochemistry a.d Molecula. Biology III a.d Immunology Faculty of SciencesUniversity of GranadaGranada 18071Spain Institute of Biopa.hology a.d Regenera.ive Medicine(IBIMER) Center of Biomedical Research(CIBM)University of GranadaGranada 18100Spain Depa.tment of Medica. Oncology Hospital Universitario Virgen de las NievesGranada 18011Spain School for Interna.iona. Postgra.ua.e Studies University of GranadaGranada 18071Spain

Pa.crea.ic ca.cer(PC)continues to pose a.ma.or clinica. *** ha. been little improvement in pa.ient surviva. over the pa.t few deca.es,a.d it is projected to become the second lea.ing ca.se of ca.cer morta.ity by *** disma. 5-yea. surviva. ra.e of less tha. 10%a.ter the dia.nosis is a.tributa.le to the la.k of ea.ly symptoms,the a.sence of specific bioma.kers for a. ea.ly dia.nosis,a.d the ina.equa.y of a.a.la.le *** pa.ients a.e dia.nosed when the disea.e ha. a.rea.y meta.ta.ized a.d ca.not be *** interception is vita.,a.tively intervening in the ma.igniza.ion process before the development of a.full-blown a.va.ced *** ea.ly dia.nosis of PC ha. a.dra.a.ic impa.t on the surviva. of pa.ients,a.d improved techniques a.e urgently needed to detect a.d eva.ua.e this disea.e a. a. ea.ly *** is difficult to obta.n tissue biopsies from the pa.crea. due to its a.a.omica. position;however,liquid biopsies a.e rea.ily a.a.la.le a.d ca. provide useful informa.ion for the dia.nosis,prognosis,stra.ifica.ion,a.d follow-up of pa.ients with PC a.d for the design of individua.ly ta.lored *** a.m of this review wa. to provide a. upda.e of the la.est a.va.ces in knowledge on the a.plica.ion of ca.bohydra.es,proteins,cell-free nucleic a.ids,circula.ing tumor cells,meta.o-lome compounds,exosomes,a.d pla.elets in blood a. potentia. bioma.kers for PC,focusing on their clinica. releva.ce a.d potentia. for improving pa.ient outcomes.

关键词： Pa.crea.ic ca.cer Bioma.kers Liquid biopsy Clinica. ma.a.ement Ca.cer interception Ca.cer monitoring