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Microsystems & Na.oengineering 2024年第2期10卷 133-141页

作者： Ta.suya.Fukuta.Ryo kato Ta.uo Ta.a.a.Ta.a.a.i Ya.o Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innova.ive Photon Ma.ipula.ion Resea.ch Tea. RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Meta.a.eria.s La.ora.ory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon na.ostructures with unique Mie resona.ces ha.e ga.nered considera.le a.tention in the field of ***,we present a.simple a.d efficient method for the fa.rica.ion of silicon(Si)na.opa.ticle substra.es using continuous-wa.e(CW)la.er *** resulting silicon na.opa.ticles exhibit Mie resona.ces in the visible region,a.d their resona.t wa.elengths ca. be precisely ***,la.er-a.nea.ed silicon na.opa.ticle substra.es show a.60-fold enha.cement in *** tuna.le a.d fluorescence-enha.cing silicon na.opa.ticle pla.form ha. tremendous potentia. for highly sensitive fluorescence sensing a.d biomedica. ima.ing a.plica.ions.

关键词： na.opa.ticles a.nea.ing resona.t

Twisted fiber microfluidics:a.cutting-edge a.proa.h to 3D spira. devices

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Microsystems & Na.oengineering 2024年第1期10卷 193-202页

作者： Shunsuke kato Da.iel W.Ca.lson a.y Q.Shen Yua.yua. Guo Depa.tment of Electrica. Information and Physics EngineeringSchool of EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Micro/Bio/Na.ofluidics Unit Okinawa Institute of Science and TechnologyOnnaKunigami-gun 904-0495 OkinawaJapan Frontier Resea.ch Institute for Interdisciplina.y Sciences(FRIS) Tohoku UniversityAoba-kuSendai 980-0845 MiyagiJapan Gra.ua.e School of Biomedica. Engineering Tohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Depa.tment of Physiology Graduate School of MedicineTohoku UniversityAoba-kuSendai 980-8575 MiyagiJapan

The development of 3D spira. microfluidics ha. opened new a.enues for levera.ing inertia. focusing to a.a.yze sma.l fluid volumes,thereby a.va.cing resea.ch a.ross chemica.,physica.,a.d biologica. *** tra.itiona. stra.ght microcha.nels rely solely on inertia. lift forces,the novel spira. geometry genera.es Dea. dra. forces,elimina.ing the necessity for externa. fields in fluid ***,fa.rica.ing 3D spira. microfluidics rema.ns a.la.or-intensive a.d costly endea.or,hindering its widesprea. ***,conventiona. lithogra.hic methods prima.ily yield 2D pla.a. devices,thereby limiting the selection of ma.eria.s a.d geometrica. *** a.dress these cha.lenges,this work introduces a.strea.lined fa.rica.ion method for 3D spira. microfluidic devices,employing rota.iona. force within a.minia.urized therma. dra.ing process,termed a. *** innova.ion a.lows for ra.id prototyping of twisted fiber-ba.ed microfluidics fea.uring versa.ility in ma.eria. selection a.d heightened geometric *** va.ida.e the performa.ce of these devices,we combined computa.iona. modeling with microtomogra.hic pa.ticle ima.e velocimetry(uTPiM)to comprehensively cha.a.terize the 3D flow *** results corrobora.e the presence of a.stea.y seconda.y flow,underscoring the effectiveness of our *** 3D spira. microfluidics pla.form pa.es the wa. for exploring intrica.e microflow dyna.ics,with promising a.plica.ions in a.ea. such a. drug delivery,dia.nostics,a.d la.-on-a.chip systems.

关键词： thereby stra.ght twisted

PdPtCuNiP高熵非晶合金蠕变机理研究

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力学学报 2024年

作者：段亚娟徐宗睿郝奇 H.kato 乔吉超西北工业大学力学与土木建筑学院加泰罗尼亚理工大学能源技术研究所物理系日本东北大学材料研究所

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研... 详细信息

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研究结果表明，该合金的蠕变行为明显依赖于温度和应力，低温及低应力环境下合金表现出较好的抗蠕变性能，主要以弹性变形为主.随着温度增加，合金抗蠕变能力减弱，粘弹性（粘塑性）变形成为主导.循环应力在低温下对蠕变变形影响较小，而在高温下其影响显著，表明循环载荷能加剧蠕变行为，导致准稳态蠕变速率上升.回复时间对合金的瞬时弹性变形和滞弹性变形有显著影响，但对粘塑性变形的调节作用有限.卸载后合金变形能力逐渐增强，蠕变抑制得到缓解.此外，变形单元弛豫时间的广泛分布和对循环应力的敏感反应，揭示了蠕变机制的复杂性和多时间尺度的结构演化.本研究通过系统的实验和分析，深化了对高熵非晶合金蠕变行为及其调控机制的理解.为高性能高熵非晶合金的设计和应用提供了重要的理论依据和实践指导，对未来开发更具抗蠕变能力的先进材料具有一定意义.

关键词：高熵非晶合金蠕变滞弹性变形动力学微观结构非均匀性

Correla.ing dyna.ic rela.a.ion a.d viscoela.ticity in meta.lic gla.ses

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Science China.Physics,Mecha.ics & a.tronomy) 2024年第5期67卷 81-90页

作者： Gua.gHui Xing Qi Ha. Fa. Zhu Yun-Jia.g Wa.g Yong Ya.g Hidemi kato Eloi Pineda.Si La. JiCha. Qia. School of Mecha.ics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China Sta.e Key La.ora.ory of Nonlinea. Mecha.ics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Depa.tment of Mecha.ica. Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Depa.tment of Ma.eria.s Science a.d Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Institute for Ma.eria.s Resea.ch Tohoku UniversitySendai 980-8577Japan Depa.tment of Physics Institute of Energy TechnologiesUniversitat Politècnica de CatalunyaBarceona 9Spain School of Ma.eria. Science a.d Engineering Herbert Gleiter Institute of NanoscienceNanjing University of Science and Technology.Nanjing 210094China Sta.e Key La.ora.ory of Clea. a.d Efficient Turboma.hinery Power Equipment Northwestern Polytechnical UniversityXi'an 710072China

Rela.a.ion dyna.ics,essentia. for the structura. evolution of non-equilibrium systems like gla.sy ma.eria.s,rema.n ***,we explore rela.a.ion dyna.ics a.d viscoela.tic properties in three types of meta.lic gla.ses with distinctβrela.a.ion *** systems with significa.tβrela.a.ion,stress rela.a.ion a.d creep experiments revea. a.tra.sition from two-step to one-step rela.a.ion with rising ***,such a.phenomenon is a.sent in systems with wea.erβ*** model the two-step rela.a.ion process using a.double Kohlra.sch-Willia.s-Wa.ts equa.ion,a.d the obta.ned rela.a.ion times elega.tly a.here to the a.rhenius *** combining fitted a.tiva.ion energies with theoretica. a.a.ysis,we conclusively a.tribute these rela.a.ion processes toβrela.a.ion a.dαrela.a.ion,***,we a.a.yze the rela.a.ion time spectra.of two processes a.d esta.lish a.comprehensive picture linking dyna.ic rela.a.ion with *** study provides new stra.egies for probing the complex rela.a.ion beha.iors of gla.ses from the perspective of viscoela.ticity.

关键词： creep rela.a.ion gla.ses

The evolution of ca.cer genomic medicine in Ja.a. a.d the role of the Na.iona. Ca.cer Center Ja.a.

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Ca.cer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida.Ya.ushi Ya.a.e Ken kato Genichiro Ishii a.inobu Ha.a.a.Hiroyuki Ma.o Kuniko Suna.i Noboru Ya.a.oto Ta.a.hi Kohno Depa.tment of Genetic Medicine a.d Services National Cancer Center HospitalTokyo 104-0045Japan Depa.tment of Dia.nostic Pa.hology National Cancer Center HospitalTokyo 104-0045Japan Clinica. Resea.ch Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Depa.tment of Pa.hology a.d Clinica. La.ora.ories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecula. Pha.ma.ology National Cancer Center Research InstituteTokyo 104-0045Japan Na.iona. Ca.cer Center Resea.ch Institute Tokyo 104-0045Japan Depa.tment of La.ora.ory Medicine National Cancer Center HospitalTokyo 104-0045Japan Depa.tment of Experimenta. Thera.eutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement ca.cer genomic medicine(CGM)in oncology pra.tice bega. in the 1980s,which is considered the da.n of genetic a.d genomic ca.cer *** the time,a.va.iety of a.tiva.ing oncogenic a.tera.ions a.d their functiona. significa.ce were unveiled in ca.cer cells,which led to the development of molecula. ta.geted thera.ies in the 2000s a.d *** CGM is still a.rela.ively new discipline a.d it is difficult to predict to wha. extent CGM will benefit the diverse pool of ca.cer pa.ients,the Na.iona. Ca.cer Center(NCC)of Ja.a. ha. a.rea.y contributed considera.ly to CGM a.va.cement for the conquest of *** ba.k a. these pa.t a.hievements of the NCC,we predict tha. the future of CGM will involve the following:1)a.bioba.k of pa.red ca.cerous a.d non-ca.cerous tissues a.d cells from va.ious ca.cer types a.d sta.es will be *** qua.tity a.d qua.ity of these sa.ples will be compa.ible with omics *** bioba.k sa.ples will be linked to longitudina. clinica. informa.ion.2)New technologies,such a. whole-genome sequencing a.d a.tificia. intelligence,will be introduced a.d new bioresources for functiona. a.d pha.ma.ologic a.a.yses(e.g.,a.pa.ient-derived xenogra.t libra.y)will be systema.ica.ly deployed.3)Fa.t a.d bidirectiona. tra.sla.iona. resea.ch(bench-to-bedside a.d bedside-to-bench)performed by ba.ic resea.chers a.d clinica. investiga.ors,prefera.ly working a.ongside ea.h other a. the sa.e institution,will be implemented;4)Close colla.ora.ions between a.a.emia.industry,regula.ory bodies,a.d funding a.encies will be esta.lished.5)There will be a. investment in the other bra.ch of CGM,persona.ized preventive medicine,ba.ed on the individua.'s genetic predisposition to ca.cer.

关键词： Ca.cer genomic medicine bioba.k pa.ient-derived xenogra.t multi-gene pa.el test whole genome sequencing

DPY19L3 promotes va.culogenicmimicry by its C-ma.nosyltra.sfera.e a.tivity

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Oncology Resea.ch 2024年第4期32卷 607-614页

作者： Ha.Sa. Ba.DOUN YUJI kato HIROKI Ka.O a.Na.HÜSCH Ha.a.O MIZUTa.RYOTa.Ka.a.a.a.SIRO SIMIZU Depa.tment of a.plied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Depa.tment of Pha.ma.y a.d Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-ma.nosyla.ion is a.post-tra.sla.iona. modifica.ion tha. occurs intra.ellula.ly in the endopla.mic *** huma.s,biosynthesis of C-ma.nosyla.ion in proteins conta.ning thrombospondin type 1 repea. is ca.a.yzed by the DPY19 fa.ily;nonetheless,biologica. functions of protein C-ma.nosyla.ion a.e not yet fully understood,especia.ly in tumor *** mimicry(VM)is the forma.ion of fluid-conducting cha.nels by highly inva.ive a.d genetica.ly deregula.ed tumor cells,ena.ling the tumors to form ma.rix-embedded va.culogenic structures,conta.ning pla.ma.a.d blood cells to meet the meta.olic dema.ds of ra.idly growing *** this study,we focused on DPY19L3,a.C-ma.nosyltra.sfera.e,a.d a.med to unra.el its role in *** of DPY19L3 inhibited the forma.ion of VM in HT1080 huma. fibrosa.coma.***-expression of wild-type DPY19L3 recovered VM forma.ion;however,DPY19L3 isoform2,a. enzyma.ic a.tivity-defect muta.t,did not restore it,suggesting tha. the C-ma.nosyltra.sfera.e a.tivity of DPY19L3 is crucia. to its ***,the knockdown of DPY19L3 in MDa.MB-231 brea.t ca.cer cells hindered its network forma.ion ***,our findings suggest tha. DPY19L3 is required for VM forma.ion a.d stipula.e the releva.ce of C-ma.nosyla.ion in oncogenesis.

关键词： C-ma.nosyla.ion Va.culogenic mimicry DPY19L3

Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃的热稳定性和热塑成形性

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稀有金属材料与工程 2024年第1期53卷 1-7页

作者： Ca.dina. Sa.drine Pelletier Jea.-Ma.c kato Hidemi 里昂大学里昂国立应用科学学院法国里昂F-69621 东北大学金属材料研究所日本仙台980-8577

采用差示扫描量热法、X射线衍射和热力学分析研究了Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃(HEMG)的热稳定性和热力学性能。结果表明,与其他经典贵金属基金属玻璃相比,Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)HEMG具有相当的性能... 详细信息

采用差示扫描量热法、X射线衍射和热力学分析研究了Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)高熵金属玻璃(HEMG)的热稳定性和热力学性能。结果表明,与其他经典贵金属基金属玻璃相比,Pd_(20)Pt_(20)Cu_(20)Ni_(20)P_(20)HEMG具有相当的性能和鲜明的特点。

关键词：高熵合金金属玻璃热塑性成形结晶

Na.ura. history of a.ymptoma.ic ga.lbla.der stones in clinic without beds:a.long-term prognosis over 10 yea.s

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World Journa. of Clinica. Ca.es 2024年第1期12卷 42-50页

作者： Yuji Sa.a. Toshio Tsuyuguchi Hiroshi Ohya.a.Junichiro Kuma.a. Ta.a.hi Ka.ho Ma.a.uki Ohtsuka.Na.ya.kato Ta.a. Sa.a. Depa.tment of Ga.troenterology Sakai ClinicKimistu 299-1162Japan Depa.tment of Ga.troenterology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Depa.tment of Ga.troenterology Chiba Prefectural Sawara HospitalChiba Prefectural Sawara HospitalSawara 287-0003Japan Depa.tment of Ga.troenterology Kimitsu Central HospitalKisarazu 292-8535Japan Depa.tment of Surgery Kimitsu Central HospitalKisarazu 292-8535Japan Depa.tment of Genera. Surgery Graduate School of MedicineChiba UniversityChiba 260-8677Japan

Ba.KGROUND Severa. studies ha.e explored the long-term prognosis of pa.ients with a.ymp-toma.ic ga.lbla.der *** reports were prima.ily conducted in fa.ilities equipped with beds for a.dressing symptoma.ic *** To report the long-term prognosis of pa.ients with a.ymptoma.ic ga.lbla.der stones in clinics without bed *** We investiga.ed the prognoses of 237 pa.ients dia.nosed with a.ymptoma.ic ga.lbla.der stones in clinics without beds between Ma.ch 2010 a.d October *** symptoms developed,pa.ients were tra.sferred to hospita.s where a.propria.e trea.ment wa. *** investiga.ed the a.ymptoma.ic a.d surviva. periods during the *** a.ong the 237 pa.ients,214(90.3%)rema.ned a.ymptoma.ic,with a.mea. a.ymptoma.ic period of 3898.9279±46.871 d(50-4111 d,10.7 yea.s on a.era.e).Bilia.y complica.ions developed in 23 pa.ients(9.7%),with a.mea. surviva. period of 4010.0285±31.2788 d(53-4112 d,10.9 yea.s on a.era.e).No pa.ient died of bilia.y *** The long-term prognosis of a.ymptoma.ic ga.lbla.der stones in clinics without beds wa. *** the condition beca.e symptoma.ic,the pa.ients were tra.sferred to hospita.s with beds tha. could a.dress it;thus,no dea.hs rela.ed to bilia.y complica.ions were *** finding suggests tha. follow-up ca.e in clinics without beds is possible.

关键词： Ga.lbla.der stone a.ute chola.gitis a.ute cholecystitis a.ymptoma.ic ga.lbla.der stone Symptoma.ic ga.lbla.der stone

Genomic medicine in clinica. pra.tice:na.iona. genomic medicine progra. in Ja.a.

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Ca.cer Biology & Medicine 2024年第1期21卷 4-9页

Ca.cer sta.istics in Ja.a. Ca.cer is the most common ca.se of dea.h in Ja.a. ba.ed on Sta.istics 2021~*** sta.istics were first ga.hered,infectious disea.es,such a. tuberculosis,a.d cerebrova.cula. disea.e ha.e been the ma.n ca.ses of dea.h in *** surpa.sed cerebrova.cula. disea.e a. the ma.n ca.se of dea.h in 1981,a.d the number of ca.cer dea.hs ha. *** 38,000 people died of ca.cer in *** Na.iona. Ca.cer Center(NCC)reported tha. the 5-yea. surviva. ra.e for pa.ients with ca.cer wa. improving(62%for ma.es a.d 66.9%for fema.es)in a.popula.ion-ba.ed ca.cer registry.

关键词： Ca.cer ca.cer dea.h

No-touch isola.ion technique in emergency pa.crea.icoduodenectomy for neopla.tic hemorrha.e: Two ca.e reports a.d review of litera.ure

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World Journa. of Ga.trointestina. Surgery 2024年第6期16卷 1910-1917页

作者： a.ihiro Cho Sa.oshi Ka.a.iri Ma.a. Ota.Shunsuke Oniza.a.Ryota.Higuchi Toshiya.Sugishita.Yukiko Niwa.Ta.eshi Ishita.Toshihiko Mouri a.ita.kato Moe Iwa.a Division of Ga.troenterologica. Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

Ba.KGROUND Emergency pa.crea.icoduodenectomy(EPD)is a.ra.e event for complex peria.-pulla.y *** intra.pera.ive blood loss is correla.ed with poor post-opera.ive *** SUMMa.Y Two pa.ients underwent EPD using a.no-touch isola.ion technique,in which a.l a.teries supplying the pa.crea.ic hea. region were liga.ed a.d divided before ma.ipula.ion of the pa.crea.ic hea. a.d *** opera.ive times were 220 a.d 239 min,a.d the blood loss wa. 70 a.d 270 g,*** pa.ients were discha.ged on the 14^(th) a.d 10^(th) postopera.ive da.,***-two pa.ients underwent EPD for the trea.ment of neopla.tic *** mea. opera.ive time wa. 361.6 min,a.d the mea. blood loss wa. 747.3 *** comp-lica.ion ra.e wa. 37.5%.The in-hospita. morta.ity ra.e wa. 9.38%.CONCLUSION The no-touch isola.ion technique is fea.ible,sa.e,a.d effective for reducing intra.pera.ive blood loss in EPD.

关键词： No-touch isola.ion technique Pa.crea.icoduodenectomy Emergency pa.cre-a.icoduodenectomy Neopla.tic bleeding Superior mesenteric a.tery first a.proa.h Ca.e report