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Realization of T_(e0)>10 keV long pulse operation over 100 s on EAST

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Plasma Science and Technology 2023年第2期25卷 6-10页

作者：龚先祖徐立清钱金平黄娟丁锐 a m garofalo Annika EKEDAHL 曾龙李二众张斌林士耀沈飙王茂徐旵东张新军李妙辉左桂忠臧庆刘海庆吕波王亮孙有文徐国盛胡建生姚达毛武玉胡立群肖炳甲项农陆坤宋云涛万宝年李建刚 the EAST Team Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People's Republic of China General Atomics San Diego 92186-5608United States of America CEA Institute for Magnetic Fusion Research(IRFM)Saint-Paul-lez-Durance F-13108France

In 2021,EAST realized a steady-state long pulse with a duration over 100 s and a core electron temperature over 10 *** is an integrated operation that resolves several key issues,including active control of wall conditioning,long-lasting fully noninductive current and divertor heat/particle *** fully noninductive current is driven by pure radio frequency(RF)waves with a lower hybrid current drive power of 2.5 mW and electron cyclotron resonance heating of 1.4 *** is an excellent experimental platform on the timescale of hundreds of seconds for studying multiscale instabilities,electron-dominant transport and particle recycling(plasma-wall interactions)under weak collisionality.

关键词： EAST tokamak high T_(e) integrated operation scenario

EAST高参数稳态运行模式中等离子体与壁相互作用关键物理问题（英文）

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EAST高参数稳态运行模式中等离子体与壁相互作用关键物理问题（英...

The redshift distribution of BL Lacs and FSRQs

第十八届全国等离子体科学技术会议

作者：王亮万宝年龚先祖梁云峰李建刚徐国盛项农孙有文钱金平丁芳余耀伟张凌黄娟刘海庆曾龙吕波丁斯晔夏天阳张晓东胡立群胡建生罗广南肖炳甲高翔郭后扬 A.m.garofalo 中国科学院等离子体物理研究所 Forschungszentrum Jülich GmbH General Atomics

The excessive divertor power load,particle exhaust and impurity control are key critical plasma-wall interaction(PWI) issues during long-pulse high-performance operations in tokamaks,especially for superconducting devices like EAST,ITER and *** is now equipped with water-cooled,ITER-like tungsten(W) divertor and 30 mW RF dominant H&CD capability for steady state operations,which poses a great challenge for divertor target plates and thus *** talk will show recent physics advances in active control of power/particle flux and impurity accumulation,PWI towards advanced steady-state high-performance operations on *** 3D edge magnetic topology change,induced by either LHWs or RmPs,has been applied for active control of heat and particle fluxes deposited on divertor targets in steady-state operation on *** comparing the particle fluxes deposited on the target plates in the same poloidal location while different toroidal locations,we find the 3D divertor footprints,induced by LHW,closely fits the pitch of the edge magnetic field line in a wider range of ***-induced particle and heat flux striations are also present in H-mode plasmas,reducing the peak heat flux and erosion at the strike point,thus facilitating long-pulse operation with fully non-inductive H-mode extended over 60 s(H98>1.1).In addition,3D divertor footprint splitting and ELm suppression over 20 s with n=1 RmP have also been achieved in *** addition to the reduction of divertor W sputtering via target heat flux and Te control,active exhaust of core W accumulation has been *** in the edge,high-frequency ELms,ECH application,LHW heating,were all effectively employed in reducing core high-Z impurity *** impurity seeding with argon and neon to reduce heat load have been performed on *** is shown that neon is a good radiator for EAST with strong radiation in the divertor region,while argon seeding could cause significant core radiation and thus degrades the pl

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Research in Astronomy and Astrophysics 2019年第1期19卷 131-140页

作者： David garofalo Chandra B.Singh Dylan T.Walsh Damian J.Christian Andrew m.Jones Alexa Zack Brandt Webster matthew I.Kim Department of Physics Kennesaw State University The Raymond and Beverly Sackler School of Physics and Astronomy Tel Aviv University Department of Physics & Astronomy California State University Boise State University Computational Science & Engineering

Flat spectrum radio quasars(FSRQs) and BL Lacertae objects(BL Lacs) are powerful jet producing active galactic nuclei associated with supermassive black holes accreting at high and low Eddington rates, respectively. Based on the millennium Simulation, Gardner & Done have predicted their redshift distribution by appealing to ideas from the spin paradigm in a way that exposes a need for a deeper discussion on three interrelated issues:(1) an overprediction of BL Lacs compared to FSRQs;(2) a difference in FSRQ and BL Lac distributions;(3) a need for powerful but different jets at separated cosmic times. Beginning with Gardner & Done's determination of Fermi observable FSRQs based on the distribution of thermal accretion across cosmic time from the millennium Simulation, we connect FSRQs to BL Lacs by way of the gap paradigm for black hole accretion and jet formation to address the above issues in a unified way. We identify a physical constraint in the paradigm for the numbers of BL Lacs that naturally leads to separate peaks in time for different albeit powerful jets. In addition, we both identify as puzzling and ascribe physical significance to a tail end in the BL Lac curve versus redshift that is unseen in the redshift distribution for FSRQs.

关键词： black hole physics BL Lacertae objects:general galaxies:ets gamma-rays:galaxies

Journey to the morpho-textural traits, microbiota, and volatilome of Ciauscolo PGI salami

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FOOD BIOSCIENCE 2023年第3期53卷 911-928页

作者： Osimani, Andrea Belleggia, Luca Botta, Cristian Ferrocino, Ilario milanovic, Vesna Cardinali, Federica Haouet, m. Naceur garofalo, Cristiana mozzon, massimo Foligni, Roberta Aquilanti, Lucia Univ Politecn marche Dipartimento Sci Agr Alimentari & Ambientali Via Brecce Bianche I-60131 Ancona Italy Univ Turin Dept Agr Forest & Food Sci Largo Paolo Braccini 2 I-10095 Grugliasco Torino Italy Ist Zooprofilatt Sperimentale Umbria & marche Via Salvemini Perugia Italy

Two independent manufacturing batches of naturally fermented Ciauscolo PGI salami were studied from the day of production to the end of ripening (20 days). The microbiota compositional shift of samples was studied through culture-dependent and metataxonomic analysis. Analyses of physico-chemical, morpho-textural, and volatilome traits were also carried out. Latilacobacillus sakei was the dominant species from t5, together with Dellaglioa algida and Leuconostoc carnosum. Among eumycetes, Cladosporium cladosporioides, Debaryomyces hansenii, Kurtzmaniella zeylanoides, and malassezia restricta/globosa were the most abundant taxa occurring in all samples. Candidate starter or adjunct cultures of Lat. sakei were isolated and characterized for: i) acidification performance;ii) enzymatic activity;iii) production of exopolysaccharides;iv) production of bacteriocins;v) quantification of the hdcA gene of Gram-positive bacteria. The 44 Lat. sakei cultures showed a suitable acid production capacity, together with the capability to cope with the main environmental stresses occurring in fermented sausages. For most of the isolates, strong aminopeptidase activity (leucine arylamidase and the valine arylamidase) was observed. moreover, the majority of isolates showed the in vitro production of sucrosedependent exopolysaccharides. No Lat. sakei isolates positive for the hdcA gene were observed. Based on these evidences, a few candidate starter or adjunct cultures, with potential use for product safety and quality improvement, were highlighted, namely Lat. sakei C5, C7, C11, C31, C45, C48, C53, C55, and C60. In the analyzed Ciauscolo PGI samples, 53 volatile substances were fully or tentatively identified;among these, spicesderived components (black pepper and garlic cloves) were constantly detected throughout the whole ripening time.

关键词： Fermented sausages metataxonomic analysis Latilactobacillus sakei Acidification performances Enzymatic activity

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聚丙烯腈基碳纤维前驱体生产新方法

国际纺织导报 2018年第10期46卷 10-12页

作者： F.Francalanci L.garofalo m.marinetti R.Proserpio 乔士亚(译) 于俊荣(校) Astris Carbon公司意大利不详

在聚丙烯腈(PAN)基碳纤维前驱体的不同工业生产方法中,最常用的是在二甲基亚砜(DmSO)溶液中聚合纺丝,和在二甲基乙酰胺(DmAC)水相悬浮液中聚合纺丝。介绍了一种结合上述两种方法优点的新方法,即在工业上实现经水相悬浮聚合后再在DmSO中... 详细信息

在聚丙烯腈(PAN)基碳纤维前驱体的不同工业生产方法中,最常用的是在二甲基亚砜(DmSO)溶液中聚合纺丝,和在二甲基乙酰胺(DmAC)水相悬浮液中聚合纺丝。介绍了一种结合上述两种方法优点的新方法,即在工业上实现经水相悬浮聚合后再在DmSO中纺丝的两步法。该方法成功的关键,是由聚合物粉末和水性溶剂开始,有效地制备良好的纺丝溶液。

关键词：聚丙烯腈(PAN) 前驱体碳纤维

microRNAs in lung cancer

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World Journal of methodology 2014年第2期4卷 59-72页

作者： Pooja Joshi Justin middleton Young-Jun Jeon michelagarofalo Department of molecular Virology Immunologyand Medical GeneticsComprehensive Cancer CenterTheOhio State University Wexner Medical CenterThe Ohio StateUniversityColumbusOH 43210United States

microRNAs have become recognized as key players in the development of cancer. They are a family of small non-coding RNAs that can negatively regulate the expression of cancer-related genes by sequence-selective targeting of mRNAs, leading to either mRNA degradation or translational repression. Lung cancer is the leading cause of cancer-related death worldwide with a substantially low survival rate. microRNAs have been confirmed to play roles in lung cancer develop-ment, epithelial-mesenchymal transition and response to therapy. They are also being studied for their future use as diagnostic and prognostic biomarkers and as potential therapeutic targets. In this review we focus on the role of dysregulated microRNA expression in lung tumorigenesis. We also discuss the role of microRNAs in therapeutic resistance and as biomarkers. We further look into the progress made and challenges remaining in using microRNAs for therapy in lung cancer.

关键词： Lung cancer microRNA miRNA

动态血压再评估可改善非透析慢性肾脏病患者的风险分层

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中华高血压杂志 2015年第7期23卷 699-699页

作者： minutolo R Gabbai FB Chiodini P garofalo C Stanzione G Liberti mE Pacilio m Borrelli S Provenzano m Conte G Nicola L 李金凤叶鹏

在非透析慢性肾脏病风险预后评估中,动态血压比诊室血压更有效,但是动态血压再评估能否进一步明确预后尚未知。研究人员纳入间隔1年行2次动态血压测量的高血压合并非透析慢性肾脏病患者182例,分析由距离基线测量1年后获取的第2次动态血... 详细信息

在非透析慢性肾脏病风险预后评估中,动态血压比诊室血压更有效,但是动态血压再评估能否进一步明确预后尚未知。研究人员纳入间隔1年行2次动态血压测量的高血压合并非透析慢性肾脏病患者182例,分析由距离基线测量1年后获取的第2次动态血压测定值对肾病复合终点（死亡,慢性透析,估算的肾小球滤过率下降≥40%）的评估是否有帮助。

关键词：动态血压测量慢性肾脏病预后评估非透析风险患者研究人员慢性透析

小胶质细胞控制成年小鼠海马中的谷氨酸能突触

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神经损伤与功能重建 2021年第10期16卷 F0003-F0003页

作者： Bernadette Basilico Laura Ferrucci Patrizia Ratano maria T Golia Alfonso Grimaldi maria Rosito Valentina Ferretti Ingrid Reverte Caterina Sanchini maria C marrone maria Giubettini Valeria De Turris Debora Salerno Stefano garofalo marie-Kim St-Pierre micael Carrier massimiliano Renzi Francesca Pagani Brijesh modi marcello Raspa Ferdinando Scavizzi Cornelius T Gross Silvia marinelli marie-Ève Tremblay Daniele Caprioli Laura maggi Cristina Limatola Silvia Di Angelantonio Davide Ragozzino Department of Physiology and Pharmacology Sapienza University of RomeRomeItaly. Neurophysiology and Neuropharmacology Inflammaging Unit IRCCS NeuromedMediterranean Neurological InstitutePozzilliISItaly. Center for Life Nano-and Neuro-science Istituto Italiano di TecnologiaRomeItaly. Dipartimento di Biologia e Biotecnologie“Charles Darwin” Sapienza University of RomeRomeItaly. Santa Lucia Foundation(IRCCS Fondazione Santa Lucia) RomeItaly. European Brain Research Institute(EBRI)‘Rita Levi-montalcini’ RomeItaly. CrestOptics S.p.A RomeItaly. Centre de Recherche du CHU de Québec Axe Neurosciences QuébecQuebec CityCanada. Département de médecine moléculaire UniversitéLaval QuébecQuebec CityCanada.1 National Research Council Institute of Biochemistry and Cell Biology(CNR-IBBC/EMMA/Infrafrontier/IMPC)International Campus“A.Buzzati-Traverso”Monterotondo(Rome)Italy.1 Epigenetics and Neurobiology Unit European Molecular Biology Laboratory(EMBL)MonterotondoItaly.1 Division of medical Sciences University of VictoriaVictoriaCanada.1 Department of Physiology and Pharmacology Sapienza UniversityLaboratory affiliated to Istituto Pasteur ItaliaRomeItaly.

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低... 详细信息

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低相关的自发和诱发谷氨酸能活动的减少,出现未成熟突触特征以及突触的可塑性提高。小胶质细胞耗竭的小鼠在新物体识别任务的获取方面表现出缺陷。海马星形胶质细胞出现增生,但并没有神经炎症反应。在Cx3cr1-/-小鼠中,PLX不能导致海马出现上述改变。这说明CX3CL1/CX3CR1轴在小胶质细胞对突触功能的控制中有重要作用。PLX5622停用后,小胶质细胞的重新增殖,海马突触恢复,小鼠的学习功能也出现恢复。综上所述,小胶质细胞对维持成人大脑的突触的正常功能用重要的作用,去除小胶质细胞会导致谷氨酸能突触组织和活动的可逆变化。

关键词：谷氨酸能传递海马体学习小胶质细胞神经元-小胶质细胞相互作用突触