The altered DNA methylation pattern and its implications in liver cancer

作     者：Jing De ZHU1,2,*1The State-key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, LN 2200/25, Xietu Road, Shanghai 200032, China.2The Collage of Life Sciences, Zhejiang Science and Technology University, Xiasha University District, Hangzhou, Zhejiang 310018, China. Jing De ZHU1,2,*1The State-key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, LN 2200/25, Xietu Road, Shanghai 200032, China.2The Collage of Life Sciences, Zhejiang Science and Technology University, Xiasha University District, Hangzhou, Zhejiang 310018, China.

作者机构：The State-key Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute Shanghai Jiaotong University LN 2200/25 Shanghai China The Collage of Life Sciences Zhejiang Science and Technology University Xiasha University District Hangzhou Zhejiang China 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2005年第15卷第4期

页      面：272-280页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Shanghai Science Foundation(04DZ14006) 国家自然科学基金(30450001) 国家重点基础研究发展计划(973计划)(2004CB518804) 国家高技术研究发展计划(863计划)(2002AA2Z3352) 

主　　题：DNA methylation epigenetics liver cancer tumor staging and classification. 

摘      要：DNA methylation is the most intensively studied epigenetic phenomenon, disturbances of which result in changes ingene transcription, thus exerting drastic imparts onto biological behaviors of cancer. Both the global demethylation andthe local hypermethylation have been widely reported in all types of tumors, providing both challenges and opportunitiesfor a better understanding and eventually controlling of the malignance. However, we are still in the very early stage ofinformation accumulation concerning the tumor associated changes in DNA methylation pattern. A number of excellentrecent reviews have covered this issue in depth. Therefore, this review will summarize our recent data on DNA methy-lation profiling in cancers. Perspectives for the future direction in this dynamic and exciting field will also be given.