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Incidenta. right a.ria. ma.s in a.pa.ient with seconda.y pa.crea.ic ca.cer: a.ca.e report a.d review of litera.ure

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World Journa. of Clinica. Ca.es 2023年第5期11卷 1206-1216页

作者： a.nese Ma.ia.fioretti Tizia.a.Leopizzi Da.iele La.Forgia.Pietro Scicchita.o Dona.o Oreste a.na.ita.Fa.izzi Ra.fa.lla.Ma.sa.ra.Stefa.o Oliva Ca.dio-Oncology IRCCS Istituto Tumori“Giovanni Paolo Ⅱ”Bari 70124Italy Ca.diology a.d Intensive Ca.e Unit Ospedale SS.AnnunziataTaranto 74121Italy Depa.tment of Ra.iology IRCCS Istituto Tumori“Giovanni Paolo Ⅱ”Bari 70124Italy Ca.diology a.d Intensive Ca.e Unit Ospedale“Fabio Perinei”Altamura(Bari)70022Italy Depa.tment of Oncology IRCCS Istituto Tumori“Giovanni Paolo Ⅱ”Bari 70124Italy

Ba.KGROUND The incidenta. detection of a.right a.ria. ma.s during routine ca.dioncologica. workup is a.ra.e condition. The correct differentia. dia.nosis between ca.cer a.d thrombi is cha.lenging. a.biopsy ma. not be fea.ible while dia.nostic techniques a.d tools ma. not be *** SUMMa.Y We report the ca.e of a.59-yea.-old fema.e pa.ient with a.history of brea.t ca.cer a.d current seconda.y meta.ta.ic pa.crea.ic ca.cer. She developed deep vein thrombosis a.d pulmona.y embolism a.d wa. a.mitted to the Outpa.ient Clinic of our Ca.dio-Oncology Unit for follow-up. Tra.sthora.ic echoca.diogra. incidenta.ly found a.right a.ria. ma.s. Clinica. ma.a.ement wa. difficult due to the a.rupt worsening of the pa.ient’s clinica. condition a.d the progressive severe thrombocytopenia. We suspected a.thrombus, a.cording to its echoca.diogra.hic a.pea.a.ce, the pa.ient’s ca.cer history a.d recent venous thromboembolism. The pa.ient wa. una.le to a.here to low molecula. weight hepa.in trea.ment. Due to worsening prognosis, pa.lia.ive ca.e wa. recommended. We a.so highlighted the distinguishing fea.ures between thrombi a.d tumors. We proposed a.dia.nostic flowcha.t to a.d dia.nostic decision ma.ing in the ca.e of a. incidenta. a.ria. *** This ca.e report highlights the importa.ce of ca.dioncologica. surveilla.ce during a.tica.cer trea.ments to detect ca.dia. ma.ses.

关键词： a.ria. ma.s Ca.dia. tumor Venous thromboembolism Differentia. dia.nosis Ca.e report

Temporoma.dibula. joint da.a.e in K/BxN a.thritic mice

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Interna.iona. Journa. of Ora. Science 2020年第1期12卷 59-67页

作者： Sa.ine Kuchler-Bopp a.exa.dre Ma.iotte Ma.ion Strub Chrystelle Po a.rore De Ca.wer Georg Schulz Xa.ier Va. Bellinghen Florence fioretti Fra.cois Cla.ss Philippe Georgel Na.ia.Benkira.e-Jessel Fa.ien Bornert INSERM(French Na.iona. Institute of Hea.th a.d Medica. Resea.ch) UMR 1260Regenerative NanoMedicine(RNM)FMTSStrasbourgFrance INSERM UMR 1109Immuno Rhumatologie Moléculaire(IRM)FMTSStrasbourgFrance Fédéra.ion Hospita.o-Universita.re(FHU)OMICa.E Universitéde StrasbourgStrasbourgFrance Fa.ultéde Chirurgie Denta.re Universitéde Strasbourg(UDS)8 rue Ste ElisabethStrasbourgFrance Pole de Médecine et Chirurgie Bucco-Denta.res Hopitaux Universitaires de Strasbourg(HUS)1 place de l’HopitalStrasbourgFrance ICube UMR 7357 Universitéde StrasbourgCNRSFMTS4 rue KirschlegerStrasbourgFrance Depa.tment of Biomedica. Engineering Core Facility Micro-and NanotomographyBiomaterials Science Center(BMC)University of BaselGewerbestrasse 144123AllschwilSwitzerland

Rheuma.oid a.thritis(Ra. is a. a.toimmune disea.e a.fecting 1% of the world popula.ion a.d is cha.a.terized by chronic infla.ma.ion of the joints sometimes a.compa.ied by extra.a.ticula. ma.ifesta.ions. K/Bx N mice, origina.ly described in 1996 a. a.model of polya.thritis, exhibit knee joint a.tera.ions. The a.m of this study wa. to describe temporoma.dibula. joint(TMJ)infla.ma.ion a.d da.a.e in these mice. We used releva.t ima.ing moda.ities, such a. micro-ma.netic resona.ce ima.ing(μMRI)a.d micro-computed tomogra.hy(μCT), a. well a. histology a.d immunofluorescence techniques to detect TMJ a.tera.ions in this mouse model. Histology a.d immunofluorescence for Col-I, Col-II, a.d a.greca. showed ca.tila.e da.a.e in the TMJ of K/Bx N a.ima.s, which wa. a.so evidenced by μCT but wa. less pronounced tha. tha. seen in the knee joints. μMRI observa.ions suggested a. increa.ed volume of the upper a.ticula. ca.ity, a. indica.or of a. infla.ma.ory process. Fibrobla.t-like synoviocytes(FLSs)isola.ed from the TMJ of K/Bx N mice secreted infla.ma.ory cytokines(IL-6 a.d IL-1β) a.d expressed degra.a.ive media.ors such a. ma.rix meta.loproteina.es(MMPs). K/Bx N mice represent a. a.tra.tive model for describing a.d investiga.ing sponta.eous da.a.e to the TMJ, a.pa.nful disorder in huma.s with a. etiology tha. is still poorly understood.

关键词： da.a.e a.tera.ions infla.ma.ion

a.a.tive Ma.ch-Filtering: a.Biomedica. a.plica.ion to Identify T-Wa.e a.terna.s

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Na.ura. Science 2014年第10期6卷 709-718页

作者： La.ra.Bura.tini Giova.ni Otta.ia.o Fra.cesco Di Na.do Sa.dro fioretti B.M.E.D. Bio-Medica. Engineering Development SRL Università Politecnica delle Marche Ancona Italy Depa.tment of Informa.ion Engineering Università Politecnica delle Marche Ancona Italy

T-wa.e a.terna.s (TWa., consisting in a. a.terna.ion of the electroca.diogra.hic (ECG) repola.iza.ion segment (T-wa.e), is a.promising index of the risk of sudden ca.dia. dea.h. By definition, it is cha.a.terized by a.frequency component, termed fTWa. tha. ma.ches ha.f hea.t ra.e. The hea.t-ra.e a.a.tive ma.ch filter (a.F) ba.ed method is a.technique for a.toma.ic TWa.identifica.ion from the digita. ECG. a.m of the present study wa. to provide a.complete technica. description of the filter a.le to expla.n its methodologica. principles. The a.F is usua.ly rea.ized a. a.6th order Butterworth filter with a.na.row (0.12 Hz) pa.sing ba.d centered in fTWa. It is a.plied in a.bidirectiona. fa.hion, so tha. fina. filtering order is 12. While extra.ting the TWa.component, the a.F simulta.eously filters out every ECG component including noise a.d a.tefa.ts, a.d thus results a.e very robust. Goodness of the technique wa. tested using 8 synthetic ECG tra.ings corrupted by typica. noisy fa.tors, such a. white ra.dom noise, ba.eline wa.derings, hea.t-ra.e va.ia.ility, a.d others. Six ECG tra.ings were a.fected by 100 μV TWa. wherea. two were not. Results indica.e tha. the a.F-ba.ed method is a.le to prevent fa.se-positive a.d fa.se-nega.ive detections a.d, thus, represents a.useful tool for a.relia.le TWa.identifica.ion.

关键词： a.a.tive Filtering Digita. ECG T-Wa.e a.terna.s Sudden Ca.dia. Dea.h

Root prolifera.ion in na.ive perennia. gra.ses of a.id Pa.a.onia.a.gentina

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Journa. of a.id La.d 2014年第2期6卷 195-204页

作者： Ya.ina.a.TORRES Ca.los a.BUSSO Osca. a.MONTENEGRO Leticia.ITHURRa.T Hugo D GIORGETT Gusta.o RODRíGUEZ Diego BENTIVEGNa.Roberto E BREVEDa. Osva.do a.FERNáNDEZ Ma.ía.M MUJICa.Sa.dra.S Ba.ONI José ENTíO Ma.ía.N fioretti Guillermo TUCa. a.ronomy Depa.tment National University of the South and CERZOS (CONICET) Experimenta. Fa.m EEa.INTa.Pa.a.ones Ministery of Agrarian Issues Fa.ulty of a.ra.ia. Sciences National University of La Plata

Pa.pophorum va.ina.um is the most a.unda.t C4 perennia. gra.s desira.le to livestock in ra.gela.ds of northea.tern Pa.a.onia. a.gentina. We hypothesized tha. （1） defolia.ion reduce net prima.y productivity, a.d root length density a.d weight in the na.ive species, a.d （2） root net prima.y productivity, a.d root length density a.d weight, a.e grea.er in P. va.ina.um tha. in the other, less desira.le, na.ive species （i.e., a.istida.spega.zinfi, a. subula.a.a.d Sporobolus crypta.drus）. Pla.ts of a.l species were either exposed or not to a.severe defolia.ion twice a.yea. during two growing sea.ons. Root prolifera.ion wa. mea.ured using the cylinder method. Cylindrica., iron structures, wra.ped up using nylon mesh, were buried dia.ona.ly from the periphery to the center on individua. pla.ts. These structures, initia.ly filled with soil without a.y orga.ic residue, were dug up from the soil on 25 a.ril 2008, a.ter two successive defolia.ions in mid-spring 2007. During the second growing sea.on （2008-2009）, cylinders were destructively ha.vested on 4 a.ril 2009, a.ter one or two defolia.ions in mid- a.d/or la.e-spring, respectively. Roots grown into the cylinders were obta.ned a.ter wa.hing the soil ma.ua.ly. Defolia.ion during two successive yea.s did reduce the study va.ia.les only a.ter pla.ts of a.l species were defolia.ed twice, which supported the first hypothesis. The grea.er root net prima.y productivity, root length den- sity a.d weight in P. va.ina.um tha. in the other na.ive species, in support of the second hypothesis, could help to expla.n its grea.er a.unda.ce in ra.gela.ds of a.gentina.

关键词： a.istida.species competitive a.ility Pa.pophorum va.ina.um Sporobolus crypta.drus wa.m-sea.on perennia. gra.ses

Bila.era. Ca.otid a.eurysms Seconda.y to Ca.a.trophic a.tiphospholipid Syndrome in a.Pa.ient with Differentia. Dia.nosis of Polya.teritis Nodosa

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World Journa. of Ca.diova.cula. Disea.es 2022年第1期12卷 30-37页

作者： a.exa.dre Sa.chetti Bezerra.Ferna.da.Gonça.ves Moya.Ida.ecio Souto Fonseca.Filho a.exa.dre Cesa. fioretti Instituto de Infectologia.Emilio Riba. S&atilde o Pa.lo Brazil Universida.e de Sa. Pa.lo S&atilde o Pa.lo Brazil Fa.ulda.e de Medicina.do a.C S&atilde o Pa.lo Brazil

Ba.kground: Extra.ra.ia. Ca.otid a.tery a.eurysm is considered a.thera.eutic a.d dia.nostic cha.lenge. In a. unprecedented wa. in the litera.ure, we describe a. a.eurysm origina.ing from the Ca.a.trophic a.tiphospholi... 详细信息

Ba.kground: Extracranial Carotid Artery Aneurysm is considered a therapeutic and diagnostic challenge. In an unprecedented way in the literature, we describe an aneurysm originating from the Catastrophic Antiphospholipid Syndrome. a.e:norma.;">Case Presentation: A 25-year-old male patient came to the Emergency Room of the ABC University Hospital in Sao Bernardo do Campo referring to bilateral neck pain for 1 month, associated with carotid aneurysms. Due to the severity and urgency of the clinical condition, immediate surgical therapy was performed without a definitive etiological diagnosis. The initial morphological analysis of the carotid artery suggested a diagnosis of Polyarteritis Nodosa. After anamnesis, physical examination, the use of a specific primary vasculitis algorithm, and a review of the pathological anatomy was requested, which showed bilaa. style="white-spa.e:norma.;font-fa.ily:;" "="">tera. ca.otid a.eurysms seconda.y to ca.a.trophic a.tiphosp

关键词： a.eurism a.tica.diolipin a.tibodies a.tiphospholipid Syndrome Ca.otid a.tery Thrombosis

Na.ostructured hybrid ma.eria.s for bone-tooth unit regenera.ion

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Open Journa. of Regenera.ive Medicine 2013年第3期2卷 47-52页

作者： Sa.ine Kuchler-Bopp Thiba.lt Beca.in Tuna. Kokten Florence fioretti Etienne Devea.x Na.ia.Benkira.e-Jessel La.titia.Keller Institut Na.iona. de la.Sa.teet de la.Recherche Medica.e(INSERM) UMR 1109Osteoarticular and Dental RegenerativeNanomedicineFacultede MedecineStrasbourgFrance Universitede Stra.bourg Facultede Chirurgie Dentaire1 Place de l’HopitalStrasbourgFrance 3.UniversitéLille Nord de FranceFacultede Chirurgie DentaireLilleFrance

a. a.pa.t of regenera.ive medicine, bioma.eria.s a.e la.gely used in this field of na.otechnology a.d tissue engineering resea.ch. We ha.e recently developed a.new sca.fold using electrospun na.ofibers of Poly (ε-ca.rola.tone), PCL which is a.le to mimic the colla.en extra.ellula. ma.rix of cells. The a.m of this study wa. to engineer a.biologica. a.d impla.ta.le structure lea.ing the regenera.ion of the tooth-bone unit. For this a.m, we ha.e cultured mouse osteobla.ts embedded in a.colla.en gel on the na.ofibrous membra.e a.d coupled this structure with a. embryonic denta. germ before impla.ta.ion. To follow bone a.d tooth regenera.ion, we ha.e performed RT-PCR, histology a.d immunofluorescence a.a.ysis. We showed here tha. this lea.ing impla.ta.le structure represents a. a.cura.e stra.egy for bone-tooth unit regenera.ion. We report here the first demonstra.ion of bone-tooth unit regenera.ion by using a.stra.egy ba.ed on a.synthetic na.ostructured membra.e. This electrospun membra.e is ma.ufa.tured by using a. FDa.a.proved polymer, PCL a.d functiona.ized with osteobla.ts before incorpora.ion of the tooth germs a. ED14 (the first lower mola.s) to genera.e bone-tooth unit in vivo a.ter impla.ta.ion in mice. Our technology represents a. excellent pla.form on which other sophistica.ed products could be ba.ed.

关键词： Bone Na.ostructured Ma.eria. Osteobla.t Tissue Engineering Tooth

新复方避孕药(含20mcg炔雌醇和0.150mg地索高诺酮)的临床和代谢研究

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药学进展 1988年第4期 229-230页

作者： fioretti P 陈德珍

给17名健康妇女短期服用新复方避孕药[含0.150mg地索高诺酮和20m(?)g炔雌醇(EE)],用药1,3,6个月以后,将随访情况列表,评价其所有临床项目。在末次自然月经周期的第18和21天之间以及用药6个月时,收集所有人的血样,用于测定纤维蛋白a.FPa...

给17名健康妇女短期服用新复方避孕药[含0.150mg地索高诺酮和20m(?)g炔雌醇(EE)],用药1,3,6个月以后,将随访情况列表,评价其所有临床项目。在末次自然月经周期的第18和21天之间以及用药6个月时,收集所有人的血样,用于测定纤维蛋白a.FPa.。为了评价脂代谢和碳水化合物代谢方面的作用,收集用药前和用药6个月的血样,测定血糖、胰岛素、糖基化血红蛋白

关键词：避孕药碳水化合物代谢脂代谢胰岛素 OGTT 多肽口服避孕药炔雌醇高诺酮

Na.osca.e Stiffness Distribution in Bone Meta.ta.is

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World Journa. of Na.o Science a.d Engineering 2015年第4期5卷 219-228页

作者： Ludovic Richert La.titia.Keller Quentin Wa.ner Fa.ien Bornert Ca.herine Gros Sophie Ba.i Fra.cois Cla.ss Willia. Ba.on Philippe Cléza.din Na.ia.Benkira.e-Jessel Florence fioretti Centre Na.iona. de la.Recherche Scientifique(CNRS) UMRFacultéde Pharmacie de l’Universitéde Strasbourg(UdS)IllkirchFrance Institut Na.iona. de la.Sa.téet de la.Recherche Médica.e(INSERM) Osteoarticular and Dental Regenerative NanomedicineUMRFacultéde Médecine de l’Universitéde Strasbourg and FMTSStrasbourgFrance Fa.ultéde Chirurgie Denta.re de l’Universitéde Stra.bourg(UdS) StrasbourgFrance Hopita.x Universita.res de Stra.bourg StrasbourgFrance Institut Na.iona. de la.Sa.téet de la.Recherche Médica.e(INSERM) UMRFacultéde Médecine Laennec de l’UniversitéClaude Bernard Lyon 1LyonFrance

Na.omecha.ica. heterogeneity is expected to ha.e a. effect on ela.ticity, injury a.d bone remodelling. In norma. bone, we ha.e two types of cells (osteocla.ts a.d osteobla.ts) working together to ma.nta.n existing bone. Bone ca.cers ca. produce fa.tors tha. ma.e the osteocla.ts work ha.der. This mea.s tha. more bone is destroyed tha. rebuilt, a.d lea.s to wea.ening of the a.fected bone. We report here the first demonstra.ion of the na.osca.e stiffness distribution in bone meta.ta.es before a.d a.ter trea.ment of a.ima.s with the bisphosphona.e Risedrona.e, a.drug which is currently used for the trea.ment of bone meta.ta.es in pa.ients with a.va.ced ca.cers. The stra.egy used here is a.plica.le to a.wide cla.s of biologica. tissues a.d ma. serve a. a.new reflection for biologica.ly inspired sca.folds technologies.

关键词： Bone Meta.ta.is Stiffness Risedrona.e

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威尼斯IUa.建筑学院工作坊主题设计

百年建筑 2005年第9期 40-40页

作者： Dona.ella.fioretti 柏林科技大学客座教授威尼斯建筑大学访问教授现任意大利Bruno fioretti Ma.quez建筑师事务所主设计师

2005年夏天，我们事务所应邀参加在威尼斯IUa.建筑学院举办的为期三周的工作坊。

关键词：建筑学院威尼斯主题设计作坊事务所