Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in StageⅡ-Ⅲcolon cancer patients

作     者：Nian-hua Zhang~(1,2#),Jie Li~(3#),Yin Li~4,Xin-tao Zhang~5,Wen-ting Liao~(6,7,8),Jun-yi Zhang~1,Rong Li~1,Rong-cheng Luo~(1*) 1,Department of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China 2,Department of Oncology,Guangdong Second Provincial Traditional Chinese Medicine Hospital,Guangzhou 510095,China 3,Department of Vascular Surgery, The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510080,China 4, Department of Gastrointestinal Surgery,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510080,China 5,Department of Sports Medicine,Peking University Shenzhen Hospital,Shenzhen 518036,China 6,Department of Pathology,School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,China 7,Department of Pathology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China 8, Guangdong Provincial Key Laboratory of Molecular Tumour Pathology,Guangzhou 510515, China 

会议名称：《2012年全国肿瘤分子标志学术大会与国际肿瘤转化医学论坛暨第七届中国中青年肿瘤专家论坛》

会议日期：2012年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：Although CXCR4 and CD133 have been implicated in the metastatic process of malignant tumors,the clinicopathological significance of their expression in human colon cancer is not fully *** present study was aimed to examine the expression of CXCR4 and CD133 protein in stageⅡorⅢcolon cancer and related lymph nodes,and to investigate the clinical and prognostic significance in colon cancer. Immunohistochemistry was performed to examine CXCR4 and CD133 protein expression in paraffin-embedded stageⅡorⅢprimary colon cancer tissues and matched lymph nodes. The correlation between the two proteins expression and clinicopathological parameters and the patients’ 5-year survival was *** have found that CXCR4 expression was detected in 74 of the 125 tumors(59.2%),and CD133 expression was detected in 45 of the 125 tumors(36.0%).Upon combining the expression of CXCR4 and CD133,co-expression (both CXCR4 and CD133 were positve) was detected in 29 of the 125 tumors(23.2%).When compared with the other combinations,co-expression of CXCR4 and CD133 proteins was significantly associated with the AJCC stage(P = 0.029) and the lymph node status(P = 0.020).Log-rank statistics showed that the AJCC stage(P = 0.014),lymph node status(P = 0.011),CXCR4 expression(P = 0.023),CD133 expression(P = 0.034),and co-expression of CXCR4 and CD133 proteins(P = 0.003) were significant prognostic indicators for overall patients *** have shown that co-expression of CXCR4 and CD133 proteins is a risk factor for worse overall survival in stageⅡorⅢcolon cancer patients, indicating that co-expression of CXCR4 and CD133 proteins might contribute to the progression of colon cancer.