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ACE-dd基因型与绝经后女性发生急性冠状动脉综合征相关

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 57-57页

作者： méthot J. Hamelin B.A. Bogaty P. P. Poirier 杜媛 Quebec Heart Institute Laval Hospital 2725 Chemin Ste-Foy Ste-Foy Que. G1V 4G5 Canada

The insertion/deletion(I/d)polymorphism of the angiotensin converting enzyme(ACE), the A1166C polymorphism in the angiotensin type 1 receptor(AT1R), and the m235T polymorphism of the angiotensinogen gene are associated with cardiovascular disease mostly in men. Few data are available on the effects of these genetic v ariations in postmenopausal women according to hormone replacement therapy(HRT)use. In this case-control study,we determine the frequency of mutant alleles in the ACE I/d, m235T and A1166C polymorphisms in postmenopausal Caucasian women with and without a diagnosis of acute coronary syndrome(ACS). data from 198 women with ACS(63±10 years)and 149 controls(62±7 years)showed that ACE-dd genotype was more prevalent in women with ACS compared to controls(30%vs. 19%, Pdifference in genotype distributions for either the m235T or the A1166C polymorphisms between groups. The difference in ACE genotype distribution between ACS women and controls was driven by current HRT users with 30%of ACS and 15%of controls carrying the ACE-dd genotype(Pmbina tion of ACE-dd and m235T-TT genotypes was higher in ACS compared to controls. Among carriers of m235T-TT, 7%of ACS and 1%of controls also had the ACEdd gen otype, Pdd genotype may be associated with ACS in postmen opausal women, particularly in HRT users.

关键词：急性冠状动脉综合征 ACS 基因型遗传型 ACE-dd 绝经后女性 dd

p16^(INK4a)和p21^(Waf1/Cip1)的表达与外阴癌临床预后的关系

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 45-45页

作者： Knopp S. Bjφrge T. Nesland J.m. 张剑萍

Aberrant expression of the cell cycle kinase inhibitors p16,p21,and p27has been associated with poor prognosis in a variety of human *** le is known,however,about their clinical impact in vulvar carcinoma ***,we analyzed a larger series of v ulvar squamous cell carcinomas and compared the results with clinical outcome.A total of 224vulvar squamous cell carcinomas were im-munohistochemically investigated for expression of p16,p21,and p27using the biotin -strept avidin -peroxidase method and the Optimax Plus automate d cell staining *** p16(≥5%)positive nuclear immunostaining was found in 69(31%)cases,high p21(any staining)protein levels was detected in 95(42%)cases,and lowp27(≤50%positive nuclei)staining was seen in 170(76%)*** expression of p16was related to lower patient age and low expression of *** expression of p16indicated a better prognosis in t he multivariate analysis(RR =0.5,95%CI =0.2-1.0)and less risk of de-veloping lymph node metastasis(OR =0.3,95%CI =0.2-0.7).High level of p21was significantly associated with shorter survival in patients staged FIGO I and II(RR=3.4,95%CI =1.3-9.3).We found no significant correlation between the expression of p27and any of the clinicopathological *** study indicates a prog-nostic relevance for p16and p21immu *** level of p16protein and high level of p21protein were as-sociated with a shorter disease -related *** did not find p27protein expression to be useful as a prognostic indicator in vulvar carcinoma patie nts.

关键词： INK4a Waf1/Cip1 p16 p21 外阴鳞状细胞癌低表达细胞周期免疫组织化学临床病理学淋巴结转移

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin david Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti di Lorenzo daniele Corti Flavio dal Corso Olivia dalager Christophe de La Taille Zhi deng Ziyan deng Wilfried depnering marco diaz Xuefeng ding Yayun ding Bayu dirgantara Sergey dmitrievsky Tadeas dohnal dmitry dolzhikov Georgy donchenko Jianmeng dong Evgeny doroshkevich marcos dracos Frédéric druillole Ran du Shuxian du Stefano dusini martin dvorak Timo Enqvist Heike Enzmann Andrea Fabbri donghua Fan Lei Fan Jian Fang Wenxing Fang marco Fargetta dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Nunzio Giudice maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel marco Grassi vasily Gromov minghao Gu Xiaofei Gu Yu Gu mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

前列腺组织结构和mR测量:AdC、T2、Ktrans、ve和相关组织特征之间关系的研究

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国际医学放射学杂志 2010年第4期 374-374页

作者： d.L.Langer T.H.van der Kwast A.J.Evans A.Plotkin J.Trachtenberg B.C.Wilson 李宁 department of medical Imaging Princess Margaret Hospital University Health Network and mount Sinai Hospital 610 University AveRoom 3-958TorontoONCanada M5G 2M9

目的调查mRI测量和潜在的正常和恶性前列腺组织基本成分间的相关性。材料与方法该研究经伦理委员会批准,24例病人签署知情同意书。前列腺切除术前,所有病人均于1.5T mR设备

关键词： mR 前列腺男生殖器 trans v_e T2 AdC

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经皮腔内血管成形术后室壁瘤消退一例

Oncology and Translational medicine 1995年第2期 26-26页

作者： m.P.Heintzen,T.Neubaur,W.motz,B.E.Strauer,方红,马业新 medizinische Klinik und Poliklinik B der Universitat düsseldorf Germany medizinische Klinik und Poliklinik B der Universitat düsseldorf Germany medizinische Klinik und Poliklinik B der Universitat düsseldorf Germany medizinische Klinik und Poliklinik B der Universitat düsseldorf Germany 同济医院大学附属同济医院同济医院大学附属同济医院

患者男性,76岁,1986年以来出现典型的心绞痛症状并进行性加重。1989年9月发生非透壁性前壁心肌梗塞,4周后入院。心电图示:v2-v4导联呈QS型,S-T段抬高,提示透壁性的壁心梗伴室壁瘤形成。经消心痛(120mg)和心痛定(10mg,每日3次)等抗心绞... 详细信息

患者男性,76岁,1986年以来出现典型的心绞痛症状并进行性加重。1989年9月发生非透壁性前壁心肌梗塞,4周后入院。心电图示:v2-v4导联呈QS型,S-T段抬高,提示透壁性的壁心梗伴室壁瘤形成。经消心痛(120mg)和心痛定(10mg,每日3次)等抗心绞痛治疗,心绞痛仍长时间持续发作,后施行了冠脉造影和左室造影术。冠脉造影示左前降支冠状动脉几乎完全性闭塞,左回旋支亦有病变但较轻,极少侧支循环,左室造影示前壁收缩功能明显障碍(室壁瘤形成)。因左前降支高度狭窄引起的胸痛症状不能缓解,梗塞后8周对左前降支(RIvA)施行了球囊扩张术。扩张后狭窄部明显增宽,残余狭

关键词：室壁瘤冠脉造影收缩功能心电图膨胀瘤冠状动脉造影电诊断图透壁性心肌梗塞贯穿性心肌梗塞顿抑心肌胸前导联左室造影

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黄斑裂孔术后视功能及主观视力知觉研究

世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 24-24页

作者： Tranos P.G. Ghazi-Nouri S.m.S. Rubin G.S. 王海燕

To evaluate the functional and anatomical results of macular hole surgery and to explore its effect on patients’Health-Related Quality Of Life (HR-QOL) and to investigate the associations between self-reported HR-QOL and conventional measures of visual function. Case series. The National Eye Institute 25-Item v isual Function Questionnaire (vFQ-25) and the 36-Item Short-Form Health Surve y (SF-36) were self-administered by 30 patients before and 4 months after macu lar hole surgery. Preoperative, intraoperative, and postoperative clinical data were collected including visual acuity, contrast sensitivity, and metamorphopsia . multi-item scales rating different aspects of HR-QOL were compared before an d after surgery, and their correlation with traditional methods of outcome evalu ation was analyzed. macular hole closure was achieved in 26 patients (87%). mea n LogmAR visual acuity improved by 6±10 letters for distance and 7 ±12 letters for near. metamorphopsia was reduced by a mean of 35±70 squares on Amsler char t, and Pelli-Robson contrast sensitivity decreased by a mean of -0.09 ±0.3 lo g units postoperatively. The vFQ-25 composite score as well as scale scores ass ociated with general vision, near vision, vision-related mental health, and rol e difficulties were significantly improved (P macular hole. Conversely out of the eight SF-36 health concepts, limitation i n usual role activities because of emotional problems was the only one that sign ificantly improved postoperatively. Both baseline and postoperative best-correc ted visual acuity significantly correlated with most of the vFQ subscale scores before and after surgery, respectively. In this case-se-ries, macular hole sur gery appears to have a beneficial effect on patients’subjective perception of v isual function. The use of vision-targeted health status questionnaires in conj unction with detailed clinical examination provides a more comprehensive overvie w of indivi

关键词：黄斑裂孔视功能视物变形手术干预对比敏感度简明健康调查表功能恢复情况临床数据眼科研究所系列分析

钛合金表面新型生物玻璃/羟基磷灰石涂层的体内动物实验

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生物骨科材料与临床研究 2008年第1期5卷 4-7,11页

作者：杜瑞林赵兰岗胡誉怀曾绍先谢鑫荟上海海赛科技开发有限公司上海200333

目的为促进钛合金植入体与骨的结合,在其表面制备了生物玻璃/羟基磷灰石复合涂层,并植入兔子股骨内进行动物试验,采用等离子喷涂羟基磷灰石涂层和未涂层的Ti6Al4v合金作为对照。方法种植到期的植入体取出后进行组织学切片,采用品红-苦... 详细信息

目的为促进钛合金植入体与骨的结合,在其表面制备了生物玻璃/羟基磷灰石复合涂层,并植入兔子股骨内进行动物试验,采用等离子喷涂羟基磷灰石涂层和未涂层的Ti6Al4v合金作为对照。方法种植到期的植入体取出后进行组织学切片,采用品红-苦味酸染色后进行组织学观察,采用SEm高倍观察种植体与骨的结合界面,并对骨接触率和凹槽内骨长入量进行了统计分析和比较。结果三种植入体都具有良好的生物相容性。Ti6Al4v合金与骨之间是一种形态固定,而生物玻璃/羟基磷灰石涂层、等离子喷涂羟基磷灰石涂层可与骨形成骨键合。生物玻璃/羟基磷灰石涂层在植入期间与基体没有脱落,同时其与骨的接触率和凹槽内骨长入量要明显高于其余两个植入体,显示出促进骨生长的作用。结论由于具有良好的生物相容性和促进新骨生长的能力,生物玻璃/羟基磷灰石涂层可加快植入体与骨的愈合速度,在骨替代修复方面显示出优势和广阔的应用前景。

关键词：生物玻璃/羟基磷灰石涂层钛合金动物实验

终极腐霉(Pythium ultimum)和土壤淹水对两个大豆品种的影响

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大豆科技 2015年第1期 37-37页

作者：向新华 m.T.Kirkpatrick C.S.Rothrock J.C.Rupe E.E.Gbur .department of Plant Pathology Agriculture Statistics Lab University of Arkansas Fayetteville 72701

采用2个大豆品种Hutcheson和Archer,通过温室一系列试验研究了水淹和终极腐霉（Pythium ultimum）对大豆的影响。一个试验是,大豆种子播种到经过灭菌土壤中,一部分土壤里接种沙子-玉米面的终极腐霉接菌体使之侵染,另一部分未接种病原菌... 详细信息

采用2个大豆品种Hutcheson和Archer,通过温室一系列试验研究了水淹和终极腐霉（Pythium ultimum）对大豆的影响。一个试验是,大豆种子播种到经过灭菌土壤中,一部分土壤里接种沙子-玉米面的终极腐霉接菌体使之侵染,另一部分未接种病原菌;水淹处理是分别在出苗期水淹2 d、4叶节期（v4）水淹5 d,在每个试验中都有一个没有水淹的对照处理。

关键词：大豆品种终极腐霉土壤淹水种子播种水淹试验玉米面

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CT灌注成像检测肝硬化病人肝细胞肝癌

国际医学放射学杂志 2016年第1期 83-83页

作者： m.A.Fischer N.Kartalis A.Grigoriadis L.Loizou P.Stal B.Leidner 张鑫 department of Clinical Science Intervention and TechnologyDivision of Medical Imaging and TechnologyKarolinska Institute

摘要目的评估动态CT灌注成像(P-CT)对肝硬化病人肝细胞肝癌(HCC)检测的诊断效能。材料与方法收集怀疑HCC的肝硬化病人26例[男19例,平均年龄(69±10)岁,利用双源系统的4d螺旋模态(100/80 k v;150/175 m As/rot)行肝脏P-CT检查。2名阅片... 详细信息

摘要目的评估动态CT灌注成像(P-CT)对肝硬化病人肝细胞肝癌(HCC)检测的诊断效能。材料与方法收集怀疑HCC的肝硬化病人26例[男19例,平均年龄(69±10)岁,利用双源系统的4d螺旋模态(100/80 k v;150/175 m As/rot)行肝脏P-CT检查。2名阅片者评估:1分别独立评估动脉期肝脏灌注(ALP)、门静脉期肝脏灌注(PLP)、肝脏灌注指数

关键词：肝硬化 HCC 肝细胞肝癌灌注成像病人 CT