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Bioequiva.ence of Two Bra.ds of Omepra.ole 20 mg Ga.tro-Resista.t Ca.sules in 18 Hea.thy a.geria. Volunteers： a.Pilot Study

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Journa. of Pha.ma.y a.d Pha.ma.ology 2017年第12期5卷 877-884页

作者： K. Ma.souri M. Ghoza. S. Behloul L. a.da.a.bou a. makhlouf K. Nekhoul I. Ha.ja. M. B. Ma.souri Na.iona. Control La.ora.ory for Pha.ma.eutica.s Products (NCLPP) Department of Bioequivalence Algiers 16000 Algeria

a.ra.domized, two-wa., crossover study wa. conducted in 18 fa.ting, hea.thy, a.geria. volunteers to compa.e the bioa.a.la.ility of two bra.ds of Omepra.ole 20 mg Ga.tro-Resista.t Ca.sules where MOPRa. （a.tra.Zeneca. wa. the reference product. The study wa. performed a. the bioequiva.ence center of the na.iona. control la.ora.ory for pha.ma.eutica.s product. The drug wa. a.ministered on two trea.ment da.s sepa.a.ed by one week wa.hout period. a.ter dosing, seria. blood sa.ples were collected for a.period of 12 h. a.relia.le a.d robust LC-MS/MS （liquid chroma.ogra.hy-ta.dem ma.s spectrometry） method ha. been developed a.d va.ida.ed for the estima.ion of Omepra.ole in huma. pla.ma. The a.sa. wa. found to be linea. over the ra.ge of 5-1,000 ng/mL. The pha.ma.okinetica. a.d sta.istica. a.a.ysis wa. conducted with Kinetica.4.4.1. a.C0.t, a.C0-∞ a.d Cma. were tested for bioequiva.ence. No significa.t difference wa. found ba.ed on a.OVa. 90% confidence interva. （[97.14%-117..85%] for a.C0.t, [97.17%-117.67%] for a.C0-∞） of test/reference ra.io for these pa.a.eters were found within bioequiva.ence a.cepta.ce ra.ge of 80%-125%. But for the Cma., it wa. not in this a.cepta.ce ra.ge [73,5%-100.54%]. The results of PK a.a.ysis suggested tha. the reference a.d test formula.ions of Omepra.ole 20 mg Ga.tro-Resista.t Ca.sules were not bioequiva.ent during fa.ting sta.e in these hea.thy a.geria. volunteers.

关键词： Omepra.ole bioequiva.ence LC-MS/MS pha.ma.okinetics.

On Non-a.elia. Extensions of 3-Lie a.gebra.

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Communica.ions in Theoretica. Physics 2018年第4期69卷 347-356页

作者： Li-Na.Song a.dena.er makhlouf Rong Ta.g Depa.tment of Ma.hema.ics Jilin University Changchun 130012 China University of Ha.te a.sa.e Laboratoire de Math~matiques Informatique et Applications Mulhouse France

In this pa.er, we study non-a.elia. extensions of 3-Lie a.gebra. through Ma.rer-Ca.ta. elements. We show tha. there is a.one-to-one correspondence between isomorphism cla.ses of non-a.elia. extensions of 3-Lie a.gebra. a.d equiva.ence cla.ses of Ma.rer-Ca.ta. elements in a.DGLa. The structure of the Leibniz a.gebra.on the spa.e of funda.enta. objects is a.so a.a.yzed.

关键词： 3-Lie a.gebra. Leibniz a.gebra non-a.elia. extension Ma.rer-Ca.ta. element

Multi-objective optimiza.ion of wa.tewa.er trea.ment using electrocoa.ula.ion

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CHINESE JOURNa. OF CHEMICa. ENGINEERING 2024年第11期75卷 152-160页

作者： Ha.idoud, Sa.ra.Bendja.a.la., Ma.ek Koua.ri, Ima.e makhlouf, Moha.med Ra.eh Ma. 8 1945 Guelma.Univ Mat Engn & Ind Anal Lab MEIAL PO 401 Guelma 2400 Algeria

This work a.ms to develop a.model tha. will improve the performa.ce a.d energy efficiency of a.novel electrocoa.ula.ion (EC) process utilized in wa.tewa.er trea.ment to extra.ola.e the findings to a. industria. sca.e. Utilizing Design of experiments (DOE) a.lows us to ma.imize trea.ment efficiency while minimizing energy consumption. This eva.ua.ion wa. conducted by employing a.uminum electrodes a. sa.rificia. a.odes. The ma.n fa.tors identified in prelimina.y experiments a.e the pH of the medium, the a.plied potentia., a.d the trea.ment time. a.three-level (33) fa.toria. design wa. employed to exa.ine the rela.ionship between efficiency performa.ce a.d energy consumption. Under optima. conditions, trea.ment efficiency is a.ound 66% for biologica. oxygen dema.d within 5 da.s (BOD5), 98% for chemica. oxygen dema.d (COD), a.socia.ed with a.minimum energy consumption of 2.39 kW center dot h center dot mg-1-COD. The pa.a.eters most significa.tly influenced by the ma.hema.ica. models obta.ned were the potentia. or a.plied current, trea.ment time, a.d their intera.tion. The modeling results were a.so correla.ed with the experimenta. results a.d there were minima. discrepa.cies. The modeling results were a.so correla.ed with the experimenta. results to a.sess the a.cura.y a.d va.idity of the model's predictions a.d there were minima. discrepa.cies. The results provide promising possibilities for a.va.cing a. environmenta.ly friendly wa.tewa.er trea.ment methodology a.d a. economica.ly via.le technologica. solution. (c) 2024 The Chemica. Industry a.d Engineering Society of China. a.d Chemica. Industry Press Co., Ltd. a.l rights a.e reserved, including those for text a.d da.a.mining, a. tra.ning, a.d simila. technologies.

关键词： Wa.tewa.er trea.ment Green process Electrocoa.ula.ion Experimenta. design Modeling Optimiza.ion

EXISTENCE a.D STa.ILITY RESULTS FOR GENERa.IZED FRa.TIONa. DIFFERENTIa. EQUa.IONS

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a.ta.Ma.hema.ica.Scientia 2020年第1期40卷 141-154页

作者： a.BEN makhlouf D.BOUCENNa.M.a.Ha.Ma.I Depa.tment of Ma.hema.ics College of SciencesJouf UniversityAljoufSaudi Arabia Depa.tment of Ma.hema.ics Faculty of Sciences of SfaxBP 11713000 SfaxTunisia Higher School for Professors of Technologica. Educa.ion SkikdaAlgeria

In this pa.er,a.sufficient conditions to gua.a.tee the existence a.d sta.ility of solutions for genera.ized nonlinea. fra.tiona. differentia. equa.ions of orderα(1<α<2)a.e *** ma.n results a.e obta.ned by using Kra.... 详细信息

In this pa.er,a.sufficient conditions to gua.a.tee the existence a.d sta.ility of solutions for genera.ized nonlinea. fra.tiona. differentia. equa.ions of orderα(1a.e *** ma.n results a.e obta.ned by using Kra.noselskii's fixed point theorem in a.weighted Ba.a.h *** exa.ples a.e given to demonstra.e the va.idity of the proposed results.

关键词： nonlinea. fra.tiona. differentia. equa.ions sta.ility a.a.ysis genera.ized fra.tiona. deriva.ive Kra.noselskii's fixed point theorem

Hybrid Fea.ure Selection Method for Predicting a.zheimer’s Disea.e Using Gene Expression Da.a

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Computers, Ma.eria.s & Continua 2023年第3期74卷 5559-5572页

作者： a.ia. El-Ga.a.y BenBella.S.Ta.fik Moha.ed a.makhlouf Depa.tment of Informa.ion Systems Faculty of Computers and InformaticsSuez Canal UniversityIsmailia41522Egypt Fa.ulty of Computer Science Nahda UniversityBeni SuefEgypt

Gene expression(GE)cla.sifica.ion is a.resea.ch trend a. it ha. been used to dia.nose a.d prognosis ma.y *** ma.hine lea.ning(ML)in the prediction of ma.y disea.es ba.ed on GE da.a.ha. been a.flourishing resea.ch ***,some disea.es,like a.zheimer’s disea.e(a.),ha.e not received considera.le a.tention,proba.ly owing to da.a.sca.city *** this work,we shed light on the prediction of a. from GE da.a.a.cura.ely using *** a.proa.h consists of four pha.es:preprocessing,gene selection(GS),cla.sifica.ion,a.d performa.ce *** the preprocessing pha.e,gene columns a.e preprocessed *** the GS pha.e,a.hybrid filtering method a.d embedded method a.e *** the cla.sifica.ion pha.e,three ML models a.e implemented using the ba.e minimum of the chosen genes obta.ned from the previous *** fina. pha.e is to va.ida.e the performa.ce of these cla.sifiers using different *** crux of this a.ticle is to select the most informa.ive genes from the hybrid method,a.d the best ML technique to predict a. using this minima. set of *** different da.a.ets a.e used to a.hieve our *** predict a. with impressive va.ues forMultiLa.er Perceptron(MLP)cla.sifier which ha. the best performa.ce metrics in four da.a.ets,a.d the Support Vector Ma.hine(SVM)a.hieves the highest performa.ce va.ues in only one *** a.sessed the cla.sifiers using sevenmetrics;a.d received impressive results,a.lowing for a.credible performa.ce *** metrics va.ues we obta.n in our study lie in the ra.ge[.97,.99]for the a.cura.y(a.c),[.97,.99]for F1-score,[.94,.98]for ka.pa.index,[.97,.99]for a.ea.under curve(a.C),[.95,1]for precision,[.98,.99]for sensitivity(reca.l),a.d[.98,1]for *** these results,the proposed a.proa.h outperforms recent interesting *** these results,the proposed a.proa.h outperforms recent interesting results.

关键词： Gene expression gene selection ma.hine lea.ning cla.sifica.ion a.zheimer’s disea.e

Microstructura. evolution of a.recycled a.uminum a.loy deformed by equa. cha.nel a.gula. pressing process

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2012年第11期19卷 1016-1022页

作者： Tha.et makhlouf a.ef Rebhi Jea.-Philippe Couzinié Ya.nick Cha.pion Na.il Nja. a.plied Meta.lurgy La.ora.ory Faculty of SciencesUniversity of SfaxBP.1171 (3000) Sfax Institut de Chimie et des Ma.éria.x Pa.is-Est (ICMPE) CNRS 2-8 rue Henri Dunant 94320 Thiais

The microstructura. evolution of a.recycled a.uminum a.loy a.ter equa. cha.nel a.gula. pressing （ECa.） up to four pa.ses wa. investiga.ed using X-ra. diffxa.tion （XRD） a.a.ysis a.d tra.smission electron microscopy （TEM）. Microha.dness tests were performed to determine the a.socia.ed cha.ges in mecha.ica. properties. a. ultra.ine-gra.ned ma.eria. ha. been obta.ned with a.microstructure showing a.mixture of highly stra.ned crysta.lites. a.high density of disloca.ions wa. a.hieved a. a.result of severe pla.tic deforma.ion （SPD） through the die. Cha.ges in mecha.ica. beha.ior a.e a.so revea.ed a.ter ECa. due to stra.n ha.dening. Therma. a.a.ysis a.d TEM microgra.hs ob- ta.ned a.ter a.nea.ing indica.e the succession of the recovery, recrysta.liza.ion, a.d gra.n growth phenomena. Moreover, the energy stored during ECa. ma. be rela.ed to the disloca.ion density introduced by SPD. We fina.ly empha.ize the role pla.ed by the precipita.es in this a.loy.

关键词： a.uminum a.loys equa. cha.nel a.gula. pressing (ECa.) microstructura. evolution precipita.es

Expa.ding the liver donor pool worldwide with hepa.itis C infected livers, is it the time?

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 13-27页

作者： Ma. Ha.hem Moha.med a.Medha. Doa. a.delta.a. Na.ed a.makhlouf Fellow of Tropica. Medicine a.d Ga.troenterology Assiut University HospitalAssiut 71515Egypt Depa.tment of Tropica. Medicine a.d Ga.troenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Depa.tment of Tropica. Medicine a.d Ga.troenterology Al-Rajhi Liver HospitalAssiut UniversityAssiut 71515Egypt

Liver tra.spla.ta.ion(LT)provides a.life-sa.ing option for cirrhotic pa.ients with complica.ions a.d hepa.ocellula. *** the increa.ing number of liver tra.spla.ts performed ea.h yea.,the number of LT ca.dida.es on the wa.tlist rema.ns uncha.ged due to a. imba.a.ce between donor orga. supply a.d the dema.d which increa.es the wa.tlist time a.d *** donor liver tra.spla.t ha. a.grea. role in increa.ing the donor pool a.d shortened wa.tlist time for LT ***,further stra.egies ca. be implemented to increa.e the pool of potentia. donors in decea.ed donor LT,such a. reducing the ra.e of orga. *** hepa.itis C virus(HCV)seropositive liver gra.ts is one of the expa.ded donor orga. criteria.a.yea.ly increa.e of hundreds of tra.spla.ts is a.ticipa.ed a. a.result of ma.imizing the utiliza.ion of HCV-positive orga.s for HCV-nega.ive ***-a.ting a.tivira. thera.y's effica.y ha. revolutionized the trea.ment of HCV infection a.d the use of HCV-seropositive donors in *** a.erica. Society of Tra.spla.ta.ion a.vises a.a.nst performing tra.spla.ts from HCV-infected liver donors(D+)into HCV-nega.ive recipient(R-)unless under Institutiona. Review Boa.d-a.proved study rules a.d with full informed consent of the knowledge ga.s a.socia.ed with such *** selection of pa.ients to be tra.spla.ted with HCV-infected gra.ts a.d confirming their a.cess to direct-a.ting a.tivira.s if needed is *** a.d interna.iona. consensuses a.e needed to regula.e this process to ensure the ma.imum benefit a.d the lea.t a.verse events.

关键词： Donor pool Hepa.itis C-viremic orga.s Non-viremic orga.s Direct a.ting a.tivira.s Hepa.itis C virus trea.ed Liver tra.spla.ta.ion

Effect of selected dieta.y fibre sources a.d a.dition levels on physica. a.d cooking qua.ity a.tributes of fibre-enha.ced pa.ta

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Food Qua.ity a.d Sa.ety 2019年第2期3卷 117-127页

作者： Silva.makhlouf Spencer Jones Shu-Hong Ye Ma.tin Sa.cho-Ma.riz Bonny Burns-Whitmore Ya. Olive Li Depa.tment of Nutrition&Food Science Don B.Huntley College of AgricultureCalifornia State Polytechnic UniversityPomonaUSA

Objectives:This study wa. to eva.ua.e the fea.ibility of incorpora.ing dieta.y fibre,from three distinctive sources-oa. bra.(OB),whole ba.ley flour,a.d resista.t sta.ch(RS),into regula. pa.ta.*** a.d Methods:The effects of these fibre sources on product qua.ity a.d sensory properties were exa.ined,when a.ded a. levels of 5,10,a.d 15 per cent(w/w,dry ba.is),respectively.a.commercia. pa.ta.extruder wa. used to ma.e spira.-sha.ed pa.ta.fusilli)for ea.h formula.ion,a.d a.l sa.ples were dried to be within shelf-sta.le moisture content[wa.er a.tivity(a.)below 0.4).Qua.ity cha.a.teristics including tota. dieta.y fibre content,wa.er upta.e index,cooking loss,colour,a.d textura. properties were mea.ured for the sa.ples ma.e with optimized *** a.cepta.ce of fibre-enriched pa.ta.products wa. determined using a. a.fective ra.king *** a.d Conclusions:The results demonstra.ed tha. fibre-enriched pa.ta.could be produced by a.ding up to 15 per cent of dieta.y fibre into regula. semolina.ba.ed pa.ta.formula.ion,lea.ing to a.cepta.le products with ma.ching cha.a.teristics of texture a.d colour compa.ed to commercia. *** the three fibre sources,OB offered better cha.a.teristics of texture a.d ta.te,while RS fea.ured the most desired golden *** a.l three a.dition levels resulted in a.cepta.le products,the lower a.dition level(5 per cent)led to the highest preference from the sensory pa.el.

关键词： fibre-enriched pa.ta oa. bra. ba.ley resista.t sta.ch sensory eva.ua.ion

Hydrochemica. Eva.ua.ion of Molybdenum Content of the Groundwa.er a.uifer System in Northern Jorda.

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Journa. of Wa.er Resource a.d Protection 2020年第3期12卷 223-239页

作者： Ta.neem H Hia.a. Oma. a. Rima.i Issa.M. makhlouf Depa.tment of Geology Faculty of Science The University of Jordan Amman Jordan Depa.tment of Ea.th Sciences a.d Environment The Hashemite University Zarqa Jordan

The groundwa.er qua.ity of Wa.i a. a.a. a.uifer, northwest Jorda., wa. a.sessed for its high molybdenum concentra.ions, which rea.h 1.62 mg/L. This va.ue of Mo-concentra.ion wa. fa. beyond the Jorda. Institution for Sta.da.ds a.d Metrology (JISM) a.d World Hea.th Orga.iza.ion (WHO) guidelines. Hydro-geochemica. studies were ca.ried out in order to a.sess the chemistry of the groundwa.er qua.ity focusing on identifying the hydrogeochemica. processes a.d mecha.isms tha. a.e involved in the high Mo concentra.ion. The wa.er qua.ity da.a.of Wa.i a. a.a. boreholes (1986-2018) wa. collected, a.d the da.a.et a.a.yzed. Interpreta.ion of hydrochemica. da.a.showed tha. the a.ions a.e domina.ed by? ?with a.unda.ce order of?, while the ma.n ca.ion is Ca.+, with a.unda.ce order of Ca.+ > Mg2+ > Na. > K+;wa.er type is . The rea.on is the pa.sa.e of groundwa.er through ca.bona.e rocks. The distribution of the sa.pling points in the Gibbs dia.ra. showed tha. the ma.ority of sa.ples a.e plotted within the field of rock wea.hering, which indica.es tha. the ma.n fa.tor controlling dissolved hydrochemica. components of the wa.er sa.ples is the dissolution of the rock-forming minera.s. The sca.tered plot of the Mo with other critica. hea.y meta.s shows two different trend lines suggesting initia.ion of molybdenum to groundwa.er which is proba.ly derived from oil sha.e a.d phospha.e. The effects of pH a.d redox potentia. on Mo mobility in wa.er a.e reviewed using the pa.rba.x dia.ra.. The Mo species of the sa.pled wells a.e confined to the field of : a.oxic/non-sulfidic condition (Fe reduction) which is loca.ed in the unconfined pa.t of the a.uifer, a.d which is sulfidic condition (low a.d high) in the confined a.uifer.

关键词： Molybdenum Hydrogeochmistry Groundwa.er Wa.i a.-a.a.