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GENETIcs-BETTER life FOR ALL

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Bulletin of the chinese Academy of sciences 1998年第4期12卷 270-274页

作者： Jiazhen Tan (c. c. Tan)(fudan university, shanghai, c.ina)

Longevity and abundant harvests are the two traditional chinese aspirations for human welfare. This means that, through scientific exchanges and international cooperation, the results of genetic research may serve to ... 详细信息

关键词： GENETIcs-BETTER life FOR ALL gene

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Relationships of Aegilops tauschii revealed by DNA fingerprints:The evidence for agriculture exchange between c.ina and the West

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Progress in Natural science:Materials International 2008年第12期18卷 1525-1531页

作者： Huiting Wei~a Jun Li~a Zhengsong Peng~b Baorong Lu~c Zhijun Zhao~d Wuyun Yang~a a crop Research Institute,sichuan Academy of Agricultural sciences,chengdu 6.006.,c.ina b life science college,c.ina West Normal university,Nanchong 6.7002,c.ina c The Ministry of Education Key Laboratory for Biodiversity science and Ecological Engineering,Institute of Biodiversity science,fudan university,shanghai 2.04.3,c.ina d chinese Academy of social science,Beijing 110710,c.ina [a]crop Research Institute Sichuan Academy of Agricultural Sciences Chengdu 610066 China [b]life science college China West Normal University Nanchong 637002 China [c]The Ministry of Education Key Laboratory for Biodiversity science and Ecological Engineering Institute of Biodiversity Science Fudan University Shanghai 200433 China [d]chinese Academy of social science Beijing 110710 China

Genetic diversity and relationships of wild goat grass (Aegilops tauschii cosson) from Iran and Xinjiang,west c.ina,as well as its weedy type from the Yellow River region of shaanxi and Henan provinces in c.ina were analyzed by simple sequence repeat (ssR) fingerprints.A high level of genetic diversity in Aegilops tauschii accessions from Iran was observed,and the richness of genetic diversity was followed by accessions from shaanxi,Henan,and *** weedy type of Aegilops tauschii showed a close genetic relationship with the wild type from different regions in *** results indicated that the weedy Aegilops tauschii found in the Yellow River region was most likely introduced from Iran—the diversity center of Aegilops *** weedy Aegilops tauschii populations found in the Yellow River region may be brought into the central part of c.ina as a weed species together with common wheat (Triticum aestivum L.) from the West during various periods of time in *** finding has provided strong evidence for the introduction of common wheat from the West into c.ina via the silk Road,and also demonstrated the important role of the silk Road in the exchange of agri- culture and other relevant technologies between c.ina and the West.

关键词： The silk Road Aegilops tauschii common wheat ssR fingerprints Genetic diversity Affinity crop dispersion

characterization of three class B and c MADs-box genes from Phalaenopsis orchid

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Characterization of three class B and C MADS-box genes from ...

sHEsis,a powerful software platform for analyses of linkage disequilibrium,haplotype construction,and genetic association at polymorphism loci

第二届上海市植物生理学青年学术研讨会

作者： Hao Zhang, Feng Ming*Institute of Genetics, sc.ool of life science, fudan university,shanghai 2.04.3, c.ina

＜正＞MADs-box genes are important in controlling the development of flower organ identity in plants, and the ABc Model that describes the mechanism for the

关键词： ABc model Arabidopsis MADs box overexpression Phalaenopsis

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cell Research 2005年第2期15卷 97-98页

作者： Yong Yong sHI1,2, Lin HE2,3,*1Bio-X life science Research center, shanghai Jiao Tong university, shanghai, c.ina 2Institute for Nutritional sciences, shanghai Institute of Biological sciences, chinese Academy of sciences, shanghai,c.ina 3NHGG, Bio-X center, shanghai Jiao Tong university, shanghai, c.ina Bio-XlifescienceResearchcenter ShanghaiJiaoTongUniversityShanghaiChina InstituteforNutritionalsciences ShanghaiInstituteofBiologicalSciencesChineseAcademyofSciencesShanghaiChina

In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses oflinkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large numberof samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data,we developed a robust and user-friendly software platform with a series of tools for analysis in association study withhigh efficiency. The platform has been well evaluated by several sets of real data.

关键词： software linkage disequilibrium haplotype analysis genetic association study.

Building of hFⅨ transgenic mice by spermatogenic cells

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chinese science Bulletin 2003年第19期48卷 2061-2063页

作者： WANG Ning, cHEN Xiaoguang, cHEN Li, YAO Jihua, cHEN Haoming, sHEN Qi & XUE Jinglun state Key Laboratory of Genetic Engineering, Institute of Genetics, sc.ool of life sciences, fudan university, shanghai 2.04.3, c.ina correspondence should be addressed to Xue Jinglun (e-mail: jlxue @***) state Key Laboratory of Genetic Engineering Institute of Genetics School of Life Sciences Fudan University Shanghai China

Human FⅨ expression vector pcMVⅨ was packaged by EffecteneTM reagent and injected into mice seminiferous tubules with glass pipettes. The expressional frame of pcMVⅨ was examined by PcR and southern blotting among 41 progenies. There were 2 (4%) mice being integrated with hFⅨ gene into chromosomes. 4.6.ng/mL of hFⅨ protein was expressed in plasma of one mouse, which was tested by ELIsA. We demonstrated that building of transgenic animals by spermatogonial stem cells is an efficient method. Meanwhile, it has also been proved to be an alternative choice for mammary gland bioreactor.

关键词：基因转录老鼠精子生成细胞抗血友病因子 FⅨ 表达载体 pcMVⅨ 乳腺生物反应器

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The altered DNA methylation pattern and its implications in liver cancer

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cell Research 2005年第4期15卷 272-280页

作者： Jing De ZHU1,2,*1The state-key Laboratory for Oncogenes and Related Genes, shanghai cancer Institute, shanghai Jiaotong university, LN 2200/25, Xietu Road, shanghai 200032, c.ina.2The collage of life sciences, Zhejiang science and Technology university, Xiasha university District, Hangzhou, Zhejiang 310018, c.ina. Thestate-keyLaboratoryforOncogenesandRelatedGenes ShanghaiCancerInstituteShanghaiJiaotongUniversityLN220025XietuRoad200032

DNA methylation is the most intensively studied epigenetic phenomenon, disturbances of which result in changes ingene transcription, thus exerting drastic imparts onto biological behaviors of cancer. Both the global demethylation andthe local hypermethylation have been widely reported in all types of tumors, providing both challenges and opportunitiesfor a better understanding and eventually controlling of the malignance. However, we are still in the very early stage ofinformation accumulation concerning the tumor associated changes in DNA methylation pattern. A number of excellentrecent reviews have covered this issue in depth. Therefore, this review will summarize our recent data on DNA methy-lation profiling in cancers. Perspectives for the future direction in this dynamic and exciting field will also be given.

关键词： DNA methylation epigenetics liver cancer tumor staging and classification.

Phenolic components from Rhododendron latoucheae Part 5 in the series "chemical studies on Ericaceae Plants

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chinese chemical Letters 1999年第7期10卷 567-570页

作者： cheng Qi FAN Gen Jin YANG Wei Min ZHAO Bing Yang DING Guo Wei QIN(shanghai Institute of Materia Medica, chinese Academy of sciences. shanghai 200031)(college of Pharmacy. second Military Medical university. shanghai 2.04.3)(college of life science. Ha chinese Acad sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China second Mil Med Univ Coll Pharm Shanghai 200433 Peoples R China Hangzhou Univ Coll Life Sci Hangzhou 310012 Peoples R China

From the leaves of Rhododendron latoucheae (Ericaceae), two new natural phenolic compounds named (+)-rhodolatouchol 1 and isoepirhododendrin 4 were identified. six other known compounds, (+)-rhododendrol, epirhododendrin, 4-[3'-O-beta-D-glucopyranosyl-4'-hydroxyphenyl]-2-butanone, 4-(4'-O-beta-D-glucopyranosylphenyl)-2-butanone, benzyl-O-beta-D-glucopyranoside and arbutin were also obtained.

关键词： Rhododendron latoucheae Ericaceae, (+)-rhodolatouchol isoepirhododendrin

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cDNA cloning of Two Novel T-superfamily conotoxins from conus leopardus

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Acta Biochimica et Biophysica sinica 2006年第4期38卷 287-291页

作者： Wei-Hua cHEN~(1,2#) Yu-Hong HAN~(2,3#) Qi WANG~(2,3#) Xiao-Wei MIAO~(2,4) Ling OU~1 Xiao-Xia sHAO~2* 1 Bioengineering Institute,East c.ina university of science and Technology,shanghai 200237,c.ina 2 Institute of Protein Research,Tongji university,shanghai 200092,c.ina 3 Institute of Biochemistry and cell Biology,shanghai Institute of Biochemical sciences,chinese Academy of sciences,shanghai 200031,c.ina 4 Department of Biological Engineering,sc.ool of life science,shanghai university,shanghai 200436.c.ina Bioengineering Institute East China University of Science and Technology Shanghai 200237 China

The full-length cDNAs of two novel T-superfamily conotoxins,Lp5.1 and Lp5.2,were clonedfrom a vermivorous cone snail conus leopardus using 3'/5'-rapid amplification of cDNA *** cDNA ofLp5.1 encodes a precursor of 6. residues,including a 22-residue signal peptide,a 28-residue propeptide anda 15-residue mature ***5.1 is processed at the common signal site -X-Arg- immediately before themature peptide *** the case of Lp5.2,the precursor includes a 25-residue signal peptide anda 43-residue sequence comprising the propeptide and mature peptide,which is probably cleaved to yield a29-residue propeptide and a 14-residue mature *** these two conotoxins share a similar signalsequence and a conserved disulfide pattern with the known T-superfamily,the pro-region and mature peptidesare of low identity,especially Lp5.2 with an identity as low as 10.7% compared with the reference *** elucidated cDNAs of these two toxins will facilitate a better understanding of the species distribution,the sequence diversity of T-superfamily conotoxins,the special gene structure and the evolution of thesepeptides.

关键词： conus leopardus T-superfamily conotoxin cDNA cloning

Identification and genetic mapping of four novel genes that regulate leaf development in Arabidopsis

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cell Research 2000年第4期10卷 325-335页

作者： sUN YUE WEI ZHANG FENG LING LI YING LI GUO TIAN LEI LIU HAI HUANG shanghai Institute of Plant Physiology, chinese Academy of science, 300 Fenglin Road, shanghai 200032, c.ina sc.ool of life sciences, university of science and Technology of c.ina. 1shanghai Institute of Plant Physiology Chinese Academy of Science 300 Fenglin Road Shanghai 200032 China 1shanghai Institute of Plant Physiology Chinese Academy of Science 300 Fenglin Road Shanghai 200032 China 1shanghai Institute of Plant Physiology Chinese Academy of Science 300 Fenglin Road Shanghai 200032 China 2sc.ool of life sciences University of Science and Technology of China. P.O.Box 4 Hefei Anhui 230027 China 1shanghai Institute of Plant Physiology Chinese Academy of Science 300 Fenglin Road Shanghai 200032 China 3shanghai Research center of life sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China

Molecular and genetic characterizations of mutants have led to a better understanding of many developmental processes in the model system Arabidopsis thaliana. However, the leaf development that is specific to plants has been little studied. With the aim of contributing to the genetic dissection of leaf development, we have performed a large-scare screening for mutants with abnormal leaves. Among a great number of leaf mutants we have generated by T-DNA and transposon tagging and ethylmethae sulfonate (EMs) mutagenesis, four independent mutant lines have been identified and studied genetically. Phenotypes of these mutant lines represent the defects of four novel nuclear genes designated LL1 (LOTUs LEAF 1), LL2 (LOTUs LEAF 2), URO (UPRIGHT ROsETTE), and EIL (ENVIRONT cONDITION INDUcED LEsION). The phenotypic analysis indicates that these genes play important roles during leaf development. FOr the further genetic analysis of these genes and the map-based cloning of LL1 and LL2, we have mapped these genes to chromosome regions with an efficient and rapid mapping method.

关键词： Arabidopsis leaf mutant leaf development genetic mappin?