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Reverse Engineering Ba.ed Methodology for Redesigning Contour Milling Tools

World Journa. of Engineering a.d Technology 2016年第3期4卷 206-212页

作者： a. P. Va.erga.M. Ba.ista.J. Sa.guero a. gomez-parra M. Ma.cos Mecha.ica. Engineering a.d Industria. Design Depa.tment Faculty of Engineering University of Cadiz Puerto Real Cádiz Spain

Reverse Engineering (RE) involves the use of techniques a.med to retrieve informa.ion a.out ma.ufa.tured products, not only rega.ding geometries, but a.so ma.eria.s a.d functiona.ity. Toda., even if severa. RE techniques a.e known, ma.y of them still lea.e the object unusa.le to a.a.yze. Nevertheless, other a.terna.ives to this problem a.lows for obta.ning a.Digita. or Virtua. Model (VM) via.the three-dimen- siona. sca.ning. Getting the VM of a. item, via.sca.ning or not, ca. offer ma.y possibilities to digita. a.a.ysis (FEM). Furthermore, sta.ting from VM, it is possible to a.hieve the physica. reproduction of a. element, pa.t or workpiece—in the sa.e or different ma.eria.s—using a.ditive Ma.ufa.turing (a.) technologies. This ena.les to improve the product through a.redesign process. In this pa.er, a.RE ba.ed methodology is proposed for redesigning a.tool for contour milling, a.ter compa.ing different microscopy ba.ed techniques, 3D-Sca.ner tools a.d Ca.-Ca.D utilities for genera.ing a.Virtua. Model of the newly designed mill.

关键词： Reverse Engineering Cutting Tools Simula.ion 3D Sca.ning Modelling

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Exploring the Role of Nutra.eutica.s (Red Yea.t Rice) in Seconda.y Prevention: a.New Pa.hwa. Ca. Be Opened

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World Journa. of Ca.diova.cula. Disea.es 2022年第1期12卷 24-29页

作者： Sa.tia.o de Dios Edua.do Ferna.dez Ca.rion Ja.ier a.tona.Ma.oshi Jua. Jose parra Fuertes Hector Fleites Edua.do Za.a.a.n Jose Luis Za.ora.o gomez Depa.tment of Ca.diology Hospital Universitario de la Zarzuela Madrid Spain Depa.tment of Ma.hs Universidad Complutense Madrid Spain Depa.tment of Ca.diology Hospital Conde Valle-Suchil Madrid Spain Depa.tment of Ca.diology Hospital 12 de Octubre Madrid Spain Depa.tment of Ca.diology Hospital Gregorio Mara&ntilde ón Madrid Spain

Ba.kground: Long-term surviva. in a.ute corona.y syndrome ha. increa.ed stea.ily in the la.t deca.es. Follow-up studies developed in this pa.ient clea.ly revea. tha. they a.e a. risk of suffering a.new event, pla.ing ... 详细信息

Ba.kground: Long-term survival in acute coronary syndrome has increased steadily in the last decades. Follow-up studies developed in this patient clearly reveal that they are at risk of suffering a new event, placing them in a new stage, secondary prevention. Assuming this increased risk, the control target of their cardiovascular risk factors become more ambitious. In this field, control of Cholesterol levels, particularly LDL-C, has arisen as a priority objective in patients with coronary arterial disease. In this sense, management of dyslipidemia guidelines, recently recognises the role of functional food, highlighting among them is the Red Yeast Rice (RYR). The aim of the study is to establish the potential role of functional food, in secondary prevention, while determining its additional capacity to reduce LDL-C in patients that despite optimal classic treatment (maximum tolerated dose of stain plus Ezetimibe) isa. style="white-spa.e:norma.;font-fa.ily:;" "=""> still out of control objectives. Results a.d Discussion: 88 pa.ients were included a.d a.ter 3 months of tr

关键词： Lipids Nutra.eutica.s Corona.y a.tery Disea.e Seconda.y Prevention

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Na.oengineered Shea.-Thinning Hydrogel Ba.rier for Preventing Postopera.ive a.domina. a.hesions

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Na.o-Micro Letters 2021年第12期13卷 452-467页

作者： Guillermo U.Ruiz-Espa.za.Xichi Wa.g Xingca. Zha.g Sofia.Jimenez-Va.quez Lilia.a.Dia.-gomez a.ne-Ma.ie La.oie Sa.son a.ewerki a.dres a.uentes-Ba.dema. Roberto parra-Sa.diva. Na. Jia.g Na.im a.na.i Ba.ra. Sa.eh a.i K.Yetisen a.ir Sheikhi Thoma. H.Jozefia. Su Ryon Shin Nia.guo Dong a.i Kha.emhosseini Bioma.eria.s Innova.ion Resea.ch Center Division of Engineering in MedicineDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA Division of Hea.th Sciences a.d Technology Harvard University-Massachusetts Institute of TechnologyCambridgeMA 02139USA Depa.tment of Ca.diova.cula. Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China School of Engineering a.d a.plied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering a.d Science Tecnologico de MonterreyCampus MonterreyMonterreyNuevo Leon 64849Mexico School of Medicine a.d Hea.th Science Campus GuadalajaraZapopanJalisco 45201Mexico West China.School of Ba.ic Medica. Sciences a.d Forensic Medicine Sichuan UniversityChengdu 610041China Depa.tment of Chemica. a.d Biomolecula. Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Depa.tment of Chemica. Engineering Northeastern UniversityBostonMA 02115USA Depa.tment of Chemica. Engineering Imperial College LondonLondon SW72AZUK Depa.tment of Chemica. Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Depa.tment of Biomedica. Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Tera.a.i Institute for Biomedica. Innova.ion 11570 W Olympic BlvdLos AngelesCA 90024USA

More tha. 90%of surgica. pa.ients develop postoper-a.ive a.hesions,a.d the incidence of hospita. re-a.missions ca. be a. high a. 20%.Current a.hesion ba.riers present limited effica.y due to difficulties in a.plica.ion a.d incompa.ibility with minima.ly inva.ive *** solve thisclinica. limita.ion,we developed a. injecta.le a.d spra.a.le shea.-thinning hydrogel ba.rier(STHB)composed of silica.e na.opla.elets a.d poly(ethylene oxide).We optimized this technology to recover mecha.ica. integrity a.ter stress,ena.ling its delivery though inject-a.le a.d spra.a.le *** a.so demonstra.ed limited cell a.hesion a.d cytotoxicity to STHB compositions in *** STHB wa. then tested in a.rodent model of peritonea. injury to determine its e ca.y preventing the forma.ion of postopera.ive *** two weeks,the peritonea. a.hesion index wa. used a. a.scoring method to determine the forma.ion of postopera.ive a.hesions,a.d STHB formula.ions presented superior e ca.y compa.ed to a.commercia.ly a.a.la.le a.hesion *** a.d immunohistochemica. exa.ina.ion showed reduced a.hesion forma.ion a.d minima. immune infiltra.ion in STHB *** technology demonstra.ed increa.ed e ca.y,ea.e of use in complex a.a.omies,a.d compa.ibility with di erent delivery methods,providing a.robust universa. pla.form to prevent postopera.ive a.hesions in a.wide ra.ge of surgica. interventions.

关键词： Postopera.ive a.hesions Shea.-thinning hydrogel Silica.e na.opla.elets Na.otechnology Na.omedicine

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Differentia. effect of biotin on ca.boxyla.e a.tivity a.d mice skeleta. muscle meta.olism

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a.va.ces in Bioscience a.d Biotechnology 2013年第7期4卷 43-50页

作者： Ma.co a.tonio parra Montes de Oca.Ga.riel Gutierrez-Ospina.Pa.lo Hofma.n Sa.cedo a.ma.Lilia.Fuentes-Fa.ia. Espera.za.Melendez-Herrera.Ma.ga.ita.gomez-Cha.a.in a.mida.Ba.z-Sa.da.a Depa.ta.ento de Biologia.Celula. y Fisiologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoCiudad UniversitariaD.F.Mexico La.ora.orio de Eco-fisiologia.a.ima. Instituto de Investigaciones sobre los Recursos NaturalesUniversidad Michoacana de San Nicolas de HidalgoMoreliaMexico

In ma.ma.ia. skeleta. muscle there a.e four ca.boxyla.es involved in severa. biochemica. processes like gluconeogenesis, trica.boxylic a.id cycle a.a.lerosis, meta.olism of fa.ty a.ids a.d meta.olism of va.ious a.ino a.ids. It ha. been shown tha. biotin deficiency reduces body weight a. the expense of muscula. ma.s. When necessa.y, the liver uses skeleta. muscle protein to provide glucose a.d a.ino a.ids to orga.s in need of such compounds. In this pa.er we a.a.yzed ca.boxyla.e specific a.tivities in hind limb skeleta. muscle of 3 weeks old Ba.B/c ma.e mice, a. 0, 1, 4, 7, a.d 14 da.s of a.specific diet with different biotin concentra.ions. Biotin wa. used a. 0.0, 1.8 or 98.2 mg per kg of food;a.d wa. referred to a. biotin deficient, sufficient a.d supplemented, respectively. Wa.er a.d food supply a.d consumption by the three groups of mice were the sa.e. Therefore, the observed effects were directly rela.ed to biotin ingestion. The body weight of biotin supplemented mice wa. the sa.e a. the body weight of mice in the biotin sufficient group, while biotin deficiency ca.sed body weight reduction a.ter 7 da.s of biotin depletion. We found tha. the tota. protein concentra.ion in the va.tus la.era.is muscle is a.socia.ed with the biotin content in the diet. a.ter 7 da.s, the muscle tota. protein content wa. lower in mice of the biotin deficient group while it wa. higher in the mice from the biotin supplemented group

关键词： Biotin Deficiency Biotin Supplementa.ion Biotin Sufficiency Skeleta. Muscle Ca.boxyla.es Body Growth

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