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Research p rogress on Chinese herbal drugs in the TGF- β signaling pathway involved in epithelial-mesenchymal transition

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Cancer Advances 2024年第17期7卷 1-12页

作者： Hui-juan Cao Chen-Xi wu Xiao-Le Xian Yong-Sen Jia Yue-Yue Yu Shu Zhao Ting-Ting fu Traditional Chinese Medicine College North China University of Science and TechnologyTangshan 063210China.

Epithelial-mesenchymal transition is a well-defined,reversible process in which epithelial cells lose their epithelial phenotype and acquire mesenchymal-like ***-mesenchymal transition contributes significantly to the metastasis,invasion,and development of treatment resistance in cancer *** have been many studies on suppression of tumor epithelial-mesenchymal transition by Chinese medicine in recent years,mainly based on Chinese herbal drug monomers and *** this review,we aim to describe the research progress on Chinese medicine in the t ransforming growth factor beta(T GF-β)sig naling pathway,we hope these will provide some guidance for further research on Chinese medicine targeting epithelial-mesenchymal transition.

关键词： epithelial-mesenchymal transition cancer Chinese medicine invasion metastasis

宁夏第三排水沟中PAHs的污染特征、来源解析及生态风险评估

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环境科学 2024年第9期45卷 5254-5263页

作者：吴海娟高礼李富娟李凌云郑兰香宁夏大学地理科学与规划学院教育部中阿旱区特色资源与环境治理国际合作联合实验室银川750021 宁夏大学生态环境学院银川750021

为了明确宁夏第三排水沟中多环芳烃(PAHs)的污染特征、来源和生态风险,分别于2021年11月、2022年3月和7月采集排水沟水样,采用气相色谱-质谱法对16种PAHs进行了定量检测分析.结果表明,宁夏第三排水沟中ρ(ΣPAHs)范围为324.11~530.77 ng... 详细信息

为了明确宁夏第三排水沟中多环芳烃(PAHs)的污染特征、来源和生态风险,分别于2021年11月、2022年3月和7月采集排水沟水样,采用气相色谱-质谱法对16种PAHs进行了定量检测分析.结果表明,宁夏第三排水沟中ρ(ΣPAHs)范围为324.11~530.77 ng·L^(−1),平均值为414.73 ng·L^(−1).单体检出率均在90%以上,其中,二苯并[a,h]蒽的检出浓度最高,平均值为48.53 ng·L^(−1);其次为茚苯[1,2,3-cd]芘.与国内其它河流相比,宁夏第三排水沟中PAHs处于中等污染水平.ΣPAHs浓度和高环单体浓度在夏季显著高于冬季和春季.空间上,排水沟中ΣPAHs浓度平均值大小为:上游贺兰段>中游平罗段>下游惠农段.第三排水沟中PAHs组分占比大小为:高环(5~6环)>低环(2~3环)>中环(4环),5环PAHs组成占主导地位.运用正定矩阵因子分解(PMF)模型对PAHs的来源贡献进行了定量分析,结果表明,第三排水沟中PAHs主要来源于煤化工排放(27.36%)、交通排放(27.64%)、煤炭燃烧(26.85%)和石油化工排放(18.15%).生态风险评估结果表明,5种单体(苯并[a]蒽、苯并[b]荧蒽、苯并[ghi]苝、二苯并[a,h]蒽和茚苯[1,2,3-cd]芘)存在高风险,其余单体均处于中风险,需尽快采取控制措施.本研究可为宁夏入黄排水沟PAHs污染防控提供科学依据.

关键词：多环芳烃(PAHs) 污染特征来源解析生态风险第三排水沟

高质量发展背景下的西部高校人才培养差距分析——基于顾客满意度差距理论的解释

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民族高等教育研究 2024年第2期12卷 39-47页

作者：付娟吴迪石河子大学师范学院新疆石河子832003 乌鲁木齐市实验学校新疆乌鲁木齐830046

人才培养质量是衡量高等教育整体水平的关键,以学生视角分析西部高校人才培养过程的质量差距,对西部高等教育高质量发展具有重要意义。基于顾客满意度差距理论,构建了高等教育服务质量评价“差距模型”,对以S大学为代表的西部高校选派... 详细信息

人才培养质量是衡量高等教育整体水平的关键,以学生视角分析西部高校人才培养过程的质量差距,对西部高等教育高质量发展具有重要意义。基于顾客满意度差距理论,构建了高等教育服务质量评价“差距模型”,对以S大学为代表的西部高校选派的国内联合培养学生进行访谈,应用“差距模型”比较分析西部高校与国内优质教育资源院校在人才培养过程中存在的差距,结果表明,西部高校课程安排以院校为主导,课程教学以教师为中心,课程评价多为终结性评价;西部高校存在师资队伍与物质资源的双重匮乏;西部高校多以外部约束进行学风建设,第二课堂活动较为单一。西部高校高质量发展应以学生收获为核心革新教育教学,以学生需求为核心弥补资源弱势,以学生体验为核心更新管理理念。

关键词：西部高等教育教育高质量发展人才培养学生视角

The Tianma 65 m radio telescope at Shanghai

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Astronomical Techniques and Instruments 2024年第5期1卷 239-246页

作者： Qinghui Liu Zhiqiang Shen Xiaoyu Hong Qian Ye Bin Li Jinqing Wang Rongbing Zhao Li fu Weiye Zhong Lingling Wang juan Li Zhen Yan wu Jiang Bo Xia Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

The Shanghai Tianma 65 m radio telescope(TMRT)is a large,fully rotatable radio telescope with multiple scientific *** main body of the telescope and four low-frequency receiving systems,including L,C,and S/X bands,were completed between 2008 and *** 2013 to 2017,four high-frequency receiving systems,including Ku,K,Ka,and Q bands,were constructed and their performance was comprehensively *** are three main innovations.(1)A fully movable large radio telescope system with advanced performance and complete functions has been built.(2)An advanced,reliable main reflector adjustment system has been completed,overcoming gravity deformation and creating a large antenna with a main reflective surface accuracy of 0.28 mm(root mean square)for any elevation.(3)Five innovative technologies have been developed to achieve high-precision pointing in any direction within 3″.The TMRT has made a crucial contribution to the orbital measurement and positioning of China’s lunar and deep space *** enhancing China's ability to participate in international VLBI observations and radio astronomy,this has facilitated a series of achievements in observational radio astronomical research,in areas such as VLBI,spectral lines,and pulsars.

关键词： Radio telescope Tianma Large antenna Receiving system Surface accuracy

Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui Lin Yi-juan Liu Shao-Wei Lin Yan-Feng Shao Feng Qiu Qing-wu Qiu Zhang-Kun Xu Jin-Xian Chen Liang-Huo Chen Zhen-Qun Lin Wen-Hua Dai Ming-Qing Zhang Qi Jiang Zhong-Qin Xiao Xian-Xing Cheng Xiang-Fei Zhang Wen-Bin You Wei Chen Long-Qin Li Wei-Xing Lin Yong-fu Wang fu-Jin Lai Long-Qun Chen Zhong-Hua Huang Wen-Qi Zheng Jin-Qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 23 centers in fujian,China(May 2021-April 2022).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2%[95%confidence interval(95%CI):71.4%-86.8%],93.2%(86.6%-96.7%),92.2%(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2%),and 93.9%(87.4%-97.2%)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.022 and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(25.27%and 13.73%vs 37.62%,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

基于倾向性评分逆概率加权法的视网膜母细胞瘤疗效评价及其预后影响因素分析

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解放军医学杂志 2024年第3期49卷 302-307页

作者：石丽娟李丽石福艳周希彬吴志鸿潍坊医学院临床医学院眼科学教研室山东潍坊261053 解放军总医院第三医学中心眼科医学部北京100039 潍坊医学院公共卫生学院卫生统计学教研室山东潍坊261053

目的评估手术、化疗及手术联合化疗3种治疗方式对视网膜母细胞瘤(RB)的疗效,分析RB患者的预后影响因素。方法选取2000年1月1日-2019年12月31日美国监测、流行病学和最终结果(SEER)数据库登记的RB患者1188例临床资料进行回顾性分析。采... 详细信息

目的评估手术、化疗及手术联合化疗3种治疗方式对视网膜母细胞瘤(RB)的疗效,分析RB患者的预后影响因素。方法选取2000年1月1日-2019年12月31日美国监测、流行病学和最终结果(SEER)数据库登记的RB患者1188例临床资料进行回顾性分析。采用倾向性评分逆概率加权法(IPTW)对接受手术、化疗或手术联合化疗治疗的3组患者基线特征进行平衡。采用Log-rank检验比较3组患者的生存概率,采用Cox回归模型分析RB患者预后影响因素。结果共纳入RB1188例,其中手术组426例,化疗组200例,手术联合化疗组562例。经IPTW加权后,患者的年龄、性别、种族等基线资料均达到平衡(P>0.05)。Log-rank检验结果显示,加权前后3组生存曲线比较差异均有统计学意义(P0.05)。加权后患者1年、3年和5年的生存概率为:手术组99.7%、98.9%和98.6%;化疗组97.4%、95.8%和95.8%;手术联合化疗组97.9%、95.8%和95.0%。Cox回归分析结果显示,与手术组比较,化疗组患者特异性死亡风险比为1.367(95%CI 1.100~1.700),手术联合化疗组特异性死亡风险比为1.132(95%CI0.963~1.330);与RB病灶为1个的患者比较,RB病灶数≥2个的患者特异性死亡风险比为0.399(95%CI0.268~0.594)。结论RB患者接受治疗后生存概率较高;在控制年龄、性别等因素的影响后,3种治疗方式中手术的疗效更好;多灶性可能是RB患者预后的独立影响因素。

关键词：视网膜母细胞瘤逆概率加权疗效生存分析

丙泊酚介导细胞自噬及mTOR信号通路对脊髓损伤小鼠的保护机制

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颈腰痛杂志 2024年第2期45卷 199-204页

作者：吴驰曹殿青傅彩娟广东医科大学附属医院广东湛江524022 广东医科大学第二附属医院广东湛江524000

目的探讨丙泊酚介导细胞自噬及雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路对脊髓损伤(spinal cord injury,SCI)小鼠的保护机制。方法将60只健康C57BL/6雌性小鼠随机分为假手术组(S组)、模型组(I组)、甲泼尼龙组(M组)... 详细信息

目的探讨丙泊酚介导细胞自噬及雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路对脊髓损伤(spinal cord injury,SCI)小鼠的保护机制。方法将60只健康C57BL/6雌性小鼠随机分为假手术组(S组)、模型组(I组)、甲泼尼龙组(M组)和丙泊酚组(P组),每组15只。S组仅切除T9全椎板、不损伤脊髓,其余各组均采用Allen’s打击方法制备SCI模型。S组和I组均于术后30 min内腹腔注射等容量的0.9%生理盐水,M组和P组分别于造模成功后30 min内腹腔注射甲泼尼龙(30 mg/kg)和丙泊酚(50 mg/kg)。给药即刻、3 h、6 h时,采用改良Tarlov评分评估运动功能。给药6 h后,处死各组小鼠,取新鲜脊髓组织,H-E染色观察脊髓组织病理变化,透射电镜观察脊髓组织超微结构变化,Western blot法检测自噬相关蛋白P62、LC3Ⅱ及mTOR信号通路相关因子mTOR、p-mTOR蛋白的表达。结果随着给药时间的延长,M组和P组的Tarlov评分均升高,差异有统计学意义(P0.05)。S组小鼠脊髓结构完整,神经元形态正常且分布均匀,脊髓组织无出血、水肿,细胞呈现正常的超微结构;I组小鼠脊髓细胞肿胀、变形,正常神经元大量减少,坏死神经元增多,脊髓组织出血、水肿严重,细胞明显变性;M组和P组小鼠脊髓细胞肿胀、变形减轻,神经元坏死数目减少,正常神经元增多,脊髓组织内仅少部分区域可见间质水肿和出血,胶质细胞结构基本正常。与S组比较,I组P62、mTOR、p-mTOR蛋白表达明显上调,LC3Ⅱ蛋白表达明显下调,差异均有统计学意义(P0.05)。结论丙泊酚对于SCI小鼠的神经保护作用可能是通过抑制mTOR信号通路、诱导细胞自噬来实现的。

关键词：脊髓损伤丙泊酚细胞自噬雷帕霉素靶蛋白信号通路

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua fu Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan wu Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng wu Ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

5%咪喹莫特乳膏联合CO_(2)激光和高锰酸钾粉封包治疗对跖疣患者创面愈合和复发率的影响

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首都食品与医药 2024年第14期31卷 53-56页

作者：付兰红艾和平吴相华黄贵义江西省南丰县疾病预防控制中心江西抚州344500

目的分析5%咪喹莫特乳膏联合CO_(2)激光和高锰酸钾粉封包治疗对跖疣患者创面愈合和复发率的影响。方法于2022年1月-2022年6月选取江西省南丰县疾病预防控制中心跖疣患者110例,随机分为两组,对照组(n=55)行CO_(2)激光和高锰酸钾粉封包治... 详细信息

目的分析5%咪喹莫特乳膏联合CO_(2)激光和高锰酸钾粉封包治疗对跖疣患者创面愈合和复发率的影响。方法于2022年1月-2022年6月选取江西省南丰县疾病预防控制中心跖疣患者110例,随机分为两组,对照组(n=55)行CO_(2)激光和高锰酸钾粉封包治疗,试验组(n=55)加用5%咪喹莫特乳膏治疗。观察两组治疗后2周、4周、2个月创面愈合情况、疣体复发情况、治疗效果及治疗期间出现水肿、灼烧感、红斑、感染等不良反应情况。结果与对照组对比,治疗后2周、4周、2个月,试验组创面积减小,差异具有统计学意义(P83.64%),差异具有统计学意义(P0.05)。结论5%咪喹莫特乳膏联合CO_(2)激光和高锰酸钾粉封包治疗跖疣患者,创面愈合效果好,治疗效果显著,疣体复发率低,不良反应未增加,安全性高。

关键词： 5%咪喹莫特乳膏 CO_(2)激光高锰酸钾粉封包跖疣创面愈合疣体复发