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Deficiency of a.enoma.ous Polyposis Coli protein in spora.ic colorecta. a.enoma. a.d its a.socia.ions with clinica. phenotype a.d histology

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World Journa. of Ga.troenterology 2006年第24期12卷 3901-3905页

作者： Ma.tin Bortlík Iva.a.vítková Ma.tina.Pa.e(z|ˇ)ová Mila.a.Kohoutová a.e(s|ˇ) Novotn(y|') Sta.isla. a.a.ec Petra.Cha.upná Mila. Luká(s|ˇ) Ga.troenterology Center 4th Interna. Depa.tment General Faculty Hospital1st School of MedicineCharles UniversityPragueCzech Republic Depa.tment of Pa.hology Genera. Fa.ulty Hospita. 1st School of MedicineCharles UniversityPragueCzech Republic Institute for Biology a.d Medica. Genetics Genera. Fa.ulty Hospita. 1st School of MedicineCharles UniversityPragueCzech Republic

a.M： To eva.ua.e the frequency of the loss of the a.enoma.ous Polyposis Coil （a.C） protein a.d to compa.e the a.C sta.us with the cha.a.teristics of colorecta. a.enoma.. METHODS： Immunohistochemica. a.a.ysis of the a.C protein wa. performed on 118 a.enoma. a.d the results were compa.ed with pa.a.eters of ma.igna.t potentia., loca.ion of a.enoma., ma.roscopic a.pea.a.ce a.d a.e of the pa.ients. RESULTS： a.complete loss of the a.C protein wa. found in 28 （24%） a.enoma., while 90 （76%） were a.C positive. The mea. size of a.enoma. wa. 13.5± 14.2 mm （95% CI 10.5-16.5） in a.C-positive, a.d 13.8 ±15.5 mm （95% CI 7.8-19.8） in a.C-nega.ive a.enoma. （P = 0.364）. Sta.istica. a.a.ysis revea.ed no difference between a.C-positive a.d nega.ive a.enoma. a. to the histologica. type （P = 0.327） a.d gra.e of dyspla.ia.（P =0.494）. We found tha. even a.va.ced a.enoma. did not differ in their a.C sta.us from the non-a.va.ced tumors （P = 0.414）. Fina.ly, no difference wa. found when the loca.ion （P = 0.157）, ma.roscopic a.pea.a.ce （P = 0.571） a.d a.e of pa.ients （P = 0.438） were a.a.ysed a.d compa.ed between both a.C positive a.d nega.ive a.enoma.. CONCLUSION： Most a.enoma. expressed full-length a.C protein, suggesting tha. protein expression is not a.relia.le ma.ker for a.sessment of a.C gene muta.ion. Complete loss of a.C protein did not influence morphology, loca.ion, or a.pea.a.ce of a.enoma., nor wa. it a.fected by the pa.ient＇s a.e.

关键词： a.enoma.ous Polyposis Coli protein a.eno-ma Immunohistochemistry Histology

Diversity of folia. endophytes in wind-fa.len Picea.a.ies trees

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Funga. Diversity 2012年第3期54卷 69-77页

作者： Ondřej Koukol Mirosla. Kola.ík Zuza.a.Kolářová Petr Ba.dria. Depa.tment of Bota.y Faculty of ScienceCharles University in PragueBenátská212801 Prague 2Czech Republic La.ora.ory of Genetics Physiology and Bioengineering of FungiInstitute of Microbiology of the ASCRv.v.i.Vídeňská108314220 Prague 4Czech Republic La.ora.ory of Environmenta. Microbiology Institute of Microbiology of the ASCRv.v.i.Vídeňská108314220 Prague 4Czech Republic

The unma.a.ed Norwa. spruce monta.e forests in the Bohemia. Forest Na.iona. Pa.k(Czech Republic)suffered from repea.ed la.ge-sca.e ba.k beetle outbrea.s in la.t *** this study,the diversity of cultura.le folia. endophyte microfungi in needles origina.ing from eleven recently wind-fa.len trees in this a.ea.wa. *** a.ms were to describe their diversity a.d to determine the rela.ive host a.d orga. specificities of isola.ed endophyte species to estima.e the species pool a.d a.unda.ce of folia. endophytes before the forest *** were isola.ed from surfa.e-sterilized needles,a.d the outgrowing stra.ns were identified ba.ed on morphologica. a.d molecula. cha.a.teristics(a.a.yses of ITS1,ITS2 a.d pa.tia. 28S rDNa..Funga. communities in the needles were diverse,with a.comycetes(mostly a.a.orphs of Helotia.es)domina.ing *** most frequent species(Pha.idiopycnis sp.,Cistella.a.uum,Sirococcus *** two species of Cha.a.a.did not correspond with those recorded in previous studies of Picea.*** exa.ple,the widely distributed Lophodermium picea. wa. ra.ely recorded in this *** pa.tern ma. be ca.sed by different methods of steriliza.ion a.d cultiva.ion or by physiologica. cha.a.teristics of the needles,or it ma. reflect the species distribution in the studied *** of the Helotia.es,a.ong with sequences from GenBa.k,showed substa.tia. overla. in host a.finities,most prominently between Pinus a.d Picea.a.d a.so a.ong species from dista.t pla.t linea.es.

关键词： Morphospecies ITS rDNA Cultura.le microfungi Pha.idiopycnis Host a.finity

Isola.ed ga.lbla.der tuberculosis mimicking a.ute cholecystitis:a.ca.e report

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World Journa. of Ga.trointestina. Surgery 2020年第3期12卷 123-128页

作者： Ka. Sia.g Cha. visha. G Shela. cher Heng Ta. Yee Lin Ta.g Sa.eer P Junna.ka. Kong Chia. School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Depa.tment of Genera. Surgery Tan Tock Seng HospitalSingapore 308433Singapore Depa.tment of Dia.nostic Ra.iology Tan Tock Seng HospitalSingapore 308433Singapore Depa.tment of Pa.hology Tan Tock Seng HospitalSingapore 308433Singapore

Ba.KGROUND Isola.ed tuberculosis of the ga.lbla.der is extremely ra.e due to its intrinsic resista.ce to tuberculous *** a.e reports of ga.lbla.der tuberculosis mimicking cholecystitis or ***,these presenta.ions were *** dia.nosis of ga.lbla.der tuberculosis wa.ra.ts the need for investiga.ion of a.ditiona. sites of inocula.ion a.d conta.t tra.ing of a.l tuberculosis *** tuberculosis is a.ra.e entity but should be suspected in pa.ients from endemic regions with risk fa.tors such a. underlying immunosuppression or history of *** SUMMa.Y We present a.ca.e of ga.lbla.der tuberculosis presenting a. a.ute cholecystitis.a.44-yea.-old Filipino la.y presented with a.11-d history of right hypochondrium a.d epiga.tric pa.n which worsened a.ter mea.s with no significa.t pa.t medica. *** underwent la.a.oscopic cholecystectomy on the presumptive dia.nosis of a.ute cholecystitis a.d dia.nosed a. ga.lbla.der tuberculosis a.ter histopa.hologica. *** pa.ient did not ha.e fea.ures of pulmona.y or systemic tuberculosis nor wa. she *** recovered *** wa. subsequently discha.ged a.d followed-up a. a.hospita. in her home country due to fina.cia. a.d socia. *** Clinicia.s should ha.e a.high index of suspicion for pa.ients in endemic regions presenting with cholecystitis.

关键词： Cholecystectomy Cholecystitis Ga.lbla.der Extra.pulmona.y tuberculosis Ca.e report

Use of computed tomogra.hy in the ma.a.ement of colorecta. ca.cer

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World Journa. of Ra.iology 2010年第5期2卷 151-158页

作者： cher Heng Ta. Reva.hy Iyer Depa.tment of Dia.nostic Ra.iology Tan Tock Seng Hospital Division of Dia.nostic Ima.ing MD Anderson Cancer Center

Computed tomogra.hy (CT) pla.s a. importa.t role in the ma.a.ement of colorecta. ca.cer (CRC). The use of CT (colonogra.hy) a. a.screening tool for CRC ha. been va.ida.ed a.d is expected to rise over time. The results of prior studies suggest tha. CT is suboptima. for a.sessment of loca. T sta.e a.d modera.e for N sta.e disea.e. Recent a.va.ces in CT technology a.e expected to lea. to some improvement in sta.ing a.cura.y. a. present, the ma.n role of CT in pretrea.ment ima.ing a.sessment lies in its use for the detection of dista.t meta.ta.es, especia.ly in the liver. In a.select group of pa.ients, routine post-trea.ment surveilla.ce with CT confers surviva. benefits. The role of CT for post-trea.ment a.sessment ha. been ra.ica.ly a.tered a.d improved with the a.vent of fusion positron emission tomogra.hy/CT. Perfusion CT shows promise a. a.other functiona. ima.ing moda.ity but further experience with this technique is necessa.y before it ca. be a.plied to routine clinica. pra.tice.

关键词： Computed tomogra.hy Perfusion Positron emission tomogra.hy Recta. ca.cer

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时滞系统控制算法的改进

基础自动化 2000年第6期7卷 9-10,39页

作者：韩绍坤 Nоviкov v.А . 北京理工大学北京100081 St.Petersburg ETU russia197396

针对著名的 Smith预估器,为了补偿变化的时滞,采用自适应补偿算法,使补偿时滞的模型可以跟踪时滞的变化,从而提出一种新型控制算法.仿真结果表明,改进的方案可以明显地提高控制系统精度.

关键词：时滞系统控制算法 Smith预估器自适应控制

Ima.ing of ga.troenteropa.crea.ic neuroendocrine tumors

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World Journa. of Clinica. Oncology 2011年第1期2卷 28-43页

作者： Eik Hock Ta. cher Heng Ta. Depa.tment of Nuclea. Medicine a.d PET Singapore General HospitalOutram RoadSingapore 169608Singapore Depa.tment of Dia.nostic Ra.iology Tan Tock Seng Hospital11 Jalan Tan Tock SengSingapore 308433Singapore

Ima.ing of ga.troenteropa.crea.ic neuroendocrine tumors ca. be broa.ly divided into a.a.omic a.d functiona. *** ima.ing determines the loca. extent of the prima.y lesion,providing crucia. informa.ion required for surgica. *** ima.ing,not only determines the extent of meta.ta.ic disea.e sprea.,but a.so provides importa.t informa.ion with rega.d to the biologic beha.ior of the tumor,a.lowing clinicia.s to decide on the most a.propria.e forms of *** review the current litera.ure on this subject,with empha.is on the strengths of ea.h ima.ing moda.ity.

关键词： Ma.netic resona.ce ima.ing Neuroendocrine tumor Positron emission tomogra.hy Soma.osta.in receptor scintigra.hy

a.a.ysis of Higher Order System with Impulse Exciting Functions in Z-Doma.n

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Circuits a.d Systems 2016年第11期7卷 3951-3970页

作者： Bra.isla. Dobrucký Pa.ol Štefa.ec Ma.ia.a.Beňová Oleg v. chernoya.ov Micha. Pokorný Fa.ulty of Electrica. Engineering University of ?ilina ?ilina Slovak Republic Depa.tment of Ra.io Engineering Devices a.d a.tenna.Systems National Research University Moscow Power Engineering Institute Moscow Russia

This pa.er dea.s with ma.hema.ica. modelling of impulse wa.eforms a.d impulse switching functions used in electrica. engineering. Impulse switching functions a.e la.er investiga.ed using direct a.d inverse z-tra.sforma.ion. The results ma.e possible to present those functions a. infinite series expressed in pure numerica., exponentia. or trigonometric forms. The ma.n a.va.ta.e of used a.proa.h is the possibility to ca.cula.e investiga.ed va.ia.les directly in a.y insta.t of time;dyna.ic sta.e ca. be solved with the step of sequences (T/6, T/12) tha. mea.s very fa.t. Theoretica.ly derived wa.eforms a.e compa.ed with simula.ion worked-out results a. well a. results of circuit emula.or LT spice which a.e given in the pa.er.

关键词： Impulse Systems Switching Function Z-Tra.sforma.ion Inverse Z-Tra.sforma.ion Stea.y Sta.e Opera.ion Dyna.ica. Sta.e Model Modelling a.d Simula.ion

Experience a.ter 100 pa.ients trea.ed with cytoreductive surgery a.d hyperthermic intra.eritonea. chemothera.y

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World Journa. of Ga.troenterology 2012年第17期18卷 2061-2066页

作者： Ingma. Knigsra.ner Derek Zieker Jrg Gla.zle Olivia.La.k Julia.Klimek Stepha. Symons Bjrn Brücher Stefa. Beckert a.fred Knigsra.ner Depa.tment of Surgery University of TübingenHoppeSeyler-Strasse 3D-72076 TübingenGermany Center for Bioinforma.ics Tübingen Sand 14D-72076 TübingenGermany

a.M:To investiga.e periopera.ive pa.ient morbidity/morta.ity a.d outcome a.ter cytoreductive surgery(CRS) a.d hyperthermic intra.eritonea. chemothera.y(HIPEC).METHODS:Of 150 pa.ients 100 were trea.ed with cytoreductive surgery a.d HIPEC a.d retrospectively *** a.d postopera.ive follow-up da.a.were *** ma.s index(BMI),a.e a.d peritonea. ca.cinoma.osis index(PCI) were chosen a. selection criteria.with rega.d to tumor-free surviva. a.d periopera.ive morbidity for this multimoda. ***:CRS with HIPEC wa. successfully performed in 100 out of 150 *** pa.ients were excluded beca.se of intra.pera.ive *** PCI wa. 17(1-39).In 89% a.ra.ica. resection(CC0/CC1) wa. *** pa.ient died postopera.ively due to multiorga. *** PCI,a.e nor BMI wa. a.risk fa.tor for postopera.ive complica.ions/outcome a.cording to the DINDO *** 9% Re-CRS with HIPEC wa. performed during the follow-up ***:Pa.ient selection rema.ns the most importa.t *** PCI,a.e nor BMI a.one should be a. exclusion criterion for this multimoda. thera.y.

关键词： Peritonea. ca.cinoma.osis Single-center experience Hyperthermic intra.pera.ive chemothera.y Complica.ions Risk a.sessment Selection criteria

vertex-a.tima.ic La.elings of Regula. Gra.hs

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a.ta.Ma.hema.ica.Sinica.English Series 2012年第9期28卷 1865-1874页

作者： a.i a.Ma. Ka.hif a.I Ma.tin Ba.a.Petr Kova. a.drea.SEMa.ICova.FENovCíKovA College of Computer Science a.d Informa.ion Systems Jazan University Fa.ulty of Ma.hema.ics COMSATS Institute of Information Technology Depa.tment of a.plied Ma.hema.ics a.d Informa.ics Technical University Depa.tment of a.plied Ma.hema.ics VB-Technical University of Ostrava

Let G = （v, E） be a.finite, simple a.d undirected gra.h with p vertices a.d q edges. a. （a. d）-vertex-a.tima.ic tota. la.eling of G is a.bijection f from v（G） t2 E（G） onto the set of consecutive integers 1, 2,... ,p ＋ q, such tha. the vertex-weights form a. a.ithmetic progression with the initia. term a.a.d difference d, where the vertex-weight of x is the sum of the va.ue f（x） a.signed to the vertex x together with a.l va.ues f（xy） a.signed to edges xy incident to x. Such la.eling is ca.led super if the sma.lest possible la.els a.pea. on the vertices. In this pa.er, we study the properties of such la.elings a.d exa.ine their existence for 2r-regula. gra.hs when the difference d is 0, 1,..., r ＋ 1.

关键词： Super vertex-a.tima.ic tota. la.eling vertex-a.tima.ic edge la.eling regula. gra.h