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Endoscopic submucosa. dissection a.d endoscopic mucosa. resection for esopha.ea. a.d ga.tric lesions:a.compa.ison of procedures

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La.a.oscopic, Endoscopic a.d Robotic Surgery 2024年第2期7卷 66-71页

作者： Gusta. holm Schæbel a.drea. Weise Mucha.Cha.lotte Egela.d Micha.l Pa.rick a.hia. Depa.tment of Surgery a.d Tra.spla.ta.ion Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esopha.ea. a.d ga.tric lesions a.e effectively ma.a.ed with minima.ly inva.ive upper endoscopic procedures such a. endoscopic mucosa.resection(EMR)a.d endoscopic submucosa. dissection(ESD),offering pa.ients a.terna.ives to inva.ive *** ESD is well esta.lished in Ea.tern a.ia.its a.option in Denma.k for superficia. esopha.ea. ca.cer is *** study presents rea.-world da.a.on the fea.ibility,sa.ety,a.d hospita.iza.ion dura.ion a.socia.ed with ESD a.d EMR for esopha.ea. a.d ga.tric *** a.retrospective a.a.ysis wa. conducted on pa.ients who underwent ESD or EMR a. a.specia.ized center in Denma.k from October 2016 to June *** on trea.ment,indica.ion,lesion loca.ion,hospita.iza.ion dura.ion,procedure dura.ion,specimen size,complica.ions,recurrence,a.d one-yea. overa.l surviva. were *** compa.isons utilized the Ma.n-Whitney U test,independent sa.ple media. test,a.d chi-squa.ed *** The study included 130 pa.ients(144 procedures):72 underwent ESD a.d 58 underwent *** with EMR,ESD resulted in grea.er percenta.es of en bloc a.d R0 resections(98.8%vs.64.1%,pa.d 83.9%vs.23.8%,pa.er complica.ion ra.es(28.7%vs.3.1%,pa.d longer procedure times(119.5 min vs.37.0 min,pa.tly decrea.ed over time(p=0.01).The loca. recurrence ra.es were 14.5%for ESD a.d 23.8%for EMR(p=0.767).The one-yea. overa.l surviva. ra.es were simila. between the groups(95.8%vs.94.8%,p=0.553).Conclusion Both ESD a.d EMR a.e sa.e a.d via.le for trea.ing esopha.ea. a.d ga.tric *** offers a.va.ta.es but requires more time a.d *** findings support the litera.ure,empha.izing the importa.ce of considering pa.ient-specific fa.tors a.d surgeon proficiency in selecting the a.propria.e procedure.

关键词： Endoscopic submucosa. dissection Endoscopic mucosa.resection Ga.troesopha.ea. ca.cer Rea.-world da.a

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燃料灵活性是航运脱碳的关键——访瓦锡兰海洋业务总裁兼集团执行副总裁Roger holm

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中国船检 2024年第6期 56-60页

作者：薛龙玉 Roger holm 不详瓦锡兰

随着航运业脱碳进程加速推进,越来越多替代燃料开始在船上应用。究竟哪些燃料将成为未来的主流船舶燃料?为了帮助业界应对未来燃料选择与应用相关的各种不确定性,为船东和运营商定制最适合他们的脱碳最优解,船用和能源市场全球领先的创... 详细信息

随着航运业脱碳进程加速推进,越来越多替代燃料开始在船上应用。究竟哪些燃料将成为未来的主流船舶燃料?为了帮助业界应对未来燃料选择与应用相关的各种不确定性,为船东和运营商定制最适合他们的脱碳最优解,船用和能源市场全球领先的创新技术提供商瓦锡兰(Wärtsilä)对各类潜在未来燃料选项进行了广泛的研究和投资,开发了具有高度燃料灵活性的发动机技术和生命周期解决方案,全面赋能航运业的脱碳之旅。

关键词：航运业能源市场瓦锡兰替代燃料生命周期不确定性技术提供商船舶燃料

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TILLING a.d Ecotilling the Pla.t Kingdom

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分子植物育种 2007年第2期5卷 238-239页

作者： B. Till J. Cooper C. Codomo a. holm M. Da.low E. Greene L. Coma. S. Henikoff Fred Hutchinson Ca.cer Resea.ch Center 1100 Fairview Ave N Seattle WA 98109-1024 USA Section of Pla.t Biology a.d Genome Center UC Davis Davis California 95616 USA

The modern crop scientist ha. a.la.ge a.ount of a.a.la.le nucleotide sequence informa.ion to identify genes of potentia. a.ronomic importa.ce. Using reverse genetic a.proa.hes, specifi c genes ca. be disrupted, a.d hy-

关键词：基因突变植物耕种

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The tensor embedding for a.Grothendieck cosmos

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Science China.Ma.hema.ics 2023年第11期66卷 2471-2494页

作者： Henrik holm Sinem Oda.a.i Depa.tment of Ma.hema.ica. Sciences University of CopenhagenCopenhagen 02100Denmark Instituto de Ciencia. Física. y Ma.emática. Universidad Austral de ChileValdivia 5090000Chile

While the Yoneda.embedding a.d its genera.iza.ions ha.e been studied extensively in the litera.ure,the so-ca.led tensor embedding ha. only received a.little *** this pa.er,we study the tensor embedding for closed symmetric monoida. ca.egories a.d show how it is connected to the notion of geometrica.ly purity,which ha. recently been investiga.ed in the works of Enochs et a..(2016)a.d Estra.a.et a..(2017).More precisely,for a.Grothendieck cosmos,i.e.,a.bicomplete Grothendieck ca.egory V with a.closed symmetric monoida. structure,we prove tha. the geometrica.ly pure exa.t ca.egory(V,ε■)ha. enough rela.ive injectives;in fa.t,every object ha. a.geometrica.ly pure injective *** a.so show tha. for some regula. ca.dina.λ,the tensor embedding yields a. exa.t equiva.ence between(V,ε■)a.d the ca.egory ofλ-cocontinuous V-functors from Presλ(V)to V,where the former is the full V-subca.egory ofλ-presenta.le objects in *** ma.y ca.es of interest,λca. be chosen to be■0 a.d the tensor embedding identifies the geometrica.ly pure injective objects in V with the(ca.egorica.ly)injective objects in the a.elia. ca.egory of V-functors from fp(V)to *** we expla.n,the developed theory a.plies,e.g.,to the ca.egory Ch(R)of cha.n complexes of modules over a.commuta.ive ring R a.d to the ca.egory Qcoh(X)of qua.i-coherent shea.es over a.suita.ly nice)scheme X.

关键词： enriched functor exa.t ca.egory (pre)envelope (pure)injective object purity symmetric monoida. ca.egory tensor embedding Yoneda.embedding

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On the Performa.ce of a.tive a.a.og Self-Interference Ca.cella.ion Techniques for Beyond 5G Systems

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China.Communica.ions 2021年第10期18卷 158-168页

作者： Ha.feng Luo Ma.k holm Tha.ma.inga. Ra.na.a.a. Institute for Digita. Communica.ions School of EngineeringThe University of EdinburghEdinburghUK Hua.ei Technologies(Sweden)a. GothenburgSweden

The in-ba.d full-duplex(IBFD)mecha.ism is of interest in beyond 5 G systems due to its potentia. to enha.ce spectra. efficiency a.d reduce *** a.hieve the ma.imum ga.n of IBFD systems,the significa.t self-interference(SI)must be efficiently *** cha.lenges of wideba.d selfinterference ca.cella.ion(SIC)lie in the ra.io frequency(RF)doma.n,where the performa.ce will be limited by the *** pa.er reviews current RF ca.cella.ion mecha.isms a.d investiga.es a. efficient mecha.ism for future wideba.d systems with minimum *** working principle a.d implementa.ion deta.ls of multi-ta. ca.cellers a.e first introduced,then a. optica. doma.n-ba.ed RF ca.celler is reviewed,a.d a.novel low-cost design is *** minimize the cost a.d complexity of the ca.celler,the minimum required number of ta.s a.e *** results show tha. with the commonly used 12-bits a.a.og-to-digita. converter(a.C)a. the receiver,the novel optica. doma.n-ba.ed ca.celler ca. ena.le efficient SIC in the 3 GPP LTE specifica.ions compa.ible system within 400 MHz ba.dwidth.

关键词： full-duplex beyond 5G system self-interference ca.cella.ion optica. doma.n-ba.ed ca.celler

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Sta.e Modelling a.d Simulta.eous Control of Discrete Pa.t Ma.ufa.turing Product Tra.sforma.ion Processes a.d Resource a.loca.ion

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厦门大学学报（自然科学版） 2002年第S1期41卷 251-252页

作者： Ha.s holm Depa.tment of Production

a. competition in the ma.ket for discrete pa.t prod uc ts gets ha.der a.d ha.der the requirements for extreme ma.ufa.turing opera.i on efficiencies get increa.ingly a.centua.ed. Therefore requirements for well beha.ed ma.ufa.turing opera.ion control get more a.d more significa.t. The purpose of the pa.er is to esta.lish a.fra.ework for development of forma. m ethods for design of systems for simulta.eous control of continuous ma.ufa.turin g ta.k processes a.d resource a.loca.ion of discrete pa.t ma.ufa.turing. In the pa.er sta.es which a.e needed for feedba.k control of continuous ma.ufa.t uring ta.k processes a.e defined a.d a. exa.ple is presented. Sta.es which a.e necessa.y for feedba.k control of distribution of ma.ufa.turing resources a.e defined. The definition is ba.ed on the sta.es defined for feedba.ck control of the continuous processes of discrete pa.t ma.ufa.turing ta.ks. a. exemple is presented. Ba.ed on use of the sta.e va.ia.les two types of equa.ions a.e described, the pu rpose of which it is to represent the constra.nts to which control of the ma.ufa.cturing system is subject. Cha.a.teristic insta.ces of the equa.ions a.e presen ted. Methods for design of systems which ca. control continuous ta.ks a.e presented. Methods for design of systems which ca. control resource a.loca.ion a.e presente d. Methods for design of systems which ca. simulta.eously control continuous ta. k processes a.d resource a.loca.ion a. the resource a.loca.ion is subject to con tinuos ta.k execution constra.nts a.e presented.

关键词： Tra.sforma.ion a.loca.ion competition simulta.eous beha.ed extreme forma. constra.nts execution

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Moisture a.sorption, Ma.s Loss a.d Eva.ora.ive Resista.ce of Clothing in Tra.sient Condition

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Journa. of Donghua.University(English Edition) 2006年第5期23卷 54-58页

作者： Chua.si Ga. Ingva. holmr The Therma. Environment La.ora.ory Division of Ergonomics Department of Design Sciences Faculty of Engineering Lund University Box 118 22100 Lund Sweden

The wa.er va.our resista.ce of clothing ensembles is not a. commonly determined a. dry therma. insula.ion. The mea.urement techniques a.e more complica.ed a.d the mea.urement va.ues differ a.ong la.ora.ories. Due to complica.ed moisture tra.sfer process through clothing ensemble, the moisture a.sorbed a.d eva.ora.ed va.ies in tra.sient a.d stea.y sta.e pha.es depending on properties, thickness of clothing, a.d environmenta. conditions. The purpose of this study wa. to mea.ure moisture ga.n inside hygroscopic underwea., a.d hydrophobic a.d permea.le outer wea. a. a.function of time, to investiga.e ma.s loss from ＂skin＂ a. well a. from the ma.ikin, to qua.tify eva.ora.ive hea. loss a.d tota. hea. loss from the ma.ikin, a.d to determine wa.er va.onr resista.ce of clothing. Ma.ikin Tore wa. used by wea.ing wet ＂skin＂ to simula.e swea.ing condition. Moisture content in the inner ga.ment ga.n shows a. exponentia. rela.ion a.a.nst time. Moisture in the outer permea.le la.er shows little ga.n. On the contra.y, ma.s loss directly from the wet skin decrea.es exponentia.ly. The ma.s loss from the ma.ikin is rela.ively sta.le throughout three test pha.es. The eva.ora.ive hea. loss is a.out 2/3 of the tota. hea. loss from the swea.ing ma.ikin. While mea.uring the eva.ora.ive resista.ce of clothing ensembles with hygroscopic inner ga.ment a.d permea.le outer ga.ment, unlike to mea.ure ensembles with impermea.le outer la.er, one hour mea.urement time is enough to get rela.ively sta.le results. The va.ia.ion between the 1^rt hour a.d the 3^nd hour is less tha. 5%. The length of tra.sient period a.d mea.urement time is dependent on the permea.ility, thickness of clothing ensembles a.d environmenta. conditions.

关键词： moisture a.sorption ma.s loss eva.ora.ive resista.ce tra.sient condition clothing ensemble.

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Cha.lenges a.d trends in a.omorphine drug delivery systems for the trea.ment of Pa.kinson's disea.e

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a.ia. Journa. of Pha.ma.eutica. Sciences 2018年第6期13卷 507-517页

作者： Nrupa.Borka. Huiling Mu René holm Depa.tment of Pha.ma.y Faculty of Health and Medical Sciences University of Copenhagen Drug Product Development Janssen Research and Development Johnson & Johnson

Pa.kinson's disea.e(PD) is a.chronic debilita.ing disea.e a.fecting a.proxima.ely 1% of the popula.ion over the a.e of 60. The severity of PD is correla.ed to the degree of dopa.inergic neurona. loss. a.omorphine ha. a.simila. chemica. structure a. the neurotra.smitter dopa.ine a.d ha. been used for the trea.ment of a.va.ced PD pa.ients. In PD pa.ients,a.omorphine is norma.ly a.ministered subcuta.eously with frequent injections beca.se of the compound's extensive hepa.ic first-pa.s meta.olism. There is, hence, a.la.ge unmet need for a.terna.ive a.ministra.ive routes for a.omorphine to improve pa.ient *** present review focuses on the resea.ch a.d development of a.terna.ive delivery of a.omorphine, a.ming to highlight the potentia. of non-inva.ive a.omorphine thera.y in PD,such a. sublingua. delivery a.d tra.sderma. delivery.

关键词： a.omorphine Drug delivery Pa.kinson’s disea.e a.terna.ive a.omorphine thera.y Non-inva.ive delivery Excipients

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Qua.tita.ive a.a.ysis of a.ctic ice flow a.celera.ion with increa.ing tempera.ure

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a.ta.Ocea.ologica.Sinica 2021年第1期40卷 22-32页

作者： Zemin Wa.g Boya.Ya. Songta. a. Kim holmén Jia.hun a. Hongmei Ma Chinese a.ta.ctic Center of Surveying a.d Ma.ping Wuhan UniversityWuhan 430079China Norwegia. Pola. Institute Longyearbyen 9170Norway Pola. Resea.ch Institute of China Shanghai 200136China

This study explores the ice flow a.celera.ion(21.1%)of Pedersenbreen during 2016–2017 a.ter the extremely wa.m winter throughout the whole a.ctic in 2015/2016 using in situ da.a.a.d qua.tita.ively a.a.yses the fa.tors contributing to this *** da.a.sets,including 2008–2018 a.r tempera.ure da.a.from Ny-?lesund,ten-yea. in situ GPS mea.urements a.d Elmer/Ice ice flow modelling under different ice tempera.ure scena.ios,suggest tha. the following fa.tors contributed to the ice flow a.celera.ion:the softened gla.ier ice ca.sed by a. increa.e in the a.r tempera.ure(1.5℃)contributed 2.7%–30.5%,while ba.a. lubrica.ion contributed 69.5%–97.3%.The enha.ced ba.a. sliding wa. mostly due to the increa.ed surfa.e meltwa.er penetra.ing to the bedrock under the rising a.r tempera.ure conditions;consequently,the gla.ier ice flow a.celera.ion wa. ca.sed ma.nly by a. increa.e in subgla.ia. *** Pedersenbreen,there wa. a. a.proxima.ely one-yea. time la. between the cha.ge in a.r tempera.ure a.d the cha.ge in gla.ier ice flow velocity.

关键词： ice flow velocity a.ctic tempera.ure rising Pedersenbreen Elmer/Ice meltwa.er

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Systema.ic review of the preva.ence a.d development of osteoporosis or low bone minera. density a.d its risk fa.tors in pa.ients with infla.ma.ory bowel disea.e

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World Journa. of Ga.troenterology 2020年第35期26卷 5362-5374页

作者： Sofia.Kärnsund Bobby Lo Flemming Bendtsen Ja.ob holm Joha. Burisch Ga.trounit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark Depa.tment of Endocrinology Copenhagen University Hospital HerlevHerlev 4600Denmark

Ba.KGROUND The infla.ma.ory bowel disea.es(IBD),Crohn’s disea.e(CD)a.d ulcera.ive colitis(UC)a.e chronic,immune-media.ed disorders of the digestive *** is considered to be a.risk fa.tor for developing osteoporosis;however current litera.ure on this ma.ter is *** To a.sess preva.ence a.d development of osteoporosis a.d low bone minera. density(BMD),a.d its risk fa.tors,in IBD *** Systema.ic review of popula.ion-ba.ed *** were identified by electronic(Ja.ua.y 2018)a.d ma.ua. sea.ches(Ma. 2018).Da.a.a.es sea.ched included EMBa.E a.d PubMed a.d a.stra.ts from 2014-2018 presented a. the United Europea. Ga.troenterology Week,the Europea. Crohn’s a.d Colitis Orga.isa.ion congress,a.d Digestive Disea.e Week were *** were eligible for inclusion if they investiga.ed either the preva.ence of osteoporosis or osteopenia.a.d/or risk fa.tors for osteoporosis or low BMD in IBD *** on children under the a.e of 18 were *** popula.ion-ba.ed studies were *** risk fa.tors for osteoporosis a.d low BMD investiga.ed in a.y included a.ticle were *** qua.ity a.d the possibility of bia. were a.a.ysed using the Newca.tle-Otta.a.*** Twelve studies including 3661 IBD pa.ients a.d 12789 hea.thy controls were *** of osteoporosis va.ied between 4%-9%in studies including both CD a.d UC pa.ients;2%-9% in studies including UC pa.ients, a.d 7%-15% instudies including CD pa.ients. a.ong hea.thy controls, preva.ence ofosteoporosis wa. 3% a.d 10% in two studies. CD dia.nosis, lower body ma.sindex (BMI), a.d lower body weight were risk fa.tors a.socia.ed withosteoporosis or low BMD. Findings rega.ding gender showed inconsistent *** pa.ients ha. a. increa.ed risk for osteoporosis or low BMD over time, whileUC pa.ients did not. Increa.ed a.e wa. a.socia.ed with decrea.ed BMD, a.d therewa. a.positive a.socia.ion between weight a.d BMI a.d BMD over time. Grea.heterogeneity wa.

关键词： Infla.ma.ory bowel disea.e Osteoporosis Systema.ic review Epidemiology Bone minera. density

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