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2012年全国肿瘤分子标志学术大会与国际肿瘤转化医学论坛暨第七届中国中青年肿瘤专家论坛

作者： Nian-hua Zhang~(1,2#),Jie Li~(3#),Yin Li~4,Xin-tao Zhang~5,Wen-ting Liao~(6,7,8),Jun-yi Zhang~1,Rong Li~1,Rong-cheng Luo~(1*) 1,department of Oncology,nanfang hospital,southern medical university,guangzhou 510515,china 2,department of Oncology,Guangdong Second Provincial Traditional Chinese Medicine hospital,guangzhou 510095,china 3,department of Vascular Surgery, The First Affiliated hospital,Sun Yat-Sen university,guangzhou 510080,china 4, department of Gastrointestinal Surgery,The First Affiliated hospital,Sun Yat-Sen university,guangzhou 510080,china 5,department of Sports Medicine,Peking university Shenzhen hospital,Shenzhen 518036,china 6,department of pathology,School of Basic medical Sciences,southern medical university,guangzhou 510515,china 7,department of pathology,nanfang hospital,southern medical university,guangzhou 510515,china 8, Guangdong Provincial Key Laboratory of Molecular Tumour pathology,guangzhou 510515, china

Although CXCR4 and CD133 have been implicated in the metastatic process of malignant tumors,the clinicopathological significance of their expression in human colon cancer is not fully *** present study was aimed to examine the expression of CXCR4 and CD133 protein in stageⅡorⅢcolon cancer and related lymph nodes,and to investigate the clinical and prognostic significance in colon cancer. Immunohistochemistry was performed to examine CXCR4 and CD133 protein expression in paraffin-embedded stageⅡorⅢprimary colon cancer tissues and matched lymph nodes. The correlation between the two proteins expression and clinicopathological parameters and the patients’ 5-year survival was *** have found that CXCR4 expression was detected in 74 of the 125 tumors(59.2%),and CD133 expression was detected in 45 of the 125 tumors(36.0%).Upon combining the expression of CXCR4 and CD133,co-expression (both CXCR4 and CD133 were positve) was detected in 29 of the 125 tumors(23.2%).When compared with the other combinations,co-expression of CXCR4 and CD133 proteins was significantly associated with the AJCC stage(P = 0.029) and the lymph node status(P = 0.020).Log-rank statistics showed that the AJCC stage(P = 0.014),lymph node status(P = 0.011),CXCR4 expression(P = 0.023),CD133 expression(P = 0.034),and co-expression of CXCR4 and CD133 proteins(P = 0.003) were significant prognostic indicators for overall patients *** have shown that co-expression of CXCR4 and CD133 proteins is a risk factor for worse overall survival in stageⅡorⅢcolon cancer patients, indicating that co-expression of CXCR4 and CD133 proteins might contribute to the progression of colon cancer.

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Proteomics-based Identification of Proteins with Altered Expression Induced by 12-O-Tetradecanoylphorbol 13-acetate In Nasopharyngeal Carcinoma CNE2 Cells

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Acta Biochimica et Biophysica Sinica 2005年第2期37卷 97-106页

作者： Pei-Zhou JIANG Ming GAN Hua HUANG Xin-Ming SHEN Shuang WANG Kai-Tai YAO Cancer Research Institute.southern medical university,guangzhou 510515,china department of Histology and Embryology.southern medical university,guangzhou 510515,china department of Parasitology,Zhongshan medical College.SUN Yat-sen university,guangzhou 510080.china Cancer Research Institute Southern Medical UniversityGuangzhou 510515 China department of Histology and Embryology Southern Medical UniversityGuangzhou 510515 China department of Parasitology Zhongshan Medical College SUN Yat-sen UniversityGuangzhou 510080 China

Nasopharyngeal carcinoma(NPC)is a malignancy with high incidence in southern china andSouth-East *** studies indicate that chemical carcinogen promoters,such as 12-O-tetradecanoylphorbol-13-acetate(TPA),are important ... 详细信息

关键词： 12-O-tetradecanoyl-phorbol-13-acetate nasopharyngeal carcinoma proteomics apoptosis

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Synthesis of molecularly imprinted polymers for the application of selective clean-up vinblastine from Catharanthus roseus extract

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中国科学：化学英文版 2010年第12期53卷 2587-2592页

作者： ZHU QuanHong,HUANG DanDan,LI Li & YIN YongGuan College of Traditional Chinese Medicine,southern medical university,guangzhou 510515,china College of Traditional Chinese Medicine Southern Medical University Guangzhou China

Molecularly imprinted polymers (MIPs) are synthetic tailor-made polymers with high selectivity towards a particular substance (template).An MIP using vinblastine (VLB) as the template molecule was synthesized and *** presence of monomer-template complexes in a non-covalent way was confirmed by UV-vis spectrometry *** polymerization was performed using methacrylic acid (MAA) as the functional monomer,ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent,and toluene as the porogenic solvent by a thermo-polymerization *** characterization of the obtained MIP was evaluated by scanning electron microscopy (SEM) and Brunauer-Emmett-Teller (BET) *** was observed that the morphology of the MIP was more porous and rough,and the surface area had a significant increase compared with that of the non-imprinted polymer (NIP).This MIP was used as the sorbents of solid-phase extraction (SPE) to assess the selectivity of the MIP after optimization of the SPE *** was specifically adsorbed on the MIP cartridge,while to vincristine (VCR),the chemical analog of VLB,almost no selective binding *** the basis of the results,Catharanthus roseus extract was applied to the MIP cartridge for investigating its capability to extract VLB from the plant extract,and the capacity of the MIP cartridge was also *** was shown that the MIP could effectively enrich VLB from *** extract and the recovery amounted to 93.8%.The solvents dissolving the samples had significant influence on the capacity of the MIP cartridge;it was 750 μg/g in toluene,625 μg/g in chloroform,and 250 μg/g in methanol.

关键词： molecular imprinting polymer vinblastine selective extraction Catharanthus roseus extract

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Surgical treatment of pancreatic carcinoma

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 139-141页

作者： Jie Zhou Chao-Long Li Guo-Wei Zhang the department of Hepatobiliary & Vascular Surgery, nanfang hospital, First Military medical university, guangzhou 510515, china department of Hepatobiliary & Vascular Surgery Nanfang Hospital First Military Medical University Guangzhou 510515 China. jacky@***

OBJECTIVE: To evaluate the surgical treatment of pancreatic carcinoma. METHODS: 101 patients with pancreatic carcinoma admitted from 1995 to 2002 were studied retrospectively. Of 83 patients undergoing surgery, 56 (64.5%) were subjected to tumor resection. Whipple' s procedure was performed in 48 patients, extended regional pancreatectomy and autograft intestinal transplantation in 2, combined resection of pancreatic body or tail carcinoma in 6, and 27 patients with unresectable pancreatic carcinoma were given inner drainage. RESULTS: Wound dehiscence and digestive bleeding were found in one patient respectively. Pancreatic fistula was found in one patient undergoing extended regional pancreatectomy and autograft intestinal transplantation. Other patients recovered uneventfully. CONCLUSIONS: Most patients with pancreatic carcinoma could undergo tumor resection. Blood vessel repair or transplantation can be used if the tumor adherent to the superior mesenteric-portal vein. Extended regional pancreatectomy and autograft intestinal transplantation are feasible. Simple inner drainage should be used in the patient whose neoplasm is unresectable.

关键词： pancreas neoplasm operation

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Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma

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World Journal of Gastroenterology 2001年第3期7卷 425-430页

作者： Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1department of pathology,nanfang hospital of the First Military medical university,guangzhou 510515,Guangdong Province,china ~2The Northern hospital of PLA,Shenyang 110015,Liaoning Province,china ~3department of Electronmicroscopy,First Military medical university,guangzhou 510515,Gangdong Province,chinaDr.Xiao Wei Li graduated from the First Military medical university with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published. department of pathology Nanfang Hospital of the First Military Medical University Tonghe Guangzhou 510515 Guangdong Province China.

INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, *** adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells .

关键词： Animals Antibodies, Monoclonal Antigens, CD15 Cell Adhesion Colorectal Neoplasms E-Selectin Endothelium, Vascular Flow Cytometry HT29 Cells Humans Immunohistochemistry In Situ Hybridization Liver Neoplasms Mice Mice, Inbred BALB C Mice, Nude Microscopy, Electron Microscopy, Electron, Scanning N-Acetylneuraminic Acid RNA, Messenger Research Support, Non-U.S. Gov't Tumor Cells, Cultured Umbilical Veins

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Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination

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World Journal of Gastroenterology 2008年第12期14卷 1823-1827页

作者： Dan Huang, Xiang Du, department of pathology, Cancer hospital of Fudan university department of Oncology, Shanghai medical College, Fudan university, Shanghai 200032, china department of pathology Cancer Hospital Fudan University Shanghai 200032 China.

Invasion and metastasis are the deadly face of malignant tumors. Considering the high rate of incidence and mortality of colorectal cancer, it is critical to determine the mechanisms of its dissemination. In the parallel investigation of the invasive front and tumor center area of colorectal cancer (CRC), observation of heterogeneous β-catenin distribution and epithelial-mesenchymal transition (EMT) at the invasive front suggested that there might be a crosstalk between tumor cells and the tumor microenvironment. Wnt signaling pathway is also involved in the cancer progression due to its key role in CRC tumorigenesis. Moreover, in recent years, there is increasing evidence that the regulators of microenvironment, including extracellular matrix, growth factors and inflammatory factors, are associated with the activation of Wnt pathway and the mobility of tumor cells. In this review, we will try to explain how these molecules trigger metastasis via the Wnt pathway.

关键词： Invasion Microenvironment Colorectalcancer Epithelial-mesenchymal transition Wnt β-catenin

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JTE-522-induced apoptosis in human gastric adenocarinoma cell line AGS cells by caspase activation accompanying cytochrome C release,membrane translocation of Bax and loss of mitochondrial membrane potential

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World Journal of Gastroenterology 2002年第2期8卷 217-223页

作者： Hong-Liang Li Xiao-Hong Li Jun-Hua Lü Xian-Da Ren,department of Pharmacology,Jinan university Pharmacy College,guangzhou 510632,Guangdong Province,china Dan-Dan Chen,department of Cardiology,First Affiliated hospital,Zhongshan university,guangzhou 510089,Guangdong Province,china Hai-Wei Zhang,department of pathology,Jinan university medical College,guangzhou 510632,Guangdong Province,china Cun-Chuan Wang,department of laparoscopic surgery,First Affiliated hospital,Jinan university medical College,guangzhou 510632,Guangdong Province,china department of Pharmacology Jinan University Pharmacy College Guangzhou 510632 Guangdong Province China. tsam@***

AIM: To investigate the role of the mitochondrial pathway in JTE-522-induced apoptosis and to investigate the relationship between cytochrome C release, caspase activity and loss of mitochondrial membrane potential (Deltapsim). METHODS: Cell culture, cell counting, ELISA assay, TUNEL, flow cytometry, Western blot and fluorometric assay were employed to investigate the effect of JTE-522 on cell proliferation and apoptosis in AGS cells and related molecular mechanism. RESULTS: JTE-522 inhibited the growth of AGS cells and induced the apoptosis. Caspases 8 and 9 were activated during apoptosis as judged by the appearance of cleavage products from procaspase and the caspase activities to cleave specific fluorogenic substrates. To elucidate whether the activation of caspases 8 and 9 was required for the apoptosis induction, we examined the effect of caspase-specific inhibitors on apoptosis. The results showed that caspase inhibitors significantly inhibited the apoptosis induced by JTE-522. In addition, the membrane translocation of Bax and cytosolic release of cytochrome C accompanying with the decrease of the uptake of Rhodamin 123, were detected at an early stage of apoptosis. Furthermore, Bax translocation, cytochrome C release, and caspase 9 activation were blocked by *** and Z-IETD-CHO. CONCLUSION: The present data indicate a crucial association between activation of caspases 8, 9, cytochrome C release, membrane translocation of Bax, loss of Deltapsim and JTE-522-induced apoptosis in AGS cells.

关键词： Adenocarcinoma Stomach Neoplasms Amino Acid Chloromethyl Ketones Anti-Inflammatory Agents, Non-Steroidal Apoptosis Benzenesulfonates Caspases inhibitors Cyclooxygenase Inhibitors Cysteine Proteinase Inhibitors Cytochrome c Group Enzyme Activation Humans In Situ Nick-End Labeling Membrane Potentials Mitochondria Oxazoles Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Research Support, Non-U.S. Gov't Tumor Cells, Cultured bcl-2-Associated X Protein

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Gastrin,somatostatin,and experimental disturbance of the gastrointestinal tract in rats

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World Journal of Gastroenterology 2001年第3期7卷 399-402页

作者： Yong Li Yao~1 Bo Xu~2 Wan Dai Zhang~1 Yu Gang Song~1 ~1Institute of Gastrointestinal Diseases,nanfang hospital,First Military medical university,guangzhou 510515,Guangdong Province,china ~2department of Orthopedics nanfang hospital,First Military medical university,guangzhou 510515,Guangdong Province,chinaYong Li Yao graduated from First Military Mcdical university with a master degree in 1998.She now works in the Institute of Gastrointestinal Diseases,nanfang hospital as a doctoral candidate majoring gastrointestinal diseases and gastrointestinal hormones,she has published 8 papers. Institute of Gastrointestinal Diseases Nanfang Hospital First Military Medical University Guangzhou 510515 Guangdong Province China. xbyyl@***

INTRODUCTIONThe field of gastrointestinal hormones has expanded at a dizzying rate[1-4].Gastrointestinal hormones as regulatory peptides that appear to be major components of bodily integration and have important regulatory actions on physioligical function of the gastrointestinal tract .The successful isolation of some gastrointestinal hormones and the development of sensitive methods for their detection have led to the unexpected finding that they also exist in the brain .

关键词： Adrenergic Uptake Inhibitors Animals Body Fluids Cell Count Duodenum Gastrin-Secreting Cells Gastrins Jejunum Male Pyloric Antrum Rats Rats, Sprague-Dawley Research Support, Non-U.S. Gov't Reserpine Somatostatin Somatostatin-Secreting Cells Stomach Diseases

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My road on interventional radiology

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World Journal of Radiology 2010年第10期2卷 414-416页

作者： Yan-Hao Li,department of Interventional Radiology,nanfang hospital,southern medical university,guangzhou 510515,Guangdong Province,china Yan-Hao Li Department of Interventional Radiology Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China.

The author tells a story of how he has become an expert of interventional radiotherapy from a graduate of middle *** his childhood,he wanted to become an ***,he was forced to go to the countryside as a school *** 1974,he was enrolled as a"worker-peasant-soldier"student in Henan medical *** graduated from the college,he was assigned to the Radiology department of the First Affiliated hospital of Henan medical College where he worked hard as an assistant ***,he was transferred to nanfang hospital(guangzhou,china) where he achieved great successes and thus has become an expert of interventional radiology.

关键词： School graduate 'Worker-peasant-soldier' student Interventional radiology

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Percutaneous transhepatic metal versus plastic biliary stent in treating malignant biliary obstruction: a multiple center investigation

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Hepatobiliary & Pancreatic Diseases International 2003年第4期2卷 594-597页

作者： Yuan-Xing Guo Yan-Hao Li Yong Chen Ping-Yan Chen Peng-Fei Luo Yong Li Hong Shan Zai-Bo Jiang the department of Interventional Radiology, nanfang hospital, First Military medical university, guangzhou 510515, china department of medical Statistics, First Military medical university, guangzhou 510515, china department of Radiology, Guangdong Provincial People’s hospital, guangzhou 510080, china department of Radiology, Third Affiliated hospital of Sun Yat-Sen university of medical Sciences, guangzhou 510630, china department of Interventional Radiology Nanfang Hospital First Military Medical University Guangzhou 510515 China. guoyuanxing@***

OBJECTIVE: To compare the efficacy of metal versus plastic biliary stent implantation in the treatment of malignant biliary obstruction. METHODS: Percutaneous transhepatic self-expandable metal stent (MS, n=61) and 10F plastic stent (PS, n=34) were placed in 95 patients with malignant biliary obstruction in three hospitals of Guangdong province. All patients were followed up until death or at least one year after the procedure. Kaplan-Meier analysis was used to compare the survival of the patients and the rates of stent patency. RESULTS: The 30-day mortality rate was lower in the MS group (6/61, 9.8%) than in the PS group (9/34, 26.5%, P<0.05). The 30-day reobstruction rate and the complication rate were 15.0%, 16.4% in the MS group and 32. 4%, 29. 4% in the PS group, respectively (P<0. 01). The median patency period of stents and median survival period of the patients were 230 days, 224 days in the MS group and 90 days, 94 days in the PS group, respectively (P<0. 01). CONCLUSION: Metal stent is clinically superior to plastic stent in the treatment of malignant biliary obstruction.

关键词： radiology interventional stent biliary obstruction

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